Heterocyclic Building Blocks-benzodioxan

In 2021 ASIAN J ORG CHEM published article about BAEYER-VILLIGER OXIDATION; RETRO-CLAISEN CONDENSATION; C-NUCLEOSIDE SYNTHESIS; CARBON-CYANO; DIRECT CONVERSION; ORGANIC-ACIDS; HALLER-BAUER; CLEAVAGE; ESTERS; MILD in [Rammurthy, Banothu; Peraka, Swamy; Vasu, Amrutham; Sai, Gajula Krishna; Rohini, Yennamaneni Divya; Narender, Nama] Acad Sci & Innovat Res, CSIR HRDG Campus,Sect 19, Ghaziabad 201002, UP, India; [Rammurthy, Banothu; Peraka, Swamy; Vasu, Amrutham; Sai, Gajula Krishna; Rohini, Yennamaneni Divya; Narender, Nama] CSIR Indian Inst Chem Technol, C&FC Div, Hyderabad 500007, Telangana, India in 2021, Cited 88. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. COA of Formula: C8H7NO3

A novel metal-free catalytic one-pot approach has been developed for the esterification of aralkyl ketones with alcohols under open-air atmospheric conditions. The inexpensive iodide/oxone reagent system allowed the cascade C(sp(3))-H bond oxygenation, selective C-C bond cleavage and esterification through the both radical and ionic pathways in a stepwise manner in one-pot. This mild, convenient and economically viable catalytic method tolerates the various functional groups to provide the corresponding alkyl benzoates in up to 98% yields with up to 99% selectivity. The efficiency and feasibility of scale-up of the present catalytic system was demonstrated with gram scale experiments (up to 10 gram scale).

COA of Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Rammurthy, B; Peraka, S; Vasu, A; Sai, GK; Rohini, YD; Narender, N or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Formula: C8H7NO3. Shu, B; Zeng, P; Kang, SS; Li, PH; Hu, DX; Kuang, GT; Cao, JJ; Li, XY; Zhang, ML; An, LK; Huang, ZS; Li, D in [Shu, Bing; Zeng, Ping; Kang, Shuangshuang; Li, Peng-Hui; Hu, Dexuan; Kuang, Guotao; Cao, Jiaojiao; Li, Xiaoya; Zhang, Meiling; An, Lin-Kun; Huang, Zhi-Shu; Li, Ding] Sun Yat Sen Univ, Sch Pharmaceut Sci, 132 Waihuan East Rd, Guangzhou 510006, Guangdong, Peoples R China; [Shu, Bing] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China published Syntheses and evaluation of new Quinoline derivatives for inhibition of hnRNP K in regulating oncogene c-myc transcription in 2019, Cited 54. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Aberrant overexpression of heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a key feature in oncogenesis and progression of many human cancers. hnRNP K has been found to be a transcriptional activator to up-regulate c-myc gene transcription, a critical proto-oncogene for regulation of cell growth and differentiation. Therefore, down-regulation of c-myc transcription by inhibiting hnRNP K through disrupting its binding to c-myc gene promoter is a potential approach for cancer therapy. In the present study, we synthesized and screened a series of Quinoline derivatives and evaluated their binding affinity for hnRNP K. Among these derivatives, (E)-1-(4-methoxyphenyl)-3-(4 morpholino-6-nitroquinolin-2-yl)prop-2-en-1-one (compound 25) was determined to be the first-reported hnRNP K binding ligand with its K-D values of 4.6 and 2.6 mu M measured with SPR and MST, respectively. Subsequent evaluation showed that the binding of compound 25 to hnRNP K could disrupt its unfolding of c-myc promoter i-motif, resulting in down-regulation of c-myc transcription. Compound 25 showed a selective anti-proliferative effect on human cancer cell lines with IC50, values ranged from 1.36 to 3.59 mu M. Compound 25 exhibited good tumor growth inhibition in a Hela xenograft tumor model, which might be related to its binding with hnRNP K. These findings illustrated that inhibition of DNA-binding protein hnRNP K by compound 25 could be a new and selective strategy of regulating oncogene transcription instead of targeting promoter DNA secondary structures such as G-quadruplexes or i-motifs.

Formula: C8H7NO3. Welcome to talk about 100-19-6, If you have any questions, you can contact Shu, B; Zeng, P; Kang, SS; Li, PH; Hu, DX; Kuang, GT; Cao, JJ; Li, XY; Zhang, ML; An, LK; Huang, ZS; Li, D or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article On Water Catalytic Aldol Reaction between Isatins and Acetophenones: Interfacial Hydrogen Bonding and Enamine Mechanism WOS:000473116200008 published article about HENRY NITROALDOL REACTIONS; ORGANIC-SYNTHESIS; ENANTIOSELECTIVE CONSTRUCTION; CONDENSATION; DERIVATIVES; ALDEHYDES in [Han, Jinsong; Zhang, Jin-Lei; Zhang, Wei-Qiang; Gao, Ziwei; Xu, Li-Wen; Jian, Yajun] Shaanxi Normal Univ, Sch Chem & Chem Engn, MOE, Key Lab Appl Surface & Colloid Chem, Xian 710062, Shaanxi, Peoples R China; [Xu, Li-Wen] Hangzhou Normal Univ, Minist Educ, Key Lab Organosilicon Chem & Mat Technol, Hangzhou 310012, Zhejiang, Peoples R China in 2019.0, Cited 38.0. Product Details of 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

On water catalytic aldol reaction catalyzed by polyetheramine (D230) has been developed for easy access to 3-substituted 3-hydroxyindolin-2-ones through the reaction between various substituted isatins and acetophenones/cyclic ketones in high yields under room temperature. Systematic mechanism investigation uncovers the secret for the on water catalytic aldol reaction: comparison of the heterogeneous and homogeneous reaction circumstances with yields of 95 and 20%, respectively, indicates the on-water reaction dominating; interfacial hydrogen bonding between isatin with H2O is tested based on the downfield shift of the C2 and C3’s C-13 NMR signals when water was added to the CDCl3 solution of isatin; Lewis base polyetheramine D230 catalyzes the aldol reaction via the enamine mechanism verified by in situ NMR and ESI-MS analysis.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article A Highly Practical Copper(II)/TEMPO-SO4H Catalyst System for Aerobic Oxidations of Primary Benzylic and Allylic Alcohols on Gram-Scale in Water WOS:000477382000001 published article about ACTIVATED DIMETHYL-SULFOXIDE; SELECTIVE OXIDATION; ALDEHYDES; TEMPO; GREEN; EFFICIENT; REAGENTS in [Chen, Tianyou; Wang, Zihao; Xiao, Juncong; Yi, Changfeng; Xu, Zushun] Hubei Univ, Hubei Collaborat Innovat Ctr Adv Organ Chem Mat, Minist Educ, Key Lab Green Preparat & Applicat Funct Mat,Sch M, Wuhan 430062, Hubei, Peoples R China; [Cao, Zheng] Changzhou Univ, Jiangsu Key Lab Environm Friendly Polymer Mat, Sch Mat Sci & Engn, Jiangsu Collaborat Innovat Ctr Photovolta Sci & E, Changzhou 213164, Peoples R China in 2019.0, Cited 47.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Computed Properties of C8H7NO3

We report a highly practical copper(II)/TEMPO-SO4H catalyst system for aerobic oxidations of primary benzylic and allylic alcohols. A higher activity was achieved when TEMPO-SO4H, an economically feasible 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO) derivative containing a sulfonic acid group, was used to replace TEMPO. The use of such Cu-II/TEMPO-SO4H catalysts can significantly simplify the removal of catalysts and dramatically reduce the amount of organic solvents used. The aerobic oxidation of primary benzylic and allylic alcohols was conducted in water on gram scale using air as the oxidant, and in the absence of surfactant, leading to green catalysis.

Computed Properties of C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Chen, TY; Wang, ZH; Xiao, JC; Cao, Z; Yi, CF; Xu, ZS or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Stereoselective synthesis of trifluoromethyl-substituted 2H-furan-amines from enaminones WOS:000514651200026 published article about KETONE N-TOSYLHYDRAZONES; C-H FUNCTIONALIZATION; REGIOSELECTIVE SYNTHESIS; 3+2 CYCLOADDITION; 2,3-DIHYDROFURAN; ACCESS; ANNULATION; ALKYNES; FURANS; DIHYDROFURANS in [Liang, Xiaoyu; Guo, Pan; Yang, Wenjie; Li, Meng; Jiang, Chengzhou; Sun, Wangbin; Loh, Teck-Peng; Jiang, Yaojia] Nanjing Tech Univ, Inst Adv Synth, Nanjing 211816, Peoples R China; [Loh, Teck-Peng] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637616, Singapore in 2020.0, Cited 70.0. Computed Properties of C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A straightforward strategy for synthesis of highly functionalized trifluoromethyl 2H-furans is described. The copper catalyzed method relies on a cascade cyclic reaction between enaminones and N-tosylhydrazones. This method allows the synthesis of 2-amino-3-trifluoromethyl-substituted 2H-furan derivatives carrying a quaternary stereogenic center as single diastereomers. The proposed reaction mechanism involves an amino-cyclopropane intermediate formed in the cyclopropanation of enaminones. The developed method tolerates a broad spectrum of functionalities, and the obtained 2H-furan derivatives are useful synthetic intermediates for preparing other trifluoromethyl-substituted compounds.

Computed Properties of C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Liang, XY; Guo, P; Yang, WJ; Li, M; Jiang, CZ; Sun, WB; Loh, TP; Jiang, YJ or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about ELECTRON-TRANSFER REACTIONS; CYTOCHROME P450 REDUCTASE; FERREDOXIN-NADP(+) REDUCTASE; SINGLE-ELECTRON; 1,4-DI-N-OXIDE DERIVATIVES; NADPH; QUINONES; FAD; TIRAPAZAMINE; POTENTIALS, Saw an article supported by the European Social FundEuropean Social Fund (ESF) [09.33-LMT-K-712, DOTSUT-34/09.3.3.-LMT-K712-01-0058/LSS-600000-58]; Universita degli Studi di Milano. Recommanded Product: 1-(4-Nitrophenyl)ethanone. Published in MDPI in BASEL ,Authors: Lesanavicius, M; Aliverti, A; Sarlauskas, J; Cenas, N. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Ferredoxin:NADP(+) oxidoreductase from Plasmodium falciparum (PfFNR) catalyzes the NADPH-dependent reduction of ferredoxin (PfFd), which provides redox equivalents for the biosynthesis of isoprenoids and fatty acids in the apicoplast. Like other flavin-dependent electrontransferases, PfFNR is a potential source of free radicals of quinones and other redox cycling compounds. We report here a kinetic study of the reduction of quinones, nitroaromatic compounds and aromatic N-oxides by PfFNR. We show that all these groups of compounds are reduced in a single-electron pathway, their reactivity increasing with the increase in their single-electron reduction midpoint potential (E-7(1)). The reactivity of nitroaromatics is lower than that of quinones and aromatic N-oxides, which is in line with the differences in their electron self-exchange rate constants. Quinone reduction proceeds via a ping-pong mechanism. During the reoxidation of reduced FAD by quinones, the oxidation of FADH(.) to FAD is the possible rate-limiting step. The calculated electron transfer distances in the reaction of PfFNR with various electron acceptors are similar to those of Anabaena FNR, thus demonstrating their similar intrinsic reactivity. Ferredoxin stimulated quinone- and nitro-reductase reactions of PfFNR, evidently providing an additional reduction pathway via reduced PfFd. Based on the available data, PfFNR and possibly PfFd may play a central role in the reductive activation of quinones, nitroaromatics and aromatic N-oxides in P. falciparum, contributing to their antiplasmodial action.

About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Lesanavicius, M; Aliverti, A; Sarlauskas, J; Cenas, N or concate me.. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Meng, TT; Han, J; Zhang, PF; Hu, J; Fu, JJ; Yin, J in [Meng, Tingting; Zhang, Pengfei; Hu, Jing; Fu, Junjie; Yin, Jian] Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China; [Meng, Tingting; Fu, Junjie] Nanjing Med Univ, Sch Pharm, Nanjing 211166, Jiangsu, Peoples R China; [Han, Jing] Jiangsu Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Green Synthet Chem Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China published Introduction of the alpha-ketoamide structure: en route to develop hydrogen peroxide responsive prodrugs in 2019.0, Cited 44.0. Quality Control of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Leveraging the elevated levels of hydrogen peroxide (H2O2) in cancer, inflammatory diseases and cardiovascular disorders, H2O2-activated promoieties have been widely used in drugs and biomaterials design. However, the overwhelming majority of the promoieties only share the common structure of a H2O2-responsive arylboronic acid/ester moiety with low diversity. We report here an unprecedented strategy to construct novel H2O2-responsive prodrugs based on an alpha-ketoamide structure. As a proof of concept, we designed and synthesized a panel of alpha-ketoamide based nitrogen mustard prodrugs, among which KAM-2 showed potent growth inhibitory activity and high selectivity toward cancer cells. The H2O2-trigged decomposition of KAM-2 was validated, and the DNA damaging and apoptosis promoting activity attributed to the released nitrogen mustard were demonstrated. Our work unveils alpha-ketoamide as a new scaffold for prodrug design and may quickly inspire future developments.

Quality Control of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Meng, TT; Han, J; Zhang, PF; Hu, J; Fu, JJ; Yin, J or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Novel one step synthesis of imidazo[1,2-a]pyridines and Zolimidine via iron/iodine-catalyzed Ortoleva-King type protocol WOS:000480664500014 published article about WATER; AMINOPYRIDINES; DERIVATIVES; ARYLATION; ALKYNES; ARYL in [Ujwaldev, Sankuviruthiyil Mohanan; Rohit, K. R.; Harry, Nissy Ann; Anilkumar, Gopinathan] Mahatma Gandhi Univ, Sch Chem Sci, PD Hills PO, Kottayam 686560, Kerala, India in 2019.0, Cited 24.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Imidazo[1,2-a]pyridines form versatile scaffolds in pharmaceutical industry arising from their diverse biological activities. The synthesis of these molecules thus has been of great interest and resulted in the development of a large number of new methodologies. Herein we describe the first iron-catalyzed Ortoleva-King type protocol towards the synthesis of these fused heterocyclic compounds. This methodology employs cheap and easily available FeCl3 center dot 6H(2)O and molecular iodine as the catalytic system. The procedure has been well explored by extending the substrate scope with a variety of aromatic ketones and 2-aminopyridines to furnish different imidazo[1,2-a]pyridine derivatives in moderate to good yields. A successful application of this protocol was also demonstrated by achieving direct one step synthesis of the gastro protective drug, Zolimidine. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 100-19-6, If you have any questions, you can contact Ujwaldev, SM; Rohit, KR; Harry, NA; Anilkumar, G or send Email.. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Category: benzodioxans. In 2020 CHEM SCI published article about SINGLET OXYGEN GENERATION; TRIPLET EXCITED-STATE; VISIBLE-LIGHT ABSORPTION; N-HETEROCYCLIC CARBENE; BODIPY DYES; ELECTROGENERATED CHEMILUMINESCENCE; IRIDIUM(I) COMPLEXES; CARBON-MONOXIDE; PHOTOSENSITIZERS; LIGAND in [Wang, Danfeng; Malmberg, Robert; Pernik, Indrek; Roemer, Max; Venkatesan, Koushik; Keaveney, Sinead T.; Messerle, Barbara A.] Macquarie Univ, Dept Mol Sci, N Ryde, NSW 2109, Australia; [Prasad, Shyamal K. K.; Schmidt, Timothy W.] Univ New South Wales, ARC Ctr Excellence Exciton Sci, Sch Chem, Kensington, NSW 2052, Australia; [Pernik, Indrek; Roemer, Max; Messerle, Barbara A.] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia in 2020, Cited 83. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3.

While dual photocatalysis-transition metal catalysis strategies are extensively reported, the majority of systems feature two separate catalysts, limiting the potential for synergistic interactions between the catalytic centres. In this work we synthesised a series of tethered dual catalysts allowing us to investigate this underexplored area of dual catalysis. In particular, Ir(i) or Ir(iii) complexes were tethered to a BODIPY photocatalyst through different tethering modes. Extensive characterisation, including transient absorption spectroscopy, cyclic voltammetry and X-ray absorption spectroscopy, suggest that there are synergistic interactions between the catalysts. The tethered dual catalysts were more effective at promoting photocatalytic oxidation and Ir-catalysed dihydroalkoxylation, relative to the un-tethered species, highlighting that increases in both photocatalysis and Ir catalysis can be achieved. The potential of these catalysts was further demonstrated through novel sequential reactivity, and through switchable reactivity that is controlled by external stimuli (heat or light).

Category: benzodioxans. Bye, fridends, I hope you can learn more about C14H11N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about ONE-POT SYNTHESIS; KETOXIME CARBOXYLATES; VINYL AZIDES; CYCLIZATION; DIKETOPYRROLOPYRROLE; STRATEGY; VIOLACEIN; PYRIDINE; FUNCTIONALIZATION; HETEROANNULATION, Saw an article supported by the Natural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu Province [BK20181462]; Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology [BM2012110]; Advanced Catalysis and Green Manufacturing Collaborative Innovation Center. Formula: C8H7NO3. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Miao, CB; Zheng, AQ; Zhou, LJ; Lyu, XY; Yang, HT. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

A copper-catalyzed annulation of oxime acetates and alpha-amino acid ester derivatives for the easy preparation of 4-pyrrolin-2-ones bearing a 3-amino group has been developed. This process features the oxidation of amines with oxime esters as the internal oxidant to produce the active 1,3-dinucleophilic and 1,2-dielectrophilic species concurrently. The subsequent nucleophilic cyclization realizes the efficient construction of 4-pyrrolin-2-one derivatives.

Formula: C8H7NO3. Welcome to talk about 100-19-6, If you have any questions, you can contact Miao, CB; Zheng, AQ; Zhou, LJ; Lyu, XY; Yang, HT or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem