Category: 100-19-6

Formula: C8H7NO3. Authors Haldys, K; Goldeman, W; Anger-Gora, N; Rossowska, J; Latajka, R in MDPI published article about in [Haldys, Katarzyna; Latajka, Rafal] Wroclaw Univ Sci & Technol, Dept Bioorgan Chem, PL-50370 Wroclaw, Poland; [Goldeman, Waldemar] Wroclaw Univ Sci & Technol, Dept Organ & Med Chem, PL-50370 Wroclaw, Poland; [Anger-Gora, Natalia; Rossowska, Joanna] Polish Acad Sci, Ludwik Hirszfeld Inst Immunol & Expt Therapy, PL-53114 Wroclaw, Poland in 2021.0, Cited 58.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A set of 12 monosubstituted acetophenone thiosemicarbazone derivatives (TSCs) were synthesized and their inhibitory properties toward tyrosinase activity were tested. Moreover, their ability to inhibit melanogenesis in the B16F10 murine melanoma cell line was studied. In order to investigate the nature of interactions between the enzyme and the inhibitors, molecular docking to the active site was performed. TSCs 5, 6, 8, and 9 revealed a half maximal inhibitory concentration (IC50) below 1 mu M. Compound 6 turned out to be the most potent tyrosinase inhibitor. All investigated compounds showed reversible inhibition of competitive or mixed type. The para-substituted TSCs had higher affinity for the enzyme as compared to their ortho- and meta-analogues. All investigated compounds inhibited melanin production in B16F10 cells at the micromolar level. Molecular docking showed that the sulfur atom of the thiourea moiety penetrates the active site and interacts with copper ions. The above outcomes might be helpful in the design of new tyrosinase inhibitors in the food and cosmetic industries.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Haldys, K; Goldeman, W; Anger-Gora, N; Rossowska, J; Latajka, R or concate me.. Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Xu, DP; Xiong, ML; Kazemnejadi, M in ROYAL SOC CHEMISTRY published article about in [Xu, DaPeng] Gansu Ind Polytech Coll, Inst Chem Technol, TianShui 741000, Peoples R China; [Xiong, Meilu] Gansu Hlth Vocat Coll, Publ Fdn Coll, Lanzhou 730207, Peoples R China; [Kazemnejadi, Milad] Univ Birjand, Fac Sci, Dept Chem, Birjand, Iran in 2021.0, Cited 55.0. Safety of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A new, versatile, and green methodology has been developed for the efficient NaBH4-reduction of nitroarenes as well as the domino/reduction MCR preparation of 1-substituted-1H-1,2,3,4-tetrazoles using Pd(ii)-polysalophen coated magnetite NPs as an efficient heterogeneous magnetically recyclable nanocatalyst. Polysalophen was firstly prepared based on a triazine framework with a high degree of polymerization, then coordinated to Pd ions and, finally, the resulting hybrid was immobilized on magnetite NPs. The catalyst was characterized by various instrumental and analytical methods, including GPC, DLS, N-2 adsorption-desorption, TGA, VSM, TEM, HRTEM, EDX, XPS, XRD, and ICP analyses. The catalyst possesses dual-functionality including the reduction of nitroarenes and the construction of tetrazole rings all in one step via a domino protocol. High to excellent yields were obtained for both nitro reduction and the direct preparation of 1-substituted-1H-1,2,3,4-tetrazoles from nitro compounds. Insight into the mechanism was conducted by XPS in situ as well as DLS in situ along with several control experiments. Recyclability of the catalyst was studied for 6 consecutive runs along with metal leaching measurements in each cycle.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Xu, DP; Xiong, ML; Kazemnejadi, M or concate me.. Safety of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Category: benzodioxans. Authors Rana, M; Arif, R; Khan, FI; Maurya, V; Singh, R; Faizan, MI; Yasmeen, S; Dar, SH; Alam, R; Sahu, A; Ahmad, T; Rahisuddin in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Rana, Manish; Arif, Rizwan; Yasmeen, Shama; Dar, Sajad Hussain; Rahisuddin] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India; [Khan, Faez Iqbal] Univ Elect Sci & Technol China, Sch Elect Sci & Engn, Chengdu, Peoples R China; [Maurya, Vikas; Singh, Raja] Jawharlal Nehru Univ, Special Ctr Mol Med, New Delhi 110067, India; [Faizan, Md Imam; Ahmad, Tanveer] Jamia Millia Islamia, Multidisciplinary Ctr Adv Res & Studies, New Delhi 110025, India; [Alam, Raquib] Jamia Millia Islamia, Univ Polytech, Dept Appl Sci, New Delhi 110025, India; [Sahu, Ankita] Safdarjung Hosp Campus, ICMR Natl Inst Pathol, New Delhi 110029, India in 2021.0, Cited 77.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

N-formyl pyrazoline derivatives (3a-3l) were designed and synthesized via Michael addition reaction through cyclization of chalcones with hydrazine hydrate in presence of formic acid. The structural elucidation of N-formyl pyrazoline derivatives was carried out by various spectroscopic techniques such as H-1, C-13 NMR, FT-IR, UV-visible spectroscopy, mass spectrometry and elemental analysis. Anticancer activity of the pyrazoline derivatives (3a-3l) was evaluated against human lung cancer (A549), fibrosarcoma cell lines (HT1080) and human primary normal lung cells (HFL-1) by MTT assay. The results of anticancer activity showed that potent analogs 3b and 3d exhibited promising activity against A549 (IC50 = 12.47 +/- 1.08 and 14.46 +/- 2.76 mu M) and HT1080 (IC50 = 11.40 +/- 0.66 and 23.74 +/- 13.30 mu M) but low toxic against the HFL-1 (IC50 =116.47 +/- 43.38 and 152.36 +/- 22.18 mu M). The anticancer activity of potent derivatives (3b and 3d) against A549 cancer cell line was further confirmed by flow cytometry based approach. DNA binding interactions of the pyrazoline derivatives 3b and 3d have been carried out with calf thymus DNA (Ct-DNA) using absorption, fluorescence and viscosity measurements, circular dichroism and cyclic voltammetry. Antioxidant potential of N-formyl pyrazoline derivatives (3a-3l) has been also estimated through DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical and H2O2. Results revealed that all the compounds exhibited significant antioxidant activity. In silico molecular modelling and ADMET properties of pyrazoline derivatives were also studied using PyRx software against topoisomerase II receptor with PDB ID: 1ZXM to explore their best hits. MD simulation of 3b and 3d was also carried out with topoisomerase II for structure-function correlation in a protein. HuTopoII inhibitory activity of the analogs (3a-3l) was examined by relaxation assay at varying concentrations 100-1000 mu M.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Rana, M; Arif, R; Khan, FI; Maurya, V; Singh, R; Faizan, MI; Yasmeen, S; Dar, SH; Alam, R; Sahu, A; Ahmad, T; Rahisuddin or concate me.. Category: benzodioxans

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about DIMETHYL-SULFOXIDE; FUNCTIONALIZATION; ALKYLATION; BOND; ALCOHOLS; HYDROGENATION; SULFONYLATION; HETEROARENES; HETEROCYCLES; OXIDATION, Saw an article supported by the Foundation of the Department of Education of Guangdong Province [2018KZDXM070, 2017KZDXM085, 2017KQNCX204]; Foundation for Young Talents [2018KQNCX272, 2018KQNCX273]; College Students Innovation and Entrepreneurship Training Program of Wuyi University; Climbing Program [pdjh2019b0497]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Jiang, SH; Yang, ZH; Guo, ZY; Li, YB; Chen, L; Zhu, ZZ; Chen, XW. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Recommanded Product: 100-19-6

A practical approach to the direct alpha-methylation of 1,8-naphthyridines under mild reaction conditions has been developed using simple and readily available DMSO as a convenient and environmentally friendly carbon source. This method is transition metal-free and highly chemoselective, shows good functional group tolerance, and uses DMSO as a methyl source, providing efficient and rapid access to an important compound class, 2-methyl-1,8-naphthyridines.

Recommanded Product: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Jiang, SH; Yang, ZH; Guo, ZY; Li, YB; Chen, L; Zhu, ZZ; Chen, XW or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Huang, X; Li, ZP; Liu, ZX; Zeng, CC; Hu, LM in [Huang, Xin; Li, Zhipeng; Liu, Zixin; Zeng, Chengchu; Hu, Liming] Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China published A near-infrared fluorescent probe for endogenous hydrogen peroxide real-time imaging in living cells and zebrafish in 2019.0, Cited 44.0. Quality Control of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Hydrogen peroxide (H2O2) can be produced in mitochondria and plays a significant role in physiological metabolism. Overproduction of H2O2 is a hallmark of many diseases. Therefore, it is very important to develop a highly sensitive method for detecting H2O2 both in vivo and in vitro. Previously reported benzil-based fluorescence probes are superior to those based on boronate ester in terms of reaction selectivity. However, the near infrared (NIR) probe with biocompatibility has been rarely reported for the detection of endogenous hydrogen peroxide and the real-time imaging in biological system. Hemicyanine skeleton has been proven to be effective scaffold for NM fluorescent probes for non-invasive optical imaging in vivo. In this paper, a Cy-H2O2 probe for real-time monitoring hydrogen peroxide in organisms was designed by modifying the NIR hemicyanine framework with benzil moiety. The results showed that Cy-H2O2 exhibits high specificity and sensitivity, and has good water solubility and short response time (within 10 min) for detection of hydrogen peroxide in vitro and in vivo. The reaction mechanism was deduced by detecting product of the fluorescent probe reacting with hydrogen peroxide using HPLC. The probe shows a good linear relationship for the specific response to H2O2 within the concentration range of 0-7 mu M and the detection limit is 65 nM. In addition, the probe Cy-H2O2 has been successfully applied to H2O2 detection in living cells and zebrafish.

Quality Control of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Huang, X; Li, ZP; Liu, ZX; Zeng, CC; Hu, LM or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about BISINDOLE, Saw an article supported by the Higher Education Commission, PakistanHigher Education Commission of Pakistan [59/PAS/3437]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Shaikh, NN; Iqbal, S; Syed, N; Khan, MA; Moin, ST; Choudhary, MI; Basha, FZ. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. COA of Formula: C8H7NO3

beta-Glucuronidase enzyme is a tetrameric glycoprotein present in microsomes and lysosomes of many organs, and body fluids. Over-expression of this enzyme is observed in several melanomas and carcinomas. Therefore, it has been identified as a target for the treatment of several pathological conditions. In this regard, carbazole linked 1,2,3-triazoles (1-27) were synthesized according to our previous report, and evaluated for their in vitro beta-glucuronidase inhibitory activities. Compounds 7-10, 17-18, 20, and 22-27 showed potent activities with IC50 values between 0.55-32.5 mu M, as compared to the standard, D-saccharic acid 1,4-lactone (IC50=45.75 +/- 2.16 mu M). All active compounds were found to be non-cytotoxic against mouse fibroblast 3T3 cell line. Compounds 20, 22, 23, 25, 26, and 27 were subjected to enzyme kinetic studies for the determination of their modes of inhibition, and dissociation constants Ki. Compounds 23, 25, and 26 were also studied for their mode of inhibition by using molecular docking methods.

COA of Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Shaikh, NN; Iqbal, S; Syed, N; Khan, MA; Moin, ST; Choudhary, MI; Basha, FZ or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Name: 1-(4-Nitrophenyl)ethanone. Authors Song, T; Zhou, X; Wang, XX; Xiao, JL; Yang, Y in ROYAL SOC CHEMISTRY published article about in [Song, Tao; Zhou, Xin; Wang, Xiaoxue; Yang, Yong] Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, CAS Key Lab Biobased Mat, 189 Songling Rd, Qingdao 266101, Peoples R China; [Xiao, Jianliang] Univ Liverpool, Dept Chem, Crown St, Liverpool L69 7ZD, Merseyside, England; [Song, Tao; Zhou, Xin; Wang, Xiaoxue; Yang, Yong] Shandong Energy Inst, Qingdao 266101, Peoples R China in 2021.0, Cited 66.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A new methodology for the synthesis of alpha-diketones was reported via a one-pot cascade process from aldehydes and ketones catalyzed by a bifunctional iron nanocomposite using H2O2 as a green oxidant in water. The one-pot strategy showed excellent catalytic stability, comprehensive suitability of substrates and important practical utility for directly synthesizing biologically active and medicinally valuable N-heterocycles via an intermittent process.

Name: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Song, T; Zhou, X; Wang, XX; Xiao, JL; Yang, Y or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2020 ORG BIOMOL CHEM published article about C-H; DIRECT ACYLOXYLATION; BENZOXYLATION; BONDS; ACTIVATION; ARYL; NOX in [Xiong, Xue; Mao, Yang-Jie; Hao, Hong-Yan; He, Yu-Ting; Xu, Zhen-Yuan; Lou, Shao-Jie; Xu, Dan-Qian] Zhejiang Univ Technol, Coll Chem Engn, Key Lab Green Pesticides & Cleaner Prod Technol Z, Catalyt Hydrogenat Res Ctr,State Key Lab Breeding, Hangzhou 310014, Peoples R China; [Luo, Gen] Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Peoples R China in 2020, Cited 30. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Computed Properties of C8H7NO3

A nitrate-promoted Pd-catalysed mild cross-dehydrogenative C(sp(2))-H bond oxidation of oximes or azobenzenes with diverse carboxylic acids has been developed. In contrast to the previous catalytic systems, this protocol features mild conditions (close to room temperature for most cases) and a broad substrate scope (up to 64 examples), thus constituting a versatile method to directly prepare diverseO-aryl esters. Moreover, the superiority of the nitrate additive in this mild transformation was further determined by experimental and computational evidence.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Xiong, X; Mao, YJ; Hao, HY; He, YT; Xu, ZY; Luo, G; Lou, SJ; Xu, DQ or concate me.. Computed Properties of C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Badran, I; Tighadouini, S; Radi, S; Zarrouk, A; Warad, I in ELSEVIER published article about in [Badran, Ismail; Warad, Ismail] Qatar Univ, Dept Chem & Earth Sci, POB 2713, Doha, Qatar; [Tighadouini, Said] Hassan II Univ, Fac Sci Ain Chock, Lab Organ Synth Extract & Valorizat, Route Jadida Km 2,BP 5366, Casablanca, Morocco; [Radi, Smaail] Mohammed First Univ, Lab Appl & Environm Chem LCAE, Oujda, Morocco; [Zarrouk, Abdelkader] Mohammed V Univ, Fac Sci, Lab Mat Nanotechnol & Environm, Av I Bn Battouta,Box 1014, Rabat, Morocco in 2021.0, Cited 57.0. SDS of cas: 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Hydrazine derivatives have a wide variety of applications in organic synthesis, material science, medical treatments, as well as the dye-sensitized solar cells (DSSC). In this work, the molecular structure, electronic spectra and first principles investigation for the exo-endo isomerization in (1E,2E)-bis[1-(4-nitrophenyl)ethylidene]hydrazine were studied. The structural interactions and synthon formations have been determined experimentally via Hirshfeld surface analysis (HSA) and two-dimensional fingerprint plots (2D-FP). Furthermore, the solid-state XRD/HSA interactions have been used to explain the physical behavior of the compound. The transition state for the exo-endo isomerization was located using density functional theory (DFT). The activation barrier is estimated to be 110.5 kJ/mol (in vacuo). The endo isomer was found to be slightly more stable than the exo one. The UV-Vis spectra of the two isomers were obtained using time-dependent density functional theory (TDDFT) and compared to the experimental spectra in vacuo, water, and methanol. To explore the potential of the new compound as a DSSC sensitizer, the emission spectrum was also constructed by optimizing the singlet electronic excited state. (C) 2020 The Author(s). Published by Elsevier B.V.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Badran, I; Tighadouini, S; Radi, S; Zarrouk, A; Warad, I or concate me.. SDS of cas: 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Product Details of 100-19-6. I found the field of Chemistry; Physics very interesting. Saw the article Effect of substitution on pyrazoline based donor-acceptor molecules as luminescent and their electrochemical properties published in 2020.0, Reprint Addresses Kannan, P (corresponding author), Anna Univ, Dept Chem, Chennai 600025, Tamil Nadu, India.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.

Highly fluorescent materials composed of donor-acceptor on pyrene-pyrazoline were synthesized and characterized by H-1 NMR and FT-IR techniques. The PP-OCH3, PP-Br and PP-NO2 exhibited blue, sky-blue, orange emissions under UV light 365 nm was confirmed by fluorescence spectrometer. The chromaticity diagram confirms their color purity of emission of organic materials. Photophysical properties namely optical band gap, quantum yield and lifetime of materials are investigated. Evaluation of Density Functional Theory confirm the responsibility of electron density on HOMO-LUMO energy levels. They demonstrated as semiconducting nature and disclose for the application in organic electronics.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Karuppusamy, A; Kannan, P or concate me.. Product Details of 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem