Recently I am researching about DIHYDROFOLATE-REDUCTASE INHIBITORS; ANTIOPPORTUNISTIC INFECTION AGENTS; DUAL THYMIDYLATE SYNTHASE; DERIVATIVES; ANTITUMOR; POTENT; DISCOVERY; DESIGN, Saw an article supported by the 973 ProjectNational Basic Research Program of China [2013CB911002]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31761133012, 31530016]; Shenzhen Science and Technology Innovation Commission [JCYJ20170412113009742, JCYJ20180307182213033]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Wang, FC; Peng, B; Cao, SL; Li, HY; Yuan, XL; Zhang, TT; Shi, RF; Li, ZQ; Liao, J; Wang, HL; Li, J; Xu, XZ. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Recommanded Product: 100-19-6
Many natural or synthetic chalcones have potential anti-tumor activity. Here, we synthesized two series of chalcone analogues containing a thieno [2,3-cflpyrimidin-2-y] group and evaluated for their cytotoxic activity towards cultured human lung cancer A549 and colorectal HCT-116 cells. Among them, compound 8d was the most cytotoxic against HCT-116 cells, with an IC50 value of 2.65 mu M. Analyses of the phenotypic changes induced by this compound found a dose-dependent accumulation of HCT-116 cells in sub-G1 phase, indicating that compound 8d might induce apoptosis. Furthermore, we found that 8d triggered mitochondrial membrane potential depolarization, promoted reactive oxygen species formation in HCT-116 cells, and increased the percentage of early and late apoptotic cells. Finally, immunoblotting indicated that 8d increased PARP-1 and caspases 3, 7 and 9 cleavage. These data suggest that compound 8d induces apoptosis via the mitochondrial death pathway.
Welcome to talk about 100-19-6, If you have any questions, you can contact Wang, FC; Peng, B; Cao, SL; Li, HY; Yuan, XL; Zhang, TT; Shi, RF; Li, ZQ; Liao, J; Wang, HL; Li, J; Xu, XZ or send Email.. Recommanded Product: 100-19-6
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem