Month: October 2021

Authors Ling, J; Bennett, CS in WILEY-V C H VERLAG GMBH published article about BIOLOGICAL ROLES; OLIGOSACCHARIDES; GLUCOPYRANOSYL; KETONES; ACCESS; GALACTOSYLCERAMIDE; CONSTRUCTION; ENHANCEMENT; MECHANISMS; CHEMISTRY in [Ling, Jesse; Bennett, Clay S.] Tufts Univ, 62 Talbot Ave, Medford, MA 02155 USA in 2020.0, Cited 72.0. Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

C-Glycosides are both a common motif in many bioactive natural products and important glycoside mimetics. We demonstrate that activating a hemiacetal with a sulfonyl chloride, followed by treating the resultant glycosyl sulfonate with an enolate results in the stereospecific construction of beta-linked C-glycosides. This reaction tolerates a range of acceptors and donors, including disaccharides. The resulting products can be readily derivatized into C-glycoside analogues of beta-glycoconjugates, including C-disaccharide mimetics.

Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Ling, J; Bennett, CS or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Jiang, R; Liu, X; Mu, YX; Iqbal, Z; He, LL; Zhai, LJ; Hou, J; Yang, MH; Yang, ZX; Tang, D in WILEY-V C H VERLAG GMBH published article about POLYSUBSTITUTED PYRIDINES; OXIME ACETATES; BOND-CLEAVAGE; CYCLIZATION; 2,4,6-TRIARYLPYRIDINES; DERIVATIVES; ANNULATION in [Jiang, Rui; Mu, Yangxiu; Iqbal, Zafar; He, Lili; Zhai, Lijuan; Hou, Jing; Yang, Zhixiang; Tang, Dong] Ningxia Acad Agr & Forestry Sci, Agr Resource & Environm Inst, Ningxia Ctr Agr Organ Synth, Yinchuan 750002, Ningxia, Peoples R China; [Liu, Xiang] China Three Gorges Univ, Coll Mat & Chem Engn, Yichang 443002, Hubei, Peoples R China; [Yang, Minghua; Tang, Dong] Lishui Univ, Dept Chem, Lishui 323000, Peoples R China in 2020.0, Cited 31.0. Recommanded Product: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Polyfunctional pyridines are backbone of numerous natural products and pharmaceutical reactive intermediates. We have developed an iron-catalyzed cyclization reaction between ketoxime carboxylates and nitrones to afford trisubstituted pyridines. Employing this strategy, we have synthesized a number of trisubstituted pyridines with various functional groups in good yields under simple reaction conditions. It is worth mentioning that the nitrones can serve as a novel C1 unit in organic synthesis.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Jiang, R; Liu, X; Mu, YX; Iqbal, Z; He, LL; Zhai, LJ; Hou, J; Yang, MH; Yang, ZX; Tang, D or concate me.. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Uranium versus Thorium: Synthesis and Reactivity of [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U[eta(2)-C2Ph2] WOS:000629388600001 published article about CHEMISTRY; COMPLEXES in [Wang, Deqiang; Ding, Wanjian; Hou, Guohua; Zi, Guofu] Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China; [Walter, Marc D.] Tech Univ Carolo Wilhelmina Braunschweig, Inst Anorgan & Analyt Chem, Hagenring 30, D-38106 Braunschweig, Germany in 2021, Cited 121. Category: benzodioxans. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3

The synthesis, electronic structure, and reactivity of a uranium metallacyclopropene were comprehensively studied. Addition of diphenylacetylene (PhC equivalent to CPh) to the uranium phosphinidene metallocene [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U=P-2,4,6-tBu(3)C(6)H(2) (1) yields the stable uranium metallacyclopropene, [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U[eta(2)-C2Ph2] (2). Based on density functional theory (DFT) results the 5f orbital contributions to the bonding within the metallacyclopropene U-(eta(2)-C=C) moiety increases significantly compared to the related Th-IV compound [eta(5)-1,2,4-(Me3C)(3)C5H2](2)Th[eta(2)-C2Ph2], which also results in more covalent bonds between the [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U2+ and [eta(2)-C2Ph2](2-) fragments. Although the thorium and uranium complexes are structurally closely related, different reaction patterns are therefore observed. For example, 2 reacts as a masked synthon for the low-valent uranium(II) metallocene [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U-II when reacted with Ph2E2 (E=S, Se), alkynes and a variety of hetero-unsaturated molecules such as imines, ketazine, bipy, nitriles, organic azides, and azo derivatives. In contrast, five-membered metallaheterocycles are accessible when 2 is treated with isothiocyanate, aldehydes, and ketones.

Category: benzodioxans. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Wang, DQ; Ding, WJ; Hou, GH; Zi, GF; Walter, MD or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article Acid-Catalyzed Pseudo Five-Component Annulation for a General One-Pot Synthesis of 2,4,6-Triaryl Pyrimidines published in 2020.0. Computed Properties of C8H7NO3, Reprint Addresses Ma, YM (corresponding author), Taizhou Univ, Sch Pharmaceut & Chem Engn, Taizhou 318000, Peoples R China.; Ma, YM (corresponding author), Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 310053, Peoples R China.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

A facile and general synthesis of 2,4,6-triaryl pyrimidines has been developed. It involves a one-pot [2+1+1+1+1] pseudo five-component annulation of one methyl ketone, two aldehydes and two NH4OAc catalyzed by TfOH. One C-C and four C-N bonds are formed during the oxidative annulation process. The reaction shows good tolerance of many important functional groups in air and produces only water as the coproduct, making this methodology a highly versatile alternative to the existing methods for structuring pyrimidine framework.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Ding, YX; Ma, RC; Hider, RC; Ma, YM or concate me.. Computed Properties of C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Synthetic Approaches to Metallo-Supramolecular Co-II Polygons and Potential Use for H2O Oxidation WOS:000580381700067 published article about WATER-OXIDATION; COORDINATION CAGES; DISCRETE; CAPTURE; RELEASE; SPIN; ELECTROCATALYSTS; CATALYSIS; EXCHANGE in [Ako, Ayuk M.; Kathalikkattil, Amal Cherian; Elliott, Rory; Soriano-Lopez, Joaquin; McKeogh, Ian M.; Zubair, Muhammad; Zhu, Nianyong; Garcia-Melchor, Max; Schmitt, Wolfgang] Univ Dublin, Trinity Coll, Sch Chem, Dublin D02 PN40, Ireland; [Ako, Ayuk M.; Kathalikkattil, Amal Cherian; Elliott, Rory; Soriano-Lopez, Joaquin; McKeogh, Ian M.; Zubair, Muhammad; Zhu, Nianyong; Garcia-Melchor, Max; Schmitt, Wolfgang] Univ Dublin, Trinity Coll, AMBER Ctr, Dublin D02 PN40, Ireland; [Kruger, Paul E.] Univ Canterbury, Sch Phys & Chem Sci, MacDiarmid Inst Adv Mat & Nanotechnol, Christchurch 8041, New Zealand in 2020.0, Cited 45.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Category: benzodioxans

Metal-directed self-assembly has been applied to prepare supramolecular coordination polygons which adopt tetrahedral (1) or trigonal disklike topologies (2). In the solid state, 2 assembles into a stable halide-metal-organic material (Hal-MOM-2), which catalyzes H2O oxidation under photo- and electrocatalytic conditions, operating with a maximum TON = 78 and TOF = 1.26 s(-1). DFT calculations attribute the activity to a Co-III-oxyl species. This study provides the first account of how Co-II imine based supramolecules can be employed as H2O oxidation catalysts.

Category: benzodioxans. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Ako, AM; Kathalikkattil, AC; Elliott, R; Soriano-Lopez, J; McKeogh, IM; Zubair, M; Zhu, NY; Garcia-Melchor, M; Kruger, PE; Schmitt, W or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 J AM CHEM SOC published article about ASYMMETRIC TRANSFER HYDROGENATION; PHOTOREDOX CATALYSIS; CYCLIZATION; REDUCTION; COMPLEXES; COFACTOR; BINDING; KETONES; DESIGN; AMINES in [Wei, Jianwei; Zhao, Liang; He, Cheng; Zheng, Sijia; Duan, Chunying] Dalian Univ Technol, Zhang Dayu Coll Chem, State Key Lab Fine Chem, Dalian 116024, Peoples R China; [Reek, Joost N. H.] Univ Amsterdam, Vant Hoff Inst Mol Sci, Sci Pk 904, NL-1098 XH Amsterdam, Netherlands in 2019.0, Cited 60.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Safety of 1-(4-Nitrophenyl)ethanone

Switchable selective hydrogenation among the groups in multifunctional compounds is challenging because selective hydrogenation is of great interest in the synthesis of fine chemicals and pharmaceuticals as a result of the importance of key intermediates. Herein, we report a new approach to highly selectively (>99%) reducing C=X (X = O, N) over the thermodynamically more favorable nitro groups locating the substrate in a metal-organic capsule containing NADH active sites. Within the capsule, the NADH active sites reduce the double bonds via a typical 2e(-) hydride transfer hydrogenation, and the formed excited-state NAD(+) mimics oxidize the reductant via two consecutive 1e(-) processes to regenerate the NADH active sites under illumination. Outside the capsule, nitro groups are highly selectively reduced through a typical 1e(-) hydrogenation. By combining photoinduced 1e(-) transfer regeneration outside the cage, both 1e(-) and 2e(-) hydrogenation can be switched controllably by varying the concentrations of the substrates and the redox potential of electron donors. This promising alternative approach, which could proceed under mild reaction conditions and use easy-to-handle hydrogen donors with enhanced high selectivity toward different groups, is based on the localization and differentiation of the 2e(-) and 1e(-) hydrogenation pathways inside and outside the capsules, provides a deep comprehension of photocatalytic microscopic reaction processes, and will allow the design and optimization of catalysts. We demonstrate the advantage of this method over typical hydrogenation that involves specific activation via well-modified catalytic sites and present results on the high, well-controlled, and switchable selectivity for the hydrogenation of a variety of substituted and bifunctional aldehydes, ketones, and imines.

Safety of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Wei, JW; Zhao, L; He, C; Zheng, SJ; Reek, JNH; Duan, C or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

SDS of cas: 100-19-6. In 2020.0 BIOORG CHEM published article about BIOLOGICAL EVALUATION; PHENYL AMIDES; DERIVATIVES; PYRIDINES; DESIGN in [Attia, Mohamed H.] October 6 Univ, Dept Pharmaceut Chem, Fac Pharm, Giza, Egypt; [Elrazaz, Eman Z.; Abouzid, Khaled A. M.] Ain Shams Univ, Fac Pharm, Pharmaceut Chem Dept, Cairo 11566, Egypt; [El-Emam, Soad Z.] October 6 Univ, Fac Pharm, Dept Pharmacol & Toxicol, Giza, Egypt; [Taher, Azza T.] Cairo Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Cairo, Egypt; [Abdel-Aziz, Hatem A.] Natl Res Ctr, Dept Appl Organ Chem, Cairo 12622, Egypt; [Abouzid, Khaled A. M.] Univ Sadat City, Fac Pharm, Dept Organ & Med Chem, Sadat City, Egypt in 2020.0, Cited 27.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A series of 2-phenyl-7-(aryl)pyrazolo [1,5-a]pyrimidine-3-carbonitriles 11a-j and 2-phenyl-7-(aryl)pyrazolo[1,5-a]pyrimidine-3,6-dicarbonitriles 16a-c was synthesized by the reaction of 5-amino-3-phenyl-1H-pyrazole-4-carbonitrile (5) with 3-(dimethylamino)-1-arylprop 2 en 1 ones 6a-j or 2-aryl-3-(dimethylamino)acrylonitriles 12a-c, respectively. In addition, 7-amino-5-oxo-2-phenyl-4,5-dihydropyrazolo [1,5-a]pyrimidine-3-carbonitrile (22) was prepared from the reaction of compound 5 with ethyl cyanoacetate. The anticancer activity of the newly synthesized compounds against Huh-7, HeLa, MCF-7 and MDA-MB231 cell lines showed moderate activity of compound 11 f as anti-proliferative agent against Huh-7 cell line with IC50 = 6.3 mu M when compared with doxorubicin (IC50, = 3.2 mu M). On the other hand, compound 16b revealed potent anti-proliferative activity against HeLa cell line with IC50, = 7.8 mu M when compared with doxorubicin (IC50, = 8.1 mu M). Also compound 11i exhibited a promising anti-proliferative activity against MCF-7 cell line (IC50, = 3.0 mu M) whereas IC50 of doxorubicin = 5.9 mu M, finally compounds 11i and 16b have potent activity as anti-proliferative agents against MDA-MB231 cell line with IC50, = 4.32 and 5.74 mu M, respectively when compared with doxorubicin (IC50 = 6.0 mu M).

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Attia, MH; Elrazaz, EZ; El-Emam, SZ; Taher, AT; Abdel-Aziz, HA; Abouzid, KAM or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Recyclable Itaconic Acid with Water as Green Catalytic System: Synthesis of Substituted 1,5-Benzodiazepine Derivatives at Room Temperature WOS:000510247300016 published article about VERSATILE BUILDING-BLOCK; ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; ENVIRONMENTALLY BENIGN; O-PHENYLENEDIAMINE; ORGANIC-REACTIONS; FACILE SYNTHESIS; NANOCATALYST in [Tamuli, Kashyap J.; Bordoloi, Manobjyoti] North East Inst Sci & Technol, CSIR, Chem Sci & Technol Div, Jorhat 785006, Assam, India; [Tamuli, Kashyap J.; Bordoloi, Manobjyoti] Acad Sci & Innovat Res, Jorhat 785006, Assam, India in 2020.0, Cited 89.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. SDS of cas: 100-19-6

The construction of new C-N chemical bonds through co-condensation reaction in water media as sole solvent, especially without the use of any metal catalyst has undergoes green protocols. Herein, we describe a water-mediated and metal-free mild protocol for easily accessing of structurally and electronically diverse 1,5-benzodiazepine analogous by using biodegradable naturally occurring itaconic acid (20 mol%) in 30 minutes with excellent yields. The simplicity in reaction operation, reusability of the catalytic system and simple filtration to get the desired product make this reaction as green synthetic pathway upto multi gram scale level.

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Tamuli, KJ; Bordoloi, M or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Rapid direct analysis of river water and machine learning assisted suspect screening of emerging contaminants in passive sampler extracts WOS:000617018900002 published article about MASS-SPECTROMETRY; TRANSFORMATION PRODUCTS; RETENTION TIMES; WASTE-WATER; QUANTIFICATION; PREDICTION in [Richardson, Alexandra K.; Rapp-Wright, Helena; Sturzenbaum, Stephen; Cowan, David A.; Barron, Leon P.] Kings Coll London, Fac Life Sci & Med, Sch Populat Hlth & Environm Sci, Dept Analyt Environm Sc Forens Sci, 150 Stamford St, London SE1 9NH, England; [Chadha, Marcus] Agilent Technol UK Ltd, 5500 Lakeside, Cheadle SK8 3GR, England; [Rapp-Wright, Helena] Dublin City Univ, Sch Chem Sci, Dublin 9, Ireland; [Mills, Graham A.; Fones, Gary R.] Univ Portsmouth, Fac Sci & Hlth, White Swan Rd, Portsmouth PO1 2DT, Hants, England; [Gravell, Anthony] Swansea Univ, Nat Resources Wales, Faraday Bldg,Singleton Campus, Swansea SA2 8PP, W Glam, Wales; [Neep, David J.] Agilent Technol UK Ltd, Essex Rd, Church Stretton SY6 6AX, England; [Barron, Leon P.] Imperial Coll London, Fac Med, Sch Publ Hlth, Environm Res Grp, 80 Wood Lane, London W12 7TA, England in 2021, Cited 61. Recommanded Product: 86-29-3. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3

A novel and rapid approach to characterise the occurrence of contaminants of emerging concern (CECs) in river water is presented using multi-residue targeted analysis and machine learning-assisted in silico suspect screening of passive sampler extracts. Passive samplers (Chemcatcher (R)) configured with hydrophilic-lipophilic balanced (HLB) sorbents were deployed in the Central London region of the tidal River Thames (UK) catchment in winter and summer campaigns in 2018 and 2019. Extracts were analysed by; (a) a rapid 5.5 min direct injection targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for 164 CECs and (b) a full-scan LC coupled to quadrupole time of flight mass spectrometry (QTOF-MS) method using data-independent acquisition over 15 min. From targeted analysis of grab water samples, a total of 33 pharmaceuticals, illicit drugs, drug metabolites, personal care products and pesticides (including several EU Watch-List chemicals) were identified, and mean concentrations determined at 40 +/- 37 ng L-1. For targeted analysis of passive sampler extracts, 65 unique compounds were detected with differences observed between summer and winter campaigns. For suspect screening, 59 additional compounds were shortlisted based on mass spectral database matching, followed by machine learning-assisted retention time prediction. Many of these included additional pharmaceuticals and pesticides, but also new metabolites and industrial chemicals. The novelty in this approach lies in the convenience of using passive samplers together with machine learning-assisted chemical analysis methods for rapid, time-integrated catchment monitoring of CECs.

Recommanded Product: 86-29-3. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Richardson, AK; Chadha, M; Rapp-Wright, H; Mills, GA; Fones, GR; Gravell, A; Sturzenbaum, S; Cowan, DA; Neep, DJ; Barron, LP or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Quality Control of 1-(4-Nitrophenyl)ethanone. In 2021.0 NEW J CHEM published article about POLY(ETHYLENE GLYCOL); CYCLOADDITION; DERIVATIVES; LIBRARY; 3-AMINO-2-OXINDOLES; SPIROINDOLONES; CONSTRUCTION; ANTAGONIST; SCAFFOLDS; RECEPTOR in [Yue, Guizhou; Jiang, Dan; Dou, Zhengjie; Li, Sicheng; Feng, Juhua; Zhang, Li; Wang, Xianxiang] Sichuan Agr Univ, Coll Sci, Yaan 625014, Sichuan, Peoples R China; [Chen, Huabao; Yang, Chunping] Sichuan Agr Univ, Coll Agron, Chengdu 611130, Sichuan, Peoples R China; [Yin, Zhongqiong; Song, Xu; Liang, Xiaoxia] Sichuan Agr Univ, Coll Vet Med, Chengdu 611130, Sichuan, Peoples R China; [Lu, Cuifen] Hubei Univ, Hubei Collaborat Innovat Ctr Adv Organochem Mat, Wuhan 430062, Peoples R China; [Lu, Cuifen] Hubei Univ, Key Lab Synth & Applicat Organ Funct Mol, Minist Educ, Wuhan 430062, Peoples R China in 2021.0, Cited 62.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

The umpolung Michael addition of isatin N,N’-cyclic azomethine imine 1,3-dipoles with chalcones is reported. The reaction could be finished within a very short time (0.3-2 min), with 3,3-disubstituted oxindole derivatives obtained in moderate to excellent yields with promising dr values. Unusual Michael adducts were obtained in moderate to high yields (26-98%) with low to high diastereoselectivities (0.8 : 1 to 8.5 : 1 dr). All the synthesized compounds (3, 3′, 4, 5, 5′, 7, 7′, 9 and 9′) were well characterized by FTIR, NMR, and mass spectral analyses and further confirmed by the single-crystal X-ray diffraction analysis of compounds 3aa and 4n.

Quality Control of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Yue, GZ; Jiang, D; Dou, ZJ; Li, SC; Feng, JH; Zhang, L; Chen, HB; Yang, CP; Yin, ZQ; Song, X; Liang, XX; Wang, XX; Lu, CF or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem