Recommanded Product: 100-19-6. In 2019.0 BIOORG CHEM published article about INHIBITORS; INFLAMMATION; DERIVATIVES; CELECOXIB; DOCKING; PATHWAY in [Thangarasu, P.] Bharathiar Univ, Res & Dev Ctr, Coimbatore 641046, Tamil Nadu, India; [Manikandan, A.] VIT Univ, Sch Biosci & Technol, Dept Biotechnol, Vellore 632014, Tamil Nadu, India; [Thamaraiselvi, S.] Govt Arts Coll, PG & Res Dept Chem, Coimbatore 641018, Tamil Nadu, India in 2019.0, Cited 50.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.
As the global need for drugs getting increases, the necessity of novel and effective drugs are the need of the day. Pyrazoles are one of the active molecules in novel drug discovery. The present study deals about the synthesis of precursors 4-(4-fluorophenyl)-6-isopropyl-2-(methylsulfonyl) pyrimidine-5-carbohydrazides (3a-m) from methyl- 4-(4-fluorophenyl)-6-isopropyl-2-(methyl sulfonyl) pyrimidine-5-carboxylate (2) by treating with substituted acetophenone. Further, Vilsmeier-Haack reaction of compounds 3a-m at 70 degrees C for 8-10 hrs gave novel pyrazole carbaldehyde derivatives (4a-m) in good yield. Biological properties like antioxidant, anti-breast cancer and anti-inflammatory of newly synthesized compounds (4a-m) were determined. The enzymes Cyclooxygenase-2 and Phosphoinositide-3-Kinase are most responsible for the corresponding diseases such as inflammation and breast cancer respectively. In order to examine the interaction between these two enzymes and our synthesized compounds 4a-m, molecular docking study was carried out. From the results, few compounds of 4a-m were found to have anti-inflammatory properties by showing excellent COX-2 inhibition and HRBC membrane stabilization properties. ADMET prediction results were also valuable to screen the most effective pyrazole derivatives to establish them as future COX-2 inhibitors or anti-inflammatory drugs.
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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem