Category: benzodioxans

An article Ultrasound-assisted diversion of nitrobenzene derivatives to their aniline equivalents through a heterogeneous magnetic Ag/Fe3O4-IT nanocomposite catalyst WOS:000594503300039 published article about NANOPARTICLES; NANOCATALYST; REDUCTION; EFFICIENT; PHOTOCATALYST; ALCOHOL; SYSTEM in [Taheri-Ledari, Reza; Rahimi, Jamal; Maleki, Ali] Iran Univ Sci & Technol IUST, Dept Chem, Catalysts & Organ Synth Res Lab, Tehran 1684613114, Iran; [Shalan, Ahmed Esmail] Cent Met Res & Dev Inst CMRDI, POB 87, Cairo 11421, Egypt; [Shalan, Ahmed Esmail] UPV EHU Sci Pk, BCMat, Basque Ctr Mat Applicat & Nanostruct, Barrio Sarriena S-N, Leioa 48940, Spain in 2020.0, Cited 48.0. Computed Properties of C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A heterogeneous magnetic catalytic system is fabricated and suitably applied for the fast and direct conversion of nitrobenzene (NB) derivatives to their aniline forms. For this purpose, different conditions and methods have been checked with numerous catalytic amounts of the nanocatalyst composite, which was constructed of iron oxide and silver nanoparticles and possessed an isothiazolone organic structure. Herein, the mechanistic aspect of the catalytic functioning of this highly efficient nanocatalyst is highlighted and discussed. Firstly, a convenient preparation route assisted by ultrasonication for this metal and metal oxide nanocomposite is presented. Further, a fast and direct reduction strategy for NBs is investigated using ultrasound irradiation (50 kHz, 200 W L-1). As two great advantages of this catalyst, high magnetic property and excellent reusability are also mentioned. This report well reveals that a really convenient conversion of NBs to anilines can be achieved with a high yield during the rapid reaction time in presence of mild reaction conditions.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Taheri-Ledari, R; Rahimi, J; Maleki, A; Shalan, AE or concate me.. Computed Properties of C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Formula: C14H11N. Recently I am researching about PALLADIUM-CATALYZED CARBONYLATION; ARYL IODIDES; EXPEDITIOUS SYNTHESIS; AROMATIC SPIROKETALS; ASYMMETRIC-SYNTHESIS; NATURAL-PRODUCTS; ALKYNYL KETONES; O-IODOPHENOLS; FORMIC-ACID; CHROMONES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21472078, 21772079, 21572092]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Xiang, KR; Tong, P; Yan, BR; Long, LL; Zhao, CB; Zhang, Y; Li, Y. The CAS is 86-29-3. Through research, I have a further understanding and discovery of 2,2-Diphenylacetonitrile

A one-pot Pd-catalyzed carbonylative Sonogashira coupling in tandem with double annulation reaction to synthesize benzannulated [6,6]-spiroketals from o-iodophenols and terminal alkynols or alkynyl phenols was achieved. The protocol provides straightforward and facile access to benzannulated [6,6]-spiroketals in moderate to good yields and excellent diastereoselectivities under balloon pressure of CO at room temperature.

Formula: C14H11N. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Xiang, KR; Tong, P; Yan, BR; Long, LL; Zhao, CB; Zhang, Y; Li, Y or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2020 FOOD RES INT published article about LOW-PRESSURE PLASMA; ACID in [Akasapu, Kumudhini; Gupta, Arun Kumar; Mishra, Poonam] Tezpur Univ, Dept Food Engn & Technol, Tezpur 784028, Assam, India; [Ojah, Namita; Choudhury, Arup Jyoti] Tezpur Univ, Dept Phys, Tezpur 784028, Assam, India in 2020, Cited 24. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3. Quality Control of 2,2-Diphenylacetonitrile

In the present study, an innovative cold plasma treatment was used as a tool to fortify the white rice. The amounts of ferrous sulphate and ascorbic acid were optimized for improving the bioavailability of iron. White rice samples were treated with plasma at a constant voltage of 20 kV for varying time (10 min and 15 min). The exposure time of plasma was selected based on the surface characteristics, hydrophilicity and thermal properties. Significant improvement was observed in the characteristics of hydrophilicity, surface energy, cooking time and hardness of plasma-treated rice. Plasma treated rice was fortified with the optimum concentrations of iron and ascorbic acid solution. Optimum concentrations of iron and ascorbic acid per 100 g of rice (862.93 mg and 1398.27 mg) were found by conducing experiments using Central Composite Design of Response Surface Methodology. Further, rice was blended with untreated rice in the ratio of 1:100 and 1:200 and was packed in LDPE and PP pouches and was stored at ambient temperature for further storage analysis. The in vitro bioavailability of iron was significantly higher in the plasma-treated fortified rice at both 1.35 and 7.5 pH than in the control sample, and plasma treatment significantly reduced the rate of oxidation of iron during storage.

Quality Control of 2,2-Diphenylacetonitrile. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Akasapu, K; Ojah, N; Gupta, AK; Choudhury, AJ; Mishra, P or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

SDS of cas: 100-19-6. Authors Wang, YZ; Huang, XL; Wang, Q; Tang, YH; Xu, SL; Li, Y in AMER CHEMICAL SOC published article about in [Wang, Yongzhuang; Huang, Xiaoli; Wang, Qin; Tang, Yuhai; Xu, Silong; Li, Yang] Xi An Jiao Tong Univ, Dept Mat Chem, Sch Chem, Xian 710049, Peoples R China; [Wang, Yongzhuang; Huang, Xiaoli; Wang, Qin; Tang, Yuhai; Xu, Silong; Li, Yang] Xi An Jiao Tong Univ, Xian Key Lab Sustainable Energy Mat Chem, Xian 710049, Peoples R China in 2021.0, Cited 61.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

An efficient Cp*Rh-III-catalyzed formal C(sp(3))-H activation/spiroannulation of alkylidene Meldrum’s acids with alkynes has been developed using catalytical Cu(OAc)(2) and air as the oxidant. This reaction demonstrates a new and straightforward approach to spirocyclopentadienes with Meldrum’s acid moieties in good to excellent yields under mild reaction conditions with a broad substrate scope. Notably, this protocol provides a novel and straightforward approach to cyclopentadienes with various substitution patterns and the corresponding cyclopentadienyl-type ligands from simple substrates.

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Wang, YZ; Huang, XL; Wang, Q; Tang, YH; Xu, SL; Li, Y or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 BIOORG CHEM published article about PROLIFERATOR-ACTIVATED RECEPTORS; CYCLOOXYGENASE-2 INHIBITORS; MOLECULAR DOCKING; INFLAMMATION; GLUCOSIDASE; REGULATOR; DISCOVERY; ANALOGS; RAT in [Abdellatif, Khaled R. A.; Fadaly, Wael A. A.] Beni Suef Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Bani Suwayf, Egypt; [Abdellatif, Khaled R. A.] Ibn Sina Natl Coll Med Studies, Pharmaceut Sci Dept, Jeddah 21418, Saudi Arabia; [Kamel, Gehan M.] Cairo Univ, Fac Vet, Pharmacol Dept, Cairo, Egypt; [Elshaier, Yaseen A. M. M.] Al Azhar Univ, Pharmaceut Organ Chem Dept, Fac Pharm, Assiut 71524, Egypt; [El-Magd, Mohammed A.] Kafrelshiekh Univ, Anat Dept, Fac Vet Med, Kafrelshiekh 33516, Egypt in 2019.0, Cited 51.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Formula: C8H7NO3

Nowadays, diabetes and its associated inflammatory complications are important public health problems worldwide. Market limitations of drugs with dual actions as anti-inflammatory (AI) and anti-diabetic have been led to a temptation for focusing on the discovery and development of new compounds with potential AI and antidiabetic activities. Herein, we synthesized two new series containing pyrazole ring with vicinal diaryl rings as selective COX-2 moiety and thiazolidindione (series 12a-f) or thiazolidinone (series 13a-f) as anti-diabetic moiety and the two moieties were linked together with methylene or methylenehydrazone functionality. The two series were evaluated for their COX inhibition, AI activity and ulcerogenic liability and for the anti-diabetic activity; 12a-f and 13a-f were assessed in vitro against alpha-glucosidase, beta-glucosidase, in vivo hypoglycemic activity (one day and 15 days studies) in addition to PPAR. activation study. Four compounds (12c, 12f, 13b and 13f) had higher COX-2 S.I. (8.69-9.26) than the COX-2 selective drug celecoxib (COX-2 S.I. = 8.60) and showed the highest AI activities and the lowest ulcerogenicity than other derivatives. Also, two thiazolidindione derivatives 12e and 12f and two thiazolidinone derivatives 13b and 13c showed higher inhibitory activities against alpha- and beta-glucosidase (% inhibitory activity = 62.15, 55.30, 65.37, 59.08 for alpha-glucosidase and 57.42, 60.07, 58.19, 66.90 for beta-glucosidase respectively) than reference compounds (acarbose with % inhibitory activity = 49.50 for alpha-glucosidase and D-saccharic acid 1,4-lactone monohydrate with % inhibitory activity = 53.42 for beta-glucosidase) and also showed good PPAR-gamma activation and good hypoglycemic effect in comparison to pioglitazone and rosiglitazone. Moreover, Shape comparison and docking studies were carried out to understand their interaction and similarity with standard drugs.

Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Abdellatif, KRA; Fadaly, WAA; Kamel, GM; Elshaier, YAMM; El-Magd, MA or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Rana, M; Arif, R; Khan, FI; Maurya, V; Singh, R; Faizan, MI; Yasmeen, S; Dar, SH; Alam, R; Sahu, A; Ahmad, T; Rahisuddin in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Rana, Manish; Arif, Rizwan; Yasmeen, Shama; Dar, Sajad Hussain; Rahisuddin] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India; [Khan, Faez Iqbal] Univ Elect Sci & Technol China, Sch Elect Sci & Engn, Chengdu, Peoples R China; [Maurya, Vikas; Singh, Raja] Jawharlal Nehru Univ, Special Ctr Mol Med, New Delhi 110067, India; [Faizan, Md Imam; Ahmad, Tanveer] Jamia Millia Islamia, Multidisciplinary Ctr Adv Res & Studies, New Delhi 110025, India; [Alam, Raquib] Jamia Millia Islamia, Univ Polytech, Dept Appl Sci, New Delhi 110025, India; [Sahu, Ankita] Safdarjung Hosp Campus, ICMR Natl Inst Pathol, New Delhi 110029, India in 2021.0, Cited 77.0. Safety of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

N-formyl pyrazoline derivatives (3a-3l) were designed and synthesized via Michael addition reaction through cyclization of chalcones with hydrazine hydrate in presence of formic acid. The structural elucidation of N-formyl pyrazoline derivatives was carried out by various spectroscopic techniques such as H-1, C-13 NMR, FT-IR, UV-visible spectroscopy, mass spectrometry and elemental analysis. Anticancer activity of the pyrazoline derivatives (3a-3l) was evaluated against human lung cancer (A549), fibrosarcoma cell lines (HT1080) and human primary normal lung cells (HFL-1) by MTT assay. The results of anticancer activity showed that potent analogs 3b and 3d exhibited promising activity against A549 (IC50 = 12.47 +/- 1.08 and 14.46 +/- 2.76 mu M) and HT1080 (IC50 = 11.40 +/- 0.66 and 23.74 +/- 13.30 mu M) but low toxic against the HFL-1 (IC50 =116.47 +/- 43.38 and 152.36 +/- 22.18 mu M). The anticancer activity of potent derivatives (3b and 3d) against A549 cancer cell line was further confirmed by flow cytometry based approach. DNA binding interactions of the pyrazoline derivatives 3b and 3d have been carried out with calf thymus DNA (Ct-DNA) using absorption, fluorescence and viscosity measurements, circular dichroism and cyclic voltammetry. Antioxidant potential of N-formyl pyrazoline derivatives (3a-3l) has been also estimated through DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical and H2O2. Results revealed that all the compounds exhibited significant antioxidant activity. In silico molecular modelling and ADMET properties of pyrazoline derivatives were also studied using PyRx software against topoisomerase II receptor with PDB ID: 1ZXM to explore their best hits. MD simulation of 3b and 3d was also carried out with topoisomerase II for structure-function correlation in a protein. HuTopoII inhibitory activity of the analogs (3a-3l) was examined by relaxation assay at varying concentrations 100-1000 mu M.

Safety of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Rana, M; Arif, R; Khan, FI; Maurya, V; Singh, R; Faizan, MI; Yasmeen, S; Dar, SH; Alam, R; Sahu, A; Ahmad, T; Rahisuddin or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Monsen, PJ; Luzzio, FA in PERGAMON-ELSEVIER SCIENCE LTD published article about PORPHYROMONAS-GINGIVALIS ADHERENCE; 1,2,3-TRIAZOLE-BASED INHIBITORS; ORAL STREPTOCOCCI; PROSTAGLANDINS in [Monsen, Paige J.; Luzzio, Frederick A.] Univ Louisville, Dept Chem, 2320 South Brook St, Louisville, KY 40292 USA in 2020, Cited 25. Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

An array of arylnitro compounds with various functionality were treated with freshly-prepared aluminum amalgam in THE/water solution and resulted in the corresponding arylamines. The Al(Hg)-mediated reductions are relatively rapid with consumption of the amalgam and disappearance of starting material occurring over 20-30 min. The workup of the reductions involves only removal of the insoluble by-products by filtration followed by concentration. Only in some cases is chromatography required to secure the pure product. The desired arylamines are furnished in quantities of 25-100 mg, which in some cases, could be taken on to the next reaction without further purification. Reductions of 4-nitrobenzyl derivatives of carbohydrates or nucleosides were selective in affording the corresponding 4-aminobenzyl products. To show applicability in click chemistry, selected aminobenzyl products are directly azidated to yield products that were then used in click reactions to afford the corresponding 1,2,3-triazoles. (C) 2020 Elsevier Ltd. All rights reserved.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Monsen, PJ; Luzzio, FA or concate me.. Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019 ACS CATAL published article about AMINATION in [Chen, Wei; Chen, Kai; Chen, Wanzhi] Zhejiang Univ, Dept Chem, 38 Zheda Rd, Hangzhou 310027, Peoples R China; [Liu, Miaochang; Wu, Huayue] Wenzhou Univ, Coll Chem & Mat Engn, 588 New Chaoyang St, Wenzhou 325027, Peoples R China in 2019, Cited 33. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. SDS of cas: 100-19-6

The C-N bond formation is one of the fundamental reactions in organic chemistry, because of the widespread presence of amine moieties in pharmaceuticals and biologically active compounds. Palladium-catalyzed C-N coupling of haloarenes represents one of the most efficient approaches to aromatic amines. Nitroarenes are ideal alternative electrophilic coupling partners, since they are inexpensive and readily available. The denitration and cross-coupling using nitroarenes as the electrophilic partners is challenging, because of the low reactivity of the Ar-NO2 bond toward oxidative addition. We report here the C-N coupling of nitroarenes and amines using palladium/5-(2,4,6-triisopropylphenyl)imidazolylidene[1,5-a]pyridines as the catalyst. The ligands are readily available from commercial chemicals. The reaction shows broad substrate scope and functional group tolerance. The method is applicable to both aromatic and aliphatic amines, and many secondary and tertiary aromatic amines bearing various functional groups were obtained in high yields.

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Chen, W; Chen, K; Chen, WZ; Liu, MC; Wu, HY or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

SDS of cas: 100-19-6. Bahrami, K; Khodaei, MM; Batooie, N; Hosseinzadeh, N; Foroumadi, A in [Bahrami, Kiumars; Khodaei, Mohammad M.; Batooie, Nasim] Razi Univ, Fac Chem, Dept Organ Chem, Kermanshah 6714967346, Iran; [Hosseinzadeh, Nouraddin] Sharif Univ Technol, Dept Chem, Lab Organ Synth & Nat Prod, Azadi St,POB 11155-9516, Tehran, Iran; [Foroumadi, Alireza] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, Tehran, Iran published Hexyltriphenylphosphonium Bromide as an Absolutely Chemoselective Ionic Liquid Catalyst in the Three-Component Reaction of Aryl Aldehydes, Acetophenones and Malononitrile in 2019.0, Cited 44.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Hexyltriphenylphosphonium bromide (HTPB) is used as an efficient ionic liquid catalyst in the chemoselective addition of malononitrile to carbonyl group moiety of chalcones through the three-component reaction of aryl aldehydes, acetophenone derivatves, and malononitrile to produce (E)-2-(1,3-diarylallylidene)malononitriles at ambient temperature. The method is simple, solvent-free, environmentally friendly, and gives excellent yields in a short reaction times.

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Bahrami, K; Khodaei, MM; Batooie, N; Hosseinzadeh, N; Foroumadi, A or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article Synthesis, Spectroscopic Characterization, DFT Calculations and Preliminary Antifungal Activity of New Piperine Derivatives published in 2021.0. Category: benzodioxans, Reprint Addresses Barbosa, JM (corresponding author), Univ Fed Paraiba, Dept Ciencias Farmaceut, BR-58051900 Joao Pessoa, PB, Brazil.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Four new piperine derivatives, PC1-PC4, were synthesized, and their structures were fully characterized by infrared (IR) and H-1 and C-13 nuclear magnetic resonance (NMR) spectroscopies. Quantum chemical calculations were performed using density functional theory (DFT) with the B3LYP-D3/6-31G(d,p) and 6-311+G(2d,p) basis sets. Electronic properties, such as the energy gap between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) and some global chemical reactivity descriptors, were evaluated to study the reactivity and stability of the compounds. H-1 and C-13 NMR chemical shifts were calculated by using the gauge-invariant atomic orbital (GIAO) method and compared with experimental values. In addition, the compounds were evaluated in an antifungal study against Candida, Trichophyton and Microsporum strains, and only PC4 showed 70% inhibition in ten tested strains, with a minimum inhibitory concentration (MIC) ranging from 1.23-2.46 mu mol mL(-1) and a minimum fungicide concentration (MFC) ranging from 9.84-19.68 mu mol mL(-1), and presented a fungistatic effect.

Category: benzodioxans. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Souza, JS; Martins, EPS; Souza, HDS; de Oliveira, RF; Alves, FS; Lima, EO; Cordeiro, LV; Trindade, EO; Lira, BF; Rocha, GB; de Athayde, PF; Barbosa, JM or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem