Heterocyclic Building Blocks-benzodioxan

An article CO2-Folded Single-Chain Nanoparticles as Recyclable, Improved Carboxylase Mimics WOS:000560367900001 published article about C-H BONDS; POLYMERIC NANOPARTICLES; CO2; CARBON in [Zeng, Rongjin; Chen, Liang; Yan, Qiang] Fudan Univ, Dept Macromol Sci, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China in 2020.0, Cited 46.0. SDS of cas: 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Emulating the function of natural carboxylases to convert CO(2)under atmospheric condition is a great challenge. Herein we report a class of CO2-folded single-chain nanoparticles (SCNPs) that can function as recyclable, function-intensified carboxylase mimics. Lewis pair polymers containing bulky Lewis acidic and basic groups as the precursor, can bind CO(2)to drive an intramolecular folding into SCNPs, in which CO(2)as the folded nodes can form gas-bridged bonds. Such bridging linkages highly activate CO2, which endows the SCNPs with extraordinary catalytic ability that can not only catalyze CO2-insertion of C(sp(3))-H for imitating the natural enzyme’s function, it can also act on non-natural carboxylation pathways for C(sp(2)and sp)-H substrates. The nanocatalysts are of highly catalytic efficiency and recyclability, and can work at room temperature and near ambient CO(2)condition, inspiring a new approach to sustainable C(1)utilization.

SDS of cas: 100-19-6. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Science & Technology – Other Topics very interesting. Saw the article Graphene/pyrrolic-structured nitrogen-doped CNT nanocomposite supports for Pd-catalysed Heck coupling and chemoselective hydrogenation of nitroarenes published in 2019.0. Category: benzodioxans, Reprint Addresses Nyamori, VO (corresponding author), Univ KwaZulu Natal, Sch Chem & Phys, Westville Campus,Private Bag X54001, Durban, South Africa.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

This work focused on the synthesis of 3D Pd-based nanocomposites which were tested in Heck coupling reactions and for the hydrogenation of nitroarenes. This was achieved by fabrication of graphene oxide/nitrogen-doped carbon nanotubes (G/N-CNTs) by mechanical grinding of 2D graphene oxide (GO) and 1D oxygen-treated nitrogen-doped CNTs (N-CNTs-OT) in a 3:1 ratio, respectively. The fabrication of G/N-CNTs is to overcome the habitual aggregation and restacking of graphene sheets. Palladium nanoparticles (Pd NPs) were deposited on the 3D G/N-CNTs nanocomposites via metal organic chemical vapour deposition method. The 3D Pd-based nanocomposites were characterized by TEM, SEM, HRTEM, XRD, TGA, XPS, ICP-OES, elemental analysis, BET analysis and Raman spectroscopy. For the Heck coupling reactions, aryl halides, olefins and 3D Pd-based nanocomposites were mixed in a suitable solvent and the reaction carried under microwave irradiation.The chemoselective hydrogenation of nitroarenes was done with dry ethanol in a Paar reactor, purged with H-2 gas. These catalysts demonstrate excellent activity and selectivity in both reactions. The remarkable activity of the 3D Pd-based nanocomposites in Heck reactions and hydrogenation of nitroarenes may be attributed to the small particle size (3-10 nm) and a high degree of dispersion of Pd NPs. A comparative experiment was conducted with Pd/AC, Pd/CNTs, Pd/G/CNTs and Pd/rGO. Pd/G/N-CNTs-OT showed higher activity and selectivity than Pd/G/CNTs, Pd/G/N-CNTs, Pd/rGO and Pd/N-CNTs counterpart.

Category: benzodioxans. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Wang, B; Wang, LR; Liu, LL; Wang, W; Man, RJ; Zheng, DJ; Deng, YS; Yang, YS; Xu, C; Zhu, HL in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Wang, Bin; Wang, Li-Ren; Liu, Lu-Lu; Wang, Wei; Zheng, Da-Jun; Deng, Yu-Shan; Yang, Yu-Shun; Xu, Chen; Zhu, Hai-Liang] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China; [Man, Ruo-Jun] Guangxi Univ Nationalities, Guangxi Biol Polysaccharide Separat Purificat & M, Nanning 530006, Peoples R China in 2021.0, Cited 44.0. Quality Control of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

In this work, a series of diaryl benzo[b][1,4]thiazepine derivatives D1-D36 were synthesized and screened as tubulin polymerization inhibitors with anti-tumor potency. They were designed by introducing the seven member ring benzothiazepine as the linker for CA-4 modification for the first time. Among them, the hit compound D8 showed potential on inhibiting the growth of several cancer cell lines (IC50 values: 1.48 mu M for HeLa, 1.47 mu M for MCF-7, 1.52 mu M for HT29 and 1.94 mu M for A549), being comparable with the positive controls Colchicine and CA-4P. The calculated IC50 value of D8 as an tubulin polymerization inhibitor was 1.20 mu M. The results of the flow cytometry assay revealed that D8 could induce the mitotic catastrophe and the death of living cancer cells. D8 also indicated the anti-vascular activity. The possible binding pattern was implied by docking simulation, inferring the possibility of introducing interactions with the nearby tubulin chain. Since the novel structural trial has been conducted with preliminary discussion, this work might stimulate new ideas in further modification of tubulin-related anti-cancer agents and therapeutic approaches.

Quality Control of 1-(4-Nitrophenyl)ethanone. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Li, W; Artz, J; Broicher, C; Junge, K; Hartmann, H; Besmehn, A; Palkovits, R; Beller, M in [Li, Wu; Junge, Kathrin; Beller, Matthias] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany; [Artz, Jens; Broicher, Cornelia; Palkovits, Regina] Rhein Westfal TH Aachen, Inst Tech & Makromol Chem, Worringerweg 2, D-52074 Aachen, Germany; [Hartmann, Heinrich; Besmehn, Astrid] Forschungszentrum Julich, Wilhelm Johnen Str, D-5248 Julich, Germany published Superior activity and selectivity of heterogenized cobalt catalysts for hydrogenation of nitroarenes in 2019, Cited 51. Computed Properties of C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

The development of improved catalysts for highly selective hydrogenation of nitroarenes is described. For this purpose Co nanoparticles were supported on ordered mesoporous carbon CMK-3 and characterized in detail. The optimal CMK-3-CoPc catalyst exhibits excellent hydrogenation activity for several (hetero)aromatic nitro compounds and yielded the corresponding anilines under mild conditions (40 degrees C, 20 bar H-2).

Welcome to talk about 100-19-6, If you have any questions, you can contact Li, W; Artz, J; Broicher, C; Junge, K; Hartmann, H; Besmehn, A; Palkovits, R; Beller, M or send Email.. Computed Properties of C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 CHEMISTRYSELECT published article about ENANTIOSELECTIVE REDUCTION; MERRIFIELD; RESINS; AMINES in [Vargas-Durazo, Judas; Santacruz-Ortega, Hisila] Univ Sonora, Dept Invest Polimeros & Mat, Hermosillo 83000, Sonora, Mexico; [Aguilar-Martinez, Milagros] Univ Sonora, Unidad Reg Norte, Dept Ciencias Quim Biol & Agr, Caborca 83600, Sonora, Mexico; [Ochoa-Teran, Adrian] Tecnol Nacl Mexico, Inst Tecnol Tijuana, Ctr Grad & Invest Quim, Tijuana 22430, Baja California, Mexico; [Rocha Alonzo, Fernando; Carlos Galvez-Ruiz, Juan] Univ Sonora, Dept Ciencias Quim Biol, Hermosillo 83000, Sonora, Mexico; [Gamez Meza, Nohemi] Univ Sonora, Dept Invest Cient & Tecnol, Hermosillo 83000, Sonora, Mexico in 2019.0, Cited 24.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Product Details of 100-19-6

Twelve new chiral chelating resins have been prepared using solid phase organic synthesis with the Merrifield and Wang resins and the bidentate amine 1,2-ethylenediamine, followed by the coupling of asymmetric ketones such as 1-phenyletanone, 4-methyl-2-pentanone 4-nitroacetophenone and 4-methoxyacetophenone to form prochiral imines. The enantioselective reduction with borane and (R)-(+)-2-Methyl-CBS-oxazaborolidine leads to the chiral resins with yields greater than 86%. We used these chiral resins to prepare 24 reducing complexes with alkali tetrahydroborates in a very simple way giving yields greater than 87%. Finally, we achieved a preliminary enantioselective reduction of acetophenone employing the Merrifield’s chiral chelating resins obtaining the corresponding S alcohol in a 70:30 ratio with the R analog alcohol.

Product Details of 100-19-6. Welcome to talk about 100-19-6, If you have any questions, you can contact Vargas-Durazo, J; Aguilar-Martinez, M; Ochoa-Teran, A; Santacruz-Ortega, H; Alonzo, FR; Meza, NG; Galvez-Ruiz, JC or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 EUR J ORG CHEM published article about ESTERS; HYDROBORATION; BORYLATION; ALKYNES; DIVERSIFICATION; CARBANIONS in [Kovalenko, Maksym; Yarmoliuk, Dmytro, V; Serhiichuk, Dmytro; Chernenko, Dania; Smyrnov, Vladyslav; Breslayskyi, Artur; Hryshchuk, Oleksandr, V; Kleban, Ihor; Tymtsunik, Andriy, V; Tolmachev, Andrey A.; Kuchkovska, Yuliya O.; Grygorenko, Oleksandr O.] Enamine Ltd, Chervonotkatska St 78, UA-02094 Kiev, Ukraine; [Yarmoliuk, Dmytro, V; Smyrnov, Vladyslav; Hryshchuk, Oleksandr, V; Tolmachev, Andrey A.; Kuchkovska, Yuliya O.; Grygorenko, Oleksandr O.] Tams Shevchenko Natl Univ Kyiv, Volodymyrska St 60, UA-01601 Kiev, Ukraine; [Kleban, Ihor; Rassukana, Yuliya] Natl Acad Sci Ukraine, Inst Organ Chem, Murmanska St 5, UA-02660 Kiev, Ukraine; [Chernenko, Dania; Rassukana, Yuliya; Tymtsunik, Andriy, V] Natl Tech Univ Ukraine, Igor Sikorsky Kyiv Polytech Inst, Prospect Perem 37, UA-03056 Kiev, Ukraine in 2019.0, Cited 50.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Preparation of 2,2-disubstituted and 2-monosubstituted alkenylboronic acid esters from aliphatic and aromatic ketones and aldehydes by the boron-Wittig olefination with bis[(pinacolato)boryl]methane was examined and applied on the multigram scale. The influence of the substrate steric and electronic features on the overall efficiency and stereochemical outcome of the reaction was studied. Additionally, a series of diversely functionalized (hetera)cycloalkylidenemethyl and (hetera)cycloalkyl boronic acid-derived building blocks was synthesized.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. Welcome to talk about 100-19-6, If you have any questions, you can contact Kovalenko, M; Yarmoliuk, DV; Serhiichuk, D; Chernenko, D; Smyrnov, V; Breslayskyi, A; Hryshchuk, OV; Kleban, I; Rassukana, Y; Tymtsunik, AV; Tolmachev, AA; Kuchkovska, YO; Grygorenko, OO or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Application In Synthesis of 2,2-Diphenylacetonitrile. In 2020 ORGANOMETALLICS published article about ORGANOMETALLIC CHEMISTRY; COORDINATION CHEMISTRY; BOND-CLEAVAGE; NITRIC-OXIDE; LIGANDS; PNP; APPROXIMATION; HYDROBORATION; PLATINUM; IRIDIUM in [Pecak, Jan; Eder, Wolfgang; Linert, Wolfgang; Kirchner, Karl] Vienna Univ Technol, Inst Appl Synthet Chem, A-1060 Vienna, Austria; [Stoeger, Berthold] Vienna Univ Technol, Xray Ctr, A-1060 Vienna, Austria; [Realista, Sara] Univ Nova Lisboa, ITQB NOVA, Inst Tecnol Quim & Biol Antonio Xavier, P-2780157 Oeiras, Portugal; [Martinho, Paulo N.; Calhorda, Maria Jose] Univ Lisbon, Fac Ciencias, BioISI Biosyst & Integrat Sci Inst, DQB, P-1749016 Lisbon, Portugal in 2020, Cited 53. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3.

The reaction of coordinatively unsaturated Co(II) PCP pincer complexes with nitric oxide leads to the formation of new, air-stable, diamagnetic mono nitrosyl compounds. The synthesis and characterization of five- and four-coordinate Co(III) and Co(I) nitrosyl pincer complexes based on three different ligand scaffolds is described. Passing NO through a solution of [Co(PCPNMe-iPr)Cl], [Co(PCPO-iPr)Cl] or [Co(PCPCH2-iPr)Br] led to the formation of the low-spin complex [Co(PCP-iPr)(NO)-X] with a strongly bent NO ligand. Treatment of the latter species with (X = CI, Br) AgBF4 led to chloride abstraction and formation of cationic square-planar Co(I) complexes of the type [Co(PCP-iPr)(NO)](+) featuring a linear NO group. This reaction could be viewed as a formal two electron reduction of the metal center by the NO radical from Co(III) to Co(I), if NO is counted as NO+. Hence, these systems can be described as {CoNO}(8) according to the Enemark-Feltham convention. X-ray structures, spectroscopic and electrochemical data of all nitrosyl complexes are presented. Preliminary studies show that [Co(PCPNMe-iPr)(NO)](+) catalyzes efficiently the reductive hydroboration of nitriles with pinacolborane (HBpin) forming an intermediate {CoNO}(8) hydride species.

Application In Synthesis of 2,2-Diphenylacetonitrile. Welcome to talk about 86-29-3, If you have any questions, you can contact Pecak, J; Eder, W; Stoger, B; Realista, S; Martinho, PN; Calhorda, MJ; Linert, W; Kirchner, K or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Lamie, PF; Philoppes, JN in [Lamie, Phoebe F.; Philoppes, John N.] Beni Suef Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Bani Suwayf 62514, Egypt published 2-Thiopyrimidine/chalcone hybrids: design, synthesis, ADMET prediction, and anticancer evaluation as STAT3/STAT5a inhibitors in 2020.0, Cited 50.0. Product Details of 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A novel 2-thiopyrimidine/chalcone hybrid was designed, synthesised, and evaluated for their cytotoxic activities against three different cell lines, K-562, MCF-7, and HT-29. The most active cytotoxic derivatives were 9d, 9f, 9n, and 9p (IC50=0.77-1.74 mu M, against K-562 cell line), 9a and 9r (IC50=1.37-3.56 mu M against MCF-7 cell line), and 9a, 9l, and 9n (IC50=2.10 and 2.37 mu M against HT-29 cell line). Compounds 9a, 9d, 9f, 9n, and 9r were further evaluated for their cytotoxicity against normal fibroblast cell line WI38. Moreover, STAT3 and STAT5a inhibitory activities were determined for the most active derivatives 9a, 9d, 9f, 9n, and 9r. Dual inhibitory activity was observed in compound 9n (IC50=113.31 and 50.75 mu M, against STAT3 and STAT5a, respectively). Prediction of physicochemical properties, drug likeness score, pharmacokinetic and toxic properties was detected.

Welcome to talk about 100-19-6, If you have any questions, you can contact Lamie, PF; Philoppes, JN or send Email.. Product Details of 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Novel one step synthesis of imidazo[1,2-a]pyridines and Zolimidine via iron/iodine-catalyzed Ortoleva-King type protocol WOS:000480664500014 published article about WATER; AMINOPYRIDINES; DERIVATIVES; ARYLATION; ALKYNES; ARYL in [Ujwaldev, Sankuviruthiyil Mohanan; Rohit, K. R.; Harry, Nissy Ann; Anilkumar, Gopinathan] Mahatma Gandhi Univ, Sch Chem Sci, PD Hills PO, Kottayam 686560, Kerala, India in 2019.0, Cited 24.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Imidazo[1,2-a]pyridines form versatile scaffolds in pharmaceutical industry arising from their diverse biological activities. The synthesis of these molecules thus has been of great interest and resulted in the development of a large number of new methodologies. Herein we describe the first iron-catalyzed Ortoleva-King type protocol towards the synthesis of these fused heterocyclic compounds. This methodology employs cheap and easily available FeCl3 center dot 6H(2)O and molecular iodine as the catalytic system. The procedure has been well explored by extending the substrate scope with a variety of aromatic ketones and 2-aminopyridines to furnish different imidazo[1,2-a]pyridine derivatives in moderate to good yields. A successful application of this protocol was also demonstrated by achieving direct one step synthesis of the gastro protective drug, Zolimidine. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 100-19-6, If you have any questions, you can contact Ujwaldev, SM; Rohit, KR; Harry, NA; Anilkumar, G or send Email.. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Formula: C8H7NO3. Shaw, R; Althagafi, I; Elagamy, A; Rai, R; Shah, C; Nemaysh, V; Singh, H; Pratap, R in [Shaw, Ranjay; Elagamy, Amr; Shah, Chandan; Nemaysh, Vishal; Pratap, Ramendra] Univ Delhi, Dept Chem, North Campus, Delhi 110007, India; [Althagafi, Ismail] Umm Al Qura Univ, Dept Chem, Mecca, Saudi Arabia; [Rai, Reeta] All India Inst Med Sci, Dept Biochem, New Delhi 110029, India; [Singh, Harpreet] Indian Council Med Res, New Delhi 110029, India published Transition metal-free synthesis of sterically hindered allylarenes from 5-hexene-2-one in 2020.0, Cited 33.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A simple, efficient and transition metal-free strategy was established for the synthesis of highly functionalized, sterically hindered allylarenes (6,7&8) by base-mediated ring transformation of 2-oxo-6-aryl-4-(methylthio/sec-amino)-2H-pyran-3-carbonitriles (3/4) with 5-hexene-2-one (5). This provides a method for the synthesis of allylarenes functionalized with different electron donating and withdrawing groups in one pot. The structures of isolated products6cand7awere ascertained by spectroscopic and single crystal X-ray diffraction analyses. In addition, we have performed a molecular docking study to predict the biological activity of the synthesized molecules for binding to estrogen receptor alpha (ER alpha) and estrogen receptor beta (ER beta).

Welcome to talk about 100-19-6, If you have any questions, you can contact Shaw, R; Althagafi, I; Elagamy, A; Rai, R; Shah, C; Nemaysh, V; Singh, H; Pratap, R or send Email.. Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem