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Reactions of 3-(polyfluoroacyl)chromenones with heterocyclic amines: novel synthesis of polyfluoroalkyl-containing fused pyridines P07409SS

The selectivity of the reactions of 3-(polyfluoroacyl)-4H-chromen-4-ones with a wide range of aminoheterocycles and arylamines has been evaluated. The method described facilitates access to polyfluoroalkyl-containing fused pyridines. Georg Thieme Verlag Stuttgart.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Final Thoughts on Chemistry for 22013-33-8

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Thermochemical liquefaction of algae for bio-oil production in supercritical acetone/ethanol/isopropanol

Thermochemical conversion processes such as supercritical fluid extraction are used for producing biofuels from biomass. Supercritical fluid extraction process is decomposition process of lignocellulose or other organic materials thermally under supercritical conditions at 250-400 C temperature range under high pressure (4-5 MPa). In this study, the supercritical fluid extraction was used to produce bio-oils from algae. Supercritical fluid extraction trials were performed in a cylindrical reactor (75 mL) in organic solvents (acetone, ethanol and isopropanol) under supercritical conditions with (ferric chloride, potassium hydroxide) and without catalyst at the temperatures of 255, 275 and 295 C. The effects of process variables including temperature and catalyst on product yields were investigated. The produced liquids at 295 C in supercritical liquefaction were analyzed and characterized by elemental, GC-MS and FT-IR. 160, 122 and 108 different types of compounds were identified by GC-MS obtained in acetone, ethanol and isopropanol respectively. Bio-oils from supercritical liquefaction were composed of various organics including aromatics, nitrogenated and oxygenated compounds. Bio-oils obtained from supercritical liquefaction were found to have higher calorific values and superior fuel properties compared to feedstock.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Awesome Chemistry Experiments For 2,3-Dihydrobenzo[b][1,4]dioxin-6-amine

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 22013-33-8, help many people in the next few years.Formula: C8H9NO2

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Formula: C8H9NO2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 22013-33-8, name is 2,3-Dihydrobenzo[b][1,4]dioxin-6-amine. In an article£¬Which mentioned a new discovery about 22013-33-8

Novel inhibitors of B-RAF based on a disubstituted pyrazine scaffold. Generation of a nanomolar lead

B-RAF, a serine/threonine kinase, plays an important role in the development of certain classes of cancer, especially melanoma. As a result of high-throughput screening of a 23,000 compound library, 2-(3,4,5- trimethoxyphenylamino)-6-(3-acetamidophenyl)pyrazine, 1, was identified as a low micromolar (IC50 = 3.5 muM) B-RAF inhibitor. This compound was chosen as the starting point of a program aimed at producing potent inhibitors of B-RAF. We have synthesized a series of 40 novel compounds, which involved extensive modifications to the 2-(3,4,5-trimethoxyphenylamino) moiety (ring A) of 1. Their biological profiles against isolated B-RAF and mutated B-RAF in a cellular assay have been determined. These efforts led to the identification of two compounds exhibiting activities lower than 800 nM against B-RAF.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 22013-33-8, help many people in the next few years.Computed Properties of C8H9NO2

In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Computed Properties of C8H9NO2, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 22013-33-8, name is 2,3-Dihydrobenzo[b][1,4]dioxin-6-amine. In an article£¬Which mentioned a new discovery about 22013-33-8

O- and N-substituted derivatives of planetol as valuable bioactive compounds

The compounds bearing sulfamoyl and acetamoyl groups have been found to show various biological activities. In the present research work, a series of O- and N-substituted derivatives were synthesized, starting with planetol (1). First N-methyl-4-hydroxyanilinium sulfate (1; planetol or metol) was treated with different aryl sulfonyl chlorides (2a-i) using aq. sodium carbonate solution as reaction medium to yield N-substituted derivatives 3a-i. The electrophile, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-bromoacetamide (5) was prepared by the reaction of 2,3-dihydro-1,4-benzodioxin-6-amine (4) and 2-bromoacetylbromide in a weak basic aqueous medium. The target O-substituted molecules 6a-i, were synthesized by gearing up the electrophile 5, with the molecules 3a-i, in a polar aprotic solvent using LiH as an activator. The proposed structures of all the synthesized molecules were corroborated by IR,1H NMR and EIMS spectral data. The in vitro enzyme inhibition and antibacterial studies rendered the synthesized molecules as better cholinesterase inhibitors and moderately better antibacterial agents. To explore the binding modes of the synthesized compounds, all of them were computationally docked against the active sites of acetyl cholinesterase (AChE), butyryl cholinesterase (BChE) and lipoxygenase (LOX). The compounds showed significant interactions and good correlation with the experimental data.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Extended knowledge of 2,3-Dihydrobenzo[b][1,4]dioxin-6-amine

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Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

Compounds are disclosed that have a formula represented by the following: [image] The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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Synthesis of novel 2,3-dihydro-1,4-dioxino[2,3-g]quinoline derivatives as potential antitumor agents

New dioxinoquinolines (1-8) have been synthesized and their antiproliferative properties have been tested against several cell lines. The treatment of the 6-acetamido-2,3-dihydro-1,4-benzodioxine (10) with phosphorous oxychloride in the presence of DMF leads to a mixture of linear and angular tricyclic compounds. The key intermediates were modified and cyclized giving the corresponding dioxinoquinolines. In general, these compounds have a moderate citotoxycity.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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COMPOSITIONS AND METHODS FOR MODULATING PPP2R1A

Disclosed herein, inter alia, are compositions and methods useful for modulating PPP2R1 A and for the treatment of cancer.

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Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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Synthesis of substituted quinoline-4-carboxylic acids

A high yielding synthesis of a variety of quinoline-4-carboxylic acids has been accomplished using a modified Pfitzinger approach involving the condensation of a ketone with an isatin derivative employing aqueous acid conditions. A convenient synthesis of the substituted isatin precursor is also described.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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COMPOUNDS

Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.

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Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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FLAVIN DERIVATIVES

The present invention relates novel flavin derivatives and other flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives. The invention also provides method of making novel flavin derivatives.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem