New explortion of C9H8O4

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The nickel-catalyzed reduction of secondary and tertiary amides to give amine products is reported. The transformation is tolerant of extensive variation with respect to the amide substrate, proceeds in the presence of esters and epimerizable stereocenters, and can be used to achieve the reduction of lactams. Moreover, this methodology provides a simple tactic for accessing medicinally relevant alpha-deuterated amines.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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A novel and efficient silver catalyzed decarboxylative direct C2-alkylation of benzothiazoles with carboxylic acids for the synthesis of 2-alkyl benzothiazoles was developed.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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70918-54-6, In homogeneous catalysis, catalysts are in the same phase as the reactants. Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. In a document type is Patent, and a compound is mentioned, CAS :70918-54-6, Name is (S)-1,4-Benzodioxane-2-carboxylic acid, introducing its new discovery.

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I), wherein A1, A2, A3, A4, A5, A6, A7, A8, X4, X6, R2, R4, R5, and R6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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hemistry is a science major with cience and engineering. The main research directions are chemical synthesis, preparation and modification of special coatings, and research on the structure and performance of functional materials , HPLC of Formula: C9H8O4. Introducing a new discovery about 70918-54-6, Name is (S)-1,4-Benzodioxane-2-carboxylic acid

Monoacylated piperazine derivatives were prepared directly from carboxylic acids and piperazine using triphenylphosphine (TPP) and N-bromosuccinimide (NBS) in dichloromethane. Inexpensive and readily available reagents, excellent yields, short reaction times and mild reaction conditions are important features of this method.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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The first cobalt-catalyzed decarboxylative acetoxylation reaction was accomplished. This methodology is applicable to a wide range of amino acids and arylacetic acids.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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Synthetic Route of 70918-54-6, In homogeneous catalysis, catalysts are in the same phase as the reactants. Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. In a document type is Article, and a compound is mentioned, CAS :70918-54-6, Name is (S)-1,4-Benzodioxane-2-carboxylic acid, introducing its new discovery.

Direct decarboxylative radical allylation of aliphatic carboxylic acids is described. With K2S2O8 as the oxidant and AgNO3 as the catalyst, the reactions of aliphatic carboxylic acids with allyl sulfones in aqueous CH3CN solution gave the corresponding alkenes in satisfactory yields under mild conditions. This site-specific allylation method is applicable to all primary, secondary, and tertiary alkyl acids and exhibits wide functional group compatibility.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Discovery of C9H8O4

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In heterogeneous catalysis, the catalyst is in a different phase from the reactants. 70918-54-6, However, they have proven to be challenging because of the mutual inactivation of both catalysts. 70918-54-6, name is (S)-1,4-Benzodioxane-2-carboxylic acid. In an article,Which mentioned a new discovery about 70918-54-6

A silver-catalyzed decarboxylative trifluoromethylthiolation of secondary and tertiary carboxylic acids under mild conditions tolerates a wide range of functional groups. The reaction was dramatically accelerated by its performance in an aqueous emulsion, which was formed by the addition of sodium dodecyl sulfate to water. It was proposed that the radical, which was generated from the silver-catalyzed decarboxylation in the “oil-in-water” droplets, could easily react with the trifluoromethylthiolating reagent to form the product.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

The Absolute Best Science Experiment for C9H8O4

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A the inflammation contains 1,4-benzodioxane structure of the pyrazoline derivatives, its characteristic is that it has the following formula: In the structural formula of R 1 to: R 2 to: R 3 to: […] derivatives of this invention can be used as a potential antibacterial and anti-tumor drug. The present invention discloses the preparation method. (by machine translation)

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

A new application about (S)-1,4-Benzodioxane-2-carboxylic acid

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70918-54-6, In homogeneous catalysis, catalysts are in the same phase as the reactants. Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. In a document type is Article, and a compound is mentioned, CAS :70918-54-6, Name is (S)-1,4-Benzodioxane-2-carboxylic acid, molecular weight is 180.16, introducing its new discovery.

A new Ag-catalyzed oxidative bicyclization of N-tethered 1,7-enynes with alkylcarboxylic acids for forming 41 examples of polycyclic 3,4-dihydroquinolin-2(1H)-ones has been established using readily accessible K2S2O8 as an oxidant. The reaction pathway involves a silver-catalyzed decarboxylation/in situ-generated C-center radical-triggered alpha,beta-conjugated addition/6-exo-dig cyclization/H-abstraction/5-endo-trig cyclization/SET sequence, allowing direct site-selective decarboxylative C(sp3)-H functionalization toward the formation of multiple C-C bonds and rapid construction of complex spiroheterocycles.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner.In a patent, 70918-54-6, name is (S)-1,4-Benzodioxane-2-carboxylic acid, introducing its new discovery. Safety of (S)-1,4-Benzodioxane-2-carboxylic acid

Ribosomal protein S6 kinase beta-1 (S6K1) is an attractive therapeutic target. In this study, computational analysis of five thiophene urea-based S6K1 inhibitors was performed. Molecular docking showed that the five compounds formed hydrogen bonds with residues Glu173 and Leu175 of S6K1 and hydrophobic interactions with residues Val105, Leu97 and Met225, and these interactions were key elements for the inhibitory potency of the compounds. Binding free energy (?Gbind) decomposition analysis showed that Leu97, Glu173, Val 105, Leu175, Leu97 and Met225 contribute the most to ?Gbind. Based on the computer results, phenylpyrazole based amides (D1-D3) were designed and synthesized. Biological evaluation revealed thatD2exhibited 15.9 nM S6K1 inhibition, medium microsomal stability and desirable bioavailability.

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Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem