I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Chalcones bearing a 3,4,5-trimethoxyphenyl motif are capable of selectively inhibiting oncogenic K-Ras signaling published in 2020.0. Computed Properties of C8H7NO3, Reprint Addresses Cho, KJ (corresponding author), Wright State Univ, Dept Biochem & Mol Biol, Dayton, OH 45435 USA.; Ketcha, DM (corresponding author), Wright State Univ, Dept Chem, Dayton, OH 45435 USA.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone
Ras proteins are small GTPases which regulate cellular proliferation, differentiation, and apoptosis. Constitutively active mutant Ras are expressed in similar to 15-20% human cancers, and K-Ras mutations account for similar to 85% of all Ras mutations. Despite the significance of Ras proteins in refractory cancers, there is no anti-Ras drug available in clinic. Since K-Ras must interact with the plasma membrane (PM) for biological activity, inhibition of the K-Ras/PM interaction is a tractable approach to block oncogenic K-Ras activity. Here, we discovered chalcones 1 and 8 exhibit anti-K-Ras activity, and show that the compounds mislocalize K-Ras from the PM and block oncogenic K-Ras signal output. Also, 1 inhibits the growth of K-Ras-driven human cancer cells. Our data suggest that 1 could be a promising starting point for developing anti-K-Ras cancer drug.
Welcome to talk about 100-19-6, If you have any questions, you can contact Kovar, SE; Fourman, C; Kinstedt, C; Williams, B; Morris, C; Cho, KJ; Ketcha, DM or send Email.. Computed Properties of C8H7NO3
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Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem