Authors Tian, M; Liu, XY; He, H; Ma, XZ; Liang, C; Liu, Y; Jiang, FL in AMER CHEMICAL SOC published article about SELECTIVE FLUORESCENT; DESIGN STRATEGIES; SENSOR; CELLS; KINETICS; THIOLS; CANCER in [Tian, Ming; Liu, Xing-Yu; He, Huan; Liu, Yi; Jiang, Feng-Lei] Wuhan Univ, Sauvage Ctr Mol Sci, Coll Chem & Mol Sci, Wuhan 430072, Peoples R China; [Ma, Xian-Zheng; Liang, Chao] Wuhan Univ, Natl Engn Res Ctr Multimedia Software NERCMS, Sch Comp Sci, Wuhan 430072, Peoples R China; [Liu, Yi] Wuhan Univ Sci & Technol, Hubei Prov Key Lab Coal Convers & New Carbon Mat, Sch Chem & Chem Engn, Wuhan 430081, Peoples R China; [Liu, Yi] Nanning Normal Univ, Coll Chem & Mat Sci, Guangxi Key Lab Nat Polymer Chem, Nanning 530001, Peoples R China in 2020.0, Cited 37.0. Name: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6
Glutathione (GSH), the most abundant nonprotein thiol found in living organisms, are involved in the etiology and progression of many human diseases including cancer. So, monitoring changes of cellular GSH levels has an important guiding significance. To date, however, majority of probes can only qualitatively detect GSH in living cells. Herein, with coumarin as the read-out fluorophore and Michael addition as the sensing mechanism, six fluorescent probes were designed and synthesized. Among them, RP-2 exhibited a reversible and extremely fast response toward GSH (half time: similar to 3 s), which endowed RP2 the capacity of real-time imaging. Among the reversible probes based on Michael addition, RP-2 had both the largest forward and reverse rate constants thus far. The reaction between RP-2 and GSH was studied in detail by density functional theory and fluorescence spectroscopy. Real-time imaging of GSH levels in living cells was achieved with a temporal resolution of seconds. To simplify the processing of images, a program was developed and validated. RP-2 was expected to serve as a new fluorescent imaging tool to understand the function of intracellular GSH in the future.
Name: 1-(4-Nitrophenyl)ethanone. Welcome to talk about 100-19-6, If you have any questions, you can contact Tian, M; Liu, XY; He, H; Ma, XZ; Liang, C; Liu, Y; Jiang, FL or send Email.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem