Heterocyclic Building Blocks-benzodioxan

Recently I am researching about BIOLOGICAL EVALUATION; DERIVATIVES; ANALOGS, Saw an article supported by the Natural Science Foundation of Guangdong Province, ChinaNational Natural Science Foundation of Guangdong Province [2018B030311067]; Science and Technology Program of Guangzhou City, China [201707010198]. Recommanded Product: 1-(4-Nitrophenyl)ethanone. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Huo, XS; Jian, XE; Ou-Yang, J; Chen, L; Yang, F; Lv, DX; You, WW; Rao, JJ; Zhao, PL. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

Y By removing 5-methyl and 6-acetyl groups in our previously reported compound 3, we designed a series of novel 2,7-diaryl-[1,2,4]triazolo[1,5-a]pyrimidine derivatives as potential tubulin polymerization inhibitors. Among them, compound 5e displayed low nanomolar antiproliferative efficacy on HeLa cells which was 166-fold higher than the lead analogue 3. Interestingly, 5e displayed significant selectivity in inhibiting cancer cells over HEK-293 (normal human embryonic kidney cells). In addition, 5e dose-dependently arrested HeLa in G2/M phase through the alterations of the expression levels of p-cdc2 and cyclin B1, and caused HeLa cells apoptosis by regulation of expressions of cleaved PARP. Further evidence demonstrated that 5e effectively inhibited tubulin polymerization and was 3-fold more powerful than positive control CA-4. Moreover, molecular docking analysis indicated that 5e overlapped well with CA-4 in the colchicine-binding site. These studies demonstrated that 2,7-diaryl-[1,2,4]triazolo [1,5-a]pyrimidine skeleton might be used as the leading unit to develop novel tubulin polymerization inhibitors as potential anticancer agents. (C) 2021 Elsevier Masson SAS. All rights reserved.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Huo, XS; Jian, XE; Ou-Yang, J; Chen, L; Yang, F; Lv, DX; You, WW; Rao, JJ; Zhao, PL or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Quality Control of 1-(4-Nitrophenyl)ethanone. Authors Suslick, BA; Tilley, TD in AMER CHEMICAL SOC published article about in [Suslick, Benjamin A.; Tilley, T. Don] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA; [Suslick, Benjamin A.; Tilley, T. Don] Lawrence Berkeley Natl Lab, Chem Sci Div, Berkeley, CA 94720 USA in 2021.0, Cited 49.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A single-component Co(-I) catalyst, [(PPh3)(3)Co(N-2)]Li-(THF)(3), has been developed for olefin hydroarylations with (N-aryl)aryl imine substrates. More than 40 examples were examined under mild reaction conditions to afford the desired alkyl-arene product in good to excellent yields. Catalysis occurs in a regioselective manner to afford exclusively branched products with styrene-derived substrates or linear products for aliphatic olefins. Electron-withdrawing functional groups (e.g., -F, -CF3, and -CO2Me) were tolerated under the reaction conditions.

Quality Control of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Suslick, BA; Tilley, TD or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about SELECTIVE HYDROGENATION; CHEMOSELECTIVE HYDROGENATION; FUNCTIONALIZED NITROARENES; NANOPARTICLES; CATALYSTS; NITROGEN; EFFICIENT; SILICA; NANOTUBES; REDUCTION, Saw an article supported by the . Recommanded Product: 100-19-6. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Oliveira, RL; Ben Ghorbel, MC; Praetz, S; Meiling, D; Schlesiger, C; Schomacker, R; Thomas, A. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

A general strategy to synthesize mesoporous and macroporous carbon and N-doped mesoporous carbon is presented. The immobilization of cobalt catalysts with dispersed subnanometer particles in mesoporous N-doped carbon matrixes is also shown. These materials were used as catalysts for the hydrogenation of nitroarenes under considerably mild conditions. The surface area and the presence of nitrogen on the supports were demonstrated to be fundamental to disperse and stabilize the active metal species, which were responsible for the outstanding performance of these materials compared to cobalt catalysts deposited on silica, alumina, or mesoporous carbon. Finally, the ability to catalyze the hydrogenation of nitroarenes containing electron-donating groups (EDGs) and electron-withdrawing groups (EWGs) with good selectivity was also explored.

Recommanded Product: 100-19-6. Welcome to talk about 100-19-6, If you have any questions, you can contact Oliveira, RL; Ben Ghorbel, MC; Praetz, S; Meiling, D; Schlesiger, C; Schomacker, R; Thomas, A or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Quality Control of 1-(4-Nitrophenyl)ethanone. In 2019.0 DYES PIGMENTS published article about HIGHLY SELECTIVE DETECTION; OXIDATIVE STRESS; BORONATE; H2O2; GLUTATHIONE; CANCER in [Huang, Xin; Li, Zhipeng; Liu, Zixin; Zeng, Chengchu; Hu, Liming] Beijing Univ Technol, Beijing Key Lab Environm & Oncol, Coll Life Sci & Bioengn, Beijing 100124, Peoples R China in 2019.0, Cited 44.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Hydrogen peroxide (H2O2) can be produced in mitochondria and plays a significant role in physiological metabolism. Overproduction of H2O2 is a hallmark of many diseases. Therefore, it is very important to develop a highly sensitive method for detecting H2O2 both in vivo and in vitro. Previously reported benzil-based fluorescence probes are superior to those based on boronate ester in terms of reaction selectivity. However, the near infrared (NIR) probe with biocompatibility has been rarely reported for the detection of endogenous hydrogen peroxide and the real-time imaging in biological system. Hemicyanine skeleton has been proven to be effective scaffold for NM fluorescent probes for non-invasive optical imaging in vivo. In this paper, a Cy-H2O2 probe for real-time monitoring hydrogen peroxide in organisms was designed by modifying the NIR hemicyanine framework with benzil moiety. The results showed that Cy-H2O2 exhibits high specificity and sensitivity, and has good water solubility and short response time (within 10 min) for detection of hydrogen peroxide in vitro and in vivo. The reaction mechanism was deduced by detecting product of the fluorescent probe reacting with hydrogen peroxide using HPLC. The probe shows a good linear relationship for the specific response to H2O2 within the concentration range of 0-7 mu M and the detection limit is 65 nM. In addition, the probe Cy-H2O2 has been successfully applied to H2O2 detection in living cells and zebrafish.

Quality Control of 1-(4-Nitrophenyl)ethanone. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Application In Synthesis of 1-(4-Nitrophenyl)ethanone. In 2021.0 DALTON T published article about CHEMOSELECTIVE HYDROGENATION; COBALT ATOMS; REDUCTION; CATALYSTS; NANOPARTICLES; NITROARENES; GRAPHENE; STRATEGY; NITRIDE; ALLOY in [Liu, Yan; Zhang, Wenzhuang; Zheng, Yamin; Dong, Panpan; Lu, Ning; Mao, Junjie] Anhui Normal Univ, Key Lab Funct Mol Solids, Minist Educ, Anhui Prov Key Lab Optoelect Mat Sci & Technol, Wuhu 241002, Peoples R China; [Liu, Yan; Zhang, Wenzhuang; Zheng, Yamin; Dong, Panpan; Lu, Ning; Mao, Junjie] Anhui Normal Univ, Anhui Lab Mol Mat, Wuhu 241002, Peoples R China; [Wu, Konglin] Anhui Univ Technol, Sch Chem & Chem Engn, Maanshan 243002, Peoples R China; [He, Rong] Southwest Univ Sci & Technol, State Key Lab Environm Friendly Energy Mat, Mianyang 621010, Sichuan, Peoples R China in 2021.0, Cited 40.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

The hydrogenation of nitrobenzene to aniline is an important process in the industry of fine chemicals, but developing inexpensive catalysts with expected activity and selectivity still remains a challenge. By using density functional theory calculations, we demonstrated that the isolated Fe atom not only can weaken the adsorption of reactants and reaction intermediates as compared to Fe nanoparticles, but also remarkably decrease the reaction barrier for the hydrogenation of nitrobenzene to aniline. Thus, the Fe single-atom (Fe SA) catalyst is considered as an ideal catalyst for this reaction. This theoretical prediction has been subsequently confirmed by experimental results obtained for the Fe SAs loaded on N-doped hollow carbon spheres (Fe SAs/NHCSs) which achieved a conversion of 99% with a selectivity of 99% for the hydrogenation of nitrobenzene. The results significantly outperformed the Fe nanoparticles for this reaction. This work provides theoretical insight for the rational design of new catalytic systems with excellent catalytic properties.

Welcome to talk about 100-19-6, If you have any questions, you can contact Liu, Y; Zhang, WZ; Zheng, YM; Wu, KL; Dong, PP; He, R; Lu, N; Mao, JJ or send Email.. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about TARGETING TUBULIN; DISCOVERY; ANALOGS; AFFINITY; SERIES, Saw an article supported by the Mashhad university of medical sciences. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Oskuei, SR; Mirzaei, S; Jafari-Nik, MR; Hadizadeh, F; Eisvand, F; Mosaffa, F; Ghodsi, R. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Novel imidazole-chalcone derivatives were designed and synthesized as tubulin polymerization inhibitors and anticancer agents. The antiproliferative activity of the imidazole-chalcone was assessed on some human cancer cell lines including A549 (adenocarcinoma human alveolar basal epithelial cells), MCF-7 (human breast cancer cells), MCF-7/MX (mitoxantrone resistant human breast cancer cells), and HEPG2 (human hepatocellular carcinoma cells). Generally, the imidazole-chalcone derivatives exhibited more cytotoxicity on A549 cancer cells in comparison to the other three cell lines, among them compounds 9j’ and 9g showed significant cytotoxicity with IC50 values ranging from 7.05 to 63.43 mu M against all the four human cancer cells. The flow cytometry analysis of A549 cancer cells treated with 9g and 9j’ displayed that these compounds induced cell cycle arrest at the G2/M phase at low concentrations and increased the number of apoptotic cells (cells in subG1 phase) at higher concentrations. They have also inhibited tubulin polymerization similar to combretastatin A-4 (CA-4). Annexin V binding staining assay in A549 cancer cells revealed that compound 9j’ induced apoptosis (early and late). Finally, molecular docking studies of 9j’ into the colchicine-binding site of tubulin presented the probable interactions of these compounds with tubulin.

Application In Synthesis of 1-(4-Nitrophenyl)ethanone. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about N-TOSYLHYDRAZONES; ENANTIOSELECTIVE SYNTHESIS; SULFONYL HYDRAZONES; SIMPLE OLEFINS; BOND-CLEAVAGE; CONSTRUCTION; HETEROCYCLES; DERIVATIVES; ROUTE; ISOCYANIDES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21901124]; Jiangsu University Natural Science Research Program [19KJB150032, 19KJB610013]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019M651809]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Feng, JJ; He, TT; Xie, YX; Yu, Y; Baell, JB; Huang, F. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Computed Properties of C8H7NO3

A facile and efficient strategy for the synthesis of 1,4-dihydropyridazines and pyridazines through I-2-promoted [4 + 2] cycloaddition of in situ generated azoalkenes with enaminones has been developed. The switch in selectivity is attributed to the judicious choice of different reaction temperatures. The key features of this work include controllable and selective synthesis, good functional group tolerance, good to excellent reaction yields, metal/base-free conditions, and also applicability to one-pot methodology.

Welcome to talk about 100-19-6, If you have any questions, you can contact Feng, JJ; He, TT; Xie, YX; Yu, Y; Baell, JB; Huang, F or send Email.. Computed Properties of C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 100-19-6. Liu, CJ; Mei, M; Zang, LM; Zhou, HF; Huang, XH; Wei, C in [Liu, Chanjuan; Mei, Mei; Zang, Limin; Zhou, Huanfu; Huang, Xiaohua; Wei, Chun] Guilin Univ Technol, Collaborat Innovat Ctr Explorat Hidden Nonferrous, Key Lab New Proc Technol Nonferrous Met & Mat, Minist Educ,Sch Mat Sci & Engn, Guilin 541004, Peoples R China published Highly Thermally Stable, Organosoluble, and Hydrophobic Polyimides with Pyrrolidinylphenyl Pendant Groups and Pyridine Units in 2019.0, Cited 37.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A novel diamine monomer, 4-{4-(1-pyrrolidinyl)phenyl}-2,6-bis(4-aminophenyl) pyridine (PPAP), was synthesized using 4-(1-pyrrolidinyl)benzaldehyde as starting material, and a series of aromatic polyimides were prepared using PPAP and five aromatic dianhydrides by a two-step imidization method. The structure and properties of as-prepared polyimides were studied by Fourier transform infrared spectrometer (FTIR), nuclear magnetic resonance (NMR), thermogravimetric analysis (TG), differential scanning calorimetry (DSC), and wide angle X-ray diffraction (WAXD). The results indicated that these polymers had good solubility in highboiling organic solvents upon heating, such as N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO) and N-methyl-2-pyrrolidone (NMP). Furthermore, they had outstanding thermal properties with the glass transition temperature (T-g) exceeding 354 degrees C, as well as T-5% and T-10% mass loss temperature under a nitrogen atmosphere in the range of 521534 oC and 544594 oC, respectively. Moreover, they exhibited excellent hydrophobic properties with the contact angles ranging from 82.7 to 90.5 degrees. In addition, the results of WAXD showed that these polyimides exhibited the structure of amorphous polymers.

Recommanded Product: 100-19-6. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Application In Synthesis of 1-(4-Nitrophenyl)ethanone. I found the field of Chemistry very interesting. Saw the article Transfer Hydrogenation of Ketones and Imines with Methanol under Base-Free Conditions Catalyzed by an Anionic Metal-Ligand Bifunctional Iridium Catalyst published in 2020.0, Reprint Addresses Li, F (corresponding author), Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Peoples R China.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.

An anionic iridium complex [Cp*Ir(2,2′-bpyO)(OH)][Na] was found to be a general and highly efficient catalyst for transfer hydrogenation of ketones and imines with methanol under base-free conditions. Readily reducible or labile substituents, such as nitro, cyano, and ester groups, were tolerated under present reaction conditions. Notably, this study exhibits the unique potential of anionic metal-ligand bifunctional iridium catalysts for transfer hydrogenation with methanol as a hydrogen source.

Welcome to talk about 100-19-6, If you have any questions, you can contact Wang, RZ; Han, XY; Xu, J; Liu, P; Li, F or send Email.. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Transition Metal Oxide-Modified Ir Nanoparticles Supported on SBA-15 Silica for Selective Hydrogenation of Substituted Nitroaromatics WOS:000677582900072 published article about CHEMOSELECTIVE HYDROGENATION; CATALYTIC-SYSTEM; CARBON; FE; NITROBENZENE; EFFICIENCY; OXIDATION; ANILINE; SIZE; THIN in [Wu, Chunzheng] Zhejiang A&F Univ, Coll Sci, Hangzhou 311300, Zhejiang, Peoples R China; [Yu, Hongbo; Wang, Shiwei; Li, Tong; Yin, Hongfeng] Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China in 2021.0, Cited 46.0. Safety of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Modification of active metals with metal oxide modifiers has attracted considerable attention in heterogeneous catalysis due to their synergistic effect. However, a controllable synthesis of highly reactive and stable metal-metal oxide hybrid nanocatalysts is difficult. To solve this problem, presynthesized IrM (M = Fe, Co, and Ni) bimetallic nanoparticles were initially confined in the mesopores of SBA-15 and were then in situ transformed to Ir-MOx hybrids. The obtained Ir-MOx/SBA-15 nanocatalysts show superior activity and selectivity in the hydrogenation of substituted nitroaromatics to corresponding aromatic amines compared to Ir/SBA-15. Among these Ir-based catalysts, Ir-FeOx/SBA-15 exhibits the highest activity and selectivity and has a wider substrate scope due to the interaction between Ir and FeOx. Therefore, our research provides a way to design reactive and stable hydrogenation catalysts.

Welcome to talk about 100-19-6, If you have any questions, you can contact Yu, HB; Wu, CZ; Wang, SW; Li, T; Yin, HF or send Email.. Safety of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem