2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid, cas is 3663-80-7, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.
3663-80-7, General procedure: A mixture of amine 4 (1 equiv.), DMAP(1.2 equiv.), EDC (1.2 equiv.), and anhydrousCH2Cl2 was stirred at room temperature,and then aromatic acid (1.2 equiv.)wasadded and the mixture was stirred at roomtemperature for 4?6 h. After completion ofthe reaction as indicated by TLC, CH2Cl2was removed on the rotary evaporator togive a red solid. The solid obtained waspurified by silica gel column chromatographywith ethyl acetate/petroleum ether asthe eluent to give compounds 5a?5m.Yields: 50?90percent.
With the rapid development of chemical substances, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid
Reference£º
Article; Wang, Ke; Liu, Zhan-Zhu; Journal of Asian Natural Products Research; vol. 16; 3; (2014); p. 296 – 303;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem