Safety of 1-(4-Nitrophenyl)ethanone. Recently I am researching about MUSHROOM TYROSINASE; CRYSTAL-STRUCTURE; ANTIMICROBIAL ACTIVITY; ANTI-TYROSINASE; MECHANISM; DESIGN; ACID; ANTIBACTERIAL; ANTITUMOR; DOCKING, Saw an article supported by the Foundation of Education Department of Hunan Province, China [15A172]. Published in WILEY in HOBOKEN ,Authors: Zhang, Y; Fu, X; Yan, YT; Liu, JB. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone
In this work, we have synthesized a series of 2-thiazolylhydrazone derivatives (1-27) and investigated their biological activities as tyrosinase inhibitors and antioxidants. Some compounds showed potent tyrosinase inhibitory activities and 4-(2-(2-(1-(4-Aminophenyl)ethylidene)-hydrazinyl)thiazol-4-yl) phenol (26) showed more potent inhibitory effect than the standard tyrosinase inhibitor kojic acid (IC50: 9.8 mu M vs. 23.6 mu M). Compounds 2, 14, and 26 exhibited high antioxidant activities in 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2 ‘-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The structure-activity relationship (SAR) indicated that the substitutions of bromine, hydroxyl group, and amino groups cause great effect to the inhibition effect against tyrosinase. The mechanism and kinetic studies demonstrated that the inhibitory effect of compound 26 on the tyrosinase by acting as the reversible and uncompetitive inhibitor. Docking studies suggests that compound 26 interacts strongly with mushroom tyrosinase via hydrogen bonding.
Safety of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Zhang, Y; Fu, X; Yan, YT; Liu, JB or concate me.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem