As a common heterocyclic compound, it belong benzodioxans compound,2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde,29668-44-8,Molecular formula: C9H8O3,mainly used in chemical industry, its synthesis route is as follows.,29668-44-8
25 g of the product of Example 1,Adding 500 mL of water to raise the temperature to 70-80 DEG C,Then, 30 g of KMnO4 + 500 mL of an aqueous solution was prepared,Dropping into the above reaction solution, heating for 40 minutes and heating to reflux for 2 hours,The reaction was terminated by TLC, cooled to room temperature, alkalified by addition of 10percent aqueous KOH,Filter cake washed with water to neutral, the filtrate acidified with concentrated hydrochloric acid,A large amount of white solid was precipitated, and the filter cake was washed with water and dried to obtain 23 g of a white solid in 90percent yield.
With the synthetic route has been constantly updated, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde,belong benzodioxans compound
Reference£º
Patent; Shanghai PharmValley Corp.; Yu, Weiyong; Yang, Ling; Wang, Ailing; (4 pag.)CN105801556; (2016); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem