Month: January 2022

An article An Integrated Continuous Flow Micro-Total Ultrafast Process System (mu-TUFPS) for the Synthesis of Celecoxib and Other Cyclooxygenase Inhibitors WOS:000487577100012 published article about ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; PYRAZOLES; DIVERSE; DERIVATIVES; CATALYSIS in [Sthalam, Vinay Kumar; Singh, Ajay K.; Pabbaraja, Srihari] Indian Inst Chem Technol, CSIR, Dept Organ Synth & Proc Chem, Hyderabad 500007, Andhra Pradesh, India; [Sthalam, Vinay Kumar; Pabbaraja, Srihari] Acad Sci & Innovat Res AcSIR, CSIR HRDC Campus, Ghaziabad 201002, Uttar Pradesh, India in 2019.0, Cited 54.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Quality Control of 1-(4-Nitrophenyl)ethanone

Integrated continuous manufacturing has emerged as a promising device for the rapid manufacturing of active pharmaceutical ingredients (APIs). We herein report a newly designed continuous flow micro-total process system platform for the rapid manufacturing of celecoxib, a selective nonsteroidal anti-inflammatory drug. This approach has been proven generally for the synthesis of several alkyl and aryl substituted pyrazoles. In order to minimize the tedious work-up process of potential reaction intermediates/products, we have developed a continuous flow extraction and separation platform to carry out the entire reaction sequence resulting in a short residence time with good yield. The present process was further extended to gram scale synthesis of the COX-2-related API, viz. celecoxib, in the continuous flow process.

Welcome to talk about 100-19-6, If you have any questions, you can contact Sthalam, VK; Singh, AK; Pabbaraja, S or send Email.. Quality Control of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Formula: C8H7NO3. Zaman, K; Rahim, F; Taha, M; Wadood, A; Shah, SAA; Gollapalli, M; Ullah, F; Ahmed, A in [Zaman, Khalid; Rahim, Fazal] Hazara Univ, Dept Chem, Mansehra 21300, Pakistan; [Taha, Muhammad] Imam Abdulrahman Bin Faisal Univ, IRMC, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia; [Wadood, Abdul] Abdul Wali Khan Univ Mardan, Dept Biochem, Mardan 23200, Pakistan; [Shah, Syed Adnan Ali] Univ Teknol MARA UiTM, Atta Ur Rahman Inst Nat Prod Discovery, Puncak Alam Campus, Puncak Akan 42300, Selangor De, Malaysia; [Shah, Syed Adnan Ali] Univ Teknol MARA UiTM, Fac Pharm, Puncak Alam Campus, Puncak Alam 42300, Selangor Darul, Malaysia; [Gollapalli, Mohammed] Imam Abdulrahman Bin Faisal Univ, CCSIT, POB 1982, Dammam 3144, Saudi Arabia; [Ullah, Farhat] Univ Malakand, Dept Pharm, Khyber Pakhtunkhwa 18000, Kpk, Pakistan; [Ahmed, Ashfaq] Sarhad Univ Sci & Informat Technol, Dept Pharm, Peshawar, Pakistan published Synthesis, thymidine phosphorylase, angiogenic inhibition and molecular docking study of isoquinoline derivatives in 2019.0, Cited 35.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Isoquinoline analogues (KA-1 to 16) have been synthesized and evaluated for their E. coli thymidine phosphorylase inhibitory activity. Except compound 11, all other analogs showed outstanding thymidine inhibitory potential ranging in between 4.40 +/- 0.20 to 69.30 +/- 1.80 mu M when compared with standard drug 7-Deazaxanthine (IC50 = 38.68 +/- 4.42 mu M). Structure Activity Relationships has been established for all compounds, mainly based on substitution pattern on phenyl ring. All analogs were characterized by various spectroscopic techniques such as H-1 NMR, C-13 NMR and EI-MS. The binding interactions of isoquinoline analogues with the active site of TP enzyme, the molecular docking studies were performed. Furthermore, the angiogenic inhibitory potentials of isoquinoline analogues (KA-1-9, 14, 12 and 16) were determined in the presence of standard drug Dexamethasone based on percentage inhibitions at various concentrations. Herein this work analogue KA-12, 14 and 16 emerged with most potent angiogenic inhibitory potentials among the synthesized analogues.

Welcome to talk about 100-19-6, If you have any questions, you can contact Zaman, K; Rahim, F; Taha, M; Wadood, A; Shah, SAA; Gollapalli, M; Ullah, F; Ahmed, A or send Email.. Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about PALLADIUM NANOPARTICLES; SELECTIVE HYDROGENATION; HETEROGENEOUS CATALYST; COUPLING REACTIONS; NITRO-COMPOUNDS; EFFICIENT; HALLOYSITE; OXIDE; NANOCOMPOSITE; NANOCATALYST, Saw an article supported by the Iran Polymer and Petrochemical Institute; Iran National Science FoundationIran National Science Foundation (INSF) [99011126]. HPLC of Formula: C8H7NO3. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Sadjadi, S; Koohestani, F. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

In attempt to take advantages of naturally occurring compounds for the catalysis, a novel composite composed of beta-cyclodextrin, dendrimer and bentonite clay is fabricated and utilized as a support for the stabilization of Pd nanoparticles. To prepare the support, bentonite is amino functionalized and then successively reacted with 2,4,6-trichloro-1,3,5-triazine and ethylenediamine to furnish a dendrimer of generation II on bentonite. Afterwards, the terminal functionalities of the dendrimer were adorned with cyclodextrin. Bentonite played role in the hetemgenation of the catalyst and improvement of the stability of the composite while, cyclodextrins served as molecular shuttles and capping agent for the as-prepared Pd nanoparticles. Dendrimer with multi nitrogen atoms, on the other hand, improved Pd anchoring through electrostatic interactions. The catalyst was applied for the hydrogenation of nitmarenes under mild reaction condition in aqueous media in a selective manner. Notably, the catalyst could be recovered and reused repeatedly.

HPLC of Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Sadjadi, S; Koohestani, F or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Sun, YW; Bei, YM; Wang, LZ in [Sun, Yue-Wei; Bei, Yue-Ming; Wang, Lan-Zhi] Hebei Normal Univ, Coll Chem & Mat Sci, Shijiazhuang 050024, Hebei, Peoples R China published A catalyst-free four-component domino reaction for the synthesis of functionalized 3-acyl-1,5-benzodiazepines in 2019.0, Cited 16.0. Computed Properties of C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Various functional 3-acyl-1,5-benzodiazepines containing carboxyl, ester and acyl groups at the 2-position were synthesized via an efficient, sustainable and catalyst-free domino reaction. During the synthesis process, one new cycle and four new bonds (one C-C, two C-N and one C=C) were constructed by the nucleophilic substitution, nucleophilic addition, dehydration and cyclization reaction by the H+ shift. Furthermore, a total of 26 examples were examined by reacting inexpensive starting materials of N,N-dimethylformamide dimethyl acetal, aromatic ketones, 1,2-phenylenediamine compounds and aldehyde derivatives. Therefore, it displayed a broad substrate scope, good functional group tolerance, high yields (77-97%) and the ease of obtaining target compounds without the involvement of toxic solvents and column chromatography, which provided a novel method for the synthesis of a wide variety of biologically relevant 1,5-benzodiazepines.

Computed Properties of C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Sun, YW; Bei, YM; Wang, LZ or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

SDS of cas: 100-19-6. Recently I am researching about BEARING BENZOTHIAZOLE; ANTITUMOR-ACTIVITY; IN-VITRO; DERIVATIVES; THIOPHENE; PYRIDINE; HETEROCYCLES; INHIBITORS; THIAZOLE; MOIETY, Saw an article supported by the . Published in WILEY in HOBOKEN ,Authors: Hassan, AY; Sarg, MT; Hussein, EM. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

On the pharmaceutical account of the reported anticancer activity of benzothiazole derivatives, differently substituted benzothiazole derivatives 2a-c to 34a,b, attached at 2-position to different heterocyclic moieties, were synthesized via different chemical reactions. Thirteen of the newly synthesized compounds were selected by the National Cancer Institute, Bethesda, Maryland, USA, and evaluated for their in vitro antitumor activity against 60 human tumor cell lines in a one-dose screening panel among which two compounds 4 and 17 showed high activity and were selected for further evaluation in the five-dose full panel assay, in which compound 4 exerted powerful growth inhibitory activity against all cell lines with GI(50) ranging from 0.683 to 4.66 mu M/L in addition to excellent lethal activity against most of the cell lines.

SDS of cas: 100-19-6. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Lin, JS; Li, TT; Jiao, GY; Gu, QS; Cheng, JT; Lv, L; Liu, XY in WILEY-V C H VERLAG GMBH published article about ENANTIOSELECTIVE HYDROAMINATION; METAL CATALYSIS; STEREOCONVERGENT; TRANSFORMATIONS; CLASSIFICATION; ISOMERIZATION; RACEMIZATION; ACTIVATION; S(N)1 in [Lin, Jin-Shun] Tsinghua Univ, Key Lab Chem Biol, State Key Lab Chem Oncogen, Grad Sch Shenzhen, Shenzhen 518055, Peoples R China; [Lin, Jin-Shun] Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; [Lin, Jin-Shun; Li, Tao-Tao; Jiao, Guan-Yuan; Gu, Qiang-Shuai; Cheng, Jiang-Tao; Lv, Ling; Liu, Xin-Yuan] Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China; [Lin, Jin-Shun; Li, Tao-Tao; Jiao, Guan-Yuan; Cheng, Jiang-Tao; Lv, Ling; Liu, Xin-Yuan] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China; [Gu, Qiang-Shuai] Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen 518055, Peoples R China in 2019, Cited 71. Safety of 2,2-Diphenylacetonitrile. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3

The first highly efficient and practical chiral BrOnsted acid catalyzed dynamic kinetic asymmetric hydroamination (DyKAH) of racemic allenes and asymmetric hydroamination of unactivated dienes with both high E/Z selectivity and enantioselectivity are described herein. The transformation proceeds through a new catalytic asymmetric model involving a highly reactive pi-allylic carbocationic intermediate, generated from racemic allenes or dienes through a proton transfer mediated by an activating/directing thiourea group. This method affords expedient access to structurally diverse enantioenriched, potentially bioactive alkenyl-containing aza-heterocycles and bicyclic aza-heterocycles.

Bye, fridends, I hope you can learn more about C14H11N, If you have any questions, you can browse other blog as well. See you lster.. Safety of 2,2-Diphenylacetonitrile

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article A practical strategy for construction and regulation of multi-functional triazepinium salts via highly efficient I-2-catalyzed cyclization WOS:000537870500032 published article about LARGE STOKES SHIFT; CONJUGATED POLYMERS; SEMICONDUCTING PROPERTIES; MOLECULAR DESIGN; STATE; FLUORESCENCE; LIGHT; DERIVATIVES; ELECTROLUMINESCENCE; FLUOROPHORES in [Liu, Lang; She, Mengyao; Zhang, Jun; Wang, Zhaohui; Liu, Hua; Tang, Mi; Liu, Ping; Zhang, Shengyong; Li, Jianli] Northwest Univ, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Coll Chem & Mat Sci, Xian 710127, Shaanxi, Peoples R China; [She, Mengyao] Northwest Univ, Key Lab Resource Biol & Modern Biotechnol Western, Minist Educ, Coll Life Sci,Fac Life & Hlth Sci, Xian 710069, Shaanxi, Peoples R China in 2020, Cited 60. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Synthesis of new functional organic molecules is a critical path that may greatly accelerate the evolution of organic optoelectronic materials. We have achieved a facile synthesis strategy to produce unique saddle-shaped multi-functional triazepinium salts that exhibit excellent solid-state fluorescence. Their fluorescence performance could be easily regulated by adjusting the dihedral angle between the main skeleton and the substituted moiety, giving a large Stokes shift, non-aggregation quenching, long lifetime, and multilevel-redox characteristics.

Welcome to talk about 100-19-6, If you have any questions, you can contact Liu, L; She, MY; Zhang, J; Wang, ZH; Liu, H; Tang, M; Liu, P; Zhang, SY; Li, JL or send Email.. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about ASYMMETRIC REDUCTION; EFFICIENT CATALYST; KETONES; ALDEHYDES; HYDROSILYLATION; COMPLEXES; HYDRIDE; RUTHENIUM; POLY(SILYLETHER)S; HYDROGENATION, Saw an article supported by the National Science FoundationNational Science Foundation (NSF); NSF EPSCoR Award [IIA-1355466]. HPLC of Formula: C8H7NO3. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Vijjamarri, S; O’Denius, TM; Yao, B; Kubatov, A; Du, GD. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Hydroboration of carbonyl compounds is an important transformation in organic chemistry, and a growing interest in catalysis has focused on abundant and nontoxic base metals. Herein we describe an efficient salen manganese catalyst for the hydroboration of a broad range of carbonyl compounds with pinacolborane. The catalytic reactions proceeded rapidly (>99% conversion in <5 min) at room temperature with very low catalyst loadings. High turnover frequency (up to 5700 h(-1)) was observed under these conditions. Several synthetically important functional groups were tolerated, and chemoselective hydroboration of aldehydes over ketones was achieved. The H/D kinetic isotopic effect of borane was determined to be 2.3. The Hammett correlation plot of a series of para-substituted acetophenone substrates, p-X-C6H6COCH3 (X = H, Me, OMe, NO2, Cl, Br, and CF3) yielded a positive slope of rho = +0.99. The crossover products were detected in the competition reaction of catecholborane and deuterated pinacolborane with acetophenone. The findings indicated a potential borane-mediated pathway that could account for the observation of the crossover products. HPLC of Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Vijjamarri, S; O’Denius, TM; Yao, B; Kubatov, A; Du, GD or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis, in vitro urease inhibitory potential and molecular docking study of Benzimidazole analogues published in 2019.0. Product Details of 100-19-6, Reprint Addresses Rahim, F (corresponding author), Hazara Univ, Dept Chem, Mansehra 21300, Khyber Pakhtunk, Pakistan.; Taha, M (corresponding author), Imam Abdulrahman Bin Faisal Univ, IRMC, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Despite of many diverse biological activities exhibited by benzimidazole scaffold, it is rarely explored for the urease inhibitory potential. For that purpose, benzimidazole analogues 1-19 were synthesized and screened for in vitro urease inhibitory potential. Structures of all synthetic analogues were deduced by different spectroscopic techniques. All analogues revealed inhibition potential with IC50 values of 0.90 +/- 0.01 to 35.20 +/- 1.10 mu M, when compared with the standard thiourea (IC50 = 21.40 +/- 0.21 mu M). Limited SAR suggested that the variations in the inhibitory potentials of the analogues are the result of different substitutions on phenyl ring. In order to rationalize the binding interactions of most active compounds with the active site of urease enzyme, molecular docking study was conducted.

Product Details of 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Zaman, K; Rahim, F; Taha, M; Ullah, H; Wadood, A; Nawaz, M; Khan, F; Wahab, Z; Shah, SAA; Rehman, AU; Kawde, AN; Gollapalli, M or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about COVALENT-ORGANIC FRAMEWORKS; SUPRAMOLECULAR ASSEMBLIES; PI INTERACTIONS; ADSORPTION; COMPLEXES; LIGAND; IMINE, Saw an article supported by the Warsaw University of Technology (WUT). COA of Formula: C8H7NO3. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Kasprzak, A; Gunka, PA. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

High-yield, chromatography-free syntheses of a ferrocene-templated molecular cage and its Pd-bearing derivative are presented. The formation of a symmetric cage-type structure was confirmed by single-crystal X-ray diffraction analysis. The Pd-bearing cage was used as an innovative catalyst for the efficient synthesis of 1,1′-biphenyls under mild conditions. The presented catalyst is reusable and 1,1′-biphenyls can be obtained efficiently in a gram scale process.

COA of Formula: C8H7NO3. Welcome to talk about 100-19-6, If you have any questions, you can contact Kasprzak, A; Gunka, PA or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem