Analyzing the synthesis route of 2879-20-1

With the synthetic route has been constantly updated, we look forward to future research findings about 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,belong benzodioxans compound

As a common heterocyclic compound, it belong benzodioxans compound,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,2879-20-1,Molecular formula: C10H10O3,mainly used in chemical industry, its synthesis route is as follows.,2879-20-1

General procedure: Acetophenone 1a (120 mg, 1.0 mmol), pyridine 2a (158 mg, 2.0 mmol), and iodine (254 mg, 1.0 mmol) were placed in an oven-dried and argon filled Schlenk tube. After addition of anhydrous DMSO (5 mL), the mixture was stirred at 100 C for 36 h. After the reaction completed, the mixture was diluted with water and treated with Na2S2O3 (5% w/w, aq) until the color turned to pale yellow. The mixture was then extracted with CH2Cl2 (3¡Á20 mL), the combined organic extracts were dried over Na2SO4 and concentrated under reduced pressure. The crude product was purified by column chromatography on silica gel (eluent: CH2Cl2/EtOAc=200:1) to afford a yellow solid 3aa (122 mg, 85%).

With the synthetic route has been constantly updated, we look forward to future research findings about 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,belong benzodioxans compound

Reference£º
Article; Yang, Yan; Gao, Meng; Zhang, Dong-Xue; Wu, Liu-Ming; Shu, Wen-Ming; Wu, An-Xin; Tetrahedron; vol. 68; 36; (2012); p. 7338 – 7344;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem