I found the field of Chemistry very interesting. Saw the article A general asymmetric copper-catalysed Sonogashira C(sp(3))-C(sp) coupling published in 2019. Safety of 2,2-Diphenylacetonitrile, Reprint Addresses Liu, XY (corresponding author), Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen, Guangdong, Peoples R China.; Liu, XY (corresponding author), Southern Univ Sci & Technol, Dept Chem, Shenzhen, Guangdong, Peoples R China.. The CAS is 86-29-3. Through research, I have a further understanding and discovery of 2,2-Diphenylacetonitrile
Continued development of the Sonogashira coupling has made it a well established and versatile reaction for the straightforward formation of C-C bonds, forging the carbon skeletons of broadly useful functionalized molecules. However, asymmetric Sonogashira coupling, particularly for C(sp(3))-C(sp) bond formation, has remained largely unexplored. Here we demonstrate a general stereoconvergent Sonogashira C(sp(3))-C(sp) cross-coupling of a broad range of terminal alkynes and racemic alkyl halides (>120 examples) that are enabled by copper-catalysed radical-involved alkynylation using a chiral cinchona alkaloid-based P,N-ligand. Industrially relevant acetylene and propyne are successfully incorporated, laying the foundation for scalable and economic synthetic applications. The potential utility of this method is demonstrated in the facile synthesis of stereoenriched bioactive or functional molecule derivatives, medicinal compounds and natural products that feature a range of chiral C(sp(3))-C(sp/sp(2)/sp(3)) bonds. This work emphasizes the importance of radical species for developing enantioconvergent transformations.
Welcome to talk about 86-29-3, If you have any questions, you can contact Dong, XY; Zhang, YF; Ma, CL; Gu, QS; Wang, FL; Li, ZL; Jiang, SP; Liu, XY or send Email.. Safety of 2,2-Diphenylacetonitrile
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Benzodioxan,
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