Name is 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid, as a common heterocyclic compound, it belongs to benzodioxans compound, and cas is 3663-80-7, its synthesis route is as follows.
At 25 ¡ã C and N 2 atmosphere,Add 1,3-dicyclohexylcarbodiimide to a solution of 2,3-benzo[1,4]dioxin-2-carboxylic acid (12 mmol) and pyridine (20 mmol) in 20 mL of dry dichloromethane Amine DCC (15 mmol).After 5 minutes, 2-((1-amino-2-methylpropan-2-yl)amino)-1-(5-hydroxy-1H-pyrrole[3,2]pyridin-1-yl)B was added. ketone(10 mmol) and the mixture was stirred overnight.TLC (95:5 in dichloromethane: methanol containing 2percent ammonia) indicated that all of the starting material was consumed.The reaction was quenched with sodium bicarbonate and filtered through a pad of Celite.The plug was rinsed with dichloromethane and the aqueous layer was extracted with dichloromethane.After the combined organic layers are dried over Na 2 SO 4 ,Filtration and concentration in vacuo gave 3.6 g, m.The crude product was purified by flash chromatography.Use 2percent to 8percent MeOH:Purification by stepwise gradient of dichloromethane and 2percent ammonia,Obtained 3.2 g of white powder as N-(2-((2-(5-hydroxy-1H-pyrrole[3,2]pyridin-1-yl)-2-ethoxy)amino)-2-methylpropane Base)-(2,3-benzo[1,4]dioxin)-2-carboxamide,The yield was 85percent.
3663-80-7, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,3663-80-7 ,2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see
Reference£º
Patent; Sang Qi; (11 pag.)CN108164528; (2018); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem