Heterocyclic Building Blocks-benzodioxan

An article Reduction of nitroarenes catalyzed by microgel-stabilized silver nanoparticles WOS:000474676800046 published article about RESPONSIVE HYBRID MICROGELS; AROMATIC NITRO-COMPOUNDS; CHEMOSELECTIVE HYDROGENATION; PALLADIUM NANOPARTICLES; POLYMER MICROGELS; 4-NITROPHENOL; GOLD; NANOCLUSTERS; BOROHYDRIDE; FABRICATION in [Begum, Robina; Farooqi, Zahoor H.; Aboo, Ahmed H.; Xiao, Jianliang] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England; [Begum, Robina; Farooqi, Zahoor H.; Ahmed, Ejaz; Sharif, Ahsan] Univ Punjab, Inst Chem, New Campus, Lahore 54590, Pakistan; [Begum, Robina] Univ Punjab, Ctr Undergrad Studies, New Campus, Lahore 54590, Pakistan in 2019.0, Cited 75.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. SDS of cas: 100-19-6

Poly(N-isopropylacrylamide-co-acrylamide) (PNA-BIS-2) microgels were synthesized by free radical precipitation polymerization in aqueous medium. Spherical Ag nanoparticles with diameter of 10-20 nm were fabricated inside the PNA-BIS-2 microgels by in-situ reduction of silver nitrate using sodium borohydride as reducing agent. The Ag nanoparticles- loaded hybrid microgels were characterized by Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), Energy dispersive X-ray (EDX), Scanning transmission electron microscopy (STEM), Ultraviolet visible spectroscopy (UV Visible), Thermogravimetric analysis (TGA) and X-ray diffraction (XRD). Ag contents in the hybrid system were determined by inductively coupled plasma – optical emission spectrometry (ICP-OES). Various nitroarenes were successfully converted into their respective aromatic amines with good to excellent yields (ranging from 75% to 97%) under mild reaction conditions. The catalyst has ability to successfully convert substituted nitroarenes into desired products keeping many functionalities intact. The catalyst can be stored for long time without any sign of aggregation and can be used multiple times without any significant loss in its catalytic activity.

Welcome to talk about 100-19-6, If you have any questions, you can contact Begum, R; Farooqi, ZH; Aboo, AH; Ahmed, E; Sharif, A; Xiao, JL or send Email.. SDS of cas: 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Computed Properties of C8H7NO3. Authors Sallam, HA; Abdel-Mageid, RE; Amr, AE in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Sallam, H. A.] Ain Shams Univ, Fac Sci, Chem Dept, Synthet Organ Lab, Cairo 11566, Egypt; [Abdel-Mageid, R. E.] Natl Res Ctr, Dept Photochem, Cairo 12622, Egypt; [Amr, A. E.] King Saud Univ, Coll Pharm, DEDC, Pharmaceut Chem Dept, Riyadh 11451, Saudi Arabia; [Amr, A. E.] Natl Res Ctr, Appl Organ Chem Dept, Cairo 12622, Egypt in 2019.0, Cited 8.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

In the current study, a series of macrocyclic tripeptide Schiff bases 2-6 were synthesized by using macrocyclic tripeptide hydrazide 1 as starting material. Treatment of hydrazide 1 with active carbonyl cycloalkanones gave cycloalkanone hydrazines 2a-2d. Also, condensation of 1 with aromatic and heterocyclic aldehydes, or aromatic and heterocyclic acetyl derivatives afforded the corresponding Schiff base candidates 3a-3e, 4a-4c, 5a-5c, and 6a-6c, respectively.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 APPL SURF SCI published article about IN-SITU SYNTHESIS; DOPED CARBON; AMMONIA BORANE; SELECTIVE HYDROGENATION; GRAPHENE OXIDE; NITROARENE HYDROGENATION; AU NANOPARTICLES; CASCADE REACTION; DEHYDROGENATION; METAL in [Zhang, Longkang; Wang, Junmin; Shang, Ningzhao; Gao, Shutao; Wang, Chun] Hebei Agr Univ, Coll Sci, Baoding 071001, Peoples R China; [Gao, Yongjun] Univ Hebei, Coll Chem & Environm Sci, Baoding 071002, Peoples R China in 2019.0, Cited 52.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 1-(4-Nitrophenyl)ethanone

A non-noble heterogeneous catalyst, ultra dispersed Co anchored on ordered porous nitrogen-riched carbon (CoN@PCN) was fabricated through a sacrificial-template pyrolysis strategy, in which SBA-15 and 1, 10-phenanthroline were employed as the hard template and ligand, respectively. Co was ultra dispersed owing to the confinement effect of SBA-15 and the strong coordination effect of Co with phenanthroline. The CoN@PCN displayed excellent catalytic activity and selectivity for the hydrogenation of nitroarenes with ammonia-borane as hydrogen donor under mild conditions, which can be ascribed to the ultra dispersed Co sites, high adsorption ability of the catalyst for ammonia-borane, large specific surface area and abundant porous structure of CoN@PCN. Based on the results of density functional theory calculations, the catalytic mechanism of CoN@PCN for the hydrogenation reaction was proposed. The recycled CoN@PCN had no obvious change in catalytic performance after five consecutive cycles, indicating its durability and recyclability.

Welcome to talk about 100-19-6, If you have any questions, you can contact Zhang, LK; Wang, JM; Shang, NZ; Gao, ST; Gao, YJ; Wang, C or send Email.. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Product Details of 100-19-6. In 2019.0 ACS OMEGA published article about OXYGEN-REDUCTION; ELECTROCHEMICAL IMMUNOSENSOR; CATALYTIC-ACTIVITY; GREEN SYNTHESIS; NANOPARTICLES; SEGREGATION; ELECTROCATALYSTS; BIOSYNTHESIS; OXIDATION; KINETICS in [Liu, Miaomiao; Zhao, Shuangliang] East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, Sch Chem Engn, Shanghai 200237, Peoples R China in 2019.0, Cited 49.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Bimetallic nanocatalysts, with efficient and controllable catalytic performance, have a promising application in chemical production. In this study, surface Pt-rich bimetallic AuPt nanoparticles with different Pt/Au ratios were prepared and tested in selective hydrogenation reactions of substituted nitroaromatics. Au nanoparticles were first prepared with n-butyllithium as a rapid reducer, which were further used as seeds in the slow growth process of Pt atoms. Because of the employed sequential reduction method and the following atom diffusion, surface Pt-rich bimetallic AuPt nanoparticles were obtained. Compared with the uniform AuPt alloy nanocatalysts synthesized by the co-reduction method with n-butyllithium as the reducer and monometallic Pt nanocatalysts, the obtained surface Pt-rich AuPt bimetallic nanocatalysts presented an enhanced catalytic selectivity or activity. The performance enhancement is assigned to the optimized Au/Pt interaction in the surface Pt-rich bimetallic nanostructures. This work demonstrates that the optimization of the stoichiometry and construction of bimetallic materials is a feasible method to synthesize controllable and efficient nanocatalysts.

Product Details of 100-19-6. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Formula: C8H7NO3. I found the field of Chemistry very interesting. Saw the article Half-Sandwich Ruthenium Complexes for One-Pot Synthesis of Quinolines and Tetrahydroquinolines: Diverse Catalytic Activity in the Coupled Cyclization and Hydrogenation Process published in 2020.0, Reprint Addresses Yao, ZJ (corresponding author), Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China.; Yao, ZJ (corresponding author), Chinese Acad Sci, Fujian Inst Res Struct Matter, State Key Lab Struct Chem, Fuzhou 350002, Fujian, Peoples R China.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.

Four types of half-sandwich ruthenium complexes with an N,O-coordinate mode based on hydroxyindanone-imine ligands have been prepared in good yields. These stable ruthenium complexes exhibited high activity in the catalytic synthesis of quinolines from the reactions of amino alcohols with different 3 types of ketones or secondary alcohols under very mild conditions. Moreover, the methodology for the direct one-pot synthesis of tetrahydroquinoline derivatives from amino alcohols and ketones has been also developed on the basis of the continuous catalytic activity of this ruthenium catalyst in the selective hydrogenation of the obtained quinoline derivatives with a low catalyst loading. The corresponding products, quinolines and tetrahydroquinoline derivatives, were afforded in good to excellent yields. The efficient and diverse catalytic activity of these ruthenium complexes suggested their potential large-scale application. All of the ruthenium complexes were characterized by various spectroscopies to confirm their structures.

Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Yun, XJ; Zhu, JW; Jin, Y; Deng, W; Yao, ZJ or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Metalated Ir-CNP Complexes Containing Imidazolin-2-ylidene and Imidazolidin-2-ylidene Donors – Synthesis, Structure, Luminescence, and Metal-Ligand Cooperative Reactivity WOS:000568824900001 published article about N-HETEROCYCLIC CARBENES; MOLECULAR-ORBITAL METHODS; GAUSSIAN-TYPE BASIS; CATALYTIC-HYDROGENATION; RUTHENIUM(II) COMPLEXES; IRIDIUM(III) COMPLEXES; PINCER LIGANDS; BOND FORMATION; COORDINATION CHEMISTRY; BASIS-SET in [Hernandez-Juarez, Martin; Sanchez, Praxedes; Lopez-Serrano, Joaquin; Lara, Patricia; Rendon, Nuria; Alvarez, Eleuterio; Paneque, Margarita; Suarez, Andres] CSIC, Dept Quim Inorgan, Inst Invest Quim IIQ, Seville 41092, Spain; [Hernandez-Juarez, Martin; Sanchez, Praxedes; Lopez-Serrano, Joaquin; Lara, Patricia; Rendon, Nuria; Alvarez, Eleuterio; Paneque, Margarita; Suarez, Andres] CSIC, Ctr Innovac Quim Avanzada, ORFEO, CINQA, Seville 41092, Spain; [Hernandez-Juarez, Martin; Sanchez, Praxedes; Lopez-Serrano, Joaquin; Lara, Patricia; Rendon, Nuria; Alvarez, Eleuterio; Paneque, Margarita; Suarez, Andres] Univ Seville, Seville 41092, Spain; [Hernandez-Juarez, Martin] Univ Autonoma Estado Hidalgo UAEH, Ctr Invest Quim, Area Acad Quim, Km 14-5 Carretera Pachuca Tulancingo, Mineral De La Reforma 42184, Hidalgo, Mexico; [Gonzalez-Herrero, Pablo] Univ Murcia, Fac Quim, Dept Quim Inorgan, Murcia 30071, Spain in 2020.0, Cited 113.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. HPLC of Formula: C8H7NO3

The iridium complex1based on a metalated CNP ligand containing an imidazolin-2-ylidene fragment has been prepared by treatment of the ligand precursor4with Ag2O followed by reaction with [IrCl(COE)(2)](2). The chlorohydride imidazolidin-2-ylidene complex6, which is isostructural to1, was synthetized by reaction of the previously reported dihydride derivative3with CH2Cl2. Complexes1and6exhibit luminescence arising from a(3)MLCT/ILCT state involving the metalated CNP ligand, which is particularly intense for1in the solid state at 298 K. Furthermore, the reactivity of complexes1and6towards bases was compared. Deprotonation of1with KOtBu produced the selective formation of the dinuclear complex7; meanwhile, the reaction of6led to a complex mixture of products. The same reactions carried out in the presence of PPh(3)produced the selective deprotonation of the P-bonded methylene bridges of1and6, yielding the isostructural derivatives9and10. DFT calculations performed on theuNHC-containing tautomersIandII, and thesNHC-based isomersIIIandIV, showed that the NHC-deprotonated derivativesIIandIVare more stable by 3.20 and 2.73 kcal mol(-1), respectively, than their P-deprotonated counterparts (IandIII). However, a reverse stability order was observed for hexacoordinated tautomersI center dot LandII center dot L, andIII center dot LandIV center dot L(L = PPh3, CO, MeCN). Finally, the catalytic activity of complex3in the transfer hydrogenation of ketones has been assessed.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Hernndez-Jurez, M; Snchez, P; Lpez-Serrano, J; Lara, P; Gonzlez-Herrero, P; Rendn, N; Alvarez, E; Paneque, M; Surez, A or concate me.. HPLC of Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Osmium-Promoted Transformation of Alkyl Nitriles to Secondary Aliphatic Amines: Scope and Mechanism WOS:000541445700017 published article about H BOND ACTIVATION; SELECTIVE CATALYTIC-HYDROGENATION; HEXAHYDRIDE COMPLEX; LIGANDS PREPARATION; N-H; DEHYDROGENATION; HYDRIDE; VINYLIDENE; RUTHENIUM; REACTIVITY in [Babon, Juan C.; Esteruelas, Miguel A.; Lopez, Ana M.; Onate, Enrique] Univ Zaragoza CSIC, Dept Quim Inorgan, Inst Sintesis Quim & Catalisis Homogenea ISQCH, Ctr Innovac Quim Avanzada ORFEO CINQA, Zaragoza 50009, Spain in 2020, Cited 116. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3. Recommanded Product: 86-29-3

The transformation of alkyl nitriles to symmetrical and asymmetrical secondary aliphatic amines promoted by the hexahydride complex OsH6 ((PPr3)-Pr-i)(2) (1) is described, and the mechanisms of the reactions involved are established. Complex 1 catalyzes the aforementioned transformations of aryl-, pyridyl-, and alkoxy-functionalized alkyl nitriles with linear or branched chains. The formation of the secondary amines involves primary imines, primary amines, and secondary imines as organic intermediates. The reactions take place under mild conditions (toluene, 100 degrees C, and 4 bar of H-2). Stoichiometric reactions of 1 with pivalonitrile and 2-methoxyacetonitrile have allowed us to isolate the trihydride azavinylidene derivatives OsH3{=N=CHR}((PPr3)-Pr-i)(2) (R = Bu-t (3), CH2OMe (4)). Their formation involves the insertion of the N-C triple bond of the substrates into an Os-H bond of the unsaturated tetrahydride OsH4 ((PPr3)-Pr-i)(2) (A), which is generated by reductive elimination of H-2 from the hexahydride precursor. The reaction of these trihydride azavinylidene species with H-2 is the key step for the reduction of the N-C triple bond of the nitriles. In the absence of H-2, the attack of A to the azavinylidene ligand produces the rupture of its C(sp(2))-C(sp(3)) bond. As a consequence of this attack and the presence of primary imines and amines in the reaction media, the binuclear complexes ((PPr3)-Pr-i)(2) H4Os(mu-CN)OsH3{kappa(1)-N-(NH= CHCH2OMe)}((PPr3)-Pr-i)(2) (5) and ((PPr3)-Pr-i)(2)H4Os(mu-CN)OsH3{kappa(1)-N-(NH2CH2CH2OMe)}((PPr3)-Pr-i)(2) (6) have been isolated and characterized by X-ray diffraction analysis, for 2-methoxyacetonitrile. DFT calculations reveal noticeable similarities between the hydrogenations of nitriles to primary imines and those of primary imines to primary amines.

Welcome to talk about 86-29-3, If you have any questions, you can contact Babon, JC; Esteruelas, MA; Lopez, AM; Onate, E or send Email.. Recommanded Product: 86-29-3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Rapid direct analysis of river water and machine learning assisted suspect screening of emerging contaminants in passive sampler extracts WOS:000617018900002 published article about MASS-SPECTROMETRY; TRANSFORMATION PRODUCTS; RETENTION TIMES; WASTE-WATER; QUANTIFICATION; PREDICTION in [Richardson, Alexandra K.; Rapp-Wright, Helena; Sturzenbaum, Stephen; Cowan, David A.; Barron, Leon P.] Kings Coll London, Fac Life Sci & Med, Sch Populat Hlth & Environm Sci, Dept Analyt Environm Sc Forens Sci, 150 Stamford St, London SE1 9NH, England; [Chadha, Marcus] Agilent Technol UK Ltd, 5500 Lakeside, Cheadle SK8 3GR, England; [Rapp-Wright, Helena] Dublin City Univ, Sch Chem Sci, Dublin 9, Ireland; [Mills, Graham A.; Fones, Gary R.] Univ Portsmouth, Fac Sci & Hlth, White Swan Rd, Portsmouth PO1 2DT, Hants, England; [Gravell, Anthony] Swansea Univ, Nat Resources Wales, Faraday Bldg,Singleton Campus, Swansea SA2 8PP, W Glam, Wales; [Neep, David J.] Agilent Technol UK Ltd, Essex Rd, Church Stretton SY6 6AX, England; [Barron, Leon P.] Imperial Coll London, Fac Med, Sch Publ Hlth, Environm Res Grp, 80 Wood Lane, London W12 7TA, England in 2021, Cited 61. Safety of 2,2-Diphenylacetonitrile. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3

A novel and rapid approach to characterise the occurrence of contaminants of emerging concern (CECs) in river water is presented using multi-residue targeted analysis and machine learning-assisted in silico suspect screening of passive sampler extracts. Passive samplers (Chemcatcher (R)) configured with hydrophilic-lipophilic balanced (HLB) sorbents were deployed in the Central London region of the tidal River Thames (UK) catchment in winter and summer campaigns in 2018 and 2019. Extracts were analysed by; (a) a rapid 5.5 min direct injection targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for 164 CECs and (b) a full-scan LC coupled to quadrupole time of flight mass spectrometry (QTOF-MS) method using data-independent acquisition over 15 min. From targeted analysis of grab water samples, a total of 33 pharmaceuticals, illicit drugs, drug metabolites, personal care products and pesticides (including several EU Watch-List chemicals) were identified, and mean concentrations determined at 40 +/- 37 ng L-1. For targeted analysis of passive sampler extracts, 65 unique compounds were detected with differences observed between summer and winter campaigns. For suspect screening, 59 additional compounds were shortlisted based on mass spectral database matching, followed by machine learning-assisted retention time prediction. Many of these included additional pharmaceuticals and pesticides, but also new metabolites and industrial chemicals. The novelty in this approach lies in the convenience of using passive samplers together with machine learning-assisted chemical analysis methods for rapid, time-integrated catchment monitoring of CECs.

Welcome to talk about 86-29-3, If you have any questions, you can contact Richardson, AK; Chadha, M; Rapp-Wright, H; Mills, GA; Fones, GR; Gravell, A; Sturzenbaum, S; Cowan, DA; Neep, DJ; Barron, LP or send Email.. Safety of 2,2-Diphenylacetonitrile

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article A highly effective green catalyst Ni/Cu bimetallic nanoparticles supported by dendritic ligand for chemoselective oxidation and reduction reaction WOS:000605142300001 published article about BENZYL ALCOHOL; SELECTIVE HYDROGENATION; AEROBIC OXIDATION; CARBON; NITROARENES; METAL in [Islam, Md Sayedul; Khan, Md Wahab] Bangladesh Univ Engn & Technol BUET, Fac Engn, Dept Chem, Dhaka 1000, Bangladesh in 2021.0, Cited 40.0. Category: benzodioxans. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

The highly active Ni/Cu bimetallic nanoparticles (NPs) of the different molar ratios of Ni and Cu (1:1, 1:3, 3:1) assisted by dendritic ligand 2,4,6-Tris (di-4-chlorobenzamido)-1,3-diazine were synthesized successfully confirmed by Scanning Electron Microscopy (SEM), Electron Diffraction X-ray (EDX), X-ray fluorescence spectroscopy (XRF), X-ray diffraction (XRD), and Transmission Electron Microscopy (TEM) analysis. These NPs were studied as a heterogeneous catalyst for the chemoselective oxidation of alcohol to the corresponding aldehyde at 30 min and chemoselective reduction of aromatic nitro substituents to the corresponding amino substituents at 20 min, while the Ni/Cu (3:1) NPs were found to be the most effective among other Ni/Cu (1:1) and Ni/Cu (1:3) NPs at room temperature under mild conditions. The Ni/Cu (3:1) NPs can be recycled for at least five successive runs with no perceptible decrease in catalytic activity. Graphic abstract

Category: benzodioxans. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Islam, MS; Khan, MW or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 100-19-6. Authors Srilaxmi, D; Sreenivasulu, R; Mak, KK; Pichika, MR; Jadav, SS; Ahsan, MJ; Rao, MVB in ELSEVIER published article about in [Srilaxmi, Dandamudi; Rao, Mandava Venkata Basaveswara] Krishna Univ, Dept Chem, Machilipatnam 521001, Andhra Pradesh, India; [Sreenivasulu, Reddymasu] Jawaharlal Nehru Technol Univ, Univ Coll Engn Autonomous, Dept Chem, Kakinada 533003, Andhra Pradesh, India; [Mak, Kit-Kay; Pichika, Mallikarjuna Rao] Int Med Univ, Sch Pharm, Pharmaceut Chem Dept, 126,Jalan Jalil Perkasa 19 Bukit Jalil, Kuala Lumpur 57000, Malaysia; [Jadav, Surender Singh] Vishnu Inst Pharmaceut Educ & Res VIPER, Medak 502313, Telangana, India; [Ahsan, Mohamed Jawed] Maharishi Arvind Coll Pharm, Dept Pharmaceut Chem, Jaipur 302039, Rajasthan, India in 2021.0, Cited 69.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A series of novel chalcone derivatives pyrido[4,3-b]pyrazin-5(6H)-one (10a-j) were designed, synthesized and their structures were confirmed by H-1 NMR, C-13 NMR and mass spectral data. Further, all derivatives were tested for their anticancer activities against five human cancer cell lines such as MCF-7 (breast cancer), A-549 (lung cancer), Colo-205 (colon cancer), A2780 (ovarian cancer) and DU-145 (prostate cancer) by employing MIT assay. The clinically used drug etoposide was used as standard reference and the anticancer activity was expressed as the IC50 in mu M. Among the ten compounds examined compounds, 10b, 10c, 10d, 10h, and 10i possessed more promising anticancer activity. A molecular docking study implying ATR kinase was carried out to observe the binding mode of chalcone derivatives pyrido[4,3-b]pyrazin-5(6H)-one (10a-j) on the active site of ATR kinase. The most promising compound, 10h showed pi – pi stacking interaction of trimethoxy phenyl and pyridone moiety with the residue Trp850, while the carbonyl (alpha,beta-unsaturated carbonyl) and methoxy functions showed H-bond interaction with the residue Ser773 and Thr856 respectively. (C) 2020 Elsevier B.V. All rights reserved.

Recommanded Product: 100-19-6. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem