Day: December 24, 2021

An article Metal-Free Cross-Dehydrogenative C-O Coupling of Carbonyl Compounds with N-Hydroxyimides: Unexpected Selective Behavior of Highly Reactive Free Radicals at an Elevated Temperature WOS:000516665800016 published article about BOND FORMATION; HYDROXYPHTHALIMIDE SYNTHESIS; AMINO-ACIDS; ALDEHYDES; FUNCTIONALIZATION; ESTERIFICATION; DERIVATIVES; EFFICIENT; OLIGOMERIZATION; DIMERIZATION in [Krylov, Igor B.; Lopat’eva, Elena R.; Budnikov, Alexander S.; Nikishin, Gennady I.; Terent’ev, Alexander O.] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia; [Lopat’eva, Elena R.; Budnikov, Alexander S.] Mendeleev Univ Chem Technol Russia, 9 Miusskaya Sq, Moscow 125047, Russia in 2020, Cited 68. Application In Synthesis of 2,2-Diphenylacetonitrile. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3

Cross-dehydrogenative C-O coupling of N-hydroxyimides with ketones, esters, and carboxylic acids was achieved employing the di-tertbutyl peroxide as a source of free radicals and a dehydrogenating agent. The proposed method is experimentally simple and demonstrates the outstanding efficiency for the challenging CH substrates, such as unactivated esters and carboxylic acids. It was shown that N-hydroxyphthalimide drastically affects the oxidative properties of t-BuOOt-Bu by intercepting the t-BuO center dot radicals with the formation of phthalimide-N-oxyl radicals, a species responsible for both hydrogen atom abstraction from the CH reagent and the selective formation of the C-O coupling product by selective radical cross-recombination. The practical applicability of the developed method was exemplified by the single-stage synthesis of commercial reagent (known as Baran aminating reagent precursor) from isobutyric acid and N-hydroxysuccinimide, whereas in the standard synthetic approach, four stages are necessary.

Application In Synthesis of 2,2-Diphenylacetonitrile. Bye, fridends, I hope you can learn more about C14H11N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Synthesis and biological evaluation of thiazole derivatives as LbSOD inhibitors WOS:000454391600001 published article about IRON SUPEROXIDE-DISMUTASE; TRYPANOSOMA-CRUZI; OPTIMIZATION; PROTEIN; ASSAYS; IDENTIFICATION; DENATURATION; CYTOTOXICITY; CALORIMETRY; STABILITY in [Bitencourt Brito, Camila C.; Castilho, Marcelo Santos] Univ Estadual Feira de Santana, Programa Posgrad Biotecnol, Feira De Santana, BA, Brazil; [Carneiro da Silva, Helder Vinicius; Ximenes, Rafael Matos; de Albuquerque, Julianna F. C.] Univ Fed Pernambuco, Dept Antibiot, Recife, PE, Brazil; [Brondanic, Daci Jose; de Faria, Antonio Rodolfo] Univ Fed Pernambuco, Dept Farm, Recife, PE, Brazil; [da Silva, Ivanildo Mangueira] Fac Belo Jardim, Recife, PE, Brazil; [Castilho, Marcelo Santos] Univ Fed Bahia, Fac Farm, Salvador, BA, Brazil in 2019.0, Cited 46.0. Quality Control of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Leishmaniasis is considered as one of the major neglected tropical diseases due to its magnitude and wide geographic distribution. Leishmania braziliensis, responsible for cutaneous leishmaniasis, is the most prevalent species in Brazil. Superoxide dismutase (SOD) belongs to the antioxidant pathway of the parasites and human host. Despite the differences between SOD of Leishmania braziliensis and human make this enzyme a promising target for drug development efforts. No medicinal chemistry effort has been made to identify LbSOD inhibitors. Herein, we show that thermal shift assays (TSA) and fluorescent protein-labeled assays (FPLA) can be employed as primary and secondary screens to achieve this goal. Moreover, we show that thiazole derivatives bind to LbSOD with micromolar affinity.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Quality Control of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 TETRAHEDRON LETT published article about ACID-CATALYZED OXIDATION; AROMATIC-AMINES; BENZYLAMINES; AMIDES; CALCIUM in [Gupta, Sampa; Ansari, Alisha; Sashidhara, Koneni V.] CSIR Cent Drug Res Inst, Med & Proc Chem Div, Sect 10,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Ansari, Alisha; Sashidhara, Koneni V.] Acad Sci & Innovat Res, New Delhi 110025, India in 2019.0, Cited 33.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Computed Properties of C8H7NO3

A useful and efficient approach for the synthesis of nitroarenes from several aromatic amines (including heterocycles) using peroxide and base has been developed. This oxidative reaction is very easy to handle and afforded the products in good yields. Formation of benzamides from benzylamine was also successfully carried out with this metal-free catalytic system in good to excellent yields. (C) 2019 Elsevier Ltd. All rights reserved.

Computed Properties of C8H7NO3. Welcome to talk about 100-19-6, If you have any questions, you can contact Gupta, S; Ansari, A; Sashidhara, KV or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Gao, S; Niggeman, M in WILEY-V C H VERLAG GMBH published article about LIGHT PHOTOREDOX CATALYSIS; ALPHA-AMINOALKYL RADICALS; CENTERED RADICALS; RECENT PROGRESS; RATE CONSTANTS; GENERATION; FUNCTIONALIZATION; METHODOLOGY; CYCLIZATION; HYDRAZONYL in [Gao, Shuang; Niggeman, Meike] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany in 2019, Cited 56. Quality Control of 2,2-Diphenylacetonitrile. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3

N-Alkylanilines have rarely been used in oxyamination reactions, due to the normally necessary pre-functionalization of the N-atom. Also, the formation of aminium radical cations (ARCs) of anilines bearing alkyl substituents is plagued by the ARC’s tendency to instantaneously convert to alpha-amino radicals or iminium ions. We present a readily available reagent combination that addresses both challenges, and thus allows for an oxyamination with N-alkylanilines via ARCs as the crucial reactive intermediates and excellent diastereoselectivity.

Welcome to talk about 86-29-3, If you have any questions, you can contact Gao, S; Niggeman, M or send Email.. Quality Control of 2,2-Diphenylacetonitrile

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2020.0 NEW J CHEM published article about ASSISTED SYNTHESIS; TERMINAL ALKYNES; 1,3-DIPOLAR CYCLOADDITION; STEREOSELECTIVE-SYNTHESIS; 3-COMPONENT REACTIONS; CYCLIZATION REACTION; NATURAL-PRODUCTS; DERIVATIVES; ANTICANCER; DESIGN in [Singh, Manpreet; Singh, Virender] Dr BR Ambedkar Natl Inst Technol NIT, Dept Chem, Jalandhar 144011, Punjab, India; [Paul, Avijit Kumar] Natl Inst Technol Kurukshetra, Dept Chem, Kurukshetra 136119, Haryana, India; [Singh, Virender] Cent Univ Punjab, Dept Chem, Bathinda 151001, Punjab, India in 2020.0, Cited 86.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Quality Control of 1-(4-Nitrophenyl)ethanone

An efficient metal-free approach has been devised for the synthesis of novel beta-carboline C-1 tethered 2,3-dihydropyrroles and pyrrolesviaone-pot assembly involving 1-formyl beta-carbolines, aryl methyl ketones, and isonitriles. The reaction advances through the formation of beta-carboline linked enones followed by [3+2] cycloaddition with isonitriles. This methodology features an operationally simple procedure, multicomponent character, high atom economy, a broad substrate scope, short reaction times, and high regioselectivity with excellent yields. The scope of the process was exemplifiedviathe synthesis of a library of 34 novel compounds with significant diversity.

Quality Control of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Singh, M; Paul, AK; Singh, V or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Abdellatif, KRA; Fadaly, WAA; Kamel, GM; Elshaier, YAMM; El-Magd, MA in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about PROLIFERATOR-ACTIVATED RECEPTORS; CYCLOOXYGENASE-2 INHIBITORS; MOLECULAR DOCKING; INFLAMMATION; GLUCOSIDASE; REGULATOR; DISCOVERY; ANALOGS; RAT in [Abdellatif, Khaled R. A.; Fadaly, Wael A. A.] Beni Suef Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Bani Suwayf, Egypt; [Abdellatif, Khaled R. A.] Ibn Sina Natl Coll Med Studies, Pharmaceut Sci Dept, Jeddah 21418, Saudi Arabia; [Kamel, Gehan M.] Cairo Univ, Fac Vet, Pharmacol Dept, Cairo, Egypt; [Elshaier, Yaseen A. M. M.] Al Azhar Univ, Pharmaceut Organ Chem Dept, Fac Pharm, Assiut 71524, Egypt; [El-Magd, Mohammed A.] Kafrelshiekh Univ, Anat Dept, Fac Vet Med, Kafrelshiekh 33516, Egypt in 2019.0, Cited 51.0. Quality Control of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Nowadays, diabetes and its associated inflammatory complications are important public health problems worldwide. Market limitations of drugs with dual actions as anti-inflammatory (AI) and anti-diabetic have been led to a temptation for focusing on the discovery and development of new compounds with potential AI and antidiabetic activities. Herein, we synthesized two new series containing pyrazole ring with vicinal diaryl rings as selective COX-2 moiety and thiazolidindione (series 12a-f) or thiazolidinone (series 13a-f) as anti-diabetic moiety and the two moieties were linked together with methylene or methylenehydrazone functionality. The two series were evaluated for their COX inhibition, AI activity and ulcerogenic liability and for the anti-diabetic activity; 12a-f and 13a-f were assessed in vitro against alpha-glucosidase, beta-glucosidase, in vivo hypoglycemic activity (one day and 15 days studies) in addition to PPAR. activation study. Four compounds (12c, 12f, 13b and 13f) had higher COX-2 S.I. (8.69-9.26) than the COX-2 selective drug celecoxib (COX-2 S.I. = 8.60) and showed the highest AI activities and the lowest ulcerogenicity than other derivatives. Also, two thiazolidindione derivatives 12e and 12f and two thiazolidinone derivatives 13b and 13c showed higher inhibitory activities against alpha- and beta-glucosidase (% inhibitory activity = 62.15, 55.30, 65.37, 59.08 for alpha-glucosidase and 57.42, 60.07, 58.19, 66.90 for beta-glucosidase respectively) than reference compounds (acarbose with % inhibitory activity = 49.50 for alpha-glucosidase and D-saccharic acid 1,4-lactone monohydrate with % inhibitory activity = 53.42 for beta-glucosidase) and also showed good PPAR-gamma activation and good hypoglycemic effect in comparison to pioglitazone and rosiglitazone. Moreover, Shape comparison and docking studies were carried out to understand their interaction and similarity with standard drugs.

Quality Control of 1-(4-Nitrophenyl)ethanone. Welcome to talk about 100-19-6, If you have any questions, you can contact Abdellatif, KRA; Fadaly, WAA; Kamel, GM; Elshaier, YAMM; El-Magd, MA or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article Synthesis of 8-oxa-2-azaspiro[4.5]decane published in 2020. Category: benzodioxans, Reprint Addresses Rakitin, OA (corresponding author), Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia.. The CAS is 86-29-3. Through research, I have a further understanding and discovery of 2,2-Diphenylacetonitrile

A convenient synthesis of new 8-oxa-2-azaspiro[4.5]decane from commercially available reagents based on tetrahydropyran-4-carbonitrile and 1-bromo-2-fluoroethane has been developed. This compound is promising for the production of important biologically active compounds.

Category: benzodioxans. Welcome to talk about 86-29-3, If you have any questions, you can contact Ogurtsov, VA; Rakitin, OA or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Swamy, PCA; Varenikov, A; de Ruiter, G in AMER CHEMICAL SOC published article about N-HETEROCYCLIC CARBENES; RHODIUM COMPLEXES; ASYMMETRIC HYDROSILYLATION; STEREODIRECTING LIGANDS; PALLADIUM COMPLEXES; CARBONYL-COMPOUNDS; OLEFIN METATHESIS; ARYL-ALKYL; CATALYSTS; EFFICIENT in [Swamy, Chinna Ayya P.; Varenikov, Andrii; de Ruiter, Graham] Technion Israel Inst Technol, Schulich Fac Chem, IL-3200008 Haifa, Israel in 2020.0, Cited 72.0. Recommanded Product: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Herein we report the synthesis and application of a versatile class of N-heterocyclic carbene ligands based on an imidazo[1,5-a]pyridine-3-ylidine backbone that is fused to a chiral oxazoline auxiliary. The key step in the synthesis of these ligands involves the installation of the oxazoline functionality via a microwave-assisted condensation of a cyano-azolium salt with a wide variety of 2-amino alcohols. The resulting chiral bidentate NHC-oxazoline ligands form stable complexes with rhodium(I) that are efficient catalysts for the enantioselective hydrosilylation of structurally diverse ketones. The corresponding secondary alcohols are isolated in good yields (typically >90%) with good to excellent enantioselectivities (80-93% ee). The reported hydrosilylation occurs at ambient temperatures (40 degrees C), with excellent functional group tolerability. Even ketones bearing heterocyclic substituents (e.g., pyridine or thiophene) or complex organic architectures are hydrosilylated efficiently, which is discussed further in this report.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Product Details of 100-19-6. Authors El-sayed, HA; Assy, MG; Mohamed, AS in WILEY-V C H VERLAG GMBH published article about in [El-sayed, Hassan A.; Assy, Mohamed G.; Mohamed, Asaad S.] Zagazig Univ, Fac Sci, Dept Chem, Zagazig 44519, Egypt in 2019.0, Cited 15.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

An efficient and facile approach has been described for the synthesis of a new series of 1-amino-2-oxo-nicotinonitriles and their sulfonamides under microwave and ultrasonic irradiation. The desired compounds 4 a-l were obtained via condensation of p-chlorobenzaldehyde, aryl or heteroaryl methyl ketone and cyanoacetohydrazide in the presence of catalytic piperidine under three synthetic methodologies (namely, conventional method, ultrasonic and microwave irradiation), the best results (short reaction times, pure products, high yield) were obtained by ultrasonic irradiation. Sulfonamides 5 a-f resulted via reaction of amines 4 a-e and 4 j with benzene sulfonyl chloride in the presence of pyridine. The synthesized compounds give no significant results when investigated against Gm (+ve) and Gm (-ve) bacteria, and fungi strains.

Product Details of 100-19-6. Welcome to talk about 100-19-6, If you have any questions, you can contact El-sayed, HA; Assy, MG; Mohamed, AS or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Name: 1-(4-Nitrophenyl)ethanone. Hagui, W; Essid, R; Amri, S; Feris, N; Khabbouchi, M; Tabbene, O; Limam, F; Srasra, E; Besbes, N in [Hagui, Wided; Amri, Sondes; Khabbouchi, Mohamed; Srasra, Ezzeddine; Besbes, Neji] Natl Ctr Res Mat Sci, Lab Composite Mat & Clay Minerals, Grp Green & Appl Organ Chem, Technopole Borj Cedria, Soliman, Tunisia; [Hagui, Wided; Amri, Sondes; Khabbouchi, Mohamed] Tunis El Manar Univ, Fac Sci Tunis, El Manar Tunis, Tunisia; [Essid, Rym; Feris, Nadia; Tabbene, Olfa; Limam, Ferid] Biotechnol Ctr Borj Cedria, Lab Bioact Subst, Technopole Borj Cedria, Soliman, Tunisia published Acid-activated clay as heterogeneous and reusable catalyst for the synthesis of bioactive cyclic ketal derivatives in 2019.0, Cited 78.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A new heterogeneous acid catalyst based on a natural resource, Tunisian clay (Clay-H0.5), has been prepared and characterized by FT-IR, FE-SEM, and powder X-ray diffraction (XRD), as well as chemical composition, cation exchange capacity, specific surface area, and pore volume. Acid treatment for 0.5 h enlarged the surface area from 78.24 to 186.10 m(2)/g and pore volume (PV) from 0.186 to 0.281 cm(3)/g. The catalytic activity of this material was investigated in ketalization reaction under mild solvent-free conditions. This achieved up to 92% isolated yield for only 10 wt.% of the catalyst. This environmentally friendly method has advantages such as simple work-up procedure, avoidance of organic solvents, and good performance in ketalization reactions. Importantly, the Clay-H0.5 catalyst showed good recyclability where insignificant activity loss was exhibited even after six runs. Synthesized cyclic ketals were tested for their possible antileishmanial and antibacterial activities as well as antifungal activity. Biological screening showed that compound 11 had important antileishmanial activity against both L. major and L. infantum, while compound 14 also had significant antibacterial activity against four gram-positive and two gram-negative bacteria, and antifungal activity against Candida albicans, with minimal inhibitory concentration values ranging from 15.62 mu g/mL to 125 mu g/mL.

Name: 1-(4-Nitrophenyl)ethanone. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem