Heterocyclic Building Blocks-benzodioxan

Safety of 2,2-Diphenylacetonitrile. Otevrel, J; Svestka, D; Bobal, P in [Otevrel, Jan; Svestka, David; Bobal, Pavel] Masaryk Univ, Dept Chem Drugs, Fac Pharm, Palackeho 1946-1, Brno 61242, Czech Republic published One-pot method for the synthesis of 1-aryl-2-aminoalkanol derivatives from the corresponding amides or nitriles in 2020, Cited 85. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3.

We have identified a novel one-pot method for the synthesis of beta-amino alcohols, which is based on C-H bond hydroxylation at the benzylic alpha-carbon atom with a subsequent nitrile or amide functional group reduction. This cascade process uses molecular oxygen as an oxidant and sodium bis(2-methoxyethoxy)aluminum hydride as a reductant. The substrate scope was examined on 30 entries and, although the respective products were provided in moderate yields only, the above simple protocol may serve as a direct and powerful entry to the sterically congested 1,2-amino alcohols that are difficult to prepare by other routes. The plausible mechanistic rationale for the observed results is given and the reaction was applied to a synthesis of a potentially bioactive target.

Safety of 2,2-Diphenylacetonitrile. Welcome to talk about 86-29-3, If you have any questions, you can contact Otevrel, J; Svestka, D; Bobal, P or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Effect of Nanoporous Structure on the Catalytic Activity of Nanoporous Palladium for Hydrogenation of Nitro Compounds WOS:000542282800031 published article about GOLD CATALYSTS; PD; FABRICATION; REDUCTION; ALCOHOLS; METHANOL; ACID; AU in [Zhao, Yuhui; Feng, Xiujuan; Yamamoto, Yoshinori; Bao, Ming] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116023, Peoples R China; [Li, Yanhui; Zhang, Wei] Dalian Univ Technol, Sch Mat Sci & Engn, Dalian 116023, Peoples R China; [Yamamoto, Yoshinori] Ritsumeikan Univ, Res Org Sci & Technol, Kusatsu, Shiga 5258577, Japan; [Bao, Ming] Dalian Univ Technol, Sch Petr & Chem Engn, Panjin 124221, Peoples R China in 2020.0, Cited 24.0. Safety of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

The effect of nanoporous structure on the catalytic activity of palladium catalysts for hydrogenation of nitro compounds was investigated. The order of the catalytic activity of the six types of nanoporous palladium (PdNPore) catalysts produced was very similar to the order of their specific surface area. Compared with other catalysts synthesized in this study, the PdNPore catalyst (Pd86Al14) with a ligament size of 20 nm and specific surface area of 40.81 m(2) g(-1)exhibited relatively high activity. The hydrogenation reactions of various nitro compounds proceeded smoothly with good functional group tolerance in the presence of this PdNPore catalyst under mild conditions. Moreover, the PdNPore catalyst could be simply recovered and reused several times without any loss of activity.

Welcome to talk about 100-19-6, If you have any questions, you can contact Zhao, YH; Feng, XJ; Li, YH; Zhang, W; Yamamoto, Y; Bao, M or send Email.. Safety of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Gurdere, MB; Aydin, A; Yencilek, B; Erturk, F; Ozbek, O; Erkan, S; Budak, Y; Ceylan, M in WILEY-V C H VERLAG GMBH published article about ANTICANCER ACTIVITY; BIOLOGICAL EVALUATION; CHALCONE DERIVATIVES; CYTO-TOXICITY; GROWTH; CANCER; LUNG; AGENTS; PARTHENOLIDE; LACTONE in [Gurdere, Meliha Burcu; Yencilek, Belkiz; Ozbek, Oguz; Budak, Yakup; Ceylan, Mustafa] Tokat Gaziosmanpasa Univ, Fac Arts & Sci, Dept Chem, TR-60250 Tokat, Turkey; [Aydin, Ali] Yozgat Bozok Univ, Fac Med, Dept Basic Med Sci, TR-66100 Yozgat, Turkey; [Erturk, Fatih] Istanbul Arel Univ, Vocat Sch, Occupat Hlth & Safety Program, TR-34100 Istanbul, Turkey; [Erkan, Sultan] Sivas Cumhuriyet Univ, Yildizeli Vocat Sch, Chem & Chem Proc Technol, TR-58140 Sivas, Turkey in 2020.0, Cited 46.0. Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Novel enamine derivatives were synthesized from the reaction of lactone and chalcones and their antiproliferative and cytotoxic activities against six cancer cell lines (e. g., HeLa, HT29, A549, MCF7, PC3 and Hep3B) and one normal cell lines (e. g., FL) were investigated along with their mode of interactions with CT-DNA. Most of the enamine derivatives with IC(50)values of 86-168 mu M demonstrated much stronger antiproliferative activity than the starting molecules against the cancer cells. While, among the enamine derivatives, four compounds displayed higher cytotoxic potency than the control drugs (5-fluorouracil and cisplatin) against the Hep3B cell lines, these compounds did not exhibit any significant toxicity against normal cells, FL. The UV/VIS spectral data suggest that eight compounds cause hypochromism with a slight bathochromic shift (similar to 6 nm), indicating that they bind to the DNA by way of an intercalative or minor groove binding mode. The binding constants of the compounds are in the range of 0.1×103 M-1-2.3×104 M-1. The antiproliferative activity of studied enamine derivatives could possibly be due to their DNA binding as well as their cytotoxic properties. In addition to these assays, the chalcones and enamine derivatives were investigated by molecular docking to calculate the synergistic effect of antiproliferative activities against six human cancer cell lines.

Formula: C8H7NO3. Welcome to talk about 100-19-6, If you have any questions, you can contact Gurdere, MB; Aydin, A; Yencilek, B; Erturk, F; Ozbek, O; Erkan, S; Budak, Y; Ceylan, M or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Cu-Catalyzed one-pot synthesis of thiochromeno-quinolinone and thiochromeno-thioflavone via oxidative double hetero Michael addition using in situ generated nucleophiles WOS:000555234200022 published article about FACILE SYNTHESIS; 4-QUINOLONES; CYCLIZATION; ANNULATION; INHIBITORS; DESIGN; WATER in [Sundaravelu, Nallappan; Sekar, Govindasamy] Indian Inst Technol Madras, Dept Chem, Chennai 600036, Tamil Nadu, India in 2020.0, Cited 41.0. COA of Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A copper catalyzed three-component synthesis of pi-conjugated tetracyclic thiochromeno-quinolinone and thiochromeno-thioflavone was establishedviaoxidative double hetero Michael addition usingin situgenerated nucleophiles. Xanthate plays a dual role as an odourless sulfur source and a chemoselective reducing agent. Thein situformed iodine plays a crucial role in the oxidation step.

COA of Formula: C8H7NO3. Welcome to talk about 100-19-6, If you have any questions, you can contact Sundaravelu, N; Sekar, G or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Beniwal, M; Jain, N in BENTHAM SCIENCE PUBL LTD published article about in [Beniwal, Meenu; Jain, Neelam] Bhagat Phool Singh Mahila Vishwavidyalaya, Dept Pharmaceut Educ & Res, Sonepat 131301, Haryana, India in 2019.0, Cited 29.0. Quality Control of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Background: This paper describes the synthesis of novel thiazolidin-4-one substituted pyrazole derivatives from the condensation reaction of hydrazide with acetophenone derivatives. Herein we describe the synthesis of fourteen compounds by microwave irradiation method. The synthesized compounds are in excellent yield by utilizing microwave irradiation heating. Objective: Compounds using different aromatic or heteroaromatic compounds should be synthesized and screened for their antibacterial activity to explore the possibility of pyrazole substituted thiazolidin- 4-ones as a novel series of antimicrobials. Methods: Synthesis of thiazolidin-4-one substituted pyrazole derivatives was carried out under microwave radiation. Results: These compounds were identified on the basis of melting point range, R-f values, IR, 1H-NMR and mass spectral analysis. These compounds were evaluated for their in vitro antimicrobial activity and their Minimum Inhibitory Concentration (MIC) was determined. Among them Comp. 4b and Comp. 4k possess appreciable antimicrobial and antifungal activities. Conclusion: A novel series of Thiazolidin-4-one substituted pyrazole were synthesized under microwave irradiation method and identified on the basis of melting point range, Rf values, IR, 1H-NMR, mass spectral data and elemental analysis. The compounds were subjected to in vitro antimicrobial screening and their Minimum Inhibitory Concentrations (MIC) were determined. Among all the tested compounds, two compounds 4b and 4k exhibited moderate to significant activity against all the tested strains of bacteria and fungus were found to have appreciable antimicrobial activities. The results of antibacterial activity showed that compounds containing electron withdrawing groups were found to be more active than the compounds containing electron releasing groups.

Welcome to talk about 100-19-6, If you have any questions, you can contact Beniwal, M; Jain, N or send Email.. Quality Control of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

SDS of cas: 100-19-6. Doubkova, S; Marek, A in [Doubkova, Sabina; Marek, Ales] Czech Acad Sci, Inst Organ Chem & Biochem, Flemingovo 542-2, Prague 16610 6, Czech Republic published Frustrated Lewis pairs: A real alternative to deuteride/tritide reductions in 2019.0, Cited 60.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Deuterium- and tritium-labeled compounds play a principal role in tracing of biologically active molecules in complicated biochemical systems. The state-of-the-art techniques using noble metal catalysts or strong reducing agents often suffers from low functional group tolerances, poor selectivity, tricky or multistep synthesis of reagents, and low specific activity of the labeled product. Herein, we demonstrate a mild and nonmetallic technique of deuteration and tritiation of polarized double bonds, such as carbonyl compounds, yielding labeled alcohols of high specific activities. This one-pot synthesis uses carrier-free hydrogen gas in situ activated by a freshly prepared frustrated Lewis pair, generating reducing reagents. This labeling strategy shows better selectivity and functional group tolerances compared with current reductive methods. Reported is an example of the selective reduction of the aldehyde moiety of 3-acetylbenzaldehyde. What makes this technology groundbreaking is its mildness, selectivity, and generation of limited amount of radioactive waste as almost no byproducts were generated after use of (B(C6F5)(3)H-3)((HTMP)-H-3) reducing reagent. Radiochemical purity of desired H-3-labeled product in a crude reaction mixture was determined of over 94%. This work provides, to the community of radiochemists, a practical protocol for frustrated Lewis pairs (FLP)-assisted deuterium/tritium labeling technology.

SDS of cas: 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Doubkova, S; Marek, A or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

I found the field of Chemistry very interesting. Saw the article Synthesis, biological evaluation, and molecular docking studies of novel pyrazole, pyrazoline-clubbed pyridine as potential antimicrobial agents published in 2021.0. Computed Properties of C8H7NO3, Reprint Addresses Desai, NC (corresponding author), Maharaja Krishnakumarsinhji Bhavnagar Univ, Dept Chem DST Fist Sponsored, Div Med Chem, Mahatma Gandhi Campus, Bhavnagar 364002, Gujarat, India.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

We have prepared 15 hybrid pyrazole, pyrazoline-clubbed pyridine-containing compounds (5a-o) and tested for their antibacterial and antifungal activities for the development of potential antimicrobial agents. The structures of this novel series were characterized by various spectral techniques like IR, H-1 NMR, C-13 NMR, LC-MS, and elemental analysis. The synthesized compounds 5d, 5e, 5i, 5k, 5m, and 5o exhibited significant antimicrobial activity in the comparison of standard drugs. Molecular docking studies that have been carried out to emphasize the binding orientations of these molecules were in good compliance with crystal structure interactions. The predicted drug-likeness (ADME) properties were found to be in the acceptable range.

Computed Properties of C8H7NO3. Welcome to talk about 100-19-6, If you have any questions, you can contact Desai, NC; Vaja, DV; Monapara, JD; Manga, V; Vani, T or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 100-19-6. Doiuchi, D; Nakamura, T; Hayashi, H; Uchida, T in [Hayashi, Hiroki; Uchida, Tatsuya] Kyushu Univ, Fac Arts & Sci, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan; [Doiuchi, Daiki; Nakamura, Tatsuya] Kyushu Univ, Grad Sch Sci, Dept Chem, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan; [Uchida, Tatsuya] Kyushu Univ, Int Inst Carbon Neutral Energy Res WPI 12CNER, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan published Non-Heme-Type Ruthenium Catalyzed Chemo- and Site-Selective C-H Oxidation in 2020.0, Cited 86.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Herein, we developed a Ru(II)(BPGA) complex that could be used to catalyze chemo- and site-selective C-H oxidation. The described ruthenium complex was designed by replacing one pyridyl group on tris(2-pyridylmethyl)amine with an electron-donating amide ligand that was critical for promoting this type of reaction. More importantly, higher reactivities and better chemo-, and site-selectivities were observed for reactions using the cis-ruthenium complex rather than the trans-one. This reaction could be used to convert sterically less hindered methyne and/or methylene C-H bonds of a various organic substrates, including natural products, into valuable alcohol or ketone products.

Recommanded Product: 100-19-6. Welcome to talk about 100-19-6, If you have any questions, you can contact Doiuchi, D; Nakamura, T; Hayashi, H; Uchida, T or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 1-(4-Nitrophenyl)ethanone. Kallitsakis, MG; Ioannou, DI; Terzidis, MA; Kostakis, GE; Lykakis, IN in [Kallitsakis, Michael G.; Ioannou, Dimitris I.; Lykakis, Ioannis N.] Aristotle Univ Thessaloniki, Dept Chem, Thessaloniki 54124, Greece; [Terzidis, Michael A.] Int Hellen Univ, Dept Nutr Sci & Dietet, Thessaloniki 57400, Greece; [Kostakis, George E.] Univ Sussex, Sch Life Sci, Dept Chem, Brighton BN1 9QJ, E Sussex, England published Selective Photoinduced Reduction of Nitroarenes to N-Arylhydroxylamines in 2020.0, Cited 63.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

We report the selective photoinduced reduction of nitroarenes to N-arylhydroxylamines. The present methodology facilitates this transformation in the absence of catalyst or additives and uses only light and methylhydrazine. This noncatalytic photoinduced transformation proceeds with a broad scope, excellent functional-group tolerance, and high yields. The potential of this protocol reflects on the selective and straightforward conversion of two general antibiotics, azomycin and chloramphenicol, to the bioactive hydroxylamine species.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Construction of a Zn(II)-containing MOF for highly selective detection of picric acid and inhibition of human glioma cell growth WOS:000501486700022 published article about METAL-ORGANIC FRAMEWORK; CO2 in [Hu, Yun-Jia; Li, Yu-Ming; Zheng, Kai; Zhang, Wei-Hao; Liu, Yu-Li; Yang, Hua] Guizhou Med Univ, Dept Neurosurg, Affiliated Hosp, Guiyang, Guizhou, Peoples R China in 2020.0, Cited 24.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Formula: C8H7NO3

A novel Zinc-based metal-organic framework [Zn-2(OH)(2)(H2TCPP)](DMF)(3) (1) was constructed by using a novel rigid symmetric tetracarboxylic connector, 2,3,5,6-tetrakis (4-carboxyphenyl)pyrazine (H4TCPP). The cross-linkage of Zn(II)-based 1D rod secondary building units (SBUs) with the H2TCPP2- ligands leads to the 3D channel structure of sea-type net with (6,8)-connected topology. Complex 1 not only exhibited the bright blue luminescence induced by H2TCPP2- ligand matrix coordination emission, but also effectively detected picric acid in solution whose quenching constant is 6.95 x 10(4) M-1. Next, the inhibitory effect of complex 1 on various types of cancer cell lines was detected via CCK-8 method. The influence of complex 1 on the U251 human glioma cells invasion, migration and proliferation ability was further explored via transwell method. (C) 2019 Published by Elsevier B.V.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem