Day: January 21, 2022

In 2019.0 EUR J ORG CHEM published article about ESTERS; HYDROBORATION; BORYLATION; ALKYNES; DIVERSIFICATION; CARBANIONS in [Kovalenko, Maksym; Yarmoliuk, Dmytro, V; Serhiichuk, Dmytro; Chernenko, Dania; Smyrnov, Vladyslav; Breslayskyi, Artur; Hryshchuk, Oleksandr, V; Kleban, Ihor; Tymtsunik, Andriy, V; Tolmachev, Andrey A.; Kuchkovska, Yuliya O.; Grygorenko, Oleksandr O.] Enamine Ltd, Chervonotkatska St 78, UA-02094 Kiev, Ukraine; [Yarmoliuk, Dmytro, V; Smyrnov, Vladyslav; Hryshchuk, Oleksandr, V; Tolmachev, Andrey A.; Kuchkovska, Yuliya O.; Grygorenko, Oleksandr O.] Tams Shevchenko Natl Univ Kyiv, Volodymyrska St 60, UA-01601 Kiev, Ukraine; [Kleban, Ihor; Rassukana, Yuliya] Natl Acad Sci Ukraine, Inst Organ Chem, Murmanska St 5, UA-02660 Kiev, Ukraine; [Chernenko, Dania; Rassukana, Yuliya; Tymtsunik, Andriy, V] Natl Tech Univ Ukraine, Igor Sikorsky Kyiv Polytech Inst, Prospect Perem 37, UA-03056 Kiev, Ukraine in 2019.0, Cited 50.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Preparation of 2,2-disubstituted and 2-monosubstituted alkenylboronic acid esters from aliphatic and aromatic ketones and aldehydes by the boron-Wittig olefination with bis[(pinacolato)boryl]methane was examined and applied on the multigram scale. The influence of the substrate steric and electronic features on the overall efficiency and stereochemical outcome of the reaction was studied. Additionally, a series of diversely functionalized (hetera)cycloalkylidenemethyl and (hetera)cycloalkyl boronic acid-derived building blocks was synthesized.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. Welcome to talk about 100-19-6, If you have any questions, you can contact Kovalenko, M; Yarmoliuk, DV; Serhiichuk, D; Chernenko, D; Smyrnov, V; Breslayskyi, A; Hryshchuk, OV; Kleban, I; Rassukana, Y; Tymtsunik, AV; Tolmachev, AA; Kuchkovska, YO; Grygorenko, OO or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Application In Synthesis of 2,2-Diphenylacetonitrile. In 2020 ORGANOMETALLICS published article about ORGANOMETALLIC CHEMISTRY; COORDINATION CHEMISTRY; BOND-CLEAVAGE; NITRIC-OXIDE; LIGANDS; PNP; APPROXIMATION; HYDROBORATION; PLATINUM; IRIDIUM in [Pecak, Jan; Eder, Wolfgang; Linert, Wolfgang; Kirchner, Karl] Vienna Univ Technol, Inst Appl Synthet Chem, A-1060 Vienna, Austria; [Stoeger, Berthold] Vienna Univ Technol, Xray Ctr, A-1060 Vienna, Austria; [Realista, Sara] Univ Nova Lisboa, ITQB NOVA, Inst Tecnol Quim & Biol Antonio Xavier, P-2780157 Oeiras, Portugal; [Martinho, Paulo N.; Calhorda, Maria Jose] Univ Lisbon, Fac Ciencias, BioISI Biosyst & Integrat Sci Inst, DQB, P-1749016 Lisbon, Portugal in 2020, Cited 53. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3.

The reaction of coordinatively unsaturated Co(II) PCP pincer complexes with nitric oxide leads to the formation of new, air-stable, diamagnetic mono nitrosyl compounds. The synthesis and characterization of five- and four-coordinate Co(III) and Co(I) nitrosyl pincer complexes based on three different ligand scaffolds is described. Passing NO through a solution of [Co(PCPNMe-iPr)Cl], [Co(PCPO-iPr)Cl] or [Co(PCPCH2-iPr)Br] led to the formation of the low-spin complex [Co(PCP-iPr)(NO)-X] with a strongly bent NO ligand. Treatment of the latter species with (X = CI, Br) AgBF4 led to chloride abstraction and formation of cationic square-planar Co(I) complexes of the type [Co(PCP-iPr)(NO)](+) featuring a linear NO group. This reaction could be viewed as a formal two electron reduction of the metal center by the NO radical from Co(III) to Co(I), if NO is counted as NO+. Hence, these systems can be described as {CoNO}(8) according to the Enemark-Feltham convention. X-ray structures, spectroscopic and electrochemical data of all nitrosyl complexes are presented. Preliminary studies show that [Co(PCPNMe-iPr)(NO)](+) catalyzes efficiently the reductive hydroboration of nitriles with pinacolborane (HBpin) forming an intermediate {CoNO}(8) hydride species.

Application In Synthesis of 2,2-Diphenylacetonitrile. Welcome to talk about 86-29-3, If you have any questions, you can contact Pecak, J; Eder, W; Stoger, B; Realista, S; Martinho, PN; Calhorda, MJ; Linert, W; Kirchner, K or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Lamie, PF; Philoppes, JN in [Lamie, Phoebe F.; Philoppes, John N.] Beni Suef Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Bani Suwayf 62514, Egypt published 2-Thiopyrimidine/chalcone hybrids: design, synthesis, ADMET prediction, and anticancer evaluation as STAT3/STAT5a inhibitors in 2020.0, Cited 50.0. Product Details of 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A novel 2-thiopyrimidine/chalcone hybrid was designed, synthesised, and evaluated for their cytotoxic activities against three different cell lines, K-562, MCF-7, and HT-29. The most active cytotoxic derivatives were 9d, 9f, 9n, and 9p (IC50=0.77-1.74 mu M, against K-562 cell line), 9a and 9r (IC50=1.37-3.56 mu M against MCF-7 cell line), and 9a, 9l, and 9n (IC50=2.10 and 2.37 mu M against HT-29 cell line). Compounds 9a, 9d, 9f, 9n, and 9r were further evaluated for their cytotoxicity against normal fibroblast cell line WI38. Moreover, STAT3 and STAT5a inhibitory activities were determined for the most active derivatives 9a, 9d, 9f, 9n, and 9r. Dual inhibitory activity was observed in compound 9n (IC50=113.31 and 50.75 mu M, against STAT3 and STAT5a, respectively). Prediction of physicochemical properties, drug likeness score, pharmacokinetic and toxic properties was detected.

Welcome to talk about 100-19-6, If you have any questions, you can contact Lamie, PF; Philoppes, JN or send Email.. Product Details of 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Novel one step synthesis of imidazo[1,2-a]pyridines and Zolimidine via iron/iodine-catalyzed Ortoleva-King type protocol WOS:000480664500014 published article about WATER; AMINOPYRIDINES; DERIVATIVES; ARYLATION; ALKYNES; ARYL in [Ujwaldev, Sankuviruthiyil Mohanan; Rohit, K. R.; Harry, Nissy Ann; Anilkumar, Gopinathan] Mahatma Gandhi Univ, Sch Chem Sci, PD Hills PO, Kottayam 686560, Kerala, India in 2019.0, Cited 24.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Imidazo[1,2-a]pyridines form versatile scaffolds in pharmaceutical industry arising from their diverse biological activities. The synthesis of these molecules thus has been of great interest and resulted in the development of a large number of new methodologies. Herein we describe the first iron-catalyzed Ortoleva-King type protocol towards the synthesis of these fused heterocyclic compounds. This methodology employs cheap and easily available FeCl3 center dot 6H(2)O and molecular iodine as the catalytic system. The procedure has been well explored by extending the substrate scope with a variety of aromatic ketones and 2-aminopyridines to furnish different imidazo[1,2-a]pyridine derivatives in moderate to good yields. A successful application of this protocol was also demonstrated by achieving direct one step synthesis of the gastro protective drug, Zolimidine. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 100-19-6, If you have any questions, you can contact Ujwaldev, SM; Rohit, KR; Harry, NA; Anilkumar, G or send Email.. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Formula: C8H7NO3. Shaw, R; Althagafi, I; Elagamy, A; Rai, R; Shah, C; Nemaysh, V; Singh, H; Pratap, R in [Shaw, Ranjay; Elagamy, Amr; Shah, Chandan; Nemaysh, Vishal; Pratap, Ramendra] Univ Delhi, Dept Chem, North Campus, Delhi 110007, India; [Althagafi, Ismail] Umm Al Qura Univ, Dept Chem, Mecca, Saudi Arabia; [Rai, Reeta] All India Inst Med Sci, Dept Biochem, New Delhi 110029, India; [Singh, Harpreet] Indian Council Med Res, New Delhi 110029, India published Transition metal-free synthesis of sterically hindered allylarenes from 5-hexene-2-one in 2020.0, Cited 33.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A simple, efficient and transition metal-free strategy was established for the synthesis of highly functionalized, sterically hindered allylarenes (6,7&8) by base-mediated ring transformation of 2-oxo-6-aryl-4-(methylthio/sec-amino)-2H-pyran-3-carbonitriles (3/4) with 5-hexene-2-one (5). This provides a method for the synthesis of allylarenes functionalized with different electron donating and withdrawing groups in one pot. The structures of isolated products6cand7awere ascertained by spectroscopic and single crystal X-ray diffraction analyses. In addition, we have performed a molecular docking study to predict the biological activity of the synthesized molecules for binding to estrogen receptor alpha (ER alpha) and estrogen receptor beta (ER beta).

Welcome to talk about 100-19-6, If you have any questions, you can contact Shaw, R; Althagafi, I; Elagamy, A; Rai, R; Shah, C; Nemaysh, V; Singh, H; Pratap, R or send Email.. Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2020 ADV SYNTH CATAL published article about REDOX CONDENSATION REACTION; CARBONYLATIVE CYCLIZATION; MULTICOMPONENT REACTIONS; BENZOTHIAZOLE FORMATION; O-HALONITROBENZENES; BIOLOGICAL-ACTIVITY; MEDIATED SYNTHESIS; ARYL KETONES; METAL; 2-AMINOBENZENETHIOLS in [Zhao, Jinwu; Luo, Zhigao; Xu, Jingxiu] Guangdong Med Univ, Sch Pharm, Dongguan 523808, Peoples R China in 2020, Cited 47. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Safety of 1-(4-Nitrophenyl)ethanone

A three-component transition-metal-free aerobic method for the generation of 1,4-benzothiazines is reported herein. The KI/DMSO/O-2 system was found to be effective for the oxidative cyclization/coupling of 2-aminobenzenethiols, anilines, and methylketones. Hence, various structurally important imino 1,4-benzothiazines were assembled with broad functional group tolerance. Mechanistic studies revealed an initial oxidation of ketone alpha C-H bonds by the KI/DMSO/O-2 oxidative system.

Welcome to talk about 100-19-6, If you have any questions, you can contact Zhao, JW; Luo, ZG; Xu, JX or send Email.. Safety of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2020.0 CHEMISTRYSELECT published article about DEEP EUTECTIC SOLVENT; IMIDAZOLIUM HYDROGEN SULFATE; TRIMETHYLSILYL PROTECTION; EFFICIENT CATALYST; SULFONIC-ACID; NANOPARTICLES; CELLULOSE; FUNCTIONALIZATION; CHLORIDE; KETONES in [Kharazmi, Azin; Ghorbani-Vaghei, Ramin; Alavinia, Sedigheh] Bu Ali Sina Univ, Fac Chem, Dept Organ Chem, Hamadan 6517838683, Hamadan, Iran in 2020.0, Cited 40.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. HPLC of Formula: C8H7NO3

Some novel pyrimidine derivatives are prepared via one-pot reaction of triethoxymethane, aromatic ketone and ammonium acetate using catalytic system including nano-magnetic pyridinium-tribromide (TBP-SCMNPs). The synthesized new catalyst was characterized by FE-SEM, EDS, TEM, XRD, and TGA analysis. The highlighting points of using TBP-SCMNPs are easy purification, reusability of the catalyst, good yields of products with short time reactions.

HPLC of Formula: C8H7NO3. Welcome to talk about 100-19-6, If you have any questions, you can contact Kharazmi, A; Ghorbani-Vaghei, R; Alavinia, S or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Re-Silane complexes as frustrated lewis pairs for catalytic hydrosilylation WOS:000561080600035 published article about ENERGY-ADJUSTED PSEUDOPOTENTIALS; MOLECULAR-ORBITAL METHODS; TRANSITION-METAL OXOS; CARBONYL-COMPOUNDS; BASIS-SETS; B(C6F5)(3)-CATALYZED HYDROSILYLATION; MECHANISM; KETONES; ELECTRON; APPROXIMATION in [Brown, Caleb A.; Abrahamse, Michael; Ison, Elon A.] North Carolina State Univ, Dept Chem, 2620 Yarbrough Dr, Raleigh, NC 27695 USA in 2020.0, Cited 54.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. SDS of cas: 100-19-6

A pathway for the catalytic hydrosilylation of carbonyl substrates with M(C6F5)(3) (M = B, Al and Ga) was calculated by DFT (B3PW91-D3) and it was shown that in the case of the Al reagent, the carbonyl substrate binds irreversibly and inhibits catalysis by generating a stable carbonyl adduct. In contrast, the reduced electrophilicity of B(C6F5)(3) disfavors the binding of the carbonyl substrate and increases the concentration of an activated silane adduct which is the species responsible for catalytic turnover. A similar mechanism was found for both cationic and neutral Re(III) species. Further, it was shown by tuning the electrophilicity of the rhenium catalysts, conditions can be found that would enable the catalytic hydrosilylation of ketone and nitrile substrates that were unreactive in previously reported systems. Thus the mechanisms proposed in this work, lay the foundation for the design of new catalytic systems.

SDS of cas: 100-19-6. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Formula: C8H7NO3. Authors Ioannou, DI; Gioftsidou, DK; Tsina, VE; Kallitsakis, MG; Hatzidimitriou, AG; Terzidis, MA; Angaridis, PA; Lykakis, IN in AMER CHEMICAL SOC published article about in [Ioannou, Dimitris I.; Gioftsidou, Dimitra K.; Tsina, Vasiliki E.; Kallitsakis, Michael G.; Hatzidimitriou, Antonios G.; Angaridis, Panagiotis A.; Lykakis, Ioannis N.] Aristotle Univ Thessaloniki, Dept Chem, Thessaloniki 54124, Greece; [Terzidis, Michael A.] Int Hellen Univ, Dept Nutr Sci & Dietet, Thessaloniki 57400, Greece in 2021, Cited 48. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

We report an efficient catalytic protocol that chemo-selectively reduces nitroarenes to arylamines, by using methylhydrazine as a reducing agent in combination with the easily synthesized and robust catalyst tris(N-heterocyclic thioamidate) Co(III) complex [Co(kappa S,N-tfmp2S)(3)], tfmp2S = 4-(trifluoromethyl)-pyrimidine-2-thiolate. A series of arylamines and heterocyclic amines were formed in excellent yields and chemoselectivity. High conversion yields of nitroarenes into the corresponding amines were observed by using polar protic solvents, such as MeOH and ‘PrOH. Among several hydrogen donors that were examined, methylhydrazine demonstrated the best performance. Preliminary mechanistic investigations, supported by UV-vis and NMR spectroscopy, cyclic voltammetry, and high-resolution mass spectrometry, suggest a cooperative action of methylhydrazine and [Co(kappa S,N-tfmp2S)(3)] via a coordination activation pathway that leads to the formation of a reduced cobalt species, responsible for the catalytic transformation. In general, the corresponding N-arylhydroxylamines were identified as the sole intermediates. Nevertheless, the corresponding nitrosoarenes can also be formed as intermediates, which, however, are rapidly transformed into the desired arylamines in the presence of methylhydrazine through a noncatalytic path. On the basis of the observed high chemoselectivity and yields, and the fast and clean reaction processes, the present catalytic system [Co(kappa S,N-tfmp2S)(3)]/MeNHNH2 shows promise for the efficient synthesis of aromatic amines that could find various industrial applications.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Application In Synthesis of 1-(4-Nitrophenyl)ethanone. I found the field of Chemistry very interesting. Saw the article An Umpolung Oxa-[2,3] Sigmatropic Rearrangement Employing Arynes for the Synthesis of Functionalized Enol Ethers published in 2021.0, Reprint Addresses Biju, AT (corresponding author), Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.

An oxa-[2,3] sigmatropic rearrangement involving arynes is reported featuring the umpolung of ketones, where the C = O bond polarity is reversed. The in situ-generated sulfur ylides from beta-keto thioethers and arynes undergo efficient rearrangement allowing the facile and robust synthesis of functionalized enol ethers in high yields and excellent functional group compatibility. Preliminary mechanistic studies rule out the possibility of Pummerer-type rearrangement operating in this case.

Welcome to talk about 100-19-6, If you have any questions, you can contact Gaykar, RN; George, M; Guin, A; Bhattacharjee, S; Biju, AT or send Email.. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem