Category: 100-19-6

Recently I am researching about ASYMMETRIC HYDROGENATION; IRON; EFFICIENT; MECHANISM; CHEMISTRY; ALDEHYDES; NITRILES; ALCOHOLS; LIGANDS; METALS, Saw an article supported by the Russian Science FoundationRussian Science Foundation (RSF) [17-73-20144]; Ministry of Science and Higher Education of the Russian Federation. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Shvydkiy, NV; Vyhiyskyi, O; Nelyubina, YV; Perekalin, DS. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. COA of Formula: C8H7NO3

Catalytic hydrogenation is one of the most important reactions both in academic research and industry. We explored ability of the manganese pi-complexes to act as Shvo-type catalysts for transfer hydrogenation of ketones. DFT calculations suggested that the transfer of hydrogen atoms from the hypothetical intermediate [(C6Me3H2OH)Mn(CO)(2)H] to acetone has low activation barrier of 10.9 kcal mol(-1). Experimentally a number of ketones with various functional groups (OMe, NH2, Cl, CF3, pyridyl) were successfully reduced in isopropanol at 90 degrees C in the presence of the complex[(C6Me3H2OH)Mn(CO)(3)]BF4 (1 mol %) and (BuOK)-Bu-t (75 mol %). However, further investigation revealed that the reduction was mainly promoted by base rather than the manganese complex.

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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Crystallography very interesting. Saw the article Crystal structure and Hirshfeld surface analysis of a chalcone derivative: (E)-3-(4-fluorophenyl)-1-(4-nitrophenyl)prop-2-en-1-one published in 2019.0. Quality Control of 1-(4-Nitrophenyl)ethanone, Reprint Addresses Kumar, CSC (corresponding author), Visvesvaraya Technol Univ, Vidya Vikas Inst Engn & Technol, Dept Engn Chem, Alanahalli 570028, Mysuru, India.; Arafath, MA (corresponding author), Shahjalal Univ Sci & Technol, Dept Chem, Sylhet 3114, Bangladesh.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

The molecular structure of the title chalcone derivative, C15H10FNO3, is nearly planar and the molecule adopts a trans configuration with respect to the C=C double bond. The nitro group is nearly coplanar with the attached benzene ring, which is nearly parallel to the second benzene ring. In the crystal, molecules are connected by pairs of weak intermolecular C-H center dot center dot center dot O hydrogen bonds into inversion dimers. The dimers are further linked by another C-H center dot center dot center dot O hydrogen bond and a C-H center dot center dot center dot F hydrogen bond into sheets parallel to (104). pi-pi interactions occur between the sheets, with a centroid-centroid distance of A 3.8860 (11) angstrom. Hirshfeld surface analysis was used to investigate and quantify the intermolecular interactions.

Quality Control of 1-(4-Nitrophenyl)ethanone. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Computed Properties of C8H7NO3. Authors Rana, M; Arif, R; Khan, FI; Maurya, V; Singh, R; Faizan, MI; Yasmeen, S; Dar, SH; Alam, R; Sahu, A; Ahmad, T; Rahisuddin in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Rana, Manish; Arif, Rizwan; Yasmeen, Shama; Dar, Sajad Hussain; Rahisuddin] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India; [Khan, Faez Iqbal] Univ Elect Sci & Technol China, Sch Elect Sci & Engn, Chengdu, Peoples R China; [Maurya, Vikas; Singh, Raja] Jawharlal Nehru Univ, Special Ctr Mol Med, New Delhi 110067, India; [Faizan, Md Imam; Ahmad, Tanveer] Jamia Millia Islamia, Multidisciplinary Ctr Adv Res & Studies, New Delhi 110025, India; [Alam, Raquib] Jamia Millia Islamia, Univ Polytech, Dept Appl Sci, New Delhi 110025, India; [Sahu, Ankita] Safdarjung Hosp Campus, ICMR Natl Inst Pathol, New Delhi 110029, India in 2021.0, Cited 77.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

N-formyl pyrazoline derivatives (3a-3l) were designed and synthesized via Michael addition reaction through cyclization of chalcones with hydrazine hydrate in presence of formic acid. The structural elucidation of N-formyl pyrazoline derivatives was carried out by various spectroscopic techniques such as H-1, C-13 NMR, FT-IR, UV-visible spectroscopy, mass spectrometry and elemental analysis. Anticancer activity of the pyrazoline derivatives (3a-3l) was evaluated against human lung cancer (A549), fibrosarcoma cell lines (HT1080) and human primary normal lung cells (HFL-1) by MTT assay. The results of anticancer activity showed that potent analogs 3b and 3d exhibited promising activity against A549 (IC50 = 12.47 +/- 1.08 and 14.46 +/- 2.76 mu M) and HT1080 (IC50 = 11.40 +/- 0.66 and 23.74 +/- 13.30 mu M) but low toxic against the HFL-1 (IC50 =116.47 +/- 43.38 and 152.36 +/- 22.18 mu M). The anticancer activity of potent derivatives (3b and 3d) against A549 cancer cell line was further confirmed by flow cytometry based approach. DNA binding interactions of the pyrazoline derivatives 3b and 3d have been carried out with calf thymus DNA (Ct-DNA) using absorption, fluorescence and viscosity measurements, circular dichroism and cyclic voltammetry. Antioxidant potential of N-formyl pyrazoline derivatives (3a-3l) has been also estimated through DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical and H2O2. Results revealed that all the compounds exhibited significant antioxidant activity. In silico molecular modelling and ADMET properties of pyrazoline derivatives were also studied using PyRx software against topoisomerase II receptor with PDB ID: 1ZXM to explore their best hits. MD simulation of 3b and 3d was also carried out with topoisomerase II for structure-function correlation in a protein. HuTopoII inhibitory activity of the analogs (3a-3l) was examined by relaxation assay at varying concentrations 100-1000 mu M.

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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Safety of 1-(4-Nitrophenyl)ethanone. Authors Hafliger, J; Livingstone, K; Daniliuc, CG; Gilmour, R in ROYAL SOC CHEMISTRY published article about in [Haefliger, Joel; Livingstone, Keith; Daniliuc, Constantin G.; Gilmour, Ryan] Westfalische Wilhelms Univ Munster, Organ Chem Inst, D-48149 Munster, Germany in 2021.0, Cited 17.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Simple alpha-(bromomethyl)styrenes can be processed to a variety of 1,1-difluorinated electrophilic building blocks via I(I)/I(III) catalysis. This inexpensive main group catalysis strategy employs p-TolI as an effective organocatalyst when combined with Selectfluor (R) and simple amine center dot HF complexes. Modulating Bronsted acidity enables simultaneous geminal and vicinal difluorination to occur, thereby providing a platform to generate multiply fluorinated scaffolds for further downstream derivatization. The method facilitates access to a tetrafluorinated API candidate for the treatment of amyotrophic lateral sclerosis. Preliminary validation of an enantioselective process is disclosed to access alpha-phenyl-beta-difluoro-gamma-bromo/chloro esters.

Welcome to talk about 100-19-6, If you have any questions, you can contact Hafliger, J; Livingstone, K; Daniliuc, CG; Gilmour, R or send Email.. Safety of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Safety of 1-(4-Nitrophenyl)ethanone. Authors El-sayed, HA; Assy, MG; Mohamed, AS in WILEY-V C H VERLAG GMBH published article about in [El-sayed, Hassan A.; Assy, Mohamed G.; Mohamed, Asaad S.] Zagazig Univ, Fac Sci, Dept Chem, Zagazig 44519, Egypt in 2019.0, Cited 15.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

An efficient and facile approach has been described for the synthesis of a new series of 1-amino-2-oxo-nicotinonitriles and their sulfonamides under microwave and ultrasonic irradiation. The desired compounds 4 a-l were obtained via condensation of p-chlorobenzaldehyde, aryl or heteroaryl methyl ketone and cyanoacetohydrazide in the presence of catalytic piperidine under three synthetic methodologies (namely, conventional method, ultrasonic and microwave irradiation), the best results (short reaction times, pure products, high yield) were obtained by ultrasonic irradiation. Sulfonamides 5 a-f resulted via reaction of amines 4 a-e and 4 j with benzene sulfonyl chloride in the presence of pyridine. The synthesized compounds give no significant results when investigated against Gm (+ve) and Gm (-ve) bacteria, and fungi strains.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Safety of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Shu, B; Zeng, P; Kang, SS; Li, PH; Hu, DX; Kuang, GT; Cao, JJ; Li, XY; Zhang, ML; An, LK; Huang, ZS; Li, D in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about NUCLEAR RIBONUCLEOPROTEIN-K; CARBON NANOTUBES BINDING; I-MOTIF DNA; CELL-PROLIFERATION; STRANDED-DNA; G-QUADRUPLEX; PROMOTER; PROTEIN; METASTASIS; MECHANISM in [Shu, Bing; Zeng, Ping; Kang, Shuangshuang; Li, Peng-Hui; Hu, Dexuan; Kuang, Guotao; Cao, Jiaojiao; Li, Xiaoya; Zhang, Meiling; An, Lin-Kun; Huang, Zhi-Shu; Li, Ding] Sun Yat Sen Univ, Sch Pharmaceut Sci, 132 Waihuan East Rd, Guangzhou 510006, Guangdong, Peoples R China; [Shu, Bing] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China in 2019, Cited 54. Recommanded Product: 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Aberrant overexpression of heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a key feature in oncogenesis and progression of many human cancers. hnRNP K has been found to be a transcriptional activator to up-regulate c-myc gene transcription, a critical proto-oncogene for regulation of cell growth and differentiation. Therefore, down-regulation of c-myc transcription by inhibiting hnRNP K through disrupting its binding to c-myc gene promoter is a potential approach for cancer therapy. In the present study, we synthesized and screened a series of Quinoline derivatives and evaluated their binding affinity for hnRNP K. Among these derivatives, (E)-1-(4-methoxyphenyl)-3-(4 morpholino-6-nitroquinolin-2-yl)prop-2-en-1-one (compound 25) was determined to be the first-reported hnRNP K binding ligand with its K-D values of 4.6 and 2.6 mu M measured with SPR and MST, respectively. Subsequent evaluation showed that the binding of compound 25 to hnRNP K could disrupt its unfolding of c-myc promoter i-motif, resulting in down-regulation of c-myc transcription. Compound 25 showed a selective anti-proliferative effect on human cancer cell lines with IC50, values ranged from 1.36 to 3.59 mu M. Compound 25 exhibited good tumor growth inhibition in a Hela xenograft tumor model, which might be related to its binding with hnRNP K. These findings illustrated that inhibition of DNA-binding protein hnRNP K by compound 25 could be a new and selective strategy of regulating oncogene transcription instead of targeting promoter DNA secondary structures such as G-quadruplexes or i-motifs.

Welcome to talk about 100-19-6, If you have any questions, you can contact Shu, B; Zeng, P; Kang, SS; Li, PH; Hu, DX; Kuang, GT; Cao, JJ; Li, XY; Zhang, ML; An, LK; Huang, ZS; Li, D or send Email.. Recommanded Product: 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Frustrated Lewis pairs: A real alternative to deuteride/tritide reductions WOS:000492827500007 published article about HETEROLYTIC DIHYDROGEN ACTIVATION; METAL-FREE HYDROGENATION; H/D-EXCHANGE; LABELED COMPOUNDS; HEAVY ISOTOPES; TRITIUM; DISCOVERY; DRUG; FUNCTIONALIZATION; DEUTERATION in [Doubkova, Sabina; Marek, Ales] Czech Acad Sci, Inst Organ Chem & Biochem, Flemingovo 542-2, Prague 16610 6, Czech Republic in 2019.0, Cited 60.0. Category: benzodioxans. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Deuterium- and tritium-labeled compounds play a principal role in tracing of biologically active molecules in complicated biochemical systems. The state-of-the-art techniques using noble metal catalysts or strong reducing agents often suffers from low functional group tolerances, poor selectivity, tricky or multistep synthesis of reagents, and low specific activity of the labeled product. Herein, we demonstrate a mild and nonmetallic technique of deuteration and tritiation of polarized double bonds, such as carbonyl compounds, yielding labeled alcohols of high specific activities. This one-pot synthesis uses carrier-free hydrogen gas in situ activated by a freshly prepared frustrated Lewis pair, generating reducing reagents. This labeling strategy shows better selectivity and functional group tolerances compared with current reductive methods. Reported is an example of the selective reduction of the aldehyde moiety of 3-acetylbenzaldehyde. What makes this technology groundbreaking is its mildness, selectivity, and generation of limited amount of radioactive waste as almost no byproducts were generated after use of (B(C6F5)(3)H-3)((HTMP)-H-3) reducing reagent. Radiochemical purity of desired H-3-labeled product in a crude reaction mixture was determined of over 94%. This work provides, to the community of radiochemists, a practical protocol for frustrated Lewis pairs (FLP)-assisted deuterium/tritium labeling technology.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Category: benzodioxans

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Borinic Acid Mediated Hydrosilylations: Reductions of Carbonyl Derivatives WOS:000458273900012 published article about HYDROSILATION; KETONES; SILYLATION; ALDEHYDES; NITRILES; IMINES; AMINES in [Chardon, Aurelien; Rouden, Jacques; Blanchet, Jerome] Normandie Univ, ENSICAEN, UNICAEN, CNRS,LCMT, F-14000 Caen, France in 2019.0, Cited 40.0. Recommanded Product: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

4-Fluoro-2-chlorophenylborinic acid acts as a precatalyst in the presence of phenylsilane for the facile reduction of ketones, aldehydes and imines. Notably, synergistic mediation of a tertiary amine was found essential to trigger silicon to boron hydride transfer to generate a key amine-diarylhydroborane Lewis complex.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Name: 1-(4-Nitrophenyl)ethanone. In 2020 ANGEW CHEM INT EDIT published article about SELECTIVE HYDROGENATION; REDUCTION; BENZIMIDAZOLES; NANOPARTICLES; DERIVATIVES; DISCOVERY; AFFINITY; IMINES; POTENT; AGENTS in [Ryabchuk, Pavel; Leischner, Thomas; Kreyenschulte, Carsten; Spannenberg, Anke; Junge, Kathrin; Beller, Matthias] Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany in 2020, Cited 50. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A bifunctional 3d-metal catalyst for the cascade synthesis of diverse pyrroles from nitroarenes is presented. The optimal catalytic system Co/NGr-C@SiO2-L is obtained by pyrolysis of a cobalt-impregnated composite followed by subsequent selective leaching. In the presence of this material, (transfer) hydrogenation of easily available nitroarenes and subsequent Paal-Knorr/Clauson-Kass condensation provides >40 pyrroles in good to high yields using dihydrogen, formic acid, or a CO/H2O mixture (WGSR conditions) as reductant. In addition to the favorable step economy, this straightforward domino process does not require any solvents or external co-catalysts. The general synthetic utility of this methodology was demonstrated on a variety of functionalized substrates including the preparation of biologically active and pharmaceutically relevant compounds, for example, (+)-Isamoltane.

Name: 1-(4-Nitrophenyl)ethanone. Welcome to talk about 100-19-6, If you have any questions, you can contact Ryabchuk, P; Leischner, T; Kreyenschulte, C; Spannenberg, A; Junge, K; Beller, M or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about SODIUM-BOROHYDRIDE REDUCTIONS; CAPILLARY-ELECTROPHORESIS; ENANTIOSEPARATION, Saw an article supported by the . Category: benzodioxans. Published in ELSEVIER in AMSTERDAM ,Authors: Kaur, N; Chopra, HK. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Chiral ionic liquids (CILs) have shown a wide range of applications in variety of domains in chemistry. Because of this, synthesis and applications of CILs have always been areas of interest for research in the last 20 years. Present work describes, the synthesis of six carbohydrate based chiral ionic liquids (CCILs) by following simple procedures and their applications. Structures of the cats were confirmed through various analytical techniques like NMR spectroscopy (H-1, C-13, B-11, P-31,F-19), El-MS, and polarimetry. Designed CCILs were tested as chiral recognising agents using sodium salt of Mosher’s acid as model substrate through (FNMR)-F-19-N- spectroscopy. Further, Cats were used as organocatalyst in the enantioselective reduction of aromatic prochiral ketones to achieve corresponding chiral secondary alcohols. (C) 2019 Elsevier B.V. All rights reserved.

Category: benzodioxans. Welcome to talk about 100-19-6, If you have any questions, you can contact Kaur, N; Chopra, HK or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem