Heterocyclic Building Blocks-benzodioxan

Safety of 1-(4-Nitrophenyl)ethanone. Recently I am researching about LAYERED DOUBLE HYDROXIDE; OXIDATIVE MANNICH REACTION; MIXED-METAL OXIDES; TERTIARY-AMINES; HIGHLY EFFICIENT; H FUNCTIONALIZATION; CARBONYL-COMPOUNDS; HYDROGEN-PEROXIDE; AEROBIC OXIDATION; ACTIVE CATALYSTS, Saw an article supported by the Advanced Catalysis and Green Manufacturing Collaborative Innovation Center of Changzhou University; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD); Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology [BM2012110]; Postgraduate Research &Practice Innovation Program of Jiangsu Province [KYCX19_1746]; Qinglan Project of Jiangsu Province; Natural Science Foundation of Jiangsu Province of ChinaNatural Science Foundation of Jiangsu Province [BK20181461]. Published in ELSEVIER in AMSTERDAM ,Authors: Zhou, WY; Lu, WMZ; Wang, H; Xia, ZZ; Zhai, SY; Zhang, Z; Ma, YJ; He, MY; Chen, Q. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

CuMgAl layered double hydroxide compounds (CuMgAl-LDHs) have been synthesized, characterized and in-vestigated in the aerobic CDC reactions. The results indicated that NH3 center dot H2O coprecipitated CuMgAl LDH (N-CuMgAl-LDH) was able to efficiently accelerate the CDC reactions between the alpha-Csp(3)-H of N-aryltetrahy-droisoquinolines and nucleophiles. A wide scope of N-aryltetrahydroisoquinoline analogues and nucleophiles with different C-H bonds (C-sp3-H, C-sp2-H and Csp-H) could be tolerated by the N-CuMgAl-LDH system. Compared with the sample using Na2CO3 as the precipitant (C-CuMgAl-LDH), N-CuMgAl-LDH showed higher catalytic activity, which probably was due to its higher surface acidity. Dual function of redox and acidity for the N-CuMgAl-LDH catalyst has been observed in the CDC reaction. According to the obtained catalytic results, kinetic isotope effect experiment and XPS analysis, iminium ion was proposed as the key intermediate, made possible by the cycle of Cu2+ and Cu+ under the aerobic conditions.

Welcome to talk about 100-19-6, If you have any questions, you can contact Zhou, WY; Lu, WMZ; Wang, H; Xia, ZZ; Zhai, SY; Zhang, Z; Ma, YJ; He, MY; Chen, Q or send Email.. Safety of 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about DERIVATIVES, Saw an article supported by the . Published in SPRINGER in NEW YORK ,Authors: Gurevich, KG; Urakov, AL; Klen, EE; Samorodov, AV; Nikitina, IL; Khaliullin, FA; Nebogatova, VA; Makarova, NN; Shepilova, SO; Bashirova, LI; Khalimov, AR. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Application In Synthesis of 1-(4-Nitrophenyl)ethanone

Ethyl 2-[8-Arylmethylidenehydrazino-3-methyl-7-(1-oxothietan-3-yl)xanth-1-yl]acetates (IV) were synthesized via reactions of ethyl 2-[8-hydrazino-3-methyl-7-(1-oxothietan-3-yl)xanth-1-yl]acetic acid (III) with various benzaldehydes and acetophenones. The structures of the compounds were elucidated using IR and NMR spectroscopy and elemental analysis. The antiplatelet, anticoagulation, antioxidant, and anti-inflammatory activities were assessedin vitroand in laboratory animals to identify promising compounds exhibiting antiplatelet (hydrazoneIVd) and antioxidant properties (hydrazoneIVb). BothIVbandIVdaccording toin silicocalculations were characterized by the absence of toxic risks (mutagenicity, oncogenicity, reproductive toxicity, local irritation) and had acceptable topological polar surface area so that they were promising.

Application In Synthesis of 1-(4-Nitrophenyl)ethanone. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Authors Rammurthy, B; Peraka, S; Vasu, A; Sai, GK; Rohini, YD; Narender, N in WILEY-V C H VERLAG GMBH published article about BAEYER-VILLIGER OXIDATION; RETRO-CLAISEN CONDENSATION; C-NUCLEOSIDE SYNTHESIS; CARBON-CYANO; DIRECT CONVERSION; ORGANIC-ACIDS; HALLER-BAUER; CLEAVAGE; ESTERS; MILD in [Rammurthy, Banothu; Peraka, Swamy; Vasu, Amrutham; Sai, Gajula Krishna; Rohini, Yennamaneni Divya; Narender, Nama] Acad Sci & Innovat Res, CSIR HRDG Campus,Sect 19, Ghaziabad 201002, UP, India; [Rammurthy, Banothu; Peraka, Swamy; Vasu, Amrutham; Sai, Gajula Krishna; Rohini, Yennamaneni Divya; Narender, Nama] CSIR Indian Inst Chem Technol, C&FC Div, Hyderabad 500007, Telangana, India in 2021, Cited 88. COA of Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A novel metal-free catalytic one-pot approach has been developed for the esterification of aralkyl ketones with alcohols under open-air atmospheric conditions. The inexpensive iodide/oxone reagent system allowed the cascade C(sp(3))-H bond oxygenation, selective C-C bond cleavage and esterification through the both radical and ionic pathways in a stepwise manner in one-pot. This mild, convenient and economically viable catalytic method tolerates the various functional groups to provide the corresponding alkyl benzoates in up to 98% yields with up to 99% selectivity. The efficiency and feasibility of scale-up of the present catalytic system was demonstrated with gram scale experiments (up to 10 gram scale).

Welcome to talk about 100-19-6, If you have any questions, you can contact Rammurthy, B; Peraka, S; Vasu, A; Sai, GK; Rohini, YD; Narender, N or send Email.. COA of Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Sanad, SMH; Mekky, AEM in [Sanad, Sherif M. H.; Mekky, Ahmed E. M.] Cairo Univ, Fac Sci, Chem Dept, Giza 12613, Egypt published Synthesis, cytotoxicity and in vitro antibacterial screening of novel hydrazones bearing thienopyridine moiety as potent COX-2 inhibitors in 2020.0, Cited 58.0. Safety of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

The starting precursors 2-carbohydrazides, bearing thienopyridine moiety, were prepared using 2-thioxopyridine-3-carbonitriles as key synthons. Next, 2-carbohydrazides were reacted with a variety of 4-substituted benzylidinemalononitriles or 4-substituted benzaldehydes to afford a new series of the target hydrazones incorporating thienopyridine moiety. The elemental analyses and spectral data were used to demonstrate the structures of new hydrazones series. The in vitro antibacterial activities of the target hydrazones were evaluated against different strains of Gram-positive and Gram-negative bacteria. In comparison with chloramphenicol as a reference drug, hydrazones 13b, 13c and 13d, linked to p-C1, p-Br and p-Me moiety, respectively, exhibited the strongest activities against all tested bacteria with MIC values in the range of 6.2-12.5 mu g/mL. In addition, several new hydrazones were tested as in vitro cytotoxic agents against each of human breast carcinoma MCF-7 cell line, colon cancer Caco2 cell line and liver hepatocellular carcinoma HEPG2 cell line. The hydrazones 13b, 13c and 13d demonstrated the best cytotoxicity against the tested eukaryotic cells. Furthermore, both experimental and docking studies could predict the promising inhibitory activities of hydrazones 13c and 13d against COX-2 enzyme with IC 50 of 0.110 and 0.104 mu M, respectively, when compared with Celecoxib (IC50 of 0.115 mu M). [GRAPHICS] .

Safety of 1-(4-Nitrophenyl)ethanone. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about C-H ACTIVATION; 3+2 ANNULATION; CATALYZED SYNTHESIS; ACCESS; KETIMINES; FUNCTIONALIZATION; CYCLIZATION; VERSATILE; SYNTHONS; INDOLES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21425415, 21774056]; National Basic Research Program of ChinaNational Basic Research Program of China [2015CB856303]; Science and Technology Department of Jiangsu Province [BRA2017360, BK20181255]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Liu, ZS; Zhang, WJ; Guo, S; Zhu, J. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Transition-metal-catalyzed C-H activation synthesis of heterocyclic spiro[4,4]nonanes has persistently witnessed the use of additional stoichiometric transition-metal oxidant when employing C=C bond as the Spiro ring closure site. Herein, we have addressed the issue by reporting a redox-neutral strategy for spiro[indene-1,4′-oxa-zolidinones] synthesis via Rh(III)-catalyzed coupling of 4-phenyl-1,3-oxazol-2(3H)-ones with alkynes. The synthesis features a broad substrate scope and high regiospecificity.

Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Syntheses and evaluation of new Quinoline derivatives for inhibition of hnRNP K in regulating oncogene c-myc transcription WOS:000462472500001 published article about NUCLEAR RIBONUCLEOPROTEIN-K; CARBON NANOTUBES BINDING; I-MOTIF DNA; CELL-PROLIFERATION; STRANDED-DNA; G-QUADRUPLEX; PROMOTER; PROTEIN; METASTASIS; MECHANISM in [Shu, Bing; Zeng, Ping; Kang, Shuangshuang; Li, Peng-Hui; Hu, Dexuan; Kuang, Guotao; Cao, Jiaojiao; Li, Xiaoya; Zhang, Meiling; An, Lin-Kun; Huang, Zhi-Shu; Li, Ding] Sun Yat Sen Univ, Sch Pharmaceut Sci, 132 Waihuan East Rd, Guangzhou 510006, Guangdong, Peoples R China; [Shu, Bing] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China in 2019, Cited 54. Name: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Aberrant overexpression of heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a key feature in oncogenesis and progression of many human cancers. hnRNP K has been found to be a transcriptional activator to up-regulate c-myc gene transcription, a critical proto-oncogene for regulation of cell growth and differentiation. Therefore, down-regulation of c-myc transcription by inhibiting hnRNP K through disrupting its binding to c-myc gene promoter is a potential approach for cancer therapy. In the present study, we synthesized and screened a series of Quinoline derivatives and evaluated their binding affinity for hnRNP K. Among these derivatives, (E)-1-(4-methoxyphenyl)-3-(4 morpholino-6-nitroquinolin-2-yl)prop-2-en-1-one (compound 25) was determined to be the first-reported hnRNP K binding ligand with its K-D values of 4.6 and 2.6 mu M measured with SPR and MST, respectively. Subsequent evaluation showed that the binding of compound 25 to hnRNP K could disrupt its unfolding of c-myc promoter i-motif, resulting in down-regulation of c-myc transcription. Compound 25 showed a selective anti-proliferative effect on human cancer cell lines with IC50, values ranged from 1.36 to 3.59 mu M. Compound 25 exhibited good tumor growth inhibition in a Hela xenograft tumor model, which might be related to its binding with hnRNP K. These findings illustrated that inhibition of DNA-binding protein hnRNP K by compound 25 could be a new and selective strategy of regulating oncogene transcription instead of targeting promoter DNA secondary structures such as G-quadruplexes or i-motifs.

Name: 1-(4-Nitrophenyl)ethanone. Welcome to talk about 100-19-6, If you have any questions, you can contact Shu, B; Zeng, P; Kang, SS; Li, PH; Hu, DX; Kuang, GT; Cao, JJ; Li, XY; Zhang, ML; An, LK; Huang, ZS; Li, D or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 MOL DIVERS published article about BENZAMIDE; DISCOVERY; ALPHA; ACIDS in [Nian, Si-Yun; Jiang, Zheng-Li] Taizhou Hosp Zhejiang Prov, Dept Clin Pharm, Xi Men St 150, Linhai 317000, Zhejiang, Peoples R China; [Nian, Si-Yun; Wang, Guo-Ping; Xiao, Ying] China State Inst Pharmaceut Ind, Shanghai Inst Pharmaceut Ind, Shanghai 201203, Peoples R China; [Nian, Si-Yun; Wang, Guo-Ping] Aurisco Pharmaceut Yangzhou Co Ltd, Yangzhou 225100, Jiangsu, Peoples R China; [Huang, Mo-Han; Zhou, Yi-Huan; Tan, Xiang-Duan] Guilin Med Univ, Coll Pharm, Guilin 541004, Peoples R China in 2019.0, Cited 21.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. COA of Formula: C8H7NO3

Most of reported steroidal FXR antagonists are restricted due to low potency. We described the design and synthesis of novel nonsteroidal scaffold SIPI-7623 derivatives as FXR antagonists. The most potent compound A-11 (IC50 = 7.8 +/- 1.1 mu M) showed better activity compared to SIPI-7623 (IC50 = 40.8 +/- 1.7 mu M) and guggulsterone (IC50 = 45.9 +/- 1.1 mu M). Docking of A-11 in FXR’s ligand-binding domain was also studied.

Welcome to talk about 100-19-6, If you have any questions, you can contact Nian, SY; Wang, GP; Jiang, ZL; Xiao, Y; Huang, MH; Zhou, YH; Tan, XD or send Email.. COA of Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about CHEMISTRY; COMPLEXES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21871029, 21573021, 21672024]; Deutsche Forschungsgemeinschaft (DFG) through the Heisenberg programGerman Research Foundation (DFG) [WA 2513/6]; Projekt DEAL. Product Details of 86-29-3. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Wang, DQ; Ding, WJ; Hou, GH; Zi, GF; Walter, MD. The CAS is 86-29-3. Through research, I have a further understanding and discovery of 2,2-Diphenylacetonitrile

The synthesis, electronic structure, and reactivity of a uranium metallacyclopropene were comprehensively studied. Addition of diphenylacetylene (PhC equivalent to CPh) to the uranium phosphinidene metallocene [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U=P-2,4,6-tBu(3)C(6)H(2) (1) yields the stable uranium metallacyclopropene, [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U[eta(2)-C2Ph2] (2). Based on density functional theory (DFT) results the 5f orbital contributions to the bonding within the metallacyclopropene U-(eta(2)-C=C) moiety increases significantly compared to the related Th-IV compound [eta(5)-1,2,4-(Me3C)(3)C5H2](2)Th[eta(2)-C2Ph2], which also results in more covalent bonds between the [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U2+ and [eta(2)-C2Ph2](2-) fragments. Although the thorium and uranium complexes are structurally closely related, different reaction patterns are therefore observed. For example, 2 reacts as a masked synthon for the low-valent uranium(II) metallocene [eta(5)-1,2,4-(Me3C)(3)C5H2](2)U-II when reacted with Ph2E2 (E=S, Se), alkynes and a variety of hetero-unsaturated molecules such as imines, ketazine, bipy, nitriles, organic azides, and azo derivatives. In contrast, five-membered metallaheterocycles are accessible when 2 is treated with isothiocyanate, aldehydes, and ketones.

Welcome to talk about 86-29-3, If you have any questions, you can contact Wang, DQ; Ding, WJ; Hou, GH; Zi, GF; Walter, MD or send Email.. Product Details of 86-29-3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2020.0 RSC ADV published article about CONTINUOUS-FLOW PROCESS; CONVERSION; NITROBENZENE; DERIVATIVES; REDUCTION; NITRATION in [Xu, Feng; Chen, Jian-Li; Cheng, Peng-Fei; Yu, Zhi-Qun; Su, Wei-Ke] Zhejiang Univ Technol, Natl Engn Res Ctr Proc Dev Act Pharmaceut Ingredi, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China; [Su, Wei-Ke] Zhejiang Univ Technol, Coll Pharmaceut Sci, Key Lab Green Pharmaceut Technol & Related Equipm, Minist Educ, Hangzhou 310014, Peoples R China; [Jiang, Zhi-Jiang] Ningbo Tech Univ, Sch Biol & Chem Engn, Ningbo 315100, Peoples R China in 2020.0, Cited 31.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Name: 1-(4-Nitrophenyl)ethanone

In this contribution, a protocol was established for the selective catalytic hydrogenation of nitroarenes to the correspondingN-arylhydroxylamines. The reduction of 1-(4-chlorophenyl)-3-((2-nitrobenzyl)oxy)-1H-pyrazole, an intermediate in the synthesis of the antifungal reagent pyraclostrobin that includes carbon-chlorine bonds, benzyl groups, carbon-carbon double bonds and other structures that are easily reduced, was chosen as the model reaction for catalyst evaluation and condition optimization. Extensive passivant evaluation showed that RANEY (R)-nickel treated with ammonia/DMSO (1 : 10, v/v) afforded the optimal result, especially with a particle size of 400-500 mesh. To combine the modified catalyst with continuous-flow reaction technology, the reaction was conducted at room temperature, rendering the desired product with a conversion rate of 99.4% and a selectivity of 99.8%. The regeneration of catalytic activity was also studied, and an in-column strategy was developed by pumping the passivate liquid overnight. Finally, the generality of the method was explored, and 7 substrates were developed, most of which showed a good conversion rate and selectivity, indicating that the method has a certain degree of generality.

Name: 1-(4-Nitrophenyl)ethanone. Welcome to talk about 100-19-6, If you have any questions, you can contact Xu, F; Chen, JL; Jiang, ZJ; Cheng, PF; Yu, ZQ; Su, WK or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

COA of Formula: C14H11N. In 2020 ORG LETT published article about FLUOROCARBON DERIVATIVES; NITROGEN; SILVER; ACID; CONSTRUCTION; COORDINATION; HYDROCARBONS; INDOLIZINES in [Li, Qiang-Qiang; Ochiai, Kotaro; Lee, Cherie-Anne; Ito, Shingo] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore in 2020, Cited 68. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3.

Here we report the 1,3-dipolar cycloaddition of polycyclic aromatic azomethine ylides with nitriles to produce highly fused imidazole derivatives, that is, tribenzo[b,g,ij]imidazo-[2,1,5-de]quinolizine. The advantages of this transformation are the broad substrate scope and the good functional group compatibility. The subsequent palladium-catalyzed intramolecular cyclization provides an efficient approach to further pi-extended imidazoles, that is, 14b(1),15-diazadibenzo[fg,ij]cyclopenta[rst]pentaphene.

Welcome to talk about 86-29-3, If you have any questions, you can contact Li, QQ; Ochiai, K; Lee, CA; Ito, S or send Email.. COA of Formula: C14H11N

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem