Sun, YW; Bei, YM; Wang, LZ in [Sun, Yue-Wei; Bei, Yue-Ming; Wang, Lan-Zhi] Hebei Normal Univ, Coll Chem & Mat Sci, Shijiazhuang 050024, Hebei, Peoples R China published A catalyst-free four-component domino reaction for the synthesis of functionalized 3-acyl-1,5-benzodiazepines in 2019.0, Cited 16.0. Computed Properties of C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.
Various functional 3-acyl-1,5-benzodiazepines containing carboxyl, ester and acyl groups at the 2-position were synthesized via an efficient, sustainable and catalyst-free domino reaction. During the synthesis process, one new cycle and four new bonds (one C-C, two C-N and one C=C) were constructed by the nucleophilic substitution, nucleophilic addition, dehydration and cyclization reaction by the H+ shift. Furthermore, a total of 26 examples were examined by reacting inexpensive starting materials of N,N-dimethylformamide dimethyl acetal, aromatic ketones, 1,2-phenylenediamine compounds and aldehyde derivatives. Therefore, it displayed a broad substrate scope, good functional group tolerance, high yields (77-97%) and the ease of obtaining target compounds without the involvement of toxic solvents and column chromatography, which provided a novel method for the synthesis of a wide variety of biologically relevant 1,5-benzodiazepines.
Computed Properties of C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Sun, YW; Bei, YM; Wang, LZ or concate me.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem