Day: October 26, 2021

Category: benzodioxans. Authors Rana, M; Arif, R; Khan, FI; Maurya, V; Singh, R; Faizan, MI; Yasmeen, S; Dar, SH; Alam, R; Sahu, A; Ahmad, T; Rahisuddin in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Rana, Manish; Arif, Rizwan; Yasmeen, Shama; Dar, Sajad Hussain; Rahisuddin] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India; [Khan, Faez Iqbal] Univ Elect Sci & Technol China, Sch Elect Sci & Engn, Chengdu, Peoples R China; [Maurya, Vikas; Singh, Raja] Jawharlal Nehru Univ, Special Ctr Mol Med, New Delhi 110067, India; [Faizan, Md Imam; Ahmad, Tanveer] Jamia Millia Islamia, Multidisciplinary Ctr Adv Res & Studies, New Delhi 110025, India; [Alam, Raquib] Jamia Millia Islamia, Univ Polytech, Dept Appl Sci, New Delhi 110025, India; [Sahu, Ankita] Safdarjung Hosp Campus, ICMR Natl Inst Pathol, New Delhi 110029, India in 2021.0, Cited 77.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

N-formyl pyrazoline derivatives (3a-3l) were designed and synthesized via Michael addition reaction through cyclization of chalcones with hydrazine hydrate in presence of formic acid. The structural elucidation of N-formyl pyrazoline derivatives was carried out by various spectroscopic techniques such as H-1, C-13 NMR, FT-IR, UV-visible spectroscopy, mass spectrometry and elemental analysis. Anticancer activity of the pyrazoline derivatives (3a-3l) was evaluated against human lung cancer (A549), fibrosarcoma cell lines (HT1080) and human primary normal lung cells (HFL-1) by MTT assay. The results of anticancer activity showed that potent analogs 3b and 3d exhibited promising activity against A549 (IC50 = 12.47 +/- 1.08 and 14.46 +/- 2.76 mu M) and HT1080 (IC50 = 11.40 +/- 0.66 and 23.74 +/- 13.30 mu M) but low toxic against the HFL-1 (IC50 =116.47 +/- 43.38 and 152.36 +/- 22.18 mu M). The anticancer activity of potent derivatives (3b and 3d) against A549 cancer cell line was further confirmed by flow cytometry based approach. DNA binding interactions of the pyrazoline derivatives 3b and 3d have been carried out with calf thymus DNA (Ct-DNA) using absorption, fluorescence and viscosity measurements, circular dichroism and cyclic voltammetry. Antioxidant potential of N-formyl pyrazoline derivatives (3a-3l) has been also estimated through DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical and H2O2. Results revealed that all the compounds exhibited significant antioxidant activity. In silico molecular modelling and ADMET properties of pyrazoline derivatives were also studied using PyRx software against topoisomerase II receptor with PDB ID: 1ZXM to explore their best hits. MD simulation of 3b and 3d was also carried out with topoisomerase II for structure-function correlation in a protein. HuTopoII inhibitory activity of the analogs (3a-3l) was examined by relaxation assay at varying concentrations 100-1000 mu M.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Rana, M; Arif, R; Khan, FI; Maurya, V; Singh, R; Faizan, MI; Yasmeen, S; Dar, SH; Alam, R; Sahu, A; Ahmad, T; Rahisuddin or concate me.. Category: benzodioxans

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019 ORG LETT published article about PALLADIUM-CATALYZED CARBONYLATION; ARYL IODIDES; EXPEDITIOUS SYNTHESIS; AROMATIC SPIROKETALS; ASYMMETRIC-SYNTHESIS; NATURAL-PRODUCTS; ALKYNYL KETONES; O-IODOPHENOLS; FORMIC-ACID; CHROMONES in [Xiang, Kuirong; Tong, Pei; Yan, Baorun; Long, Lingling; Zhao, Chunbo; Zhang, Yuan; Li, Ying] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China in 2019, Cited 86. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3. Recommanded Product: 86-29-3

A one-pot Pd-catalyzed carbonylative Sonogashira coupling in tandem with double annulation reaction to synthesize benzannulated [6,6]-spiroketals from o-iodophenols and terminal alkynols or alkynyl phenols was achieved. The protocol provides straightforward and facile access to benzannulated [6,6]-spiroketals in moderate to good yields and excellent diastereoselectivities under balloon pressure of CO at room temperature.

Recommanded Product: 86-29-3. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Xiang, KR; Tong, P; Yan, BR; Long, LL; Zhao, CB; Zhang, Y; Li, Y or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Xu, DP; Xiong, ML; Kazemnejadi, M in ROYAL SOC CHEMISTRY published article about in [Xu, DaPeng] Gansu Ind Polytech Coll, Inst Chem Technol, TianShui 741000, Peoples R China; [Xiong, Meilu] Gansu Hlth Vocat Coll, Publ Fdn Coll, Lanzhou 730207, Peoples R China; [Kazemnejadi, Milad] Univ Birjand, Fac Sci, Dept Chem, Birjand, Iran in 2021.0, Cited 55.0. Safety of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A new, versatile, and green methodology has been developed for the efficient NaBH4-reduction of nitroarenes as well as the domino/reduction MCR preparation of 1-substituted-1H-1,2,3,4-tetrazoles using Pd(ii)-polysalophen coated magnetite NPs as an efficient heterogeneous magnetically recyclable nanocatalyst. Polysalophen was firstly prepared based on a triazine framework with a high degree of polymerization, then coordinated to Pd ions and, finally, the resulting hybrid was immobilized on magnetite NPs. The catalyst was characterized by various instrumental and analytical methods, including GPC, DLS, N-2 adsorption-desorption, TGA, VSM, TEM, HRTEM, EDX, XPS, XRD, and ICP analyses. The catalyst possesses dual-functionality including the reduction of nitroarenes and the construction of tetrazole rings all in one step via a domino protocol. High to excellent yields were obtained for both nitro reduction and the direct preparation of 1-substituted-1H-1,2,3,4-tetrazoles from nitro compounds. Insight into the mechanism was conducted by XPS in situ as well as DLS in situ along with several control experiments. Recyclability of the catalyst was studied for 6 consecutive runs along with metal leaching measurements in each cycle.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Xu, DP; Xiong, ML; Kazemnejadi, M or concate me.. Safety of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Formula: C8H7NO3. Authors Haldys, K; Goldeman, W; Anger-Gora, N; Rossowska, J; Latajka, R in MDPI published article about in [Haldys, Katarzyna; Latajka, Rafal] Wroclaw Univ Sci & Technol, Dept Bioorgan Chem, PL-50370 Wroclaw, Poland; [Goldeman, Waldemar] Wroclaw Univ Sci & Technol, Dept Organ & Med Chem, PL-50370 Wroclaw, Poland; [Anger-Gora, Natalia; Rossowska, Joanna] Polish Acad Sci, Ludwik Hirszfeld Inst Immunol & Expt Therapy, PL-53114 Wroclaw, Poland in 2021.0, Cited 58.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A set of 12 monosubstituted acetophenone thiosemicarbazone derivatives (TSCs) were synthesized and their inhibitory properties toward tyrosinase activity were tested. Moreover, their ability to inhibit melanogenesis in the B16F10 murine melanoma cell line was studied. In order to investigate the nature of interactions between the enzyme and the inhibitors, molecular docking to the active site was performed. TSCs 5, 6, 8, and 9 revealed a half maximal inhibitory concentration (IC50) below 1 mu M. Compound 6 turned out to be the most potent tyrosinase inhibitor. All investigated compounds showed reversible inhibition of competitive or mixed type. The para-substituted TSCs had higher affinity for the enzyme as compared to their ortho- and meta-analogues. All investigated compounds inhibited melanin production in B16F10 cells at the micromolar level. Molecular docking showed that the sulfur atom of the thiourea moiety penetrates the active site and interacts with copper ions. The above outcomes might be helpful in the design of new tyrosinase inhibitors in the food and cosmetic industries.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Haldys, K; Goldeman, W; Anger-Gora, N; Rossowska, J; Latajka, R or concate me.. Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article From alkylarenes to anilines via site-directed carbon-carbon amination WOS:000453261100016 published article about C-C BOND; H AMINATION; CLEAVAGE; ACTIVATION; CATALYSIS; NITROGENATION; NITRATION; HYDROGEN; AMINES in [Liu, Jianzhong; Qiu, Xu; Huang, Xiaoqiang; Luo, Xiao; Zhang, Cheng; Wei, Jialiang; Pan, Jun; Liang, Yujie; Zhu, Yuchao; Qin, Qixue; Song, Song; Jiao, Ning] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China; [Jiao, Ning] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai, Peoples R China in 2019.0, Cited 50.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Anilines are fundamental motifs in various chemical contexts, and are widely used in the industrial production of fine chemicals, polymers, agrochemicals and pharmaceuticals. A recent development for the synthesis of anilines uses the primary amination of C-H bonds in electron-rich arenes. However, there are limitations to this strategy: the amination of electron-deficient arenes remains a challenging task and the amination of electron-rich arenes has a limited control over regioselectivity-the formation of meta-aminated products is especially difficult. Here we report a site-directed C-C bond primary amination of simple and readily available alkylarenes or benzyl alcohols for the direct and efficient preparation of anilines. This chemistry involves a novel C-C bond transformation and offers a versatile protocol for the synthesis of substituted anilines. The use of O-2 as an environmentally benign oxidant is demonstrated, and studies on model compounds suggest that this method may also be used for the depolymerization of lignin.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Liu, JZ; Qiu, X; Huang, XQ; Luo, X; Zhang, C; Wei, JL; Pan, J; Liang, YJ; Zhu, YC; Qin, QX; Song, S; Jiao, N or concate me.. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

SDS of cas: 100-19-6. In 2019.0 ASIAN J ORG CHEM published article about CROSS-COUPLING REACTIONS; ALKENYL SULFIDES; C-S; HYDROTHIOLATION; PALLADIUM; EFFICIENT; CATALYST; KETONES; ALKYNES; LIGAND in [Shi, Zi-Fa; Xu, Li-Ning; Chen, Jie; Luo, Hui-Xing; Zhang, Juntao; Cao, Xiao-Ping] Lanzhou Univ, State Key Lab Appl Organ Chem, 222 Tianshui Rd, Lanzhou 730000, Gansu, Peoples R China; [Shi, Zi-Fa; Xu, Li-Ning; Chen, Jie; Luo, Hui-Xing; Zhang, Juntao; Cao, Xiao-Ping] Lanzhou Univ, Coll Chem & Chem Engn, 222 Tianshui Rd, Lanzhou 730000, Gansu, Peoples R China in 2019.0, Cited 56.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

An efficient radical-mediated carbon-sulfur bond formation reaction of vinyl halides with thiols has been developed. This reaction tolerated vinyl chloride substrates, which are barely tolerated in metal-catalyzed reactions, providing vinyl sulfide products. When vinyl iodides were used as substrates, the reactions were regulated by the solvents, yielding vinyl sulfide products in protic solvents (methanol) and alkyl sulfides in aprotic solvents (toluene).

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Shi, ZF; Xu, LN; Chen, J; Luo, HX; Zhang, JT; Cao, XP or concate me.. SDS of cas: 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Formula: C8H7NO3. Recently I am researching about ASYMMETRIC-SYNTHESIS; ALPHA-ALKYLATION; ALLYLIC ALCOHOLS; INHIBITORS; DISCOVERY; ALDEHYDES; BENZYLATION; ARYLATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [NSFC22071267]; Foundation of the Open Project of State Key Laboratory of Natural Medicines [SKLNMZZ202023, CPU2018GY35]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhu, XY; Li, RB; Yao, HQ; Lin, AJ. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

A palladium-catalyzed allenamide carbopalladation/allylation with active methine compounds has been developed. Various indoles and isoquinolinones bearing a quaternary carbon center were achieved with good efficiency, a broad substrate scope and good functional group tolerance. This reaction underwent cascade oxidative addition, carbopalladation, and allylic alkylation, and two new C-C bonds were formed in one pot.

Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Zhu, XY; Li, RB; Yao, HQ; Lin, AJ or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Pd immobilized on the composite of halloysite and low-cost bio-based eutectic solvent-derived carbon: An efficient catalyst for hydrogenation in the presence of cyclodextrin WOS:000539214200005 published article about HETEROGENEOUS CATALYST; BETA-CYCLODEXTRIN; NANOPARTICLES; NANOTUBES; PRECURSORS; NANOCOMPOSITE; GRAPHENE; SUPPORTS; BIOCHAR; AGENTS in [Sadjadi, Samahe] Iran Polymer & Petrochem Inst, Fac Petrochem, Gas Convers Dept, POB 14975-112, Tehran, Iran; [Akbari, Maryam; Heravi, Majid M.] Alzahra Univ, Sch Sci, Dept Chem, POB 1993891176, Tehran, Iran; [Kahangi, Fatemeh Ghoreyshi] Univ Guilan, Dept Chem, Univ Campus 2, Rasht, Iran in 2020.0, Cited 56.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Safety of 1-(4-Nitrophenyl)ethanone

Using urea and glucose as cost effective and available raw materials, a eutectic solvent, was fabricated and applied as a precursor to form N-doped carbon. Subsequently, the eutectic solvent-derived carbon was reacted with halloysite nanoclay through hydrothermal process to produce a novel nanocomposite. The resultant compound was utilized as a support for the immobilization of Pd nanoparticles. The final nanocomposite was then employed as a highly active and selective catalyst for promoting hydrogenation reaction of nitroarenes in the presence of cyclodextrin as co-catalyst. To elucidate the roles of the eutectic solvent-derived carbon, halloysite and the ratio of halloysite: eutectic solvent-derived carbon in the catalysis, several control samples were prepared and their activities were compared with that of the catalyst. Furthermore, the role of cyclodextrin in the catalysis was approved by comparing the catalytic efficiency of the catalyst in the absence and the presence of cyclodextrin. It was found that cyclodextrin exerted its role via acing as phase transfer agent, while eutectic solvent-derived carbon could significantly increase the Pd loading. On the other hand, the ratio of halloysite: eutectic solvent-derived carbon could influence the performance of the catalyst. Notably, the catalyst was recyclable up to six reaction runs.

Safety of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Sadjadi, S; Akbari, M; Kahangi, FG; Heravi, MM or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Kumar, S; Kaushik, A; Narasimhan, B; Shah, SAA; Lim, SM; Ramasamy, K; Mani, V in BMC published article about DESIGN in [Kumar, Sanjiv; Kaushik, Archana; Narasimhan, Balasubramanian] Maharshi Dayanand Univ, Fac Pharmaceut Sci, Rohtak 124001, Haryana, India; [Shah, Syed Adnan Ali; Lim, Siang Meng; Ramasamy, Kalavathy] Univ Teknol MARA UiTM, Fac Pharm, Bandar Puncak Alam 42300, Selangor Darul, Malaysia; [Shah, Syed Adnan Ali] Univ Teknol MARA, Atta Ur Rahman Inst Nat Prod Discovery AuRIns, Bandar Puncak Alam 42300, Selangor Darul, Malaysia; [Lim, Siang Meng; Ramasamy, Kalavathy] Univ Teknol MARA UiTM, Collaborat Drug Discovery Res CDDR Grp, Shah Alam 40450, Selangor Darul, Malaysia; [Mani, Vasudevan] Qassim Univ, Coll Pharm, Dept Pharmacol & Toxicol, Buraydah 51452, Saudi Arabia in 2019.0, Cited 31.0. SDS of cas: 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Pyrimidine nucleus is a significant pharmacophore that exhibited excellent pharmacological activities. A series of pyrimidine scaffolds was synthesized and its chemical structures were confirmed by physicochemical and spectral analysis. The synthesized compounds were evaluated for their antimicrobial potential towards Gram positive and negative bacteria as well as fungal species. They were also assessed for their anticancer activity toward a human colorectal carcinoma cell line (HCT116). Whilst results of antimicrobial potential revealed that compounds Ax2, Ax3, Ax8 and Ax14 exhibited better activity against tested microorganisms, the results of antiproliferative activity indicated that compounds Ax7 and Ax10 showed excellent activity against HCT116. Further, the molecular docking of pyrimidine derivatives Ax1, Ax9 and Ax10 with CDK8 (PDB id: 5FGK) protein indicated that moderate to better docking results within the binding pocket. Compounds Ax8 and Ax10 having significant antimicrobial and anticancer activities may be selected as lead compounds for the development of novel antimicrobial and anticancer agent, respectively.

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Kumar, S; Kaushik, A; Narasimhan, B; Shah, SAA; Lim, SM; Ramasamy, K; Mani, V or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Chen, JJ; Meng, HX; Zhang, F; Xiao, FH; Deng, GJ in [Chen, Jinjin; Meng, Huanxin; Zhang, Feng; Xiao, Fuhong; Deng, Guo-Jun] Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environmentally Friendly Chem & Applicat, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China; [Zhang, Feng] Hunan Agr Univ, Coll Sci, Changsha 410128, Hunan, Peoples R China published Transition-metal-free selective pyrimidines and pyridines formation from aromatic ketones, aldehydes and ammonium salts in 2019.0, Cited 105.0. SDS of cas: 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

An efficient synthesis of pyrimidines and pyridines has been developed from readily available aromatic ketones, aldehydes and ammonium salts under transition-metal-free conditions. In this strategy, ammonium salts were used as nitrogen sources and only water was generated as a nontoxic byproduct. A catalytic amount of NaIO4 played an important role in the selectivity control, whereas substituted pyridines were dominantly formed in its absence.

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Chen, JJ; Meng, HX; Zhang, F; Xiao, FH; Deng, GJ or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem