With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4442-54-0,2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid,as a common compound, the synthetic route is as follows.
Preparation of Compound 133, N-(4-Fluoro-3-nitrophenyl)-2,3-dihydro-1,4- benzodioxine-7-carboxamide[00173] 2,3-Dihydrobenzo[b][1 ,4]dioxine-6-carboxylic acid (2.77 g, 15.37 mmol) was dissoved in DMA (25 mL) and DIPEA (6.69 mL, 38.43 mmol) and HATU (5.85 g, 15.37 mmol) added under an inert atmosphere. The reaction was allowed to stir for 15 minutes then 4-fluoro-3-nitroaniline (2.000 g, 12.81 mmol) was added and the reaction stirred at ambient temperature overnight. The reaction was heated for a further 16 hours at 40 ¡ãC then concentrated in vacuo and water added. The solids were isolated by filtration, washed with water and dried in a vacuum oven. The solids were stirred in EtOAc for an hour and then filtered. The filtrate was evaporated down and the solids were triturated with DCM then filtered. The collected solids were combined to afford the desired material as a cream solid (3.50 g, 86 percent).1H NMR (400 MHz, DMSO, 30 ¡ãC) d 4.29 – 4.36 (4H, m), 7.02 (1 H, d), 7.50 – 7.63 (3H, m), 8.15 (1 H, ddd), 8.69 (1 H, dd), 10.46 (1 H, s). m/z (ES+) (M+H)+ = 319.
4442-54-0, As the paragraph descriping shows that 4442-54-0 is playing an increasingly important role.
Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; JONES, Keith; RYE, Carl; CHESSUM, Nicola; CHEESEMAN, Matthew; PASQUA, Adele Elisa; PIKE, Kurt Gordon; FAULDER, Paul Frank; WO2015/49535; (2015); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem