Month: October 2021

Application In Synthesis of 1-(4-Nitrophenyl)ethanone. In 2021 ASIAN J ORG CHEM published article about BAEYER-VILLIGER OXIDATION; RETRO-CLAISEN CONDENSATION; C-NUCLEOSIDE SYNTHESIS; CARBON-CYANO; DIRECT CONVERSION; ORGANIC-ACIDS; HALLER-BAUER; CLEAVAGE; ESTERS; MILD in [Rammurthy, Banothu; Peraka, Swamy; Vasu, Amrutham; Sai, Gajula Krishna; Rohini, Yennamaneni Divya; Narender, Nama] Acad Sci & Innovat Res, CSIR HRDG Campus,Sect 19, Ghaziabad 201002, UP, India; [Rammurthy, Banothu; Peraka, Swamy; Vasu, Amrutham; Sai, Gajula Krishna; Rohini, Yennamaneni Divya; Narender, Nama] CSIR Indian Inst Chem Technol, C&FC Div, Hyderabad 500007, Telangana, India in 2021, Cited 88. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A novel metal-free catalytic one-pot approach has been developed for the esterification of aralkyl ketones with alcohols under open-air atmospheric conditions. The inexpensive iodide/oxone reagent system allowed the cascade C(sp(3))-H bond oxygenation, selective C-C bond cleavage and esterification through the both radical and ionic pathways in a stepwise manner in one-pot. This mild, convenient and economically viable catalytic method tolerates the various functional groups to provide the corresponding alkyl benzoates in up to 98% yields with up to 99% selectivity. The efficiency and feasibility of scale-up of the present catalytic system was demonstrated with gram scale experiments (up to 10 gram scale).

Application In Synthesis of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Rammurthy, B; Peraka, S; Vasu, A; Sai, GK; Rohini, YD; Narender, N or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Brand, S; Causero, A; Elsen, H; Pahl, J; Langer, J; Harder, S in WILEY-V C H VERLAG GMBH published article about INTRAMOLECULAR HYDROAMINATION; CRYSTAL-STRUCTURE; ALKALINE-EARTHS; COMPLEXES; IODIDE; METAL; HYDROPHOSPHINATION; REACTIVITY; POTASSIUM; CHEMISTRY in [Brand, Steffen; Causero, Andrea; Elsen, Holger; Pahl, Juergen; Langer, Jens; Harder, Sjoerd] Univ Erlangen Nurnberg, Inorgan & Organometall Chem, Egerlandstr 1, D-91058 Erlangen, Germany in 2020.0, Cited 71.0. Application In Synthesis of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

The first naked (Lewis base-free) cationic Ca amidinate complex [(AmCa)-Am-tBu-Ca-DIPP(C6H6)](+)[B(C6F5)(4)](-) was prepared in 62 % yield {(AmDIPP)-Am-tBu = tBuC(N-DIPP)(2); DIPP = 2,6-diisopropylphenyl} by reaction of [(AmCaH)-Am-tBu-Ca-DIPP](2) with [Ph3C](+)[B(C6F5)(4)](-) in chlorobenzene. The ether-free complex (AmCaN)-Am-tBu-Ca-DIPP(SiMe3)(2) was obtained by removal of diethyl ether from its ether adduct. Crystal structures show that the amidinate ligand in both complexes is N,Aryl-chelating. In this coordination mode the bulk of the amidinate ligand is comparable to that of a DIPP-substituted beta-diketiminate ligand. Isomers with N,N-coordinating amidinate ligands are circa 15 kcal/mol higher in energy and this coordination mode is only present in case additional ether ligands compensate for energy loss or in case of space limitation at the metal, e.g. in homoleptic (Am-tBu(DIPP))(2)Ca. A series of four Ca amidinate complexes, (AmCaX)-Am-tBu-Ca-DIPP, were tested in the catalytic hydroboration of ketones and aldehydes by pinacolborane (HBpin). Catalytic activities increase for X- = I- < B(C6F5)(4)(-) < (Me3Si)(2)N- approximate to H-. For catalysts with unreactive anions, like I- or B(C6F5)(4)(-), catalyst performance increases with the Lewis acidity of the metal and a mechanism is proposed in which HBpin and ketone coordinate to the Ca2+ ion which is followed by direct hydroboration. The more active catalysts with X- = (Me3Si)(2)N- or H- likely operate through a mechanism which involves intermediate metal hydride (or borate) complexes. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Brand, S; Causero, A; Elsen, H; Pahl, J; Langer, J; Harder, S or concate me.. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Zhang, YJ; Su, JY; Lin, TF; Lin, ZQ; Zhou, ZC; Li, YJ in [Zhang, Yongjian; Su, Junyi; Lin, Tengfei; Lin, Zhangqi; Zhou, Zichun; Li, Yujin] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou, Zhejiang, Peoples R China published Iodine/K2CO3-catalyzed synthesis of multisubstituted pyrrolidine-2-carboxylates via a one-pot reaction between an araldehyde, an amino acid ester, and a chalcone in 2019.0, Cited 30.0. Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A series of more than 20 multisubstituted pyrrolidine-2-carboxylates were synthesized via a one-pot cycloaddition of an araldehyde, an amino acid ester, and a chalcone catalyzed by I-2/K2CO3 in tetrahydrofuran at 80 degrees C. The advantages of this method are readily available starting materials, mild conditions, and simple operation, and it is metal free and yields are good to excellent.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Zhang, YJ; Su, JY; Lin, TF; Lin, ZQ; Zhou, ZC; Li, YJ or concate me.. Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Probing the high potency of pyrazolyl pyrimidinetriones and thioxopyrimidinediones as selective and efficient non-nucleotide inhibitors of recombinant human ectonucleotidases WOS:000475378400004 published article about ALKALINE-PHOSPHATASE; BIOLOGICAL EVALUATION; PHOSPHODIESTERASE-I; DERIVATIVES; PROTEIN; IDENTIFICATION; AGENTS; CALCIFICATION; LOCALIZATION; THIAZOLES in [Andleeb, Hina; Hameed, Shahid; Khan, Imtiaz] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan; [Andleeb, Hina] Int Islamic Univ, Fac Basic & Appl Sci, Sulaiman Bin Abdullah Aba Al Khail Ctr Interdisci, Islamabad, Pakistan; [Ejaz, Syeda Abida; Zaib, Sumera; Iqbal, Jamshed] COMSATS Inst Informat Technol, Ctr Adv Drug Res, Abbottabad 22060, Pakistan; [Khan, Imtiaz] Univ Manchester, Sch Chem, Oxford Rd, Manchester M13 9PL, Lancs, England; [Khan, Imtiaz] Univ Manchester, Manchester Inst Biotechnol, 131 Princess St, Manchester M1 7DN, Lancs, England; [Lecka, Joanna; Sevigny, Jean] Univ Laval, Fac Med, Dept Microbiol Infectiol & Immunol, Quebec City, PQ G1V 0A6, Canada; [Lecka, Joanna; Sevigny, Jean] Univ Laval, CHU Quebec, Ctr Rech, Quebec City, PQ G1V 4G2, Canada in 2019.0, Cited 52.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. SDS of cas: 100-19-6

With the aim to discover novel, efficient and selective inhibitors of human alkaline phosphatase and nucleotide pyrophosphatase enzymes, two new series of pyrazolyl pyrimidinetriones (PPTs) (6a-g) and thioxopyrimidinediones (PTPs) (6h-n) were synthesized in good chemical yields using Knoevenagel condensation reaction between pyrazole carbaldehydes (4a-g) and pharmacologically active N-alkylated pyrimidinetrione (5a) and thioxopyrimidinedione (5b). The inhibition potential of the synthesized hybrid compounds was evaluated against human alkaline phosphatase (h-TNAP and h-IAP) and ectonucleotidase (h-NPP1 and h-NPP3) enzymes. Most of the tested analogs were highly potent with a variable degree of inhibition depending on the functionalized hybrid structure. The detailed structure-activity relationship (SAR) of PPT and PTP derivatives suggested that the compound with unsubstituted phenyl ring from PPT series led to selective and potent inhibition (6a; IC50= 0.33 +/- 0.02 mu M) of h-TNAP, whereas compound 6c selectively inhibited h-IAP isozyme with IC50 value of 0.86 +/- 0.04 mu M. Similarly, compounds 6b and 6h were identified as the lead scaffolds against h-NPP1 and h-NPP3, respectively. The probable binding modes for the most potent inhibitors were elucidated through molecular docking analysis. Structure-activity relationships, mechanism of action, cytotoxic effects and druglikeness properties are also discussed.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Andleeb, H; Hameed, S; Ejaz, SA; Khan, I; Zaib, S; Lecka, J; Sevigny, J; Iqbal, J or concate me.. SDS of cas: 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Wei, JW; Zhao, L; He, C; Zheng, SJ; Reek, JNH; Duan, C in [Wei, Jianwei; Zhao, Liang; He, Cheng; Zheng, Sijia; Duan, Chunying] Dalian Univ Technol, Zhang Dayu Coll Chem, State Key Lab Fine Chem, Dalian 116024, Peoples R China; [Reek, Joost N. H.] Univ Amsterdam, Vant Hoff Inst Mol Sci, Sci Pk 904, NL-1098 XH Amsterdam, Netherlands published Metal-Organic Capsules with NADH Mimics as Switchable Selectivity Regulators for Photocatalytic Transfer Hydrogenation in 2019.0, Cited 60.0. HPLC of Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Switchable selective hydrogenation among the groups in multifunctional compounds is challenging because selective hydrogenation is of great interest in the synthesis of fine chemicals and pharmaceuticals as a result of the importance of key intermediates. Herein, we report a new approach to highly selectively (>99%) reducing C=X (X = O, N) over the thermodynamically more favorable nitro groups locating the substrate in a metal-organic capsule containing NADH active sites. Within the capsule, the NADH active sites reduce the double bonds via a typical 2e(-) hydride transfer hydrogenation, and the formed excited-state NAD(+) mimics oxidize the reductant via two consecutive 1e(-) processes to regenerate the NADH active sites under illumination. Outside the capsule, nitro groups are highly selectively reduced through a typical 1e(-) hydrogenation. By combining photoinduced 1e(-) transfer regeneration outside the cage, both 1e(-) and 2e(-) hydrogenation can be switched controllably by varying the concentrations of the substrates and the redox potential of electron donors. This promising alternative approach, which could proceed under mild reaction conditions and use easy-to-handle hydrogen donors with enhanced high selectivity toward different groups, is based on the localization and differentiation of the 2e(-) and 1e(-) hydrogenation pathways inside and outside the capsules, provides a deep comprehension of photocatalytic microscopic reaction processes, and will allow the design and optimization of catalysts. We demonstrate the advantage of this method over typical hydrogenation that involves specific activation via well-modified catalytic sites and present results on the high, well-controlled, and switchable selectivity for the hydrogenation of a variety of substituted and bifunctional aldehydes, ketones, and imines.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Wei, JW; Zhao, L; He, C; Zheng, SJ; Reek, JNH; Duan, C or concate me.. HPLC of Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Li, W; Artz, J; Broicher, C; Junge, K; Hartmann, H; Besmehn, A; Palkovits, R; Beller, M in ROYAL SOC CHEMISTRY published article about ORDERED MESOPOROUS CARBON; FISCHER-TROPSCH SYNTHESIS; CHEMOSELECTIVE HYDROGENATION; FUNCTIONALIZED NITROARENES; METAL NANOPARTICLES; SIZE; FRAMEWORKS; OXIDATION; STRATEGY; SCIENCE in [Li, Wu; Junge, Kathrin; Beller, Matthias] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany; [Artz, Jens; Broicher, Cornelia; Palkovits, Regina] Rhein Westfal TH Aachen, Inst Tech & Makromol Chem, Worringerweg 2, D-52074 Aachen, Germany; [Hartmann, Heinrich; Besmehn, Astrid] Forschungszentrum Julich, Wilhelm Johnen Str, D-5248 Julich, Germany in 2019, Cited 51. SDS of cas: 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

The development of improved catalysts for highly selective hydrogenation of nitroarenes is described. For this purpose Co nanoparticles were supported on ordered mesoporous carbon CMK-3 and characterized in detail. The optimal CMK-3-CoPc catalyst exhibits excellent hydrogenation activity for several (hetero)aromatic nitro compounds and yielded the corresponding anilines under mild conditions (40 degrees C, 20 bar H-2).

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Li, W; Artz, J; Broicher, C; Junge, K; Hartmann, H; Besmehn, A; Palkovits, R; Beller, M or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article A Lewis Base Supported Terminal Uranium Phosphinidene Metallocene WOS:000580381700080 published article about BOND-FORMING REACTIONS; TITANIUM COMPLEXES; IMIDO METALLOCENE; CRYSTAL-STRUCTURE; REACTIVITY; CHEMISTRY; ACTIVATION; PHOSPHORUS; RUTHENIUM; PHOSPHIDO in [Wang, Deqiang; Wang, Shichun; Hou, Guohua; Zi, Guofu] Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China; [Walter, Marc D.] Tech Univ Carolo Wilhelmina Braunschweig, Inst Anorgan & Analyt Chem, D-38106 Braunschweig, Germany in 2020, Cited 104. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3. COA of Formula: C14H11N

A Lewis base supported terminal uranium phosphinidene, [eta(5)-1,3-(Me3C)(2)C5H3]2U(= P-2,4,6-(Bu3C6H2)-Bu-t)(OPMe3) (5), is isolated from the reaction of the uranium methyl chloride [eta(5)- 1,3-(Me3C)(2)C5H3](2)U(Cl) Me (4) with 2, 4, 6-(Me3C)(3)C6H2PHK in toluene in the presence of Me3PO. Moreover, the reactivity of uranium phospinidene 5 toward a series of small molecules was comprehensively explored. While no reactivity of 5 with internal alkynes is observed attributed to steric hindrance, it readily reacts in good yields with various small molecules including isothiocyanates, aldehydes, imines, diazenes, carbodiimides, nitriles, isonitriles, and organic azides, yielding uranium sulfidos, oxidos, metallaheterocycles, and imido complexes.

About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Wang, DQ; Wang, SC; Hou, GH; Zi, GF; Walter, MD or concate me.. COA of Formula: C14H11N

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article Copper-Catalyzed Carbonylative Synthesis of beta-Homoprolines from N-Fluoro-sulfonamides published in 2020. Formula: C14H11N, Reprint Addresses Wu, XF (corresponding author), Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany.. The CAS is 86-29-3. Through research, I have a further understanding and discovery of 2,2-Diphenylacetonitrile

A new methodology for the carbonylative transformation of N-fluoro-sulfonamides into N-sulfonyl-beta-homoproline esters has been described. In the presence of a catalytic amount of Cu(OTf)(2), a range of beta-homoproline derivatives were prepared in moderate to good yield. The reaction proceeds via the intramolecular cyclization and intermolecular carbonylation of a free carbon radical. Notably, this procedure offers the possibility to build potential functionalized bioactive molecules.

About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Zhang, YC; Yin, ZP; Wu, XF or concate me.. Formula: C14H11N

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Category: benzodioxans. Authors Song, T; Zhou, X; Wang, XX; Xiao, JL; Yang, Y in ROYAL SOC CHEMISTRY published article about in [Song, Tao; Zhou, Xin; Wang, Xiaoxue; Yang, Yong] Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, 189 Songling Rd, Qingdao 266101, Peoples R China; [Xiao, Jianliang] Univ Liverpool, Dept Chem, Crown St, Liverpool L69 7ZD, Merseyside, England; [Song, Tao; Zhou, Xin; Wang, Xiaoxue; Yang, Yong] Shandong Energy Inst, Qingdao 266101, Peoples R China in 2021.0, Cited 66.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A new methodology for the synthesis of alpha-diketones was reported via a one-pot cascade process from aldehydes and ketones catalyzed by a bifunctional iron nanocomposite using H2O2 as a green oxidant in water. The one-pot strategy showed excellent catalytic stability, comprehensive suitability of substrates and important practical utility for directly synthesizing biologically active and medicinally valuable N-heterocycles via an intermittent process.

Category: benzodioxans. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Song, T; Zhou, X; Wang, XX; Xiao, JL; Yang, Y or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study WOS:000494258500035 published article about ALPHA-GLUCOSIDASE SYNTHESIS; IN-VITRO EVALUATION; CELL GROWTH-FACTOR; BETA-GLUCURONIDASE; BIOLOGICAL EVALUATION; ANALOGS; ACETYLCHOLINESTERASE; THIOSEMICARBAZIDES in [Zaman, Khalid; Rahim, Fazal] Hazara Univ, Dept Chem, Mansehra 21300, Khyber Pakhtunk, Pakistan; [Taha, Muhammad] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia; [Wadood, Abdul] Abdul Wali Khan Univ Mardan, Dept Biochem, Mardan 23200, Pakistan; [Shah, Syed Adnan Ali] Univ Teknol MARA, Fac Pharm, Cawangan Selangor Kampus, Selangor 42300, DE, Malaysia; [Shah, Syed Adnan Ali] Univ Teknol MARA, Atta Ur Rahman Inst Nat Prod Discovery AuRIns, Cawangan Selangor Kampus PuncakAlam, Selangor 42300, DE, Malaysia; [Ahmed, Qamar Uddin] Int Islamic Univ Malaysia, Kulliyyah Pharm, Dept Pharmaceut Chem, Pahang Dm 25200, Kuantan, Malaysia; [Zakaria, Zainul Amiruddin] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Biomed Sci, Serdang 43400, Selangor, Malaysia; [Zakaria, Zainul Amiruddin] Univ Putra Malaysia, Halal Inst Res Inst, Serdang 43400, Selangor, Malaysia in 2019.0, Cited 48.0. Recommanded Product: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Here in this study regarding the over expression of TP, which causes some physical, mental and socio problems like psoriasis, chronic inflammatory disease, tumor angiogenesis and rheumatoid arthritis etc. By this consideration, the inhibition of this enzyme is vital to secure life from serious threats. In connection with this, we have synthesized twenty derivatives of isoquinoline bearing oxadiazole (1-20), characterized through different spectroscopic techniques such as HREI-MS, H-1-NMR and C-13-NMR and evaluated for thymidine phosphorylase inhibition. All analogues showed outstanding inhibitory potential ranging in between 1.10 +/- 0.05 to 54.60 +/- 1.50 mu M. 7-Deazaxanthine (IC50 = 38.68 +/- 1.12 mu M) was used as a positive control. Through limited structure activity relationships study, it has been observed that the difference in inhibitory activities of screened analogs are mainly affected by different substitutions on phenyl ring. The effective binding interactions of the most active analogs were confirmed through docking study.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Zaman, K; Rahim, F; Taha, M; Wadood, A; Shah, SAA; Ahmed, QU; Zakaria, ZA or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem