I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis, in vitro urease inhibitory potential and molecular docking study of Benzimidazole analogues published in 2019.0. Product Details of 100-19-6, Reprint Addresses Rahim, F (corresponding author), Hazara Univ, Dept Chem, Mansehra 21300, Khyber Pakhtunk, Pakistan.; Taha, M (corresponding author), Imam Abdulrahman Bin Faisal Univ, IRMC, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone
Despite of many diverse biological activities exhibited by benzimidazole scaffold, it is rarely explored for the urease inhibitory potential. For that purpose, benzimidazole analogues 1-19 were synthesized and screened for in vitro urease inhibitory potential. Structures of all synthetic analogues were deduced by different spectroscopic techniques. All analogues revealed inhibition potential with IC50 values of 0.90 +/- 0.01 to 35.20 +/- 1.10 mu M, when compared with the standard thiourea (IC50 = 21.40 +/- 0.21 mu M). Limited SAR suggested that the variations in the inhibitory potentials of the analogues are the result of different substitutions on phenyl ring. In order to rationalize the binding interactions of most active compounds with the active site of urease enzyme, molecular docking study was conducted.
Product Details of 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Zaman, K; Rahim, F; Taha, M; Ullah, H; Wadood, A; Nawaz, M; Khan, F; Wahab, Z; Shah, SAA; Rehman, AU; Kawde, AN; Gollapalli, M or concate me.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem