Discovery of 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone

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Synthesis of Spiro[indole-3,5?-isoxazoles] with Anticancer Activity via a Formal [4 + 1]-Spirocyclization of Nitroalkenes to Indoles

An acid-assisted [4 + 1]-cycloaddition of indoles with nitrostyrenes affords 4?H-spiro[indole-3,5?-isoxazoles] in a diastereomerically pure form. Several of these spirocyclic molecules exhibit promising anticancer activity by reducing viability and inducing differentiation of neuroblastoma cells.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem