Heterocyclic Building Blocks-benzodioxan

I found the field of Chemistry very interesting. Saw the article Synthesis of pi-Extended Imidazoles by 1,3-Dipolar Cycloaddition of Polycyclic Aromatic Azomethine Ylides with Nitriles published in 2020. Name: 2,2-Diphenylacetonitrile, Reprint Addresses Ito, S (corresponding author), Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore.. The CAS is 86-29-3. Through research, I have a further understanding and discovery of 2,2-Diphenylacetonitrile

Here we report the 1,3-dipolar cycloaddition of polycyclic aromatic azomethine ylides with nitriles to produce highly fused imidazole derivatives, that is, tribenzo[b,g,ij]imidazo-[2,1,5-de]quinolizine. The advantages of this transformation are the broad substrate scope and the good functional group compatibility. The subsequent palladium-catalyzed intramolecular cyclization provides an efficient approach to further pi-extended imidazoles, that is, 14b(1),15-diazadibenzo[fg,ij]cyclopenta[rst]pentaphene.

Name: 2,2-Diphenylacetonitrile. Welcome to talk about 86-29-3, If you have any questions, you can contact Li, QQ; Ochiai, K; Lee, CA; Ito, S or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recently I am researching about ENANTIOSELECTIVE SYNTHESIS; TRANSFER HYDROGENATION; ALIPHATIC-KETONES; SILICON-COMPOUNDS; PENTACOORDINATE; REAGENTS; PHOSPHORUS; REACTIVITY; COMPLEXES, Saw an article supported by the Northern Illinois University; Ryerson University. Name: 1-(4-Nitrophenyl)ethanone. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Skrypai, V; Varjosaari, SE; Azam, F; Gilbert, TM; Adler, MJ. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

The asymmetric direct reductive amination of prochiral ketones with aryl amines using 1-hydrosilatrane with a chiral Bronsted acid catalyst is reported. This is the first known example of chiral Bronsted acid-catalyzed asymmetric reductive amination using a silane as the hydride source. The reaction features a highly practical reducing reagent and proceeds efficiently at room temperature without a specialized reaction setup or equipment to exclude air or moisture. This method provides high conversion and enantiomeric excess up to 84% of the desired chiral secondary amines with minimal side products.

Welcome to talk about 100-19-6, If you have any questions, you can contact Skrypai, V; Varjosaari, SE; Azam, F; Gilbert, TM; Adler, MJ or send Email.. Name: 1-(4-Nitrophenyl)ethanone

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Quality Control of 2,2-Diphenylacetonitrile. Recently I am researching about H BOND ACTIVATION; SELECTIVE CATALYTIC-HYDROGENATION; HEXAHYDRIDE COMPLEX; LIGANDS PREPARATION; N-H; DEHYDROGENATION; HYDRIDE; VINYLIDENE; RUTHENIUM; REACTIVITY, Saw an article supported by the MINECO of Spain [CTQ2017-82935-P, RED2018-102387-T]; Gobierno de AragonGobierno de Aragon [E06_20R, LMP148_18]; FEDEREuropean Commission; European Social FundEuropean Social Fund (ESF). Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Babon, JC; Esteruelas, MA; Lopez, AM; Onate, E. The CAS is 86-29-3. Through research, I have a further understanding and discovery of 2,2-Diphenylacetonitrile

The transformation of alkyl nitriles to symmetrical and asymmetrical secondary aliphatic amines promoted by the hexahydride complex OsH6 ((PPr3)-Pr-i)(2) (1) is described, and the mechanisms of the reactions involved are established. Complex 1 catalyzes the aforementioned transformations of aryl-, pyridyl-, and alkoxy-functionalized alkyl nitriles with linear or branched chains. The formation of the secondary amines involves primary imines, primary amines, and secondary imines as organic intermediates. The reactions take place under mild conditions (toluene, 100 degrees C, and 4 bar of H-2). Stoichiometric reactions of 1 with pivalonitrile and 2-methoxyacetonitrile have allowed us to isolate the trihydride azavinylidene derivatives OsH3{=N=CHR}((PPr3)-Pr-i)(2) (R = Bu-t (3), CH2OMe (4)). Their formation involves the insertion of the N-C triple bond of the substrates into an Os-H bond of the unsaturated tetrahydride OsH4 ((PPr3)-Pr-i)(2) (A), which is generated by reductive elimination of H-2 from the hexahydride precursor. The reaction of these trihydride azavinylidene species with H-2 is the key step for the reduction of the N-C triple bond of the nitriles. In the absence of H-2, the attack of A to the azavinylidene ligand produces the rupture of its C(sp(2))-C(sp(3)) bond. As a consequence of this attack and the presence of primary imines and amines in the reaction media, the binuclear complexes ((PPr3)-Pr-i)(2) H4Os(mu-CN)OsH3{kappa(1)-N-(NH= CHCH2OMe)}((PPr3)-Pr-i)(2) (5) and ((PPr3)-Pr-i)(2)H4Os(mu-CN)OsH3{kappa(1)-N-(NH2CH2CH2OMe)}((PPr3)-Pr-i)(2) (6) have been isolated and characterized by X-ray diffraction analysis, for 2-methoxyacetonitrile. DFT calculations reveal noticeable similarities between the hydrogenations of nitriles to primary imines and those of primary imines to primary amines.

Quality Control of 2,2-Diphenylacetonitrile. Bye, fridends, I hope you can learn more about C14H11N, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Efficient aerobic oxidation of ethylbenzene accelerated by cu species in hydrotalcite WOS:000600589400004 published article about PHASE SELECTIVE OXIDATION; METAL-ORGANIC FRAMEWORK; 1 ATM; N-HYDROXYPHTHALIMIDE; CATALYTIC-OXIDATION; ACETOPHENONE; SYSTEM; ALKYLAROMATICS; COMPLEX; KETONES in [Dai, Xuan; Li, Xingyan; Tang, Shuangling; Peng, Xinhua] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Peoples R China; [Zheng, Xuegen; Jiang, Ou] Sinopec Anqing Petrochem Co, Anqing 246000, Peoples R China in 2021.0, Cited 35.0. Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

The simply prepared CuMgAl hydrotalcite (CuMgAl-LDH) has been developed as an efficient catalyst for the aerobic oxidation of ethylbenzene to acetophenone in the presence of N-Hydroxyphthalimide (NHPI). Various alkyl arenes could be tolerated under the selected reaction conditions. The kinetic study showed that the oxidation of ethylbenzene is a first-order reaction over CuMgAl-LDH. The mechanism study indicated that CuMgAl-LDH could accelerate not only the conversion of ethylbenzene, but also the transformation of the alcohol intermediate to ketone. The positive effect of surface basicity of the catalyst on the reaction has been observed in the aerobic oxidation of the ethylbenzene.

Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Dai, X; Li, XY; Tang, SL; Peng, XH; Zheng, XG; Jiang, O or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article The use of enaminones and enamines as effective synthons for MSA-catalyzed regioselective synthesis of 1,3,4-tri- and 1,3,4,5-tetrasubstituted pyrazoles WOS:000491347800004 published article about DNA GYRASE INHIBITORS; ANTIBACTERIAL ACTIVITY; KETONES; LIGANDS; DERIVATIVES; HYDRAZONES; AMINATION in [Duan, Liancheng; Zhou, Hui; Gu, Yucheng; Gong, Ping; Qin, Mingze] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China; [Duan, Liancheng; Zhou, Hui; Gu, Yucheng; Gong, Ping; Qin, Mingze] Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England in 2019.0, Cited 31.0. Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

In the present work, an efficient regioselective synthesis of 1,3,4-tri- and 1,3,4,5-tetrasubstituted pyrazoles via a methanesulfonic acid (MSA)-catalyzed reaction of hydrazones with enaminones or enamines is reported. Mechanistically, the formation of the title compounds involves the [2+3] cycloaddition of hydrazones with enaminones or enamines followed by aromatization with acid and oxygen. This convenient method under mild conditions with various hydrazones, enaminones, and enamines was well-tolerated to afford products in good to excellent yields. Compared with the literature methods, this strategy has advantages such as materials that are available economically, metal-free catalysis, excellent regioselectivity, and high efficiency.

Formula: C8H7NO3. Welcome to talk about 100-19-6, If you have any questions, you can contact Duan, LC; Zhou, H; Gu, YC; Gong, P; Qin, MZ or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 100-19-6. Zaini, MF; Razak, IA; Khairul, WM; Arshad, S in [Zaini, Muhamad Fikri; Razak, Ibrahim Abdul; Arshad, Suhana] USM, Sch Phys, Xray Crystallog Unit, George Town 11800, Malaysia; [Khairul, Wan Mohd] Univ Malaysia Terengganu, Sch Fundamental Sci, Kuala Terengganu 21030, Terengganu, Malaysia published Crystal structure and optical properties of fused-ring chalcone (E)-3-(anthracen-9-yl)-1-(4-nitrophenyl)prop-2-en-1-one in 2019.0, Cited 22.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

The title compound, C23H15NO3, adopts an s-cis conformation with respect to the ethylene C=C and carbonyl C=O double bonds in the enone unit. The molecule is significantly twisted with a dihedral angle of 48.63 (14)degrees between the anthracene ring system and the benzene ring. In the crystal, molecules are linked into inversion dimers with an R-2(2)(10) graph-set motif via pairs of C-H center dot center dot center dot O hydrogen bonds. The intermolecular interactions were analysed and quantified by Hirshfeld surface analysis. The molecular structure was optimized and a small HOMO-LUMO energy gap of 2.55 eV was obtained using the DFT method at the B3LYP/6-311 G++(d,p) level of theory. This value is in close agreement with the experimental value of 2.52 eV obtained from the UV-vis analysis. The crystal used was a two-component merohedral twin with a refined ratio of 0.1996 (16):0.8004 (16).

Recommanded Product: 100-19-6. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Metal-free Catalytic Esterification of Aryl Alkyl Ketones with Alcohols via Free-radical Mediated C(sp(3))-H Bond Oxygenation WOS:000616773300001 published article about BAEYER-VILLIGER OXIDATION; RETRO-CLAISEN CONDENSATION; C-NUCLEOSIDE SYNTHESIS; CARBON-CYANO; DIRECT CONVERSION; ORGANIC-ACIDS; HALLER-BAUER; CLEAVAGE; ESTERS; MILD in [Rammurthy, Banothu; Peraka, Swamy; Vasu, Amrutham; Sai, Gajula Krishna; Rohini, Yennamaneni Divya; Narender, Nama] Acad Sci & Innovat Res, CSIR HRDG Campus,Sect 19, Ghaziabad 201002, UP, India; [Rammurthy, Banothu; Peraka, Swamy; Vasu, Amrutham; Sai, Gajula Krishna; Rohini, Yennamaneni Divya; Narender, Nama] CSIR Indian Inst Chem Technol, C&FC Div, Hyderabad 500007, Telangana, India in 2021, Cited 88. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 1-(4-Nitrophenyl)ethanone

A novel metal-free catalytic one-pot approach has been developed for the esterification of aralkyl ketones with alcohols under open-air atmospheric conditions. The inexpensive iodide/oxone reagent system allowed the cascade C(sp(3))-H bond oxygenation, selective C-C bond cleavage and esterification through the both radical and ionic pathways in a stepwise manner in one-pot. This mild, convenient and economically viable catalytic method tolerates the various functional groups to provide the corresponding alkyl benzoates in up to 98% yields with up to 99% selectivity. The efficiency and feasibility of scale-up of the present catalytic system was demonstrated with gram scale experiments (up to 10 gram scale).

Recommanded Product: 1-(4-Nitrophenyl)ethanone. Welcome to talk about 100-19-6, If you have any questions, you can contact Rammurthy, B; Peraka, S; Vasu, A; Sai, GK; Rohini, YD; Narender, N or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Metal-free Catalytic Esterification of Aryl Alkyl Ketones with Alcohols via Free-radical Mediated C(sp(3))-H Bond Oxygenation WOS:000616773300001 published article about BAEYER-VILLIGER OXIDATION; RETRO-CLAISEN CONDENSATION; C-NUCLEOSIDE SYNTHESIS; CARBON-CYANO; DIRECT CONVERSION; ORGANIC-ACIDS; HALLER-BAUER; CLEAVAGE; ESTERS; MILD in [Rammurthy, Banothu; Peraka, Swamy; Vasu, Amrutham; Sai, Gajula Krishna; Rohini, Yennamaneni Divya; Narender, Nama] Acad Sci & Innovat Res, CSIR HRDG Campus,Sect 19, Ghaziabad 201002, UP, India; [Rammurthy, Banothu; Peraka, Swamy; Vasu, Amrutham; Sai, Gajula Krishna; Rohini, Yennamaneni Divya; Narender, Nama] CSIR Indian Inst Chem Technol, C&FC Div, Hyderabad 500007, Telangana, India in 2021, Cited 88. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Formula: C8H7NO3

A novel metal-free catalytic one-pot approach has been developed for the esterification of aralkyl ketones with alcohols under open-air atmospheric conditions. The inexpensive iodide/oxone reagent system allowed the cascade C(sp(3))-H bond oxygenation, selective C-C bond cleavage and esterification through the both radical and ionic pathways in a stepwise manner in one-pot. This mild, convenient and economically viable catalytic method tolerates the various functional groups to provide the corresponding alkyl benzoates in up to 98% yields with up to 99% selectivity. The efficiency and feasibility of scale-up of the present catalytic system was demonstrated with gram scale experiments (up to 10 gram scale).

Welcome to talk about 100-19-6, If you have any questions, you can contact Rammurthy, B; Peraka, S; Vasu, A; Sai, GK; Rohini, YD; Narender, N or send Email.. Formula: C8H7NO3

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Discovery of thiosemicarbazone-containing compounds with potent anti- proliferation activity against drug-resistant K562/A02 cells WOS:000595378800015 published article about BIOLOGICAL EVALUATION; CYCLE ARREST; IN-VITRO; ANTIOXIDANT; DERIVATIVES; APOPTOSIS in [Gu, Xiaoke; Li, Xin; Guan, Mingyu; Jiang, Chunyu; Song, Qinghua; Sun, Nan; Qiu, Jingying] Xuzhou Med Univ, Jiangsu Key Lab New Drug Res & Clin Pharm, Xuzhou 221004, Jiangsu, Peoples R China; [Zou, Yueting; Zhou, Qingqing; Chen, Jing; Qiu, Jingying] Xuzhou Med Univ, Sch Pharm, Dept Pharmaceut Anal, Xuzhou 221004, Jiangsu, Peoples R China in 2020.0, Cited 27.0. Name: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a major obstacle to successful chemotherapy for leukemia. In this study, a series of thiosemicarbazone-containing compounds (4a-b, 7a-q) were synthesized. Biological evaluation showed that the most active compound 7e displayed potent anti-leukemia activity against P-gp overexpressing drug-resistant K562/A02 cells, with an IC50 value of 0.44 mu M. Notably, compound 7e exhibited a selective killing effect on K562/A02 cells by dose-dependently increasing the intracellular levels of reactive oxygen species (ROS), thus exerting a potential collateral sensitivity (CS)-promoting effect in vitro. Moreover, compound 7e could inhibit HDAC1 and HDAC6, and induce the apoptosis of K562/A02 cells by increasing the expression of Bax, decreasing Bcl-2 protein level, and promoting the cleavage of caspase-3 and PARP, respectively. Overall, 7e may be a potential anti-cancer agent against drug-resistant myelogenous leukemia.

Name: 1-(4-Nitrophenyl)ethanone. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

In 2019.0 ORGANOMETALLICS published article about CHEMISTRY; BORENIUM; CATION; BORINIUM; ION; REDUCTION; COMPLEXES; CATALYST; CHLORIDE; KETONES in [Tseng, Hsi-Ching; Shen, Chao-Tang; Shih, Ding-Nan; Liu, Yi-Hung; Peng, Shie-Ming; Chiu, Ching-Wen] Natl Taiwan Univ, Dept Chem, 1,Sect 4,Roosevelt Rd, Taipei 10617, Taiwan; [Matsumoto, Kentaro; Yamaguchi, Shigehiro] Nagoya Univ, Grad Sch Sci, Dept Chem, Chikusa Ku, Nagoya, Aichi 4648602, Japan; [Lin, Ya-Fan] Kaohsiung Med Univ, Dept Fragrance & Cosmet Sci, 100 Shi Chuan First Rd, Kaohsiung 80708, Taiwan in 2019.0, Cited 58.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 100-19-6

The chemistry of the boron cation has been revitalized in the past decade due to its newfound application in stoichiometric and catalytic organic reactions. To extend the frontier of boron cation catalysis, we came to discover that a mesityl-substituted eta(5)-Cp*-coordinated boron cation could serve as a powerful Lewis acid for organic catalytic transformations. The boron cation [Cp*B-Mes][B(C6F5)(4)] ([1] [B(C6F5)(4)]) stabilized in a boronium-like electronic structure binds to Et3PO readily and displays an acceptor number exceeding that of B(C6F5)(3) on the Gutmann-Beckett acidity scale. The steric and electronic stabilization exerted by the electron-donating Cp* renders the highly Lewis acidic boron cation an easy-to-handle catalyst for hydrodeoxygenation of aryl ketones at ambient temperature. The exceptional catalytic performance of [1](+) implies that the incorporation of a coordinatively flexible substituent at boron is critical in bringing catalytic activity and stability to boron cation catalysts.

Welcome to talk about 100-19-6, If you have any questions, you can contact Tseng, HC; Shen, CT; Matsumoto, K; Shih, DN; Liu, YH; Peng, SM; Yamaguchi, S; Lin, YF; Chiu, CW or send Email.. Recommanded Product: 100-19-6

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem