Category: 100-19-6

Authors Ling, J; Bennett, CS in WILEY-V C H VERLAG GMBH published article about BIOLOGICAL ROLES; OLIGOSACCHARIDES; GLUCOPYRANOSYL; KETONES; ACCESS; GALACTOSYLCERAMIDE; CONSTRUCTION; ENHANCEMENT; MECHANISMS; CHEMISTRY in [Ling, Jesse; Bennett, Clay S.] Tufts Univ, 62 Talbot Ave, Medford, MA 02155 USA in 2020.0, Cited 72.0. Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

C-Glycosides are both a common motif in many bioactive natural products and important glycoside mimetics. We demonstrate that activating a hemiacetal with a sulfonyl chloride, followed by treating the resultant glycosyl sulfonate with an enolate results in the stereospecific construction of beta-linked C-glycosides. This reaction tolerates a range of acceptors and donors, including disaccharides. The resulting products can be readily derivatized into C-glycoside analogues of beta-glycoconjugates, including C-disaccharide mimetics.

Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Ling, J; Bennett, CS or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 CHEMISTRYSELECT published article about IN-VITRO EVALUATION; DISCOVERY; DERIVATIVES; MANAGEMENT; AGENTS in [Kaur, Ramandeep; Palta, Kezia; Kumar, Manoj] Panjab Univ, Univ Inst Pharmaceut Sci, Chandigarh 160014, India in 2019.0, Cited 34.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Name: 1-(4-Nitrophenyl)ethanone

alpha-Glucosidase inhibition has been considered as an effective strategy for controlling the post-prandial hyperglycemia in diabetic patients. A series of novel isatin-pyrazole hybrids has been rationally designed, synthesized and characterized by different spectroscopic techniques. All of the synthesized compounds were evaluated for their alpha-glucosidase inhibitory potential using in vitro enzymatic assay. The tested compounds have exhibited potent alpha-glucosidase inhibition with IC50 values ranging from 3.26 +/- 0.25 to 32.33 +/- 1.08 mu M. Compound V7, having 3-nitro phenyl ring appended at pyrazole nucleus, has emerged as the most potent inhibitor among the series with an IC50 value of 3.26 +/- 0.25 mu M, which was approximately 146 fold more potent than the clinically used drug acarbose (IC50 = 478.07 +/- 1.53 mu M). Molecular docking studies were carried out to investigate the binding interactions of most active compounds with the active site of the enzyme. Further, in silico predictive pharmacokinetic parameters (ADME) and drug-like properties of the compounds were within the acceptable ranges. In vivo biological evaluations further supplemented the in vitro results.

Name: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Kaur, R; Palta, K; Kumar, M or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article On Water Catalytic Aldol Reaction between Isatins and Acetophenones: Interfacial Hydrogen Bonding and Enamine Mechanism WOS:000473116200008 published article about HENRY NITROALDOL REACTIONS; ORGANIC-SYNTHESIS; ENANTIOSELECTIVE CONSTRUCTION; CONDENSATION; DERIVATIVES; ALDEHYDES in [Han, Jinsong; Zhang, Jin-Lei; Zhang, Wei-Qiang; Gao, Ziwei; Xu, Li-Wen; Jian, Yajun] Shaanxi Normal Univ, Sch Chem & Chem Engn, MOE, Key Lab Appl Surface & Colloid Chem, Xian 710062, Shaanxi, Peoples R China; [Xu, Li-Wen] Hangzhou Normal Univ, Minist Educ, Key Lab Organosilicon Chem & Mat Technol, Hangzhou 310012, Zhejiang, Peoples R China in 2019.0, Cited 38.0. Computed Properties of C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

On water catalytic aldol reaction catalyzed by polyetheramine (D230) has been developed for easy access to 3-substituted 3-hydroxyindolin-2-ones through the reaction between various substituted isatins and acetophenones/cyclic ketones in high yields under room temperature. Systematic mechanism investigation uncovers the secret for the on water catalytic aldol reaction: comparison of the heterogeneous and homogeneous reaction circumstances with yields of 95 and 20%, respectively, indicates the on-water reaction dominating; interfacial hydrogen bonding between isatin with H2O is tested based on the downfield shift of the C2 and C3’s C-13 NMR signals when water was added to the CDCl3 solution of isatin; Lewis base polyetheramine D230 catalyzes the aldol reaction via the enamine mechanism verified by in situ NMR and ESI-MS analysis.

Computed Properties of C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Han, JS; Zhang, JL; Zhang, WQ; Gao, ZW; Xu, LW; Jian, YJ or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2020.0 J CHILD PSYCHOL PSYC published article about COGNITIVE-BEHAVIORAL THERAPY; BRIEF PSYCHOSOCIAL INTERVENTION; OBSERVER-BLIND; CHILDREN; SEVERITY; PSYCHOTHERAPY; MULTICENTER; OUTPATIENTS; DISORDERS; INVENTORY in [Davies, Sian Emma; Neufeld, Sharon A. S.; Kelvin, Raphael; Wilkinson, Paul; van Harmelen, Anne Laura; Goodyer, Ian Michael] Univ Cambridge, Dept Psychiat, Cambridge, England; [van Sprang, Eleonore] Vrije Univ Amsterdam Med Ctr, Amsterdam UMC, Dept Psychiat, Amsterdam, Netherlands; [Schweren, Lizanne] Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands; [Keivit, Rogier] Univ Cambridge, MRC Cognit & Brain Sci Unit, Cambridge, England; [Fonagy, Peter; Midgley, Nick; Target, Mary] UCL, Res Dept Clin Educ & Hlth Psychol, Div Psychol & Language Sci, London, England; [Dubicka, Bernadka] Univ Manchester, Dept Psychiat, Manchester, Lancs, England; [Reynolds, Shirley] Univ Reading, Sch Psychol & Clin Language Sci, Reading, Berks, England in 2020.0, Cited 34.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. COA of Formula: C8H7NO3

Objective To classify a cohort of depressed adolescents recruited to the UK IMPACT trial, according to trajectories of symptom change. We examined for predictors and compared the data-driven categories of patients with a priori operational definitions of treatment response. Method Secondary data analysis using growth mixture modelling (GMM). Missing data were imputed. Trajectories of self-reported depressive symptoms were plotted using scores taken at six nominal time points over 86 weeks from randomisation in all 465 patients. Results A piecewise GMM categorised patients into two classes with initially similar and subsequently distinct trajectories. Both groups had a significant decline in depressive symptoms over the first 18 weeks. Eighty-four per cent (84.1%, n = 391) of patients were classed as ‘continued-improvers’ with symptoms reducing over the duration of the study. A further class of 15.9% (n = 74) of patients were termed ‘halted-improvers’ with higher baseline depression scores, faster early recovery but no further improvement after 18 weeks. Presence of baseline comorbidity somewhat increased membership to the halted-improvers class (OR = 1.40, CI: 1.00-1.96). By end of study, compared with classes, a clinical remission cut-off score (<= 27) and a symptom reduction score (>= 50%) indexing treatment response misclassified 15% and 31% of cases, respectively. Conclusions A fast reduction in depressive symptoms in the first few weeks of treatment may not indicate a good prognosis. Halted improvement is only seen after 18 weeks of treatment. Longitudinal modelling may improve the precision of revealing differential responses to treatment. Improvement in depressive symptoms may be somewhat better in the year after treatment than previously considered.

COA of Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Davies, SE; Neufeld, SAS; van Sprang, E; Schweren, L; Keivit, R; Fonagy, P; Dubicka, B; Kelvin, R; Midgley, N; Reynolds, S; Target, M; Wilkinson, P; van Harmelen, AL; Goodyer, IM or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Formula: C8H7NO3. In 2020.0 GREEN CHEM published article about CHEMOSELECTIVE HYDROGENATION; 1 ATM; REDUCTION; CATALYST; NITROBENZENE; PERFORMANCE; ANILINE; BONDS; H-2 in [Sun, Shuting; Zhao, Ruixiang; Jv, Xinchun; Hu, Pan; Zhang, Qun; Wang, Bo] Hainan Univ, Minist Educ, Key Lab Adv Mat Trop Isl Resources, 58 Renmin AVE, Haikou 570228, Hainan, Peoples R China; [Wang, Bo] Shandong Agr Univ, Coll Sci & Engn, 7 Panhe AVE, Tai An 271017, Shandong, Peoples R China; [Du, Muyao] Shandong Univ Sci & Technol, Sch Chem & Environm Engn, 579 Qianwangang Rd, Qingdao 266590, Peoples R China in 2020.0, Cited 21.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

The hydrogenation of nitroarenes is one of the most important strategies for the preparation of anilines. However, it is still a great challenge to develop mild and efficient synthetic routes toward aniline synthesis, particularly those employing both non-precious metal catalysts and low-pressure H-2. Herein, we report a highly efficient protocol for the selective hydrogenation of nitroarenes in neutral H2O using H-2(1 atm) over a heterogeneous Zn(0) catalyst under mild conditions. The nitro groups of an array of nitroarenes can be converted into -NH(2)with up to 99% conversions and a selectivity of >99%, even when functionalized with easily reducible substituents, or in the presence of aromatic ketones or styrene. This study might open an avenue for the selective hydrogenation of nitroarenes over a zinc catalyst using 1 atm H-2.

Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Sun, ST; Du, MY; Zhao, RX; Jv, XC; Hu, P; Zhang, Q; Wang, B or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Hafliger, J; Livingstone, K; Daniliuc, CG; Gilmour, R in ROYAL SOC CHEMISTRY published article about in [Haefliger, Joel; Livingstone, Keith; Daniliuc, Constantin G.; Gilmour, Ryan] Westfalische Wilhelms Univ Munster, Organ Chem Inst, D-48149 Munster, Germany in 2021.0, Cited 17.0. Name: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Simple alpha-(bromomethyl)styrenes can be processed to a variety of 1,1-difluorinated electrophilic building blocks via I(I)/I(III) catalysis. This inexpensive main group catalysis strategy employs p-TolI as an effective organocatalyst when combined with Selectfluor (R) and simple amine center dot HF complexes. Modulating Bronsted acidity enables simultaneous geminal and vicinal difluorination to occur, thereby providing a platform to generate multiply fluorinated scaffolds for further downstream derivatization. The method facilitates access to a tetrafluorinated API candidate for the treatment of amyotrophic lateral sclerosis. Preliminary validation of an enantioselective process is disclosed to access alpha-phenyl-beta-difluoro-gamma-bromo/chloro esters.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Hafliger, J; Livingstone, K; Daniliuc, CG; Gilmour, R or concate me.. Name: 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

SDS of cas: 100-19-6. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Novel isoxazole derivatives as potential antiparkinson agents: synthesis, evaluation of monoamine oxidase inhibitory activity and docking studies published in 2019.0, Reprint Addresses Agrawal, N (corresponding author), GLA Univ, Inst Pharmaceut Res, Mathura, UP, India.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.

Selective monoamine oxidase B inhibitors are potential drug candidates for the treatment of Parkinson’s disease. A series of phenyl substituted isoxazole carbohydrazides was designed by structural modification of isocarboxazid, a nonselective MAO inhibitor and evaluated as inhibitors of MAO-A and MAO-B. The compounds were not able to inhibit MAO-A significantly, but most of the compounds exhibited potent inhibitory activity against MAO-B. The enzyme kinetic study of the most active compounds 5d, 5-phenyl-N ‘-(1-(p-tolyl)ethylidene)isoxazole-3-carbohydrazide and 5g, N ‘-(1-(3,4-dimethoxyphenyl)ethylidene)-5-phenylisoxazole-3-carbohydrazide displayed reversible and competitive MAO-B inhibition. In molecular modeling studies, compounds 5d and 5g exhibited strong binding affinity on MAO-B active site. The administration of compounds 5d and 5g exhibited prevention of MPTP-induced Parkinsonism as indicated by footprint analysis and horizontal wire tests. Further optimization studies are essential to exploit their potential for MAO-B associated neurodegenerative pathologies.

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Agrawal, N; Mishra, P or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Hydration of terminal alkynes catalyzed by cobalt corrole complex WOS:000579003400002 published article about COUNTERION in [Lai, Jia-Wei; Liu, Zhao-Yang; Chen, Xiao-Yan; Zhang, Hao; Liu, Hai-Yang] South China Univ Technol, Dept Chem, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Peoples R China in 2020.0, Cited 36.0. Application In Synthesis of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Cobalt(III) corrole was firstly applied to the hydration of terminal alkynes. The alkyne hydration proceeded in good to excellent yield with 0.03 to 0.3 mol% cobalt corrole catalyst loading. A wide range of substrates were tolerated. Particularly, the reaction can give 90% yield in a gram scale experiment. (C) 2020 Elsevier Ltd. All rights reserved.

Application In Synthesis of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Lai, JW; Liu, ZY; Chen, XY; Zhang, H; Liu, HY or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Quality Control of 1-(4-Nitrophenyl)ethanone. Kilic, A; Balci, TE; Arslan, N; Aydemir, M; Durap, F; Okumu, V; Tekin, R in [Kilic, Ahmet; Balci, Tubba Ersayan] Harran Univ, Art & Sci Fac, Chem Dept, TR-63190 Sanliurfa, Turkey; [Arslan, Nevin] Sirnak Univ, Fac Agr, Dept Field Crops, TR-73000 Sirnak, Turkey; [Aydemir, Murat; Durap, Feyyaz] Dicle Univ, Sci Fac, Dept Chem, TR-21280 Diyarbakir, Turkey; [Okumu, Veysi] Univ Siirt, Fac Sci & Art, Dept Biol, TR-56100 Siirt, Turkey; [Tekin, Recep] Dicle Univ, Dept Infect Dis & Clin Microbiol, Fac Med, TR-21280 Diyarbakir, Turkey published Synthesis of cis-1,2-diol-type chiral ligands and their dioxaborinane derivatives: Application for the asymmetric transfer hydrogenation of various ketones and biological evaluation in 2020.0, Cited 69.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Two cis-1,2-diol-type chiral ligands (T-1 and T-2) and their tri-coordinated chiral dioxaborinane (T(1-2)B(1-2)) and four-coordinated chiral dioxaborinane adducts with 4-tert-butyl pyridine sustained by N -> B dative bonds (T(1-2)B(1-2)-N) were synthesized and characterized by various spectroscopic techniques such as NMR (H-1, C-13, and B-11), FT-IR and UV-Vis spectroscopy, LC-MS/MS, and elemental analysis. It was suggested that both ferrocene and trifluoromethyl groups played key roles in the catalytic and biological studies because they could tune the solubility of the chiral dioxaborinane complexes and adjust the strength of intermolecular interactions. To assess the biological activities of newly synthesized chiral dioxaborinane compounds, DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, reducing power, antibacterial, DNA binding, and DNA cleavage activities were tested. Then, all chiral dioxaborinane complexes were investigated as catalysts for the asymmetric transfer hydrogenation of various ketones under suitable conditions. The results indicated that the chiral dioxaborinane catalysts performed well with high yields.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Kilic, A; Balci, TE; Arslan, N; Aydemir, M; Durap, F; Okumu, V; Tekin, R or concate me.. Quality Control of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Amininasab, SM; Esmaili, S; Shami, Z in [Amininasab, S. Mojtaba; Esmaili, Sahereh; Shami, Zahed] Univ Kurdistan, Fac Sci, Dept Chem, Polymer Chem Res Lab, Sanandaj 6617715175, Iran published High-performance polyimides based on pyridine and xanthene pendant groups; synthesis, characterization, photoactivity, thermal, antibacterial, and Cr(VI) ion adsorption properties in 2020.0, Cited 44.0. Safety of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A group of new polyimides (PIs) containing xanthene bulky groups and heterocyclic pyridine ring were synthesized by polycondensation reaction by using new symmetric and asymmetric diamines with available dianhydrides. The prepared diamines and PIs were characterized by Fourier transform infrared, elemental analysis, and proton nuclear magnetic resonance spectroscopy and carbon nuclear magnetic resonance spectroscopy. The PIs have desirable solubility in common aprotic solvents like dimethyl sulfoxide, N-methyl-2-pyrrolidone, dimethylacetamide, and pyridine as a less polar solvent. The PIs with inherent viscosities in the range of 0.51-0.72 dL/g were amorphous in nature, showed glass transition temperatures (T(g)s) of about 270-300 degrees C, and 10% weight loss at temperatures 384-443 degrees C. They showed fluorescence emission (quantum yield 7-12%) due to the presence of xanthene and pyridine groups in their structure. The prepared PIs showed tensile strength of 81-91 MPa with elongation at break of 19-23%. The antibacterial properties of the PIs against Gram negative and Gram positive bacteria and funguses were investigated. Also, a membrane of PI prepared by electrospinning method was used for the removal of different concentrations of Cr(VI) from aqueous solutions.

Safety of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Amininasab, SM; Esmaili, S; Shami, Z or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem