Month: November 2021

In 2019.0 TETRAHEDRON LETT published article about WATER; AMINOPYRIDINES; DERIVATIVES; ARYLATION; ALKYNES; ARYL in [Ujwaldev, Sankuviruthiyil Mohanan; Rohit, K. R.; Harry, Nissy Ann; Anilkumar, Gopinathan] Mahatma Gandhi Univ, Sch Chem Sci, PD Hills PO, Kottayam 686560, Kerala, India in 2019.0, Cited 24.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Formula: C8H7NO3

Imidazo[1,2-a]pyridines form versatile scaffolds in pharmaceutical industry arising from their diverse biological activities. The synthesis of these molecules thus has been of great interest and resulted in the development of a large number of new methodologies. Herein we describe the first iron-catalyzed Ortoleva-King type protocol towards the synthesis of these fused heterocyclic compounds. This methodology employs cheap and easily available FeCl3 center dot 6H(2)O and molecular iodine as the catalytic system. The procedure has been well explored by extending the substrate scope with a variety of aromatic ketones and 2-aminopyridines to furnish different imidazo[1,2-a]pyridine derivatives in moderate to good yields. A successful application of this protocol was also demonstrated by achieving direct one step synthesis of the gastro protective drug, Zolimidine. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 100-19-6, If you have any questions, you can contact Ujwaldev, SM; Rohit, KR; Harry, NA; Anilkumar, G or send Email.. Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article Synthesis of cis-1,2-diol-type chiral ligands and their dioxaborinane derivatives: Application for the asymmetric transfer hydrogenation of various ketones and biological evaluation published in 2020.0. Formula: C8H7NO3, Reprint Addresses Kilic, A (corresponding author), Harran Univ, Chem Dept, TR-63190 Sanliurfa, Turkey.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Two cis-1,2-diol-type chiral ligands (T-1 and T-2) and their tri-coordinated chiral dioxaborinane (T(1-2)B(1-2)) and four-coordinated chiral dioxaborinane adducts with 4-tert-butyl pyridine sustained by N -> B dative bonds (T(1-2)B(1-2)-N) were synthesized and characterized by various spectroscopic techniques such as NMR (H-1, C-13, and B-11), FT-IR and UV-Vis spectroscopy, LC-MS/MS, and elemental analysis. It was suggested that both ferrocene and trifluoromethyl groups played key roles in the catalytic and biological studies because they could tune the solubility of the chiral dioxaborinane complexes and adjust the strength of intermolecular interactions. To assess the biological activities of newly synthesized chiral dioxaborinane compounds, DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, reducing power, antibacterial, DNA binding, and DNA cleavage activities were tested. Then, all chiral dioxaborinane complexes were investigated as catalysts for the asymmetric transfer hydrogenation of various ketones under suitable conditions. The results indicated that the chiral dioxaborinane catalysts performed well with high yields.

Formula: C8H7NO3. Welcome to talk about 100-19-6, If you have any questions, you can contact Kilic, A; Balci, TE; Arslan, N; Aydemir, M; Durap, F; Okumu, V; Tekin, R or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Convenient synthesis of 4,5-unsubstituted 3-aroylisoxazoles from methyl aryl ketones and (vinylsulfonyl)benzene in water WOS:000610242900013 published article about ONE-POT SYNTHESIS; C-H ARYLATION; COPPER(I)-CATALYZED SYNTHESIS; ISOXAZOLES; CYCLOADDITION; CYCLIZATION; COUPLINGS; EFFICIENT; ALKYNES; CHLOROFORM in [Wang, Liang; Tao, Yu; Zhang, Nana; Li, Shubai] Changzhou Vocat Inst Engn, Sch Chem & Pharmaceut Engn, Changzhou 213164, Peoples R China in 2021.0, Cited 58.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 100-19-6

A convenient synthesis of 3-aroylisoxazoles from methyl ketones and (vinylsulfonyl)benzene in 2%TPGS-750-M/H2O has been developed. This reaction proceeds via tandem tert-butyl nitrite-promoted Csp(3)-H functionalization of methyl ketones, 1,3-dipolar cycloaddition and base-catalyzed aromatization, providing the corresponding products in moderate to good yields. (C) 2020 Elsevier Ltd. All rights reserved.

Recommanded Product: 100-19-6. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Formula: C8H7NO3. In 2019 CHEMISTRYSELECT published article about ONE-POT SYNTHESIS; HIGHLY EFFICIENT; BENZYL ALCOHOLS; METHYL KETONES; BENZIMIDAZOLES; QUINAZOLINONES; BENZOXAZOLES; AMINATION; IODINE; FACILE in [Khan, Danish; Ahmed, Naseem] Indian Inst Technol Roorkee, Dept Chem, Roorkee 247667, Uttarakhand, India; [Alsharif, Meshari A.; Alahmdi, Mohammed Issa; Mukhtar, Sayeed] Univ Tabuk, Fac Sci, Dept Chem, Tabuk 71491, Saudi Arabia in 2019, Cited 66. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

An interestingcyclization reactions of aryl ketones with 2-amino aniline derivatives under SeO2 (oxidant) are described for the synthesis of benzoxazole, benzothiazole, benzimidazole and quinazolinone through the C-C cleavage of acetophenone. The reaction likely involves sequential C-N, C-O and C-S bond formation followed by C(CO)-C(alkyl) bond cleavage. Various substituted fused heterocycles are obtained in good to excellent (gram scale) yields in a single step from readily available acetophenones.

Formula: C8H7NO3. Welcome to talk about 100-19-6, If you have any questions, you can contact Khan, D; Ahmed, N; Alsharif, MA; Alahmdi, MI; Mukhtar, S or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 86-29-3. In 2020 EUR J ORG CHEM published article about REDUCTIVE ELIMINATION; CARBON-CARBON; NITRILES; CYANOACETATE; HALIDES; LIGAND; HETEROARYL; COMPLEXES; EFFICIENT; ACETONE in [Yuen, On Ying; Chen, Xiangmeng; Wu, Junyu; So, Chau Ming] Hong Kong Polytech Univ, State Key Lab Chem Biol & Drug Discovery, Hung Hom, Kowloon, Hong Kong, Peoples R China; [Yuen, On Ying; Chen, Xiangmeng; Wu, Junyu; So, Chau Ming] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hung Hom, Kowloon, Hong Kong, Peoples R China; [So, Chau Ming] Hong Kong Polytech Univ, Shenzhen Res Inst, Shenzhen, Peoples R China in 2020, Cited 49. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3.

The first general palladium-catalyzed alpha-arylation of arylacetonitriles with aryl and heteroaryl sulfonates are reported. Pd(OAc)(2) associated with XPhos serves as the effective catalyst to facilitate this reaction. A broad range of electron-rich, -neutral, -deficient, and sterically hindered aryl/heteroaryl tosylates and mesylates are coupled with arylacetonitriles bearing different substituents to give the corresponding products in good to excellent yields. Catalyst loading down to 0.1 mol-% Pd was achieved, and 22 unprecedented compounds were synthesized from 43 demonstrated examples using this method. Its applicability with the modification of biological phenolic compounds was successfully demonstrated. The Pd/XPhos system catalyzed the alpha-arylation and followed by alkylation in one-pot sequential conditions, resulting in the direct synthesis of compounds containing quaternary center- and deuterium-containing compounds in good to excellent yields.

Recommanded Product: 86-29-3. Welcome to talk about 86-29-3, If you have any questions, you can contact Yuen, OY; Chen, XM; Wu, JY; So, CM or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Formula: C8H7NO3. Recently I am researching about ONE-POT SYNTHESIS; TRISODIUM CITRATE DIHYDRATE; MULTICOMPONENT REACTION; PHARMACEUTICAL-INDUSTRY; GABA(A) RECEPTOR; GREEN CHEMISTRY; EASY ACCESS; DERIVATIVES; EFFICIENT; ZOLPIDEM, Saw an article supported by the DST, New DelhiDepartment of Science & Technology (India); UGC, New DelhiUniversity Grants Commission, India. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Brahmachari, G; Nayek, N; Karmakar, I; Nurjamal, K; Chandra, SK; Bhowmick, A. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

A water-mediated and catalyst-free practical method for the synthesis of a new series of pharmaceutically interesting functionalized 5-(2-arylimidazo[1,2-a]pyridin-3-yl)pyrimidine-2,4-(1H,3H)-diones has been accomplished based on a one-pot multicomponent reaction between arylglyoxal monohydrates, 2-aminopyridines/2-aminopyrimidine, and barbituric/N,N-dimethylbarbituric acids under reflux conditions. The salient features of this protocol are avoidance of any additive/catalyst and toxic organic solvents, use of water as reaction medium, clean reaction profiles, operational simplicity, ease of product isolation/purification without the aid of tedious column chromatography, good to excellent yields, and high atom-economy and low E-factor.

Welcome to talk about 100-19-6, If you have any questions, you can contact Brahmachari, G; Nayek, N; Karmakar, I; Nurjamal, K; Chandra, SK; Bhowmick, A or send Email.. Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2020.0 APPL CATAL B-ENVIRON published article about CRYSTALLINE; OXIDATION; EFFICIENT; STORAGE; LUMINESCENT; STABILITY; SULFIDES; HYDROGEN in [Lopez-Magano, Alberto; Platero-Prats, Ana E.; Cabrera, Silvia; Mas-Balleste, Ruben] Univ Autonoma Madrid, Inorgan Chem Dept, Modulo 7, Madrid 28049, Spain; [Platero-Prats, Ana E.] Univ Autonoma Madrid, Condensed Matter Phys Ctr IFIMAC, Campus Cantoblanco, Madrid 28049, Spain; [Cabrera, Silvia; Mas-Balleste, Ruben; Aleman, Jose] Univ Autonoma Madrid, Inst Adv Res Chem Sci IAdChem, Madrid 28049, Spain; [Aleman, Jose] Univ Autonoma Madrid, Organ Chem Dept, Madrid 28049, Spain in 2020.0, Cited 55.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Quality Control of 1-(4-Nitrophenyl)ethanone

A new photoactive Pt (II) hydroxyquinoline complex has been covalently linked into the structure of an iminebased layered covalent organic framework (COF) through the monomer truncation strategy. Such strategy allows the incorporation of molecular fragments with only one functional group able to condensate into the imine-framework. The photocatalytic activity of the resulting Pt@COF has been applied to the oxidation of sulfides to sulfoxides, obtaining excellent results for all the studied cases, and showing that this reaction goes through both photoredox and energy transfer processes. The results obtained showed a great enhancement of the catalytic activity (up to 25,000 turnover number, TON), stability and a significant decrease on the reaction times, as a consequence of immobilization and isolation of Pt(II) centers into the organic framework. In addition, Pt@COF has been proved to be an excellent heterogeneous photocatalyst also in exclusive photoredox processes, reaching 7500 TON in hydrodebromination reactions.

Quality Control of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Lopez-Magano, A; Platero-Prats, AE; Cabrera, S; Mas-Balleste, R; Aleman, J or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

SDS of cas: 100-19-6. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Syntheses and evaluation of new Quinoline derivatives for inhibition of hnRNP K in regulating oncogene c-myc transcription published in 2019, Reprint Addresses Li, D (corresponding author), Sun Yat Sen Univ, Sch Pharmaceut Sci, 132 Waihuan East Rd, Guangzhou 510006, Guangdong, Peoples R China.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.

Aberrant overexpression of heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a key feature in oncogenesis and progression of many human cancers. hnRNP K has been found to be a transcriptional activator to up-regulate c-myc gene transcription, a critical proto-oncogene for regulation of cell growth and differentiation. Therefore, down-regulation of c-myc transcription by inhibiting hnRNP K through disrupting its binding to c-myc gene promoter is a potential approach for cancer therapy. In the present study, we synthesized and screened a series of Quinoline derivatives and evaluated their binding affinity for hnRNP K. Among these derivatives, (E)-1-(4-methoxyphenyl)-3-(4 morpholino-6-nitroquinolin-2-yl)prop-2-en-1-one (compound 25) was determined to be the first-reported hnRNP K binding ligand with its K-D values of 4.6 and 2.6 mu M measured with SPR and MST, respectively. Subsequent evaluation showed that the binding of compound 25 to hnRNP K could disrupt its unfolding of c-myc promoter i-motif, resulting in down-regulation of c-myc transcription. Compound 25 showed a selective anti-proliferative effect on human cancer cell lines with IC50, values ranged from 1.36 to 3.59 mu M. Compound 25 exhibited good tumor growth inhibition in a Hela xenograft tumor model, which might be related to its binding with hnRNP K. These findings illustrated that inhibition of DNA-binding protein hnRNP K by compound 25 could be a new and selective strategy of regulating oncogene transcription instead of targeting promoter DNA secondary structures such as G-quadruplexes or i-motifs.

Welcome to talk about 100-19-6, If you have any questions, you can contact Shu, B; Zeng, P; Kang, SS; Li, PH; Hu, DX; Kuang, GT; Cao, JJ; Li, XY; Zhang, ML; An, LK; Huang, ZS; Li, D or send Email.. SDS of cas: 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about PALLADIUM-CATALYZED CYANATION; HIGHLY EFFICIENT; BECKMANN REARRANGEMENT; PRIMARY AMIDES; DEHYDRATION; ARYL; ISOCYANIDES, Saw an article supported by the National Natural Science FoundationNational Natural Science Foundation of China (NSFC) [21421002, 21672242, 21971252, 21991122]; Key Research Program of Frontier Sciences (CAS) [QYZDJSSW-SLH049]; Youth Innovation Promotion Association CAS [2019256]; Fujian Institute of Innovation; Chinese Academy of SciencesChinese Academy of Sciences [FJCXY18040102]. Category: benzodioxans. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Zhang, W; Lin, JH; Zhang, PF; Xiao, JC. The CAS is 86-29-3. Through research, I have a further understanding and discovery of 2,2-Diphenylacetonitrile

For the dehydroxylation of aldoximes with 4-nitro-1-((trifluoromethyl)sulfonyl)-imidazole (NTSI), slight modifications of reaction conditions resulted in significantly different reaction paths to provide either nitriles or isonitriles. The challenging conversion of aldoximes into isonitriles was achieved under mild conditions.

Category: benzodioxans. Welcome to talk about 86-29-3, If you have any questions, you can contact Zhang, W; Lin, JH; Zhang, PF; Xiao, JC or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Quinolone-isoniazid hybrids: synthesis and preliminary in vitro cytotoxicity and anti-tuberculosis evaluation WOS:000459510800014 published article about MYCOBACTERIUM-TUBERCULOSIS; RESISTANT TUBERCULOSIS; BIOLOGICAL EVALUATION; HYDRAZIDE-HYDRAZONES; DRUGS; DESIGN; TB; DISEASE; TRENDS in [Beteck, Richard M.; Khanye, Setshaba D.] Rhodes Univ, Dept Chem, Fac Sci, ZA-6140 Grahamstown, South Africa; [Seldon, Ronnett] Univ Cape Town, Dept Chem, Drug Discovery & Dev Ctr H3 D, ZA-7701 Rondebosch, South Africa; [Jordaan, Audrey; Warner, Digby F.] Univ Cape Town, Dept Pathol, SAMRC NHLS UCT Mol Mycobacteriol Res Unit, ZA-7925 Observatory, South Africa; [Warner, Digby F.] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7952 Observatory, South Africa; [Warner, Digby F.] Univ Cape Town, Wellcome Ctr Clin Infect Dis Res Africa, ZA-7925 Observatory, South Africa; [Hoppe, Heinrich C.] Rhodes Univ, Dept Biochem & Microbiol, Fac Sci, ZA-6140 Grahamstown, South Africa; [Hoppe, Heinrich C.; Laming, Dustin; Khanye, Setshaba D.] Rhodes Univ, Ctr Chem & Biomed Res, ZA-6140 Grahamstown, South Africa; [Legoabe, Lesetja J.] North West Univ, Ctr Excellence Pharmaceut Sci, ZA-2520 Potchefstroom, South Africa; [Khanye, Setshaba D.] Rhodes Univ, Fac Pharm, ZA-6140 Grahamstown, South Africa in 2019.0, Cited 41.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. SDS of cas: 100-19-6

Herein, we propose novel quinolones incorporating an INH moiety as potential drug templates against TB. The quinolone-based compounds bearing an INH moiety attached via a hydrazide-hydrazone bond were synthesised and evaluated against Mycobacterium tuberculosis H37Rv (MTB). The compounds were also evaluated for cytotoxicity against HeLa cell lines. These compounds showed significant activity (MIC90) against MTB in the range of 0.2-8 mu M without any cytotoxic effects. Compounds 10 (MIC90; 0.9 mu M), 11 (MIC90; 0.2 mu M), 12 (MIC90; 0.8 mu M) and compound 15 (MIC90; 0.8 mu M), the most active compounds in this series, demonstrate activities on par with INH and superior to those reported for the fluoroquinolones. The SAR analysis suggests that the nature of substituents at positions -1 and -3 of the quinolone nucleus influences anti-MTB activity. Aqueous solubility evaluation and in vitro metabolic stability of compound 12 highlights favourable drug-like properties for this compound class.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Beteck, RM; Seldon, R; Jordaan, A; Warner, DF; Hoppe, HC; Laming, D; Legoabe, LJ; Khanye, SD or concate me.. SDS of cas: 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem