Day: April 8, 2022

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 5,5′-Dimethyl-2,2′-bipyridine, is researched, Molecular C12H12N2, CAS is 1762-34-1, about Five new cobalt(II) complexes based on indazole derivatives: synthesis, DNA binding and molecular docking study, the main research direction is preparation cobalt indazole derivative bipy phen complex; crystal structure cobalt indazole derivative bipy phen complex; DNA interaction cobalt indazole derivative bipy phen complex; thermal decomposition cobalt indazole derivative bipy phen complex.Synthetic Route of C12H12N2.

Five cobalt(II) complexes based on 1H-indazole-3-carboxylic acid (H2L), [Co(phen)(HL)2]·H2O (1), [Co(5,5′-dimethyl-2,2′-bipy)(HL)2] (2), [Co(2,2′-bipy)2(HL)]·5H2O (3), [Co2(2,9-dimethyl-1,10-phen)2(L)2] (4) and [Co2(6,6′-dimethyl-2,2′-bipy)2(L)2]·H2O (5) (2,2′-bipy = 2,2′-bipyridine, phen = 1,10-phenanthroline), were synthesized and structurally characterized by elemental analyses, IR and UV-visible spectroscopies and single-crystal X-ray crystallog. 1-3 Possess mononuclear Co(II) structures, while 4 and 5 exhibit binuclear structure. 1D water tape which is linked by the multiple hydrogen bonds was embedded in the 3D motif of complex 3. Complexes 4 and 5 show two orthogonal planes of motif that was constituted by phen/2,2′-bipy and indazole acid, resp. The intermol. interactions including hydrogen bonding and π-π stacking interactions are stabilizing these complexes. The interactions of the synthesized complexes with calf-thymus DNA (CT-DNA) were studied by UV-visible absorption titration, ethidium bromide displacement assay and viscosity measurements. The complexes could interact with CT-DNA via a groove binding mode. Their behavior rationalization was further theor. studied by mol. docking.

Compound(1762-34-1)Synthetic Route of C12H12N2 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(5,5′-Dimethyl-2,2′-bipyridine), if you are interested, you can check out my other related articles.

Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Category: benzodioxans. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5,5′-Dimethyl-2,2′-bipyridine, is researched, Molecular C12H12N2, CAS is 1762-34-1, about Crystal structure, thermochemical and fluorescent properties of two novel binuclear lanthanide complexes with 3-chloro-4-methoxybenzoic acid and 5,5′-dimethy-2,2′-bipyridine.

Two novel binuclear lanthanide complexes, [Ln(3-Cl-4-MOBA)3(5,5′-DM-2,2′-bipy)]2(5,5′-DM-2,2′-bipy) (Ln=Eu(1), Gd(2)), (3-Cl-4-MOBA=3-chloro-4-methoxybenzoate; 5,5′-DM-2,2′-bipy=5,5′-dimethy-2,2′-bipyridine) have been successfully synthesized under hydrothermal conditions. The complexes are characterized by single-crystal X-ray diffraction and elemental anal. Complexes 1 and 2 are isomorphous, and each metal center is eight-coordinated with a distorted square-antiprism coordination geometry. The binuclear units are assembled into 1D, 2D and 3D supramol. structures by weak hydrogen bonds (C-H···O and C-H···Cl) and π-π stacking interactions. Thermal behavior of the complexes 1 and 2 was determined by TG/DSC-FTIR techniques. Heat capacities of the complexes are measured by a DSC instrument in the temperature range of 283.15-393.15K. Based on the heat capacities date, the thermodn. functions (HT-H298.15K) and (ST-S298.15K) were obtained. The activation energy E values of the first decomposition stage for complexes 1 and 2 were calculated by integral iso-conversional nonlinear (NL-INT) method. The fluorescence spectra and lifetime of complex 1 (Eu3+ ion) were studied in depth.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5,5′-Dimethyl-2,2′-bipyridine(SMILESS: CC1=CN=C(C=C1)C1=NC=C(C)C=C1,cas:1762-34-1) is researched.Application In Synthesis of 6-Chloropyridine-2-boronic Acid. The article 《Dimeric imidazolium ionic liquids connected by bipyridiyl as a corrosion inhibitor for N80 carbon steel in HCl》 in relation to this compound, is published in Journal of Molecular Liquids. Let’s take a look at the latest research on this compound (cas:1762-34-1).

A new type of the dimeric imidazolium-type amphiphile, BDBCmIB (m = 1, 4 and 8), was synthesized using the bipyridiyl as the spacer, and its inhibition performance and mechanism for the corrosion of N80 carbon steel in 1.0 mol·L-1 HCl were evaluated using chem. and electrochem. measurements, surface analyses and d. functional theory (DFT) calculations Results show that the inhibition efficiency of BDBCmIBs increases with their concentrations and the length of tail chains. BDBC8IB exhibits the best inhibition performance among them and its inhibition efficiency almost exceeds 90% in a wide concentration range from 1.0 × 10-6 to 5.0 × 10-4 mol·L-1 at 25.0 °C, which attains the maximum over 95% at 5.0 × 10-4 mol·L-1. Moreover, three BDBCmIBs all display the high inhibition efficiency at 5.0 × 10-4 mol·L-1, nearly exceeding 90%, in the temperature range from 25.0 to 55.0 °C. As a mixed-type inhibitor, BDBCmIBs can retard both cathodic hydrogen evolution and anodic metal dissolution processes, since BDBCmIB mols. bear the imidazolium-based heterocycle with the electron-donating ability and the bipyridine with the electron-accepting ability, thereby facilitating the formation of a protective film on the surface of N80 carbon steel via electrostatic interactions, coordinated and back-donating bonds. The adsorption of BDBCmIBs obeys the Langmuir isothermal model. Our finding demonstrates that the introduction of the bipyridiyl at the spacer does favor improving the inhibition efficiency of such dimeric imidazolium-type amphiphiles, and meanwhile, the proper increase in the number of carbon atoms in the substituents on the imidazole rings can also enhance the inhibition efficiency.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Reversible H2 oxidation and evolution by hydrogenase embedded in a redox polymer film, published in 2021-03-31, which mentions a compound: 1762-34-1, mainly applied to reversible hydrogen oxidation hydrogenase redox polymer film, Reference of 5,5′-Dimethyl-2,2′-bipyridine.

Efficient electrocatalytic energy conversion requires devices to function reversibly, i.e., to deliver a substantial current at a minimal overpotential. Redox-active films can effectively embed and stabilize mol. electrocatalysts, but mediated electron transfer through the film typically makes the catalytic response irreversible. Here we describe a redox-active film for bidirectional (oxidation or reduction) and reversible hydrogen conversion, which consists of [FeFe] hydrogenase embedded in a low-potential, 2,2′-viologen-modified hydrogel. When this catalytic film served as the anode material in a H2/O2 biofuel cell, an open circuit voltage of 1.16 V was obtained-a benchmark value near the thermodn. limit. The same film also acted as a highly energy efficient cathode material for H2 evolution. We explained the catalytic properties using a kinetic model, which shows that reversibility can be achieved even though intermol. electron transfer is slower than catalysis. This understanding of reversibility simplifies the design principles of highly efficient and stable bioelectrocatalytic films, advancing their implementation in energy conversion.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1762-34-1, is researched, SMILESS is CC1=CN=C(C=C1)C1=NC=C(C)C=C1, Molecular C12H12N2Journal, Polymer Chemistry called Self-supported rhodium catalysts based on a microporous metal-organic framework for polymerization of phenylacetylene and its derivatives, Author is Zhang, Li; Cao, Qingbin; Gao, Fei; Dong, Yuping; Li, Xiaofang, the main research direction is metal organic framework supported rhodium catalyst phenylacetylene polymerization.Name: 5,5′-Dimethyl-2,2′-bipyridine.

A series of heterogeneous metal-organic framework (MOF)-supported rhodium (Rh) hybrid catalysts with varying amounts of Rh are first applied to the coordination polymerization of phenylacetylene and its derivatives with or without cocatalysts in different organic solvents under a nitrogen atm. or in water media under an air atm. In comparison with the known homogeneous and heterogeneous Rh catalysts, these MOF-supported Rh catalysts exhibit not only a channel confinement effect on the polymer mol. weight distribution but also a more remarkable cooperation effect, polar solvent acceleration effect, “”on water”” effect, and cocatalyst acceleration effect on the catalytic activity. As a result, these heterogeneous Rh catalysts have the advantages of an extremely high activity of up to 1.5 x 107 g molRh-1 h-1, cis-selectivity of up to 99%, and reusability of up to 10 times, affording cis-transoidal PPAs and their functional derivatives having single-handed helical conformation or aggregation-induced emission properties with moderate mol. weights and narrow mol. weight distributions. As far as we are aware, such extremely efficient Rh catalysts as well as multiple reusable heterogeneous Rh catalysts have never been reported.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Safety of (R)-N-((R)-(5-(Diphenylphosphanyl)-9,9-dimethyl-9H-xanthen-4-yl)(4-methoxyphenyl)methyl)-2-methylpropane-2-sulfinamide. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: (R)-N-((R)-(5-(Diphenylphosphanyl)-9,9-dimethyl-9H-xanthen-4-yl)(4-methoxyphenyl)methyl)-2-methylpropane-2-sulfinamide, is researched, Molecular C39H40NO3PS, CAS is 2160535-56-6, about Gold-Catalyzed Asymmetric Intramolecular Cyclization of N-Allenamides for the Synthesis of Chiral Tetrahydrocarbolines. Author is Wang, Yidong; Zhang, Peichao; Di, Xiaoyu; Dai, Qiang; Zhang, Zhan-Ming; Zhang, Junliang.

Highly enantioselective gold-catalyzed intramol. cyclization of N-allenamides was implemented by utilizing a designed chiral sulfinamide phosphine ligand (PC-Phos) [e.g., allenamide I → tetrahydrocarboline II (99%, 96% ee) in presence of Me2S.AuCl, AgNTf2 and ligand III in CH2Cl2 at -50°]. This represents the first example of highly enantioselective intramol. cyclization of N-allenamides. The practicality of this reaction was validated in the total synthesis of (R)-desbromoarborescidine A and formal synthesis of (R)-desbromoarborescidine C and (R)-deplancheine. Moreover, the catalyst system PC-Phos/AuNTf2 proved to be specifically efficient to promote the desymmetrization of N-allenamides in excellent yields with satisfactory ee values.

From this literature《Gold-Catalyzed Asymmetric Intramolecular Cyclization of N-Allenamides for the Synthesis of Chiral Tetrahydrocarbolines》,we know some information about this compound(2160535-56-6)Safety of (R)-N-((R)-(5-(Diphenylphosphanyl)-9,9-dimethyl-9H-xanthen-4-yl)(4-methoxyphenyl)methyl)-2-methylpropane-2-sulfinamide, but this is not all information, there are many literatures related to this compound(2160535-56-6).

Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Vicente, Ramon; Tubau, Annia; Speed, Saskia; Mautner, Franz A.; Bierbaumer, Florian; Fischer, Roland C.; Massoud, Salah S. researched the compound: 5,5′-Dimethyl-2,2′-bipyridine( cas:1762-34-1 ).Reference of 5,5′-Dimethyl-2,2′-bipyridine.They published the article 《Slow magnetic relaxation and luminescence properties in neodymium(III)-4,4,4-trifluoro-1-(2-naphthyl)butane-1,3-dionato complexes incorporating bipyridyl ligands》 about this compound( cas:1762-34-1 ) in New Journal of Chemistry. Keywords: neodymium trifluoronaphthalenylbutanedionate complex preparation magnetic relaxation luminescence; crystal structure neodymium trifluoronaphthalenylbutanedionate complex. We’ll tell you more about this compound (cas:1762-34-1).

Five new eight-coordinated Nd(III) mononuclear complexes with the formulas [Nd(ntfa)3(EtOH)2] (1), [Nd(ntfa)3(phen)] (2), [Nd(ntfa)3(bipy)] (3), [Nd(ntfa)3(5,5′-Me2bipy)] (4) and [Nd(ntfa)3(4,4′-Mt2bipy)] (5), where ntfa = 4,4,4-trifluoro-1-(naphthalen-2-yl)butane-1,3-dionate, phen = phenanthroline, bipy = 2,2′-dipyridine, 5,5′-Me2bipy = 5,5′-dimethyl-2,2′-dipyridine, and 4,4′-Mt2bipy = 4,4′-dimethoxy-2,2′-dipyridine, were synthesized and structurally characterized. Magnetic measurements were carried out on complexes 2-5. Dynamic magnetic studies revealed single-mol. magnet (SMM) behavior for complexes 2, 4 and 5 with anisotropy energy barriers and preexponential factors of Ueff = 18 cm-1, τ0 = 2.2 x 10-7 s; Ueff = 31 cm-1, τ0 = 1.0 x 10-9 s and Ueff = 19 cm-1, τ0 = 8.7 x 10-8 s, resp. The ancillary chelating bipyridyl ligands in complexes 2-5 greatly enhance the solid state luminescence emission in the visible and NIR regions through efficient energy transfer from the ligands to the central Nd3+ ion. This study highlights the bifunctionality of the Nd(III) complexes.

From this literature《Slow magnetic relaxation and luminescence properties in neodymium(III)-4,4,4-trifluoro-1-(2-naphthyl)butane-1,3-dionato complexes incorporating bipyridyl ligands》,we know some information about this compound(1762-34-1)Reference of 5,5′-Dimethyl-2,2′-bipyridine, but this is not all information, there are many literatures related to this compound(1762-34-1).

Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Application of 1762-34-1. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 5,5′-Dimethyl-2,2′-bipyridine, is researched, Molecular C12H12N2, CAS is 1762-34-1, about Synthesis, structural characterization and in vitro cytotoxic evaluation of mixed Cu(II)/Co(II) levofloxacin-bipyridyl complexes. Author is Bashir, Masrat; Yousuf, Imtiyaz.

This work features synthesis, structural characterization and biol. evaluation of two Cu(II)/Co(II)-based complexes (1 and 2) synthesized from levofloxacin (lvXn) and bipyridyl ligands. The structural elucidation of complexes 1 and 2 was carried out by anal., spectral (UV-vis, FTIR, EPR) and single crystal x-ray crystallog. techniques. The crystallog. details of complex 1 revealed a triclinic crystal system with P-1 space group and lattice parameters a = 10.32(7) Å, b = 11.75(8) Å, c = 14.85(9) Å, and α = 87.40°, β = 77.55°, γ = 66.26°. The DFT studies were performed to study the electronic structure and localization of HOMO and LUMO electron densities on the complexes. authors have also performed comparative in vitro DNA/BSA binding studies of complexes 1 and 2 by multispectroscopic methods to evaluate the cytotoxic potential of synthesized complexes which revealed better binding potential of copper analog. Furthermore, the cytotoxic assessment of copper analog was examined on a panel of five human cancer cell lines employing SRB assay which revealed remarkably good and selective cytotoxic activity towards A498 (kidney), HeLa (cervical) and HepG2 (hepatoma) cancer cell lines.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Bioorganic & Medicinal Chemistry Letters called Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists, Author is Rudolph, Dale A.; Alcazar, Jesus; Ameriks, Michael K.; Anton, Ana Belen; Ao, Hong; Bonaventure, Pascal; Carruthers, Nicholas I.; Chrovian, Christa C.; De Angelis, Meri; Lord, Brian; Rech, Jason C.; Wang, Qi; Bhattacharya, Anindya; Andres, Jose Ignacio; Letavic, Michael A., which mentions a compound: 1799971-34-8, SMILESS is O=C(N1[C@@H](C)C(NCC1)=O)OC(C)(C)C, Molecular C10H18N2O3, Electric Literature of C10H18N2O3.

The optimization efforts that led to a novel series of Me substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones that are potent rat and human P2X7 antagonists are described. These efforts resulted in the discovery of compounds with good drug-like properties that are capable of high P2X7 receptor occupancy in rat following oral administration, including compounds I (P2X7 IC50 = 7.7 nM) and II (P2X7 IC50 = 7.7 nM). These compounds are expected to be useful tools for characterizing the effects of P2X7 antagonism in models of depression and epilepsy, and several of the compounds prepared are candidates for effective P2X7 PET tracers.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Chidambaram, Ramasamy R.; Sadhasivam, Velu; Mariyappan, Mathappan; Siva, Ayyanar published the article 《Catalytic hydrogenation of aldehydes and ketones using cinchona-bipyridyl-based palladium catalyst》. Keywords: cinchona bipyridyl palladium catalyst preparation surface structure; aldehyde cinchona bipyridyl palladium catalyst hydrogenation; ketone cinchona bipyridyl palladium catalyst hydrogenation; alc preparation.They researched the compound: 5,5′-Dimethyl-2,2′-bipyridine( cas:1762-34-1 ).SDS of cas: 1762-34-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1762-34-1) here.

Understanding the need for simple, robust and low effluents, in chem. processes, an elegant protocol was developed for the catalytic reduction of aldehydes and ketones to corresponding alcs. which were used in synthetic fragrance applications using cinchona alkaloid-derived palladium catalyst. This system holds good for very low catalyst loading surfaces with the formation of fewer impurities and negligible decomposition under moderate pressure. The conversions and yields ranges from moderate to good (60-80%).

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem