Category: benzodioxans

In 2020.0 EUR J MED CHEM published article about BREAST-CANCER; CRYSTAL-STRUCTURE; CDK INHIBITORS; AGENTS DESIGN; APOPTOSIS; CELLS; IX; ENHANCEMENT; DERIVATIVES; SELECTIVITY in [Said, Mohamed A.; Soliman, Dalia H.] Egyptian Russian Univ, Coll Pharm, Dept Pharmaceut Chem, POB 11829, Cairo, Egypt; [Eldehna, Wagdy M.] Kafrelsheikh Univ, Fac Pharm, Dept Pharmaceut Chem, POB 33516, Kafrelsheikh, Egypt; [Nocentini, Alessio; Bonardi, Alessandro; Supuran, Claudiu T.] Univ Florence, Dept NEUROFARBA, Sect Pharmaceut & Nutraceut Sci, Polo Sci, Via U Schiff 6, I-50019 Florence, Italy; [Nocentini, Alessio; Bonardi, Alessandro; Gratteri, Paola] Univ Firenze, Dept NEUROFARBA, Pharmaceut & Nutraceut Sect, Via U Schiff 6, I-50019 Florence, Italy; [Nocentini, Alessio; Bonardi, Alessandro; Gratteri, Paola] Univ Firenze, Lab Mol Modeling Cheminformat & QSAR, Via U Schiff 6, I-50019 Florence, Italy; [Fahim, Samar H.; Abou-Seri, Sahar M.] Cairo Univ, Fac Pharm, Dept Pharmaceut Chem, Kasr El Aini St,POB 11562, Cairo, Egypt; [Elgazar, Abdullah A.] Kafrelsheikh Univ, Fac Pharm, Dept Pharmacognosy, POB 33516, Kafrelsheikh, Egypt; [Krystof, Vladimir] Palacky Univ, Lab Growth Regulators, Slechtitelu 27, Olomouc 78371, Czech Republic; [Krystof, Vladimir] Czech Acad Sci, Inst Expt Bot, Slechtitelu 27, Olomouc 78371, Czech Republic; [Soliman, Dalia H.] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Chem, POB 11471, Cairo, Egypt; [Abdel-Aziz, Hatem A.] Natl Res Ctr, Dept Appl Organ Chem, Cairo 12622, Egypt; [Krystof, Vladimir] Palacky Univ, Fac Med & Dent, Inst Mol & Translat Med, Hnevotinska 5, Olomouc 77900, Czech Republic in 2020.0, Cited 56.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 100-19-6

In the present study, we report the design and synthesis of novel CAN508 sulfonamide-based analogues (4, 8a-e, 9a-h and 10a-e) as novel carbonic anhydrase (CA) inhibitors with potential CDK inhibitory activity. A bioisosteric replacement approach was adopted to replace the phenolic OH of CAN508 with a sulfamoyl group to afford compound 4. Thereafter, a ring-fusion approach was utilized to furnish the 5/5 fused imidazopyrazoles 8a-e which were subsequently expanded to 6/5 pyrazolopyrimidines 9a-h and 10a-e. All the synthesized analogues were evaluated for their inhibitory activity toward isoforms hCA I, II, IX and XII. The target tumor-associated isoforms hCA IX and XII were effectively inhibited with KIs ranges 6-67.6 and 10.1-88.6 nM, respectively. Furthermore, all compounds were evaluated for their potential CDK2 and 9 inhibitory activities. Pyrazolopyrimidines 9d, 9e and 10b displayed weak CDK2 inhibitory activity (IC50 = 6.4, 8.0 and 11.6 mu M, respectively), along with abolished CDK9 inhibitory activity. This trend suggested that pyrazolopyrimidine derivatives merit further optimization to furnish more effective CDK2 inhibitor lead. On account of their excellent activity and selectivity towards hCA IX and XII, pyrazolopyrimidines 10 were evaluated for their anti-proliferative activity toward breast cancer MCF-7 and MDA-MB-468 cell lines under normoxic and hypoxic conditions. The most potent anti-proliferative agents 10a, 10c and 10d significantly increased cell percentage at sub-G1 and G2-M phases with concomitant decrease in the S phase population in MCF-7 treated cells. Finally, a docking study was undertaken to investigate the binding mode for the most selective hCA IX and XII inhibitors 10a-e, within hCA II, IX and XII active sites. (C) 2020 Elsevier Masson SAS. All rights reserved.

Recommanded Product: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Said, MA; Eldehna, WM; Nocentini, A; Fahim, SH; Bonardi, A; Elgazar, AA; Krystof, V; Soliman, DH; Abdel-Aziz, HA; Gratteri, P; Abou-Seri, SM; Supuran, CT or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about C BOND-CLEAVAGE; AEROBIC OXIDATION; ELECTRON-TRANSFER; ENAMINO ESTERS; FACILE ACCESS; H ACTIVATION; TRANSITION; TEMPO; CYCLIZATION; EFFICIENT, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21873041, 21632001, 21422205]; 111 projectMinistry of Education, China – 111 Project; Program for Changjiang Scholars and Innovative Research Team in UniversityProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT-15R28]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [lzujbky-2016-ct02, lzujbky-2016-ct08]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhan, JL; Wu, MW; Wei, D; Wei, BY; Jiang, Y; Yu, W; Han, B. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Name: 1-(4-Nitrophenyl)ethanone

A 4-HO-TEMPO-catalyzed redox strategy for the synthesis of pyridines through the annulation of cyclopropanols and oxime acetates has been developed. This protocol features good functional group tolerance and high chemoselectivity and also promises to be efficient for the late-stage functionalization of skeletons of drugs and natural products. Mechanism studies indicate that the reaction involves the in situ generated alpha,beta-unsaturated ketones and imines as the key intermediates, which are derived from cyclopropanols and oxime acetates via a TEMPO/TEMPOH redox cycle, respectively. The pyridine products are formed as a result of annulation of enones with imines followed by TEMPO-catalyzed oxidative aromatization by excess oxime acetates. This method not only realizes the TEMPO-catalyzed redox reaction but also broadens the frontiers for TEMPO in catalysis.

Name: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Zhan, JL; Wu, MW; Wei, D; Wei, BY; Jiang, Y; Yu, W; Han, B or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article Synergistic Catalysis of Se and Cu for the Activation of alpha-Hof Methyl Ketones with Molecular Oxygen/Alcohol to Produce alpha-KetoAcetals(dagger) published in 2020.0. Application In Synthesis of 1-(4-Nitrophenyl)ethanone, Reprint Addresses Yu, L (corresponding author), Yangzhou Univ, Sch Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China.; Jiang, XF (corresponding author), East China Normal Univ, Dept Chem, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Summary of main observation and conclusion Selenium and copper synergistically catalyzed the oxidation/alkoxylation of methyl ketones to synthesize alpha-keto acetals directly. Using O(2)as oxidant and alcohol as solvent and alkoxylation reagent, the reaction is practical from industrial viewpoint. Mechanistic studies revealed that copper promoted the oxidation of organoselenium intermediates with O(2)to allow the key rearrangement and selenoxidesyn-elimination regenerating the catalytically active organoselenium species.

Application In Synthesis of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Chen, C; Cao, ZC; Zhang, X; Li, YM; Yu, L; Jiang, XF or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article OH/Na co-functionalized carbon nitride: directional charge transfer and enhanced photocatalytic oxidation ability WOS:000509894100024 published article about FACILE SYNTHESIS; REACTANTS ACTIVATION; NO ADSORPTION; DOPED G-C3N4; EFFICIENT; NANOSHEETS; ZIRCONIA; REACTIVITY; VACANCIES; MECHANISM in [Wang, Jiadong; Chen, Ruimin; Yuan, Chaowei; Dong, Fan; Sun, Yanjuan] Chongqing Technol & Business Univ, Coll Environm & Resources, Chongqing Key Lab Catalysis & New Environm Mat, Chongqing 400067, Peoples R China; [Wang, Jiadong; Cui, Wen; He, Ye; Yuan, Chaowei; Sheng, Jianping; Li, Jieyuan; Dong, Fan; Sun, Yanjuan] Univ Elect Sci & Technol China, Inst Fundamental & Frontier Sci, Res Ctr Environm Sci & Technol, Chengdu 611731, Peoples R China; [Cui, Wen] Southwest Petr Univ, Sch Mat Sci & Engn, Ctr New Energy Mat & Thchnol, Chengdu 610500, Peoples R China; [Zhan, Yuxin] Chongqing Univ, Coll Mat Sci & Engn, Chongqing 400044, Peoples R China in 2020, Cited 60. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 100-19-6

Graphitic carbon nitride (g-C3N4, CN for short) is a compelling visible-light responsive photocatalyst. However, its photocatalytic efficiency is low due to the random carrier transfer in planes and insufficient redox potential. Herein, we build oxygen functional group modified sodium-doped carbon nitride (OH/Na co-functionalized carbon nitride) to promote directional transfer of charge carriers for acceleration of separation and enhance redox potential for efficient oxidation of NO in air. Specifically, the function of sodium atoms could control the directional transfer of random carriers from the intralayer to the oxygen functional group-modified surface for the purpose of effectively reducing photogenerated electron-hole recombination. Meanwhile, the modification by oxygen-containing functional groups could adjust the band structure of CN, thereby increasing the oxidation-reduction potential of NO in the photocatalyst. The transformation pathways and reaction mechanism of photocatalytic NO oxidation on CN and OH/Na co-functionalized carbon nitride have also been explicated by ESR spectroscopy and in situ DRIFTS and compared. This work provides a new method for simultaneously controlling the random transfer of carriers and adjusting the energy band structure of CN to optimize its photocatalytic efficiency. It is also possible to extend this strategy to improve the performance of other 2D layered catalysts for photocatalytic oxidation.

Recommanded Product: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Wang, JD; Cui, W; Chen, RM; He, Y; Yuan, CW; Sheng, JP; Li, JY; Zhan, YX; Dong, F; Sun, YJ or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 100-19-6. Recently I am researching about CARBONYL-COMPOUNDS; METAL-FREE; CORRESPONDING 1,3-OXATHIOLANES; SYNTHETIC APPLICATIONS; ASYMMETRIC-SYNTHESIS; RADICAL-ADDITION; SILICA-GEL; EFFICIENT; CATALYST; CONVERSION, Saw an article supported by the Ministry of Science and Technology, TaiwanMinistry of Science and Technology, Taiwan [Most 107-2113-M-005-019-MY3]; National Chung Hsing University, Research Center for Sustainable Energy and Nanotechnology (RCSEN); Innovation and Development Center of Sustainable Agriculture (IDCSA) from The Featured Areas Research Center Program within Ministry of Education (MOE) in Taiwan. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Liu, YC; Reddy, DM; Chen, XA; Shieh, YC; Lee, CF. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

In synthetic chemistry, the protection of aldehydes and ketones is crucial during multistep synthesis of complex molecules. Organic chemists have paid substantial attention to the synthesis of 1,3-oxathiolanes and 1,3-oxathianes because of their considerable stability under acidic conditions and ease of removal of protecting groups. In this paper, we report the mild and efficient oxathiacetalization of aldehydes with 2-mercaptoethanol and 3-mercaptopropan-1-ol through visible-light-promoted eosin-Y catalyzed C-S and C-O bond formation at ambient temperature under metal-free conditions. This catalytic system also affords oxathiacetalization of ketones through photoredox catalysis.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Liu, YC; Reddy, DM; Chen, XA; Shieh, YC; Lee, CF or concate me.. Recommanded Product: 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Design of Manganese Phenol Pi-complexes as Shvo-type Catalysts for Transfer Hydrogenation of Ketones WOS:000463960000006 published article about ASYMMETRIC HYDROGENATION; IRON; EFFICIENT; MECHANISM; CHEMISTRY; ALDEHYDES; NITRILES; ALCOHOLS; LIGANDS; METALS in [Shvydkiy, Nikita, V; Nelyubina, Yulia, V; Perekalin, Dmitry S.] Russian Acad Sci, Nesmeyanov Inst Organoelement Cpds, 28 Vavilova, Moscow 119991, Russia; [Vyhiyskyi, Oleksandr] Lomonosov Moscow State Univ, Dept Chem, 1-3 Leninskie Gory, Moscow 119991, Russia; [Perekalin, Dmitry S.] Plekhanov Russian Univ Econ, 36 Stremyannyi Pereulok, Moscow 117997, Russia in 2019.0, Cited 55.0. Name: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Catalytic hydrogenation is one of the most important reactions both in academic research and industry. We explored ability of the manganese pi-complexes to act as Shvo-type catalysts for transfer hydrogenation of ketones. DFT calculations suggested that the transfer of hydrogen atoms from the hypothetical intermediate [(C6Me3H2OH)Mn(CO)(2)H] to acetone has low activation barrier of 10.9 kcal mol(-1). Experimentally a number of ketones with various functional groups (OMe, NH2, Cl, CF3, pyridyl) were successfully reduced in isopropanol at 90 degrees C in the presence of the complex[(C6Me3H2OH)Mn(CO)(3)]BF4 (1 mol %) and (BuOK)-Bu-t (75 mol %). However, further investigation revealed that the reduction was mainly promoted by base rather than the manganese complex.

Name: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Shvydkiy, NV; Vyhiyskyi, O; Nelyubina, YV; Perekalin, DS or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Quality Control of 1-(4-Nitrophenyl)ethanone. In 2021.0 NEW J CHEM published article about POLY(ETHYLENE GLYCOL); CYCLOADDITION; DERIVATIVES; LIBRARY; 3-AMINO-2-OXINDOLES; SPIROINDOLONES; CONSTRUCTION; ANTAGONIST; SCAFFOLDS; RECEPTOR in [Yue, Guizhou; Jiang, Dan; Dou, Zhengjie; Li, Sicheng; Feng, Juhua; Zhang, Li; Wang, Xianxiang] Sichuan Agr Univ, Coll Sci, Yaan 625014, Sichuan, Peoples R China; [Chen, Huabao; Yang, Chunping] Sichuan Agr Univ, Coll Agron, Chengdu 611130, Sichuan, Peoples R China; [Yin, Zhongqiong; Song, Xu; Liang, Xiaoxia] Sichuan Agr Univ, Coll Vet Med, Chengdu 611130, Sichuan, Peoples R China; [Lu, Cuifen] Hubei Univ, Hubei Collaborat Innovat Ctr Adv Organochem Mat, Wuhan 430062, Peoples R China; [Lu, Cuifen] Hubei Univ, Key Lab Synth & Applicat Organ Funct Mol, Minist Educ, Wuhan 430062, Peoples R China in 2021.0, Cited 62.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

The umpolung Michael addition of isatin N,N’-cyclic azomethine imine 1,3-dipoles with chalcones is reported. The reaction could be finished within a very short time (0.3-2 min), with 3,3-disubstituted oxindole derivatives obtained in moderate to excellent yields with promising dr values. Unusual Michael adducts were obtained in moderate to high yields (26-98%) with low to high diastereoselectivities (0.8 : 1 to 8.5 : 1 dr). All the synthesized compounds (3, 3′, 4, 5, 5′, 7, 7′, 9 and 9′) were well characterized by FTIR, NMR, and mass spectral analyses and further confirmed by the single-crystal X-ray diffraction analysis of compounds 3aa and 4n.

Quality Control of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Yue, GZ; Jiang, D; Dou, ZJ; Li, SC; Feng, JH; Zhang, L; Chen, HB; Yang, CP; Yin, ZQ; Song, X; Liang, XX; Wang, XX; Lu, CF or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Rapid direct analysis of river water and machine learning assisted suspect screening of emerging contaminants in passive sampler extracts WOS:000617018900002 published article about MASS-SPECTROMETRY; TRANSFORMATION PRODUCTS; RETENTION TIMES; WASTE-WATER; QUANTIFICATION; PREDICTION in [Richardson, Alexandra K.; Rapp-Wright, Helena; Sturzenbaum, Stephen; Cowan, David A.; Barron, Leon P.] Kings Coll London, Fac Life Sci & Med, Sch Populat Hlth & Environm Sci, Dept Analyt Environm Sc Forens Sci, 150 Stamford St, London SE1 9NH, England; [Chadha, Marcus] Agilent Technol UK Ltd, 5500 Lakeside, Cheadle SK8 3GR, England; [Rapp-Wright, Helena] Dublin City Univ, Sch Chem Sci, Dublin 9, Ireland; [Mills, Graham A.; Fones, Gary R.] Univ Portsmouth, Fac Sci & Hlth, White Swan Rd, Portsmouth PO1 2DT, Hants, England; [Gravell, Anthony] Swansea Univ, Nat Resources Wales, Faraday Bldg,Singleton Campus, Swansea SA2 8PP, W Glam, Wales; [Neep, David J.] Agilent Technol UK Ltd, Essex Rd, Church Stretton SY6 6AX, England; [Barron, Leon P.] Imperial Coll London, Fac Med, Sch Publ Hlth, Environm Res Grp, 80 Wood Lane, London W12 7TA, England in 2021, Cited 61. Recommanded Product: 86-29-3. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3

A novel and rapid approach to characterise the occurrence of contaminants of emerging concern (CECs) in river water is presented using multi-residue targeted analysis and machine learning-assisted in silico suspect screening of passive sampler extracts. Passive samplers (Chemcatcher (R)) configured with hydrophilic-lipophilic balanced (HLB) sorbents were deployed in the Central London region of the tidal River Thames (UK) catchment in winter and summer campaigns in 2018 and 2019. Extracts were analysed by; (a) a rapid 5.5 min direct injection targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for 164 CECs and (b) a full-scan LC coupled to quadrupole time of flight mass spectrometry (QTOF-MS) method using data-independent acquisition over 15 min. From targeted analysis of grab water samples, a total of 33 pharmaceuticals, illicit drugs, drug metabolites, personal care products and pesticides (including several EU Watch-List chemicals) were identified, and mean concentrations determined at 40 +/- 37 ng L-1. For targeted analysis of passive sampler extracts, 65 unique compounds were detected with differences observed between summer and winter campaigns. For suspect screening, 59 additional compounds were shortlisted based on mass spectral database matching, followed by machine learning-assisted retention time prediction. Many of these included additional pharmaceuticals and pesticides, but also new metabolites and industrial chemicals. The novelty in this approach lies in the convenience of using passive samplers together with machine learning-assisted chemical analysis methods for rapid, time-integrated catchment monitoring of CECs.

Recommanded Product: 86-29-3. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Richardson, AK; Chadha, M; Rapp-Wright, H; Mills, GA; Fones, GR; Gravell, A; Sturzenbaum, S; Cowan, DA; Neep, DJ; Barron, LP or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Recyclable Itaconic Acid with Water as Green Catalytic System: Synthesis of Substituted 1,5-Benzodiazepine Derivatives at Room Temperature WOS:000510247300016 published article about VERSATILE BUILDING-BLOCK; ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; 1,3-DIPOLAR CYCLOADDITION; ENVIRONMENTALLY BENIGN; O-PHENYLENEDIAMINE; ORGANIC-REACTIONS; FACILE SYNTHESIS; NANOCATALYST in [Tamuli, Kashyap J.; Bordoloi, Manobjyoti] North East Inst Sci & Technol, CSIR, Chem Sci & Technol Div, Jorhat 785006, Assam, India; [Tamuli, Kashyap J.; Bordoloi, Manobjyoti] Acad Sci & Innovat Res, Jorhat 785006, Assam, India in 2020.0, Cited 89.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. SDS of cas: 100-19-6

The construction of new C-N chemical bonds through co-condensation reaction in water media as sole solvent, especially without the use of any metal catalyst has undergoes green protocols. Herein, we describe a water-mediated and metal-free mild protocol for easily accessing of structurally and electronically diverse 1,5-benzodiazepine analogous by using biodegradable naturally occurring itaconic acid (20 mol%) in 30 minutes with excellent yields. The simplicity in reaction operation, reusability of the catalytic system and simple filtration to get the desired product make this reaction as green synthetic pathway upto multi gram scale level.

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Tamuli, KJ; Bordoloi, M or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

SDS of cas: 100-19-6. In 2020.0 BIOORG CHEM published article about BIOLOGICAL EVALUATION; PHENYL AMIDES; DERIVATIVES; PYRIDINES; DESIGN in [Attia, Mohamed H.] October 6 Univ, Dept Pharmaceut Chem, Fac Pharm, Giza, Egypt; [Elrazaz, Eman Z.; Abouzid, Khaled A. M.] Ain Shams Univ, Fac Pharm, Pharmaceut Chem Dept, Cairo 11566, Egypt; [El-Emam, Soad Z.] October 6 Univ, Fac Pharm, Dept Pharmacol & Toxicol, Giza, Egypt; [Taher, Azza T.] Cairo Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Cairo, Egypt; [Abdel-Aziz, Hatem A.] Natl Res Ctr, Dept Appl Organ Chem, Cairo 12622, Egypt; [Abouzid, Khaled A. M.] Univ Sadat City, Fac Pharm, Dept Organ & Med Chem, Sadat City, Egypt in 2020.0, Cited 27.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A series of 2-phenyl-7-(aryl)pyrazolo [1,5-a]pyrimidine-3-carbonitriles 11a-j and 2-phenyl-7-(aryl)pyrazolo[1,5-a]pyrimidine-3,6-dicarbonitriles 16a-c was synthesized by the reaction of 5-amino-3-phenyl-1H-pyrazole-4-carbonitrile (5) with 3-(dimethylamino)-1-arylprop 2 en 1 ones 6a-j or 2-aryl-3-(dimethylamino)acrylonitriles 12a-c, respectively. In addition, 7-amino-5-oxo-2-phenyl-4,5-dihydropyrazolo [1,5-a]pyrimidine-3-carbonitrile (22) was prepared from the reaction of compound 5 with ethyl cyanoacetate. The anticancer activity of the newly synthesized compounds against Huh-7, HeLa, MCF-7 and MDA-MB231 cell lines showed moderate activity of compound 11 f as anti-proliferative agent against Huh-7 cell line with IC50 = 6.3 mu M when compared with doxorubicin (IC50, = 3.2 mu M). On the other hand, compound 16b revealed potent anti-proliferative activity against HeLa cell line with IC50, = 7.8 mu M when compared with doxorubicin (IC50, = 8.1 mu M). Also compound 11i exhibited a promising anti-proliferative activity against MCF-7 cell line (IC50, = 3.0 mu M) whereas IC50 of doxorubicin = 5.9 mu M, finally compounds 11i and 16b have potent activity as anti-proliferative agents against MDA-MB231 cell line with IC50, = 4.32 and 5.74 mu M, respectively when compared with doxorubicin (IC50 = 6.0 mu M).

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Attia, MH; Elrazaz, EZ; El-Emam, SZ; Taher, AT; Abdel-Aziz, HA; Abouzid, KAM or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem