In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 70918-54-6, However, they have proven to be challenging because of the mutual inactivation of both catalysts. 70918-54-6, name is (S)-1,4-Benzodioxane-2-carboxylic acid. In an article，Which mentioned a new discovery about 70918-54-6
Nickel-Catalyzed Esterification of Aliphatic Amides
Recent studies have demonstrated that amides can be used in nickel-catalyzed reactions that lead to cleavage of the amide C?N bond, with formation of a C?C or C?heteroatom bond. However, the general scope of these methodologies has been restricted to amides where the carbonyl is directly attached to an arene or heteroarene. We now report the nickel-catalyzed esterification of amides derived from aliphatic carboxylic acids. The transformation requires only a slight excess of the alcohol nucleophile and is tolerant of heterocycles, substrates with epimerizable stereocenters, and sterically congested coupling partners. Moreover, a series of amide competition experiments establish selectivity principles that will aid future synthetic design. These studies overcome a critical limitation of current Ni-catalyzed amide couplings and are expected to further stimulate the use of amides as synthetic building blocks in C?N bond cleavage processes.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 70918-54-6, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 70918-54-6, in my other articles.