2879-20-1, 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,2879-20-1
General procedure: To a stirred solution of 1 (0.84 mmol) in 5 N NaOH (3 mL) was added 2-heptanone (7.18 mmol) dropwise. The reaction mixture was heated to 60 C and kept for 3 h under stirring conditions. After cooling, the mixture was then extracted with CHCl3/MeOH (10:1, v/v) in a separatory funnel. The organic layer was washed to neutral status using water, dried using anhydrous MgSO4, and filtered. The filtrate was concentrated under reduced pressure to yield a crude intermediate. The crude intermediate was dissolved in anhydrous tetrahydrofuran (8 mL), followed by adding HOAc (1.0 mL) and formaldehyde (15.06 mmol) to the solution. The reaction mixture was kept refluxing for 3 h. After the reaction was halted and the reaction mixture cooled, evaporation under reduced pressure was done to remove the solvent from the reaction mixture. The residue was acidified using aqueous 2 N HCl (2 mL), and the solution was stirred at room temperature for 1 h, and extracted with CHCl3/MeOH (10:1, v/v) in a separatory funnel. The organic layer was dried using anhydrous MgSO4, filtered, and concentrated under reduced pressure to yield the crude product. The crude product was purified using silica gel CC (elutated with CHCl3:MeOH, 20:1, v/v) to yield 3e (97 mg, 23.3% yield) as a yellow solid.
As the paragraph descriping shows that 2879-20-1 is playing an increasingly important role.
Reference£º
Article; Zhang, Zhi-Hui; Yan, Yu; Deng, An-Jun; Zhang, Hai-Jing; Li, Zhi-Hong; Yuan, Tian-Yi; Fang, Lian-Hua; Wu, Lian-Qiu; Du, Guan-Hua; Qin, Hai-Lin; Chinese Chemical Letters; vol. 29; 1; (2018); p. 131 – 135;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem