Heterocyclic Building Blocks-benzodioxan

Recently I am researching about BIOLOGICAL EVALUATION; ANTIMYCOBACTERIAL; INHIBITORS; QSAR, Saw an article supported by the Department of Biotechnology, Indo-Spain, New Delhi [BT/IN/Spain/39/SM/2017-2018]. SDS of cas: 100-19-6. Published in SPRINGER BIRKHAUSER in NEW YORK ,Authors: Pola, S; Banoth, KK; Sankaranarayanan, M; Ummani, R; Garlapati, A. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

A new series of naphthyl chalcones (3a-3p) and their pyrazoline derivatives (4a-4h) were synthesized using substituted acetophenones, substituted naphthaldehydes, and hydrazine hydrate as starting materials. All the synthesized compounds were characterized by IR, NMR, and mass spectrometric analysis and screened for antimycobacterial activity againstMycobacterium tuberculosis H37Rv (ATCC 27924)and antibacterial activity againstStaphylococcus aureus (MTCC 96), Bacillus subtilis (MTCC 441), Escherichia coli (MTCC 443) and Klebsiella pneumonia (MTCC 109). Compounds3band3pexhibited significant antibacterial activity against all the tested bacterial strains. Amongst the synthesized compounds, compound4bwith 2-hydroxy-5-bromophenyl substitution at 3rd position of pyrazoline showed significant antimycobacterial activity with MIC of 6.25 mu M comparable to that of standard isoniazid. The synthesized compounds were further screened for their cytotoxic activity against the MDA-MB-231 and SKOV3 cell lines. The compounds3a,3l,4b,4c,4e, and4hdid not exhibit any cytotoxicity, and other compounds exhibited IC(50)values higher than 8 and 22 mu M against MDA-MB-231 and SKOV3 cell lines, respectively, compared to 1.20 and 1.30 mu M shown by standard doxorubicin. To find out the putative binding mode of significantly active and weakly active compounds, a molecular docking study was also performed. In that, the most active compound4b, displayed a hydrogen bond interaction with docking score of -10.50 kcal/mol and energy of -44.50 weakly active compound3hdid not show any crucial hydrogen bond interaction with the surrounded amino-acid residues and revealed a docking score of -6.74 and docking energy of -42.50.

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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Product Details of 100-19-6. In 2019.0 ASIAN J ORG CHEM published article about C-H FUNCTIONALIZATION; COPPER-CATALYZED THIOLATION; MULTICOMPONENT REACTIONS; REGIOSELECTIVE SULFENYLATION; 3-COMPONENT SYNTHESIS; COUPLING REACTION; DOMINO REACTIONS; FACILE SYNTHESIS; BOND FORMATION; SULFUR BOND in [Reddy, Raju Jannapu; Shankar, Angothu; Kumari, Arram Haritha] Osmania Univ, Univ Coll Sci, Dept Chem, Hyderabad 500007, Andhra Pradesh, India in 2019.0, Cited 118.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A metal-free sequential one-pot three-component protocol is described for the synthesis of C3-functionalized imidazo[1,2-a]pyridines. A successive construction of imidazo[1,2-a]pyridine followed by iodine-catalysed sulfenylation has been achieved in a one-pot operation from readily available alpha-bromomethyl ketones, 2-aminopyridines and thiosulfonates. An immense array of 3-sulfenylimidazo[1,2-a]pyridines were obtained in good to high yields. Also, the method extended for the synthesis of C3-halogenated imidazo[1,2-a]pyridines using sodium halides in the presence of K2S2O8. Notably, the reaction between alpha-bromomethyl ketones and 2-aminopyridines in the presence of K2S2O8 to yield 3-bromo-2-aryl-imidazo[1,2-a]pyridines, thus implies alpha-bromomethyl ketones also served as brominating agent. Overall, the present sequential one-pot protocol is straightforward, operationally simple, tolerates a broad range of functional groups, and is reliable for gram-scale experiments.

Product Details of 100-19-6. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Reddy, RJ; Shankar, A; Kumari, AH or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Liu, Y; Lv, MX; Li, L; Yu, HL; Wu, Q; Pang, JH; Liu, YX; Xie, CX; Yu, ST; Liu, SW in [Liu, Yue; Lv, Mingxin; Yu, Hailong; Wu, Qiong; Liu, Yuxiang; Yu, Shitao; Liu, Shiwei] Qingdao Univ Sci & Technol, Coll Chem Engn, 53 Zhengzhou Rd, Qingdao 266042, Shandong, Peoples R China; [Xie, Congxia] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, State Key Lab Base Ecochem Engn, 53 Zhengzhou Rd, Qingdao 266042, Shandong, Peoples R China; [Li, Lu; Pang, Jinhui] Qingdao Univ Sci & Technol, Coll Marine Sci & Biol Engn, 53 Zhengzhou Rd, Qingdao 266042, Shandong, Peoples R China published Synthesis of a highly active amino-functionalized Fe3O4@SiO2/APTS/Ru magnetic nanocomposite catalyst for hydrogenation reactions in 2019.0, Cited 34.0. Product Details of 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

An amino-functionalized silica-coated Fe3O4 nanocomposite (Fe3O4@SiO2/APTS) was synthesized. The Fe3O4@SiO2 microspheres possessed a well-defined core-shell structure, uniform sizes and high magnetization. An immobilized ruthenium nanoparticle catalyst (Fe3O4@SiO2/APTS/Ru) was obtained after coordination and reduction of Ru3+ on the Fe3O4@SiO2/APTS nanocomposite. The Ru nanoparticles were not only ultra-small with nearly monodisperse sizes but also had strong affinity with the surface of Fe3O4@SiO2/APTS. The obtained catalyst exhibited excellent catalytic performance for the hydrogenation of a variety of aromatic nitro compounds, even at room temperature. Moreover, Fe3O4@SiO2/APTS/Ru was easily recovered using a magnetic field and directly reused for at least five cycles without significant loss of its activity.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Mehiaoui, N; Kibou, Z; Gallavardin, T; Leleu, S; Franck, X; Mendes, RF; Paz, FAA; Silva, AMS; Choukchou-Braham, N in SPRINGER published article about 2-PYRIDONE DERIVATIVES; DESIGN; AGENTS in [Mehiaoui, Nawel; Kibou, Zahira; Choukchou-Braham, Noureddine] Univ Tlemcen, Lab Catalyse & Synth Chim Organ, Fac Sci, BP 119, Tilimsen 13000, Algeria; [Kibou, Zahira] Ctr Univ Ain Temouchent, Inst Sci, BP 284, Ain Temouchent 46000, Algeria; [Gallavardin, Thibault; Leleu, Stephane; Franck, Xavier] Normandie Univ, CNRS, UNIROUEN, INSA Rouen,COBRA,UMR6014, F-76000 Rouen, France; [Gallavardin, Thibault; Leleu, Stephane; Franck, Xavier] Normandie Univ, CNRS, UNIROUEN, INSA Rouen,FR 3038, F-76000 Rouen, France; [Mendes, Ricardo F.; Paz, Filipe A. Almeida] Univ Aveiro, Dept Chem, CICECO Aveiro Inst Mat, P-3810193 Aveiro, Portugal; [Silva, Artur M. S.] Univ Aveiro, Dept Chem, QOPNA, P-3810193 Aveiro, Portugal; [Silva, Artur M. S.] Univ Aveiro, LAQV REQUIMTE, P-3810193 Aveiro, Portugal in 2021.0, Cited 44.0. COA of Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Novel substituted bis-(3-cyano-2-pyridone) derivatives were prepared via a powerful method using enaminonitriles push-pull dienes as key building blocks. The synthesis was performed in three steps from easily accessible starting materials in good yields. All target products were structurally elucidated by spectroscopic data. The reaction mechanism for formation of bis (3-cyano-2-pyridone) derivatives was proposed. The structures of enaminonitriles 3a and bis-pyridones 4c were confirmed by single-crystal X-ray diffraction. The florescent study of some bis (3-cyano-2-pyridones) derivatives was reported. [GRAPHICS]

Welcome to talk about 100-19-6, If you have any questions, you can contact Mehiaoui, N; Kibou, Z; Gallavardin, T; Leleu, S; Franck, X; Mendes, RF; Paz, FAA; Silva, AMS; Choukchou-Braham, N or send Email.. COA of Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Quality Control of 2,2-Diphenylacetonitrile. Authors Babon, JC; Esteruelas, MA; Fernandez, I; Lopez, AM; Onate, E in AMER CHEMICAL SOC published article about in [Babon, Juan C.; Esteruelas, Miguel A.; Lopez, Ana M.; Onate, Enrique] Univ Zaragoza, Ctr Innovac Quim Avanzada ORFEO CINQA, Inst Sintesis Quim & Catalisis Homogenea ISQCH, Dept Quim Inorgan,CSIC, Zaragoza 50009, Spain; [Fernandez, Israel] Univ Complutense Madrid, Ctr Innovac Quim Avanzada ORFEO CINQA, Fac Ciencias Quim, Dept Quim Organ 1, Madrid 28040, Spain in 2020, Cited 69. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3

Complex OsH6((PPr3)-Pr-i)(2) is an efficient catalyst precursor for the addition of pinacolborane and catecholborane to the C-N triple bond of alkyl nitrites. In this way, a variety of N,N-diborylamines have been isolated and fully characterized, including 13 derivatives not described so far. The range of nitrites used is wide and comprises substrates having unfunctionalized linear and branched chains, and functionalized chains with methoxide, trifluoromethyl, aryl, pyridyl, benzoyl, or cyanide groups. Kinetic studies demonstrate that the overall process consists of two consecutive irreversible reactions: the catalytic metal-promoted monohydroboration of the nitrile to afford the borylimine and the metal-free stoichiometric hydroboration of the latter to give the diborylamine. The mechanism of the hydroboration has been established by combining the kinetic analysis of the catalysis, stoichiometric reactions, and DFT calculations. The rate-determining step of the catalysis is the insertion of the C-N triple bond of the nitrite into the Os-B bond of an osmium-sigma-borane intermediate and is regiodirected by the nucleophilicity of the nitrogen atom and the electrophilicity of the carbon atom of the nitrite.

Welcome to talk about 86-29-3, If you have any questions, you can contact Babon, JC; Esteruelas, MA; Fernandez, I; Lopez, AM; Onate, E or send Email.. Quality Control of 2,2-Diphenylacetonitrile

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

HPLC of Formula: C8H7NO3. Jiang, JJ; Tuo, XT; Fu, ZQ; Huang, HW; Deng, GJ in [Jiang, Jingjing; Tuo, Xiaotong; Fu, Zhuquan; Huang, Huawen; Deng, Guo-Jun] Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat,Minist, Xiangtan 411105, Peoples R China published Three-component synthesis of 1,4-benzothiazines via iodide-catalyzed aerobic C-H sulfuration with elemental sulfur in 2020, Cited 77. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Herein, iodide-catalyzed aerobic synthesis of 1,4-benzothiazines via functionalization of multiple C-H bonds with elemental sulfur is described. Beyond the well-established thiazole formation from elemental sulfur, this method provides the first access to the corresponding six-membered N,S-heterocyclic products via direct functionalization of multiple C-H bonds. Hence, 1,4-benzothiazine products were generated in satisfactory yields with a range of compatible functionalities.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. HPLC of Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

SDS of cas: 100-19-6. Recently I am researching about METAL-ORGANIC FRAMEWORK; CO2, Saw an article supported by the . Published in ELSEVIER in AMSTERDAM ,Authors: Hu, YJ; Li, YM; Zheng, K; Zhang, WH; Liu, YL; Yang, H. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

A novel Zinc-based metal-organic framework [Zn-2(OH)(2)(H2TCPP)](DMF)(3) (1) was constructed by using a novel rigid symmetric tetracarboxylic connector, 2,3,5,6-tetrakis (4-carboxyphenyl)pyrazine (H4TCPP). The cross-linkage of Zn(II)-based 1D rod secondary building units (SBUs) with the H2TCPP2- ligands leads to the 3D channel structure of sea-type net with (6,8)-connected topology. Complex 1 not only exhibited the bright blue luminescence induced by H2TCPP2- ligand matrix coordination emission, but also effectively detected picric acid in solution whose quenching constant is 6.95 x 10(4) M-1. Next, the inhibitory effect of complex 1 on various types of cancer cell lines was detected via CCK-8 method. The influence of complex 1 on the U251 human glioma cells invasion, migration and proliferation ability was further explored via transwell method. (C) 2019 Published by Elsevier B.V.

SDS of cas: 100-19-6. Welcome to talk about 100-19-6, If you have any questions, you can contact Hu, YJ; Li, YM; Zheng, K; Zhang, WH; Liu, YL; Yang, H or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Wang, B; Wang, LR; Liu, LL; Wang, W; Man, RJ; Zheng, DJ; Deng, YS; Yang, YS; Xu, C; Zhu, HL in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Wang, Bin; Wang, Li-Ren; Liu, Lu-Lu; Wang, Wei; Zheng, Da-Jun; Deng, Yu-Shan; Yang, Yu-Shun; Xu, Chen; Zhu, Hai-Liang] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China; [Man, Ruo-Jun] Guangxi Univ Nationalities, Guangxi Biol Polysaccharide Separat Purificat & M, Nanning 530006, Peoples R China in 2021.0, Cited 44.0. HPLC of Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

In this work, a series of diaryl benzo[b][1,4]thiazepine derivatives D1-D36 were synthesized and screened as tubulin polymerization inhibitors with anti-tumor potency. They were designed by introducing the seven member ring benzothiazepine as the linker for CA-4 modification for the first time. Among them, the hit compound D8 showed potential on inhibiting the growth of several cancer cell lines (IC50 values: 1.48 mu M for HeLa, 1.47 mu M for MCF-7, 1.52 mu M for HT29 and 1.94 mu M for A549), being comparable with the positive controls Colchicine and CA-4P. The calculated IC50 value of D8 as an tubulin polymerization inhibitor was 1.20 mu M. The results of the flow cytometry assay revealed that D8 could induce the mitotic catastrophe and the death of living cancer cells. D8 also indicated the anti-vascular activity. The possible binding pattern was implied by docking simulation, inferring the possibility of introducing interactions with the nearby tubulin chain. Since the novel structural trial has been conducted with preliminary discussion, this work might stimulate new ideas in further modification of tubulin-related anti-cancer agents and therapeutic approaches.

Welcome to talk about 100-19-6, If you have any questions, you can contact Wang, B; Wang, LR; Liu, LL; Wang, W; Man, RJ; Zheng, DJ; Deng, YS; Yang, YS; Xu, C; Zhu, HL or send Email.. HPLC of Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors de Melo, SCG; da Silva, MEP; da Silva, MEB; da Paz, JA; Barbosa, CMBD; de Menezes, FD; Loureiro, RNA; Navarro, M; da Costa, JAP; da Silva, GF; Villa, AAO; Vilar, M in PERGAMON-ELSEVIER SCIENCE LTD published article about ORGANIC-COMPOUNDS; CARBONYL-COMPOUNDS; ENANTIOSELECTIVE HYDROGENATION; ELECTROCHEMICAL HYDROGENATION; CHEMOSELECTIVE HYDROGENATION; GRAPHENE NANOSHEETS; BETA-CYCLODEXTRIN; GREEN CHEMISTRY; DESIGN ANALYSIS; SCALE-UP in [Galvao de Melo, Sarah Calado; Pereira da Silva, Maria Eduarda; Barreto da Silva, Maria Eduarda; de Menezes, Frederico Duarte; Albert Loureiro, Rodrigo Nogueira; Peixoto da Costa, Jose Angelo; Ochoa Villa, Alvaro Antonio; Vilar, Marcio] Inst Fed Educ Ciencia & Tecnol Pernambuco, Dept Sistemas Proc & Controles Ind, BR-50740540 Recife, PE, Brazil; [da Paz, Josinete Angela; Navarro, Marcelo] Univ Fed Pernambuco, Dept Quim Fundamental, BR-50670901 Recife, PE, Brazil; [Bezerra de Menezes Barbosa, Celmy Maria] Univ Fed Pernambuco, Dept Engn Quim, BR-50740521 Recife, PE, Brazil; [da Silva, Gabriel Francisco] Univ Fed Sergipe, Dept Quim, BR-49100000 Sao Cristovao, SE, Brazil in 2020.0, Cited 107.0. Product Details of 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Benzylic alcohols have an important role in organic synthesis as target molecules of biological interest, which can be produced from the reduction of aromatic carbonyl substrates. In this work, the sonoelectrocatalytic hydrogenation (SECH) of aryl ketones was studied in water. The ultrasonic irradiation was carried out at frequency of 20 kHz +/- 500 Hz with a cylindrical titanium probe (MS 73 microtip; Ti-6AI-4V alloy; 3.0 mm diameter; Pacoustic- = 2.11 W). The results showed that the ultrasound irradiation enhances the mass-transport of the substrates from the bulk solution to the electrode surface, increasing the substrate availability to react with the adsorbed H, leading to higher yields. Regarding the electrode material, the following hydrogenation yields of a group of acetophenones was observed: Cu (79.0 +/- 1.5%) > Ni (73.0 +/- 2.0%) approximate to Fe/Ni (72.0 +/- 1.7%) > graphite (69.0 +/- 1.7%) > Fe (67.5 +/- 2.3%). The SECH presented a slight variation in the reactivity of some reagents, and its behaviour depends on the catalytic nature of the electrode support. Besides the lower overpotential and higher exchange current density of the graphite, it was surprisingly active under ultrasound irradiation, showing higher yields and current efficiencies than others electrocatalytic hydrogenation (ECH) procedures. The ultrasound irradiation decreases more than 6-folds the energy consumption of the ECH method, making it an effective and inexpensive way to produce alcohols from the respective aryl ketones in water. (C) 2020 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.

Welcome to talk about 100-19-6, If you have any questions, you can contact de Melo, SCG; da Silva, MEP; da Silva, MEB; da Paz, JA; Barbosa, CMBD; de Menezes, FD; Loureiro, RNA; Navarro, M; da Costa, JAP; da Silva, GF; Villa, AAO; Vilar, M or send Email.. Product Details of 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 100-19-6. In 2019.0 ACS OMEGA published article about RECYCLABLE HETEROGENEOUS CATALYST; SILVER NANOPARTICLES; HIGHLY EFFICIENT; METAL NANOPARTICLES; GOLD NANOPARTICLES; GREEN SYNTHESIS; CHEMOSELECTIVE REDUCTION; CELLULOSE NANOCRYSTALS; NICKEL NANOPARTICLES; ALLOY NANOPARTICLES in [Antony, Rajendran; Marimuthu, Rajendiran; Murugavel, Ramaswamy] Indian Inst Technol, Dept Chem, Organometall & Mat Chem Lab, Mumbai 400076, Maharashtra, India; [Antony, Rajendran] Taiyuan Univ Technol, Key Lab Coal Sci & Technol, Taiyuan 030024, Shanxi, Peoples R China in 2019.0, Cited 77.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

We report an easily recoverable and reusable versatile magnetic catalyst (Fe3O4@CS_AgNi, where CS = chitosan) for organic reduction reactions. The catalytic system is prepared by dispersing AgNi bimetallic nanoparticles on the magnetite core-shell (Fe3O4@CS). The as-synthesized catalyst has been characterized by spectroscopic techniques, such as IR, UV-vis, and X-ray photoelectron spectroscopy (XPS), and analytical tools, such as thermogravimetric analysis, powder X-ray diffraction, Brunauer-Emmett-Teller adsorption, FEG-scanning electron microscopy, high-resolution transmission electron microscopy (HR-TEM), inductively coupled plasma-atomic emission spectroscopy, and magnetic measurements. HR-TEM studies indicate the core-shell structure of Fe3O4@CS and confirm the presence of AgNi nanoparticles on the surface of Fe3O4@CS spheres. IR spectral and XPS studies lend evidence for the occurrence of a strong chemical interaction between the amino groups of CS and AgNi nanoparticles. The nano-catalyst Fe3O4@CS_AgNi rapidly reduces p-nitrophenol to p-aminophenol using NaBH4 as the reductant within a few minutes under ambient conditions (as monitored by UV-visible spectroscopy). The utility of this catalytic system has also been extended to the reduction of other nitroarenes. A strong interaction between Fe3O4@CS and AgNi nanoparticles impedes the leaching of AgNi nanoparticles from the core-shell support, leading to excellent reusability of the catalyst.

Welcome to talk about 100-19-6, If you have any questions, you can contact Antony, R; Marimuthu, R; Murugavel, R or send Email.. Recommanded Product: 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem