The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5,5′-Dimethyl-2,2′-bipyridine(SMILESS: CC1=CN=C(C=C1)C1=NC=C(C)C=C1,cas:1762-34-1) is researched.Formula: C3H12Cl2N2. The article 《Heteroleptic NiII complexes: Synthesis, structural characterization, computational studies and amoebicidal activity evaluation》 in relation to this compound, is published in Journal of Inorganic Biochemistry. Let’s take a look at the latest research on this compound (cas:1762-34-1).
In this work, we present the synthesis, characterization, electrochem. studies, DFT calculations, and in vitro amoebicidal effect of seven new heteroleptic NiII coordination compounds The crystal structures of [H2(pdto)](NO3)2 and [Ni(pdto)(NO3)]PF6 are presented, pdto = 2,2′-[1,2-ethanediylbis-(sulfanediyl-2,1-ethanediyl)]dipyridine. The rest of the compounds have general formulas: [Ni(pdto)(N-N)](PF6) where N-N = 2,2′-bipyridine (bpy), 4,4′-dimethyl-2,2′-bipyridine (44dmbpy), 5,5′-dimethyl-2,2′-bipyridine (55dmbpy), 1,10-phenanthroline (phen), 4,7-dimethyl-1,10-phenanthroline (47dmphen) and 5,6-dimethyl-1,10-phenanthroline (56dmphen). The size of N-N ligand and its substituents modulate the compound electronic features and influence their antiproliferative efficiency against Entamoeba histolytica, 56dmphen derivative, shows the biggest molar volume and presents a powerful amoebicidal activity (IC50 = 1.2μM), being seven times more effective than the first-line drug for human amoebiasis metronidazole. Also, increases the reactive oxygen species concentration within the trophozoites. This could be the trigger of the E. histolytica growth inhibition. The antiparasitic effect is described using NiII electron d., molar volume, estimated by DFT, as well as the exptl. redox potential and diffusion coefficients In general, amoebicidal efficiency is directly proportional to the increment of the molar volume and decreases when the redox potential becomes more pos.
There is still a lot of research devoted to this compound(SMILES：CC1=CN=C(C=C1)C1=NC=C(C)C=C1)Computed Properties of C12H12N2, and with the development of science, more effects of this compound(1762-34-1) can be discovered.