Category: 100-19-6

Kumar, S; Kaushik, A; Narasimhan, B; Shah, SAA; Lim, SM; Ramasamy, K; Mani, V in [Kumar, Sanjiv; Kaushik, Archana; Narasimhan, Balasubramanian] Maharshi Dayanand Univ, Fac Pharmaceut Sci, Rohtak 124001, Haryana, India; [Shah, Syed Adnan Ali; Lim, Siang Meng; Ramasamy, Kalavathy] Univ Teknol MARA UiTM, Fac Pharm, Bandar Puncak Alam 42300, Selangor Darul, Malaysia; [Shah, Syed Adnan Ali] Univ Teknol MARA, Atta Ur Rahman Inst Nat Prod Discovery AuRIns, Bandar Puncak Alam 42300, Selangor Darul, Malaysia; [Lim, Siang Meng; Ramasamy, Kalavathy] Univ Teknol MARA UiTM, Collaborat Drug Discovery Res CDDR Grp, Shah Alam 40450, Selangor Darul, Malaysia; [Mani, Vasudevan] Qassim Univ, Coll Pharm, Dept Pharmacol & Toxicol, Buraydah 51452, Saudi Arabia published Molecular docking, synthesis and biological significance of pyrimidine analogues as prospective antimicrobial and antiproliferative agents in 2019.0, Cited 31.0. Recommanded Product: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Pyrimidine nucleus is a significant pharmacophore that exhibited excellent pharmacological activities. A series of pyrimidine scaffolds was synthesized and its chemical structures were confirmed by physicochemical and spectral analysis. The synthesized compounds were evaluated for their antimicrobial potential towards Gram positive and negative bacteria as well as fungal species. They were also assessed for their anticancer activity toward a human colorectal carcinoma cell line (HCT116). Whilst results of antimicrobial potential revealed that compounds Ax2, Ax3, Ax8 and Ax14 exhibited better activity against tested microorganisms, the results of antiproliferative activity indicated that compounds Ax7 and Ax10 showed excellent activity against HCT116. Further, the molecular docking of pyrimidine derivatives Ax1, Ax9 and Ax10 with CDK8 (PDB id: 5FGK) protein indicated that moderate to better docking results within the binding pocket. Compounds Ax8 and Ax10 having significant antimicrobial and anticancer activities may be selected as lead compounds for the development of novel antimicrobial and anticancer agent, respectively.

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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Cheng, P; Wang, W; Wang, L; Zeng, JG; Reiser, O; Liang, Y in [Cheng, Pi; Wang, Wei; Wang, Lin; Zeng, Jianguo] Hunan Agr Univ, Key Lab Tradit Chinese Vet Med Hunan Prov, Changsha 410128, Hunan, Peoples R China; [Reiser, Oliver] Univ Regensburg, Inst Organ Chem, Univ Str 31, D-93053 Regensburg, Germany; [Liang, Yun] Hunan Normal Univ, Key Lab Assembly & Applicat Organ Funct Mol Hunan, Changsha 410081, Hunan, Peoples R China published Ag2CO3-mediated direct functionalization of alkyl nitriles: Facile synthesis of gamma-ketonitriles through nitrile alkylation of enol acetates in 2019.0, Cited 35.0. Product Details of 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Direct C(sp3)-H functionalization of alkyl nitriles is a low toxic and facile route to nitrile-containing compounds. In this research, the Ag2CO3-mediated nitrile methylenation of enol acetates is developed to prepare gamma-ketonitriles through the direct C(sp(3))-H oxidative functionalization of acetonitrile. A radical pathway is proposed, and acetonitrile serves both as solvent and CN-containing radical source. (C) 2019 Elsevier Ltd. All rights reserved.

Product Details of 100-19-6. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 1-(4-Nitrophenyl)ethanone. Gurevich, KG; Urakov, AL; Klen, EE; Samorodov, AV; Nikitina, IL; Khaliullin, FA; Nebogatova, VA; Makarova, NN; Shepilova, SO; Bashirova, LI; Khalimov, AR in [Gurevich, K. G.] AI Evdokimov Moscow State Univ Med & Dent, 20-1 Delegatskaya St, Moscow 127473, Russia; [Urakov, A. L.; Bashirova, L., I] Minist Hlth RF, Izhevsk State Med Acad, 281 Kommunarov St, Izhevsk 426034, Udmurtia, Russia; [Klen, E. E.; Samorodov, A., V; Nikitina, I. L.; Khaliullin, F. A.; Nebogatova, V. A.; Makarova, N. N.; Shepilova, S. O.; Khalimov, A. R.] Bashkir State Med Univ, Minist Hlth RF, 3 Lenin St, Ufa 450008, Bashkortostan, Russia published Synthesis and Biological Activity of Ethyl 2-[8-Arylmethylidenehydrazino-3-Methyl-7-(1-Oxothietan-3-YL)Xanth-1-YL]Acetates in 2020.0, Cited 11.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Ethyl 2-[8-Arylmethylidenehydrazino-3-methyl-7-(1-oxothietan-3-yl)xanth-1-yl]acetates (IV) were synthesized via reactions of ethyl 2-[8-hydrazino-3-methyl-7-(1-oxothietan-3-yl)xanth-1-yl]acetic acid (III) with various benzaldehydes and acetophenones. The structures of the compounds were elucidated using IR and NMR spectroscopy and elemental analysis. The antiplatelet, anticoagulation, antioxidant, and anti-inflammatory activities were assessedin vitroand in laboratory animals to identify promising compounds exhibiting antiplatelet (hydrazoneIVd) and antioxidant properties (hydrazoneIVb). BothIVbandIVdaccording toin silicocalculations were characterized by the absence of toxic risks (mutagenicity, oncogenicity, reproductive toxicity, local irritation) and had acceptable topological polar surface area so that they were promising.

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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Safety of 1-(4-Nitrophenyl)ethanone. I found the field of Chemistry very interesting. Saw the article Synthesis, Spectroscopic Characterization, DFT Calculations and Preliminary Antifungal Activity of New Piperine Derivatives published in 2021.0, Reprint Addresses Barbosa, JM (corresponding author), Univ Fed Paraiba, Dept Ciencias Farmaceut, BR-58051900 Joao Pessoa, PB, Brazil.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.

Four new piperine derivatives, PC1-PC4, were synthesized, and their structures were fully characterized by infrared (IR) and H-1 and C-13 nuclear magnetic resonance (NMR) spectroscopies. Quantum chemical calculations were performed using density functional theory (DFT) with the B3LYP-D3/6-31G(d,p) and 6-311+G(2d,p) basis sets. Electronic properties, such as the energy gap between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) and some global chemical reactivity descriptors, were evaluated to study the reactivity and stability of the compounds. H-1 and C-13 NMR chemical shifts were calculated by using the gauge-invariant atomic orbital (GIAO) method and compared with experimental values. In addition, the compounds were evaluated in an antifungal study against Candida, Trichophyton and Microsporum strains, and only PC4 showed 70% inhibition in ten tested strains, with a minimum inhibitory concentration (MIC) ranging from 1.23-2.46 mu mol mL(-1) and a minimum fungicide concentration (MFC) ranging from 9.84-19.68 mu mol mL(-1), and presented a fungistatic effect.

Safety of 1-(4-Nitrophenyl)ethanone. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Transition metal-free alpha-methylation of 1,8-naphthyridine derivatives using DMSO as methylation reagent WOS:000479062100019 published article about DIMETHYL-SULFOXIDE; FUNCTIONALIZATION; ALKYLATION; BOND; ALCOHOLS; HYDROGENATION; SULFONYLATION; HETEROARENES; HETEROCYCLES; OXIDATION in [Jiang, Shaohua; Yang, Zhihai; Guo, Ziyin; Li, Yibiao; Chen, Lu; Zhu, Zhongzhi; Chen, Xiuwen] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China in 2019.0, Cited 50.0. Name: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A practical approach to the direct alpha-methylation of 1,8-naphthyridines under mild reaction conditions has been developed using simple and readily available DMSO as a convenient and environmentally friendly carbon source. This method is transition metal-free and highly chemoselective, shows good functional group tolerance, and uses DMSO as a methyl source, providing efficient and rapid access to an important compound class, 2-methyl-1,8-naphthyridines.

Name: 1-(4-Nitrophenyl)ethanone. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Sun, XY; Gong, M; Huang, MM; Li, YB; Kim, JK; Kovalev, V; Shokova, E; Wu, YJ in AMER CHEMICAL SOC published article about NATURAL-PRODUCTS; CONDENSATION; ACYLATION; 1,3-DIKETONES; COUMARINS; 4-PYRONES; ETHERS; DYES in [Sun, Xiangyu; Gong, Ming; Huang, Mengmeng; Li, Yabo; Kim, Jung Keun; Shokova, Elvira; Wu, Yangjie] Zhengzhou Univ, Key Lab Appl Chem Henan Univ, Coll Chem, Henan Key Lab Chem Biol & Organ Chem, Zhengzhou 450052, Peoples R China; [Kovalev, Vladimir] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia in 2020.0, Cited 84.0. Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Despite the various attractive properties of gamma-pyrones, there are still some deficiencies in their synthetic approaches such as lower atom economy, multistep processes, and prefunctionalization of the reagents. In this work, an efficient and simple (CF3CO)(2)O/CF3SO3H-mediated one-pot approach was realized to produce gamma-pyrones by applying aromatic ketones/heteroarenes and carboxylic acids as the starting materials. The target products were isolated in moderate to excellent yields. The reaction mechanism was studied by density functional theory calculational methods. The results of experimental and theoretical investigations not only helped us explain the reason of high selectivity formation of beta-diketones but also proved that 1,3,5-ketones might be important intermediates for the cyclization to afford gamma-pyrones.

Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Sun, XY; Gong, M; Huang, MM; Li, YB; Kim, JK; Kovalev, V; Shokova, E; Wu, YJ or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

HPLC of Formula: C8H7NO3. In 2019.0 J ORG CHEM published article about C-H ALKYLATION; ENANTIOSELECTIVE SYNTHESIS; SECONDARY AMIDES; DERIVATIVES; 4-PYRIDONE; 2-PYRIDONES; INHIBITORS; SULFOXIDES; OLIGOMERS; ANHYDRIDE in [Huang, Jingjia; Hu, Gang; An, Shaoyu; Chen, Dongding; Li, Minglei; Li, Pingfan] Beijing Univ Chem Technol, Fac Sci, Dept Organ Chem, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China; [Hu, Gang] Baotou Teachers Coll, Dept Chem, Baotou 014030, Peoples R China in 2019.0, Cited 72.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

N-Alkylated 4-pyridones were obtained through a one-pot procedure involving either normal or interrupted Pummerer reactions between triflic anhydride-activated sulfoxides and 4-fluoropyridine derivatives, followed by hydrolysis. On the other hand, triflic anhydride-activated benzyl 6-fluoro-2-pyridyl sulfoxide could react with alkenes or alkynes to afford thiazolo[3,2-a]pyridin-5-ones, via the pyridinium salt intermediates.

HPLC of Formula: C8H7NO3. Welcome to talk about 100-19-6, If you have any questions, you can contact Huang, JJ; Hu, G; An, SY; Chen, DD; Li, ML; Li, PF or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Desai, NC; Joshi, SB; Jadeja, KA in WILEY published article about BIOLOGICAL EVALUATION; PYRAZOLE; GREEN; CHLOROTRIMETHYLSILANE in [Desai, Nisheeth C.; Joshi, Surbhi B.; Jadeja, Krunalsinh A.] Maharaja Krishnakumarsinhji Bhavnagar Univ, Dept Chem DST FIST Sponsored & UGC NON SAP, Div Med Chem, Mahatma Gandhi Campus, Bhavnagar 364002, Gujarat, India in 2020.0, Cited 32.0. Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A convenient synthesis of pyrimidinthiones was carried out in presence of thiourea and easily available catalyst sulfamic acid (2a-t). One-pot Biginelli reaction is very important due to the use of simple and readily available chemicals, less reaction time, economically friendly, and furnishing good yield. Structures of the synthesized compounds are characterized by spectral techniques like IR, H-1-NMR, C-13-NMR, and LC-MS. Synthesized compounds were studied for their antimicrobial activity against several strains of bacteria (E. coli, P. aeruginosa, and S. aureus, S. pyogenes) and fungi (C. albicans, A. niger, and A. clavatus) using serial dilution method.

Formula: C8H7NO3. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Wu, YB; Wu, YZ; Wu, J; Xu, D; Jiang, H; Chang, WW; Ma, CY in AMER CHEMICAL SOC published article about CARBENE INSERTION; CONSTRUCTION; INHIBITORS; ACCESS in [Wu, Ye-bin; Wu, You-zhi; Wu, Jian; Xu, Dan; Ma, Chang-you] Nanjing Chia Tai Tianqing Pharmaceut Co Ltd, Qixia Nanjing 210046, Jiangsu, Peoples R China; [Jiang, Hui; Chang, Wen-wu] Pharmaron Shang Hai, Shanghai 201203, Peoples R China in 2021.0, Cited 34.0. Application In Synthesis of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

The highly regioselective N-alkylation reaction of 2-pyridones was achieved through hydrazone chemistry, especially for substrates with bulky secondary alkyl groups. Described herein is a copper-catalyzed coupling reaction of pyridone derivatives with tosylhydrazones.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Wu, YB; Wu, YZ; Wu, J; Xu, D; Jiang, H; Chang, WW; Ma, CY or concate me.. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about ASYMMETRIC TRANSFER HYDROGENATION; SECONDARY ALCOHOL-DEHYDROGENASE; DYNAMIC KINETIC RESOLUTION; CATALYZED 1,2-REDUCTION; ALLYLIC ALCOHOLS; CHIRAL ALCOHOLS; PURIFICATION; LEIFSONIA; COBALT; REGIO, Saw an article supported by the NSF of ChinaNational Natural Science Foundation of China (NSFC) [81302653]; Public Welfare Research Project of Zhejiang Province [LGG19B020003]; Scientific Foundation of Zhejiang Educational Committee [Y201328460]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Cai, S; Shao, NN; Chen, YY; Li, AB; Pan, J; Zhu, HJ; Zou, HB; Zeng, S; Sun, LL; Zhao, JH. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. HPLC of Formula: C8H7NO3

This report describes the enantioselective reduction of structurally diverse alpha,beta-unsaturated ketones and aryl ketones by perakine reductase (PR) from Rauvolfia. This enzymatic reduction produces alpha-chiral allylic and aryl alcohols with excellent enantioselectivity and most of the products in satisfactory yields. Furthermore, the work demonstrates 1 mmol scale reactions for product delivery without any detrimental effect on yield and enantioselectivity. The catalytic mechanism, determined by 3D-structure-based modeling of PR and ligand complexes, is also described.

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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem