Heterocyclic Building Blocks-benzodioxan

An article Design, synthesis, modeling studies and biological evaluation of thiazolidine derivatives containing pyrazole core as potential anti-diabetic PPAR-gamma agonists and anti-inflammatory COX-2 selective inhibitors WOS:000455479600010 published article about PROLIFERATOR-ACTIVATED RECEPTORS; CYCLOOXYGENASE-2 INHIBITORS; MOLECULAR DOCKING; INFLAMMATION; GLUCOSIDASE; REGULATOR; DISCOVERY; ANALOGS; RAT in [Abdellatif, Khaled R. A.; Fadaly, Wael A. A.] Beni Suef Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Bani Suwayf, Egypt; [Abdellatif, Khaled R. A.] Ibn Sina Natl Coll Med Studies, Pharmaceut Sci Dept, Jeddah 21418, Saudi Arabia; [Kamel, Gehan M.] Cairo Univ, Fac Vet, Pharmacol Dept, Cairo, Egypt; [Elshaier, Yaseen A. M. M.] Al Azhar Univ, Pharmaceut Organ Chem Dept, Fac Pharm, Assiut 71524, Egypt; [El-Magd, Mohammed A.] Kafrelshiekh Univ, Anat Dept, Fac Vet Med, Kafrelshiekh 33516, Egypt in 2019.0, Cited 51.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 100-19-6

Nowadays, diabetes and its associated inflammatory complications are important public health problems worldwide. Market limitations of drugs with dual actions as anti-inflammatory (AI) and anti-diabetic have been led to a temptation for focusing on the discovery and development of new compounds with potential AI and antidiabetic activities. Herein, we synthesized two new series containing pyrazole ring with vicinal diaryl rings as selective COX-2 moiety and thiazolidindione (series 12a-f) or thiazolidinone (series 13a-f) as anti-diabetic moiety and the two moieties were linked together with methylene or methylenehydrazone functionality. The two series were evaluated for their COX inhibition, AI activity and ulcerogenic liability and for the anti-diabetic activity; 12a-f and 13a-f were assessed in vitro against alpha-glucosidase, beta-glucosidase, in vivo hypoglycemic activity (one day and 15 days studies) in addition to PPAR. activation study. Four compounds (12c, 12f, 13b and 13f) had higher COX-2 S.I. (8.69-9.26) than the COX-2 selective drug celecoxib (COX-2 S.I. = 8.60) and showed the highest AI activities and the lowest ulcerogenicity than other derivatives. Also, two thiazolidindione derivatives 12e and 12f and two thiazolidinone derivatives 13b and 13c showed higher inhibitory activities against alpha- and beta-glucosidase (% inhibitory activity = 62.15, 55.30, 65.37, 59.08 for alpha-glucosidase and 57.42, 60.07, 58.19, 66.90 for beta-glucosidase respectively) than reference compounds (acarbose with % inhibitory activity = 49.50 for alpha-glucosidase and D-saccharic acid 1,4-lactone monohydrate with % inhibitory activity = 53.42 for beta-glucosidase) and also showed good PPAR-gamma activation and good hypoglycemic effect in comparison to pioglitazone and rosiglitazone. Moreover, Shape comparison and docking studies were carried out to understand their interaction and similarity with standard drugs.

Recommanded Product: 100-19-6. Welcome to talk about 100-19-6, If you have any questions, you can contact Abdellatif, KRA; Fadaly, WAA; Kamel, GM; Elshaier, YAMM; El-Magd, MA or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article Acetic acid mediated regioselective synthesis of 2,4,5-trisubstituted thiazoles by a domino multicomponent reaction published in 2019.0. Computed Properties of C8H7NO3, Reprint Addresses Khurana, JM (corresponding author), Univ Delhi, Dept Chem, Delhi 110007, India.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Acetic acid mediated regioselective synthesis of novel 2,4,5- trisubstituted thiazole derivatives has been reported by a domino reaction of thiosemicarbazide and aldehydes/ ketones/ isatin, to generate thiosemicarbazones ( in situ) followed by addition of arylglyoxal and active methylene/ activated C- H acids/ pyrazole/ indole in ethanol at 80 1C. The products are obtained in high yields by a simple work up. Metal free, short reaction time and high yields are some merits of this methodology.

Welcome to talk about 100-19-6, If you have any questions, you can contact Saroha, M; Khurana, JM or send Email.. Computed Properties of C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Fe3O4@L-lysine-Pd(0) organic-inorganic hybrid: As a novel heterogeneous magnetic nanocatalyst for chemo and homoselective [2+3] cycloaddition synthesis of 5-substituted 1H-tetrazoles WOS:000600794700001 published article about CATALYZED SYNTHESIS; 3-COMPONENT SYNTHESIS; EFFICIENT SYNTHESIS; ACID CATALYST; TETRAZOLES; NITRILES; NANOPARTICLES; 5-SUBSTITUTED-1H-TETRAZOLES; DERIVATIVES; CONVERSION in [Ashraf, Muhammad Aqeel; Li, Cheng; Zhang, Dangquan] Henan Agr Univ, Sch Forestry, Zhengzhou 450002, Peoples R China; [Ashraf, Muhammad Aqeel] China Univ Geosci, Sch Environm Studies, Wuhan 430074, Peoples R China; [Liu, Zhenling] Henan Univ Technol, Sch Management, Zhengzhou 450001, Peoples R China in 2021, Cited 46. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3. Safety of 2,2-Diphenylacetonitrile

An efficient and sustainable synthetic protocol has been presented to synthesis and 5-substituted 1H-tetrazole privileged heterocyclic substructures. The synthetic protocol involves two-component reaction between aryl nitriles and NaN3 in water using complex of L-lysine-palladium nanoparticles (NPs) modified Fe3O4 nanoparticles as magnetically separable, recyclable, and reusable heterogeneous catalyst. Magnetically retrievable L-lysine-Pd(0) modified Fe3O4 nanoparticles were applied in [2 + 3] cycloaddition synthesis of 5-substituted 1H-tetrazoles. The advantages of this strategy include easy recovery and efficient reusability of the expensive Pd NPs, obtaining high yields of [2 + 3] cycloaddition, short reaction times, and all of the reported synthetic strategies are being performed in water as green solvent for a wide range of substrates.

Safety of 2,2-Diphenylacetonitrile. Welcome to talk about 86-29-3, If you have any questions, you can contact Ashraf, MA; Liu, ZL; Li, C; Zhang, DQ or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article New synthesis of 2-aroylbenzothiazoles via metal-free domino transformations of anilines, acetophenones, and elemental sulfur WOS:000537264400052 published article about REDOX CONDENSATION REACTION; O-HALONITROBENZENES; BENZOTHIAZOLES; BOND; INHIBITORS; THIAZOLES; ACYLATION; ACCESS in [Huynh, Tien, V; Doan, Khang, V; Luong, Ngoc T. K.; Nguyen, Duyen T. P.; Doan, Son H.; Nguyen, Tung T.; Phan, Nam T. S.] Ho Chi Minh City Univ Technol HCMUT, Fac Chem Engn, 268 Ly Thuong Kiet,Dist 10, Ho Chi Minh City, Vietnam; [Huynh, Tien, V; Doan, Khang, V; Luong, Ngoc T. K.; Nguyen, Duyen T. P.; Doan, Son H.; Nguyen, Tung T.; Phan, Nam T. S.] Vietnam Natl Univ Ho Chi Minh City, Linh Trung Ward, Ho Chi Minh City, Vietnam; [Huynh, Tien, V; Luong, Ngoc T. K.; Nguyen, Duyen T. P.] Ho Chi Minh City Univ Food Ind HUFI, Fac Chem Technol, 140 Le Trang Tan, Ho Chi Minh City, Vietnam in 2020.0, Cited 43.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Safety of 1-(4-Nitrophenyl)ethanone

A new synthesis of 2-aroylbenzothiazoles via iodine-promoted domino transformations of anilines, acetophenones, and elemental sulfur was demonstrated. The highlights of this tandem synthesis are (1) easily available anilines and acetophenones as feedstock; (2) transition metal-free conditions; (3) inexpensive, nontoxic, easy handling, and abundant elemental sulfur as a building block. This synthetic strategy would complement the existing methods in the synthesis of this important heterocyclic scaffold. To our best knowledge, the formation of 2-aroylbenzothiazoles from simple anilines, acetophenones, and elemental sulfur was not previously reported in the literature.

Welcome to talk about 100-19-6, If you have any questions, you can contact Huynh, TV; Doan, KV; Luong, NTK; Nguyen, DTP; Doan, SH; Nguyen, TT; Phan, NTS or send Email.. Safety of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Wang, DQ; Ding, WJ; Hou, GH; Zi, GF; Walter, MD in WILEY-V C H VERLAG GMBH published article about CHEMISTRY; COMPLEXES in [Wang, Deqiang; Ding, Wanjian; Hou, Guohua; Zi, Guofu] Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China; [Walter, Marc D.] Tech Univ Carolo Wilhelmina Braunschweig, Inst Anorgan & Analyt Chem, Hagenring 30, D-38106 Braunschweig, Germany in 2021, Cited 121. Quality Control of 2,2-Diphenylacetonitrile. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3

The synthesis, electronic structure, and reactivity of a uranium metallacyclopropene were comprehensively studied. Addition of diphenylacetylene (PhC equivalent to CPh) to the uranium phosphinidene metallocene [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U=P-2,4,6-tBu(3)C(6)H(2) (1) yields the stable uranium metallacyclopropene, [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U[eta(2)-C2Ph2] (2). Based on density functional theory (DFT) results the 5f orbital contributions to the bonding within the metallacyclopropene U-(eta(2)-C=C) moiety increases significantly compared to the related Th-IV compound [eta(5)-1,2,4-(Me3C)(3)C5H2](2)Th[eta(2)-C2Ph2], which also results in more covalent bonds between the [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U2+ and [eta(2)-C2Ph2](2-) fragments. Although the thorium and uranium complexes are structurally closely related, different reaction patterns are therefore observed. For example, 2 reacts as a masked synthon for the low-valent uranium(II) metallocene [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U-II when reacted with Ph2E2 (E=S, Se), alkynes and a variety of hetero-unsaturated molecules such as imines, ketazine, bipy, nitriles, organic azides, and azo derivatives. In contrast, five-membered metallaheterocycles are accessible when 2 is treated with isothiocyanate, aldehydes, and ketones.

Welcome to talk about 86-29-3, If you have any questions, you can contact Wang, DQ; Ding, WJ; Hou, GH; Zi, GF; Walter, MD or send Email.. Quality Control of 2,2-Diphenylacetonitrile

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Chen, ZL; Hu, FL; Huang, SL; Zhao, ZX; Mao, H; Qin, WL in AMER CHEMICAL SOC published article about ONE-POT SYNTHESIS; ASYMMETRIC-SYNTHESIS; DERIVATIVES; WATER; ORGANOSELENIUM; DISELENIDES; SULFONES; KETONES; ACID in [Chen, Zhili; Hu, Fangli; Huang, Shengli; Zhao, Zhengxing; Qin, Wenling] Chongqing Univ, Chongqing Key Lab Nat Prod Synth & Drug Res, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China; [Huang, Shengli] Chongqing Univ, Sch Chem & Chem Engn, Chongqing 401331, Peoples R China; [Mao, Hui] Jinhua Polytech, Pharmaceut & Mat Engn Sch, Jinhua 321000, Zhejiang, Peoples R China in 2019.0, Cited 43.0. Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Organocatalytic selenosulfonylation of the C-C double bond of alpha,beta-unsaturated ketones to construct two contiguous stereogenic centers in an aqueous medium was described. A series of alpha-selenyl and beta-sulfonyl ketones with various functional groups were synthesized in good yields and enantioselectivities with saturated NaCl solution as the solvent. In addition, this protocol had been successfully scaled up to a decagram scale via a simple workup procedure.

Welcome to talk about 100-19-6, If you have any questions, you can contact Chen, ZL; Hu, FL; Huang, SL; Zhao, ZX; Mao, H; Qin, WL or send Email.. Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Efficient asymmetric synthesis of chiral alcohols using high 2-propanol tolerance alcohol dehydrogenase SmADH2 via an environmentally friendly TBCR system WOS:000505550900027 published article about CARBONYL REDUCTASE; KETONE REDUCTION; LEIFSONIA; BIOCATALYSIS; MECHANISM; ENZYMES; CHAIN in [Yang, Zeyu; Fu, Hengwei; Ye, Wenjie; Xie, Youyu; Liu, Qinghai; Wang, Hualei; Wei, Dongzhi] East China Univ Sci & Technol, New World Inst Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China in 2020.0, Cited 34.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Product Details of 100-19-6

Alcohol dehydrogenases (ADHs) together with the economical substrate-coupled cofactor regeneration system play a pivotal role in the asymmetric synthesis of chiral alcohols; however, severe challenges concerning the poor tolerance of enzymes to 2-propanol and the adverse effects of the by-product, acetone, limit its applications, causing this strategy to lapse. Herein, a novel ADH gene smadh2 was identified from Stenotrophomonas maltophilia by traditional genome mining technology. The gene was cloned into Escherichia coli cells and then expressed to yield SmADH2. SmADH2 has a broad substrate spectrum and exhibits excellent tolerance and superb activity to 2-propanol even at 10.5 M (80%, v/v) concentration. Moreover, a new thermostatic bubble column reactor (TBCR) system is successfully designed to alleviate the inhibition of the by-product acetone by gas flow and continuously supplement 2-propanol. The organic waste can be simultaneously recovered for the purpose of green synthesis. In the sustainable system, structurally diverse chiral alcohols are synthesised at a high substrate loading (>150 g L-1) without adding external coenzymes. Among these, about 780 g L-1 (6 M) ethyl acetoacetate is completely converted into ethyl (R)-3-hydroxybutyrate in only 2.5 h with 99.9% ee and 7488 g L-1 d(-1) space-time yield. Molecular dynamics simulation results shed light on the high catalytic activity toward the substrate. Therefore, the high 2-propanol tolerance SmADH2 with the TBCR system proves to be a potent biocatalytic strategy for the synthesis of chiral alcohols on an industrial scale.

Welcome to talk about 100-19-6, If you have any questions, you can contact Yang, ZY; Fu, HW; Ye, WJ; Xie, YY; Liu, QH; Wang, HL; Wei, DZ or send Email.. Product Details of 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Category: benzodioxans. Munyai, TR; Sonqishe, T; Gumbo, JR in [Munyai, Thabelo R.; Sonqishe, Thantaswa] Univ Venda, Dept Ecol & Resource Management, Thohoyandou, South Africa; [Gumbo, Jabulani R.] Univ Venda, Dept Hydrol & Water Resource Management, Thohoyandou, South Africa published Algae colonisation of brick pavement at the University of Venda: A potential slippery hazard in 2019, Cited 33. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3.

A brick pavement, tramped by humans, is exposed to atmospheric elements, thus allowing cyanobacteria and algae to colonise. In this article, we report on the factors that contribute to the slipperiness of a brick pavement at the University of Venda in the Limpopo province of the South Africa. Samples were collected from brick surfaces either colonised by green algae (treated) or not (control). The samples were acid-digested and analysed for metals by Inductively Coupled Plasma Mass Spectrometry (ICP MS) in parts per billion (ppb). The treated bricks, with green algae, had average high metal contents (ppb): Al 9456.02, Ti 731.23, V 46.44, Cr 78.85, Mn 862.93, Fe 16295.18, Co 23.57, Ni 59.36, Cu 66.31, Zn 160.57, As 7.92, Se 10.45, Mo 6.74, Cd 5.19, Sn 4.65, Sb 2.31 and Pb 19.51. In contrast, control bricks had a low average of metal content (ppb) as follows: Al 2.99, Ti 0.28, V 4.04, Cr 1.42, Mn 4.29, Fe 20.89, Co 0.36, Ni 2.74, Cu 5.64, Zn 4.21, As 0.56, Se <3.00, Mo 0.88, Cd 0.01, Sn 1.05, Sb 0.04 and Pb 0.04. Other factors that promote algae colonisation include high solar radiation, neutral pH, nutrients, low electrical conductivity and total dissolved solids. The algae colonisation of brick pavement results in an unaesthetic sighting and a slippery surface that is hazardous to humans. Category: benzodioxans. Welcome to talk about 86-29-3, If you have any questions, you can contact Munyai, TR; Sonqishe, T; Gumbo, JR or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Facile synthesis of alpha-trifluoromethylthio phosphonium ylides with a constrained trifluoromethylthiooxide via a proton-transfer procedure WOS:000479125800010 published article about ARYL BORONIC ACIDS; HYPERVALENT IODONIUM YLIDE; CATALYZED TRIFLUOROMETHYLTHIOLATION; OXIDATIVE TRIFLUOROMETHYLTHIOLATION; FLUORINATED ETHERS; NUCLEOPHILIC TRIFLUOROMETHYLATION; SUBSTITUENT CONSTANTS; CONVENIENT SYNTHESIS; THIOETHERS; MILD in [Cao, Chengyao Kimmy; Chen, Chao] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China; [Zhang, Yue; Lan, Tianlei] Tianjin Univ Sci & Technol, Coll Chem Engn & Mat Sci, Tianjin 300457, Peoples R China; [Liu, Wei] Tianjin Univ Sci & Technol, Coll Sci, Tianjin, Peoples R China in 2019.0, Cited 83.0. Computed Properties of C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Synthesis of alpha-trifluoromethylthio(CF3S-)phosphonium ylides is easily accomplished with a constrained trifluoromethylthiooxide via a proton-transfer procedure without extra base. These CF3S-substituted phosphonium ylides could be applied to Wittig reactions to provide functionalised alkenes in one-pot with high yields.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about POLY(ETHYLENE GLYCOL); CYCLOADDITION; DERIVATIVES; LIBRARY; 3-AMINO-2-OXINDOLES; SPIROINDOLONES; CONSTRUCTION; ANTAGONIST; SCAFFOLDS; RECEPTOR, Saw an article supported by the Sichuan Science and Technology Program [2020YFH0129]; National Key R&D Program of China [2019YFD1002100]; Program Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Yue, GZ; Jiang, D; Dou, ZJ; Li, SC; Feng, JH; Zhang, L; Chen, HB; Yang, CP; Yin, ZQ; Song, X; Liang, XX; Wang, XX; Lu, CF. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Recommanded Product: 1-(4-Nitrophenyl)ethanone

The umpolung Michael addition of isatin N,N’-cyclic azomethine imine 1,3-dipoles with chalcones is reported. The reaction could be finished within a very short time (0.3-2 min), with 3,3-disubstituted oxindole derivatives obtained in moderate to excellent yields with promising dr values. Unusual Michael adducts were obtained in moderate to high yields (26-98%) with low to high diastereoselectivities (0.8 : 1 to 8.5 : 1 dr). All the synthesized compounds (3, 3′, 4, 5, 5′, 7, 7′, 9 and 9′) were well characterized by FTIR, NMR, and mass spectral analyses and further confirmed by the single-crystal X-ray diffraction analysis of compounds 3aa and 4n.

Welcome to talk about 100-19-6, If you have any questions, you can contact Yue, GZ; Jiang, D; Dou, ZJ; Li, SC; Feng, JH; Zhang, L; Chen, HB; Yang, CP; Yin, ZQ; Song, X; Liang, XX; Wang, XX; Lu, CF or send Email.. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem