With the synthetic route has been constantly updated, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,belong benzodioxans compound
As a common heterocyclic compound, it belong benzodioxans compound,2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,3663-80-7,Molecular formula: C9H8O4,mainly used in chemical industry, its synthesis route is as follows.,3663-80-7
EXAMPLE 38; Methyl ({4-[4-(2,3-dihydro-1 ,4-benzodioxin-2-ylcarbonyl)piperazin-1 -yl]-6-ethylthieno[2,3- d]pyrimidin-2-yl}thio)acetate EPO To a mixture of 1 ,4-benzodioxan-2-carboxylic acid (0.069 g) in N-methyl pyrrolidinone (2.5 ml_) was added 1 ,1-carbonyldiimidazole (0.062 g). The mixture was placed in a 2 dram screw cap vial and placed in a Lab-Line MAX Q2000 orbital shaker for 1 hour at which time the hydrochloride salt of Example 34 (0.075 g) and diisopropylethylamine (0.05 g) were added. The mixture was placed back in the Lab-Line MAX Q2000 orbital shaker for 18 hours. The mixture was partitioned between brine and ethyl acetate. The layers were separated and the organic layer washed four times with brine, dried over anhydrous magnesium sulfate and concentrated. The residue was chromatographed on silica gel (100 mL) using ethyl acetate as eluent to give 0.0429 g (43percent) of the title compound: 1H NMR (CDCI3) delta 1.36 (t, 3 H), 2.88 (q, 2 H), 3.62-4.1 (m, 13 H), 4.2-4.88 (m, 4 H), 6.84-6.99 (m, 5 H).
With the synthetic route has been constantly updated, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,belong benzodioxans compound
Reference£º
Patent; PHARMACIA & UPJOHN COMPANY LLC; WO2006/100591; (2006); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem