Heterocyclic Building Blocks-benzodioxan

3663-80-7, 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,3663-80-7

0.1mol2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylic acid was added to 50 mL thionyl chloride. The mixturewas refluxed for 1 hour, and then the solvent was evaporated under reducedpressure. The residue was added 150 mL hot toluene. After stirring, 100 mLtoluene was evaporated under reduced pressure, and then the residue cooled toroom temperature. 2,3-dihydrobenzo[b][1,4]dioxine-2-carbonyl chloride wasobtained after filtration

The synthetic route of 3663-80-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Wang, Songlin; Chen, Yin; Zhao, Song; Xu, Xiangqing; Liu, Xin; Liu, Bi-Feng; Zhang, Guisen; Bioorganic and Medicinal Chemistry Letters; vol. 24; 7; (2014); p. 1766 – 1770;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

20197-75-5, Methyl 1,4-Benzodioxan-6-carboxylate is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

will be 1, 4 – benzene and dioxane -6 – methyl formate (26.0g, 133 . 9mmol) by adding acetic acid (150 ml) in, stirring to dissolve, dropping fuming nitric acid (51 ml), canada finishes, heating up to 70 ¡ãC stirring 1 hour. Cooling to room temperature, concentrated under reduced pressure, for 5percent of sodium hydroxide aqueous solution to adjust the pH to 7, adding ethyl acetate, the organic phase after the water washing, drying, concentration, be 7 – nitro – 2, 3 – dihydrobenzo [b] [1, 4] dioxin -6 – carboxylic acid methyl ester (31.1g, 97percent).

20197-75-5, 20197-75-5 Methyl 1,4-Benzodioxan-6-carboxylate 3802178, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Patent; Shanghai Huilun Life Technology Co., Ltd.; Cheng Jianjun; Qin Jihong; (25 pag.)CN104557955; (2017); B;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.,2879-20-1

To a stirred solution of coptisine (250 mg, 0.70 mmol) in 5 N NaOH (1 ml), 6-acetyl-1,4-benzodioxane (1 mL, 6.67 mmol) was added slowly. The reaction mixture was stirred at 60 C. for 3 h. The reaction mixture was extracted with CHCl3/MeOH (v/v=10:1). The organic layer was washed to neutral with water, and dried over anhydrous MgSO4, and filtered, and then concentrated under reduced pressure to give intermediate product. The intermediate product was dissolved in anhydrous tetrahydrofuran (5 mL) followed by addition of HOAc (0.5 mL) and formaldehyde (1.5 mL, 15.06 mmol) dropwise. The reaction mixture was kept refluxing for 3 h. After the reaction completed, the reaction mixture was concentrated and added with 2 N HCl (2 mL), then stirred at room temperature for 1 h and extracted with CHCl3/MeOH (v/v=10:1). The organic layer was dried over anhydrous MgSO4 and then filtered and concentrated under reduced pressure to give crude product, which was purified via silica gel column chromatography (CHCl3/MeOH (v/v)=20:1) to give pure yellow solid (110 mg, 28.1% yield).

2879-20-1 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone 76143, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Patent; Institute of Materia Medica, Chinese Academy of Medical Sciences; Qin, Hailin; Wang, Wenjie; Zhang, Zhihui; Wu, Lianqiu; Deng, Anjun; Yu, Jinqian; Li, Zhihong; US2015/31717; (2015); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.,2879-20-1

a 2-Bromo-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethan-1-one By using 1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethan-1-one (1.42 g, 7.97 mmol), the title compound was obtained as pale yellow solid by similar procedures to those of Example 38a (2.05 g, yield: 100%). 1H-NMR(CDCl3): 7.50-7.54(2H,m), 6.93(1H,m), 4.37(2H,s), 4.32-4.35(2H,m), 4.27-4.31(2H,m)

As the paragraph descriping shows that 2879-20-1 is playing an increasingly important role.

Reference£º
Patent; Yamabe, Haruko; Okuyama, Masahiro; Nakao, Akira; Ooizumi, Mitsuru; Saito, Ken-ichi; US2003/212094; (2003); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

A common heterocyclic compound, the benzodioxans compound, name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,cas is 2879-20-1, mainly used in chemical industry, its synthesis route is as follows.

General procedure: A series of sixteen novel 1, 4-benzodioxane-based thiosemicarbazones(3a-p) was synthesized by reacting appropriatethiosemicarbazide (1a-p) (5 mmol) and 1, 4-benzodioxan-6-ylmethyl ketone (2) (5 mmol) in methanol (15 mL) using glacialacetic acid (1e2 drops) as catalyst. Reflux at 80 C for 6 h wascarried out and the product formation and the reaction completion were examined by thin layer chromatography. Upon completion,the reaction mixturewas allowed to cool at r.t and the solid productwas collected by suction filtration followed by washing with hotmethanol and then dried in vacuum. Finally, the target thiosemicarbazonesderivatives were recrystallized from chloroformmethanolmixture (1:1) in good to excellent yields. The X-raymeasurements were read by mounting a 3m single crystal on agreased MiTe Gen loop and was inspected through thediffractometer (Bruker D8 Venture APEX diffractometer) at 296 (2)K by means of graphite-monochromated MoeK a radiation(l 0.71073 A); diffractometer was complimented with an areadetector (Photon 100 CCD) along with a cooler (Oxford Cryostream).APEX-II software was used to collect Data [41] and SAINTwas operated for integration [42] The SADABS (multi-scanapproach) was used for correction in absorption [43]. and intrinsicphasing (SHELXT)was employed to the solve the structure [44]. Fullleast squares refinement of all detected reflections were used todetermine the final cell constants and assign positions of all atomsother than H to the consequential difference maps via refinementagainst F2. Whereas H atoms were assigned location and addedagainst F2 and were refined by riding model. SHELXL-97 wasimplemented to refine anisotropically [45]. The CCDC (CSD depositionnumbers 1874544) of the structure has been deposited. Thedetailed characterization of compounds 3a e 3p are given insupporting informations.

2879-20-1, As the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

Reference£º
Article; Shehzad, Muhammad Tariq; Khan, Ajmal; Islam, Muhammad; Hameed, Abdul; Khiat, Mohammed; Halim, Sobia Ahsan; Anwar, Muhammad U.; Shah, Syed Raza; Hussain, Javid; Csuk, Rene; Khan, Samra; Al-Harrasi, Ahmed; Shafiq, Zahid; Journal of Molecular Structure; vol. 1209; (2020);,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

A common heterocyclic compound, the benzodioxans compound, name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,cas is 2879-20-1, mainly used in chemical industry, its synthesis route is as follows.

General procedure: Equimolar quantities of substituted benzaldehyde and 1-(2H-1,3-benzodioxol-5-yl)ethan-1-one or 1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethan-1-one were dissolved in 40% KOH and ethanol. The reactionmixture was then stirred for 10 h and poured into ice-cold water. Theprecipitated product was washed with water, dried, and recrystallizedfrom ethanol.

2879-20-1, As the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

Reference£º
Article; Parambi, Della Grace Thomas; Oh, Jong Min; Baek, Seung Cheol; Lee, Jae Pil; Tondo, Anna Rita; Nicolotti, Orazio; Kim, Hoon; Mathew, Bijo; Bioorganic Chemistry; vol. 93; (2019);,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

3663-80-7, 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,3663-80-7

1. Preparation of ethyl 2-[1-[4-(2,3-dihydrobenzo[b][1,4]dioxin-2-carboxamido)benzyl]-1H-indazol-3-yl]acetate 2,3-Dihydrobenzo[b][1,4]dioxin-2-carboxylic acid (145 mg, 0.80 mmol) was dissolved in dichloromethane (15 mL) and N,N-dimethylformamide (0.10 mL), and in an ice bath, oxalic chloride (153 mg, 1.21 mmol) was added dropwise slowly. Upon completion of the dropwise addition, it was moved to react at room temperature for 3 hours, and concentrated under reduce pressure to obtain 2,3-dihydrobenzo[b][1,4]dioxin-2-formyl chloride as a white solid.

As the paragraph descriping shows that 3663-80-7 is playing an increasingly important role.

Reference£º
Patent; Zhang, Yan; Zhang, Min; Lo, Hoyin; US2014/303186; (2014); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17413-10-4,(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanamine,as a common compound, the synthetic route is as follows.

General procedure: A solution of carboxylic acid (0.5 mmol) and HATU (0.55 mmol)in anhydrous DMF (2 mL) was stirred at ambient temperature for10 min. To this solution, DIPEA (0.6 mmol) and correspondingamine (0.54 mmol) were added successively and the mixture wasstirred for 18 h. After concentration under reduced pressure, thereaction mixture was treated with water (5 mL) and extracted withDCM (2 5 mL). After evaporation of the solvent, the residue wascrystallized from an appropriate solvent or subjected to columnchromatography on silica gel (DCM/MeOH) or preparative HPLC, 17413-10-4

As the paragraph descriping shows that 17413-10-4 is playing an increasingly important role.

Reference£º
Article; Krasavin, Mikhail; Gureyev, Maxim A.; Dar’in, Dmitry; Bakulina, Olga; Chizhova, Maria; Lepikhina, Anastasia; Novikova, Daria; Grigoreva, Tatyana; Ivanov, Gleb; Zhumagalieva, Aisulu; Garabadzhiu, Alexander V.; Tribulovich, Vyacheslav G.; Bioorganic and Medicinal Chemistry; vol. 26; 9; (2018); p. 2651 – 2673;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2879-20-1, 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,2879-20-1

The title compound was prepared according to the published protocol1. A 60 % suspension of sodium hydride in mineral oil (0.2 g, 5.0 mmol) was washed with petroleum benzin (20 ml) twice, anhydrous DMSO (4 ml) was added. After being stirred for 30 mm at room temperature under argon, the flask was cooled down to 15 00 and a solution of methyl3-chlorobenzoate (0.853 g, 5.0 mmol) and 1 -(2,3-dihydro-1 ,4-benzodioxin-6-yl)ethanone (0.712 g, 4.0 mmol) in DMSO (4 ml) was added dropwise. Upon completion of addition, the reaction mixture was stirred 24 h at room temperature, then poured slowly into crushed ice (50 g) containing 85 % phosphoric acid (1 ml). The resulting precipitate was collected by filtration, washed with water (50 ml) and air dried. The resulting crude product wasrecrystallized from methanol to provide sery595 (590 mg, 47 %) as a light-yellow powder.TLC (hexane:EtOAc, 3/1 v/v): RE = 0.53.1H NMR (400 MHz, DMSO-d6) 6 = 8.24 (t, J = 1.8 Hz, 1H), 8.10 (d, J = 7.8 Hz, 1H), 7.79-7.73(m, 2H), 7.69 (m, 1H), 7.58 (t, J 7.8 Hz, 1H), 7.32 (s, 1H), 7.02 (d, J = 8.3 Hz, 1H), 4.39-4.29 (m, 4H), (in 1H NMR spectrum 6.5% of diketone form is present).130 NMR (100.6 MHz, DMSO-d6) 6 = 186.2, 181.6, 148.1, 143.5, 136.6, 133.8, 132.4, 130.7,127.8, 126.9, 125.8, 121.7, 117.4, 116.7, 93.1, 64.6, 63.9.LC MS (RP18-100A, gradient 0% CH3CN/100% H20 – 100% CH3CN in 50 mm), RT 45.8 mm and mass 317.04 (100%), 318.99 (35%) ([M+H]).M.p. 106-1 07 C.

2879-20-1 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone 76143, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Patent; MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; LUDWIG-MAXIMILIANS-UNIVERSITAeT MUeNCHEN; GEORG-AUGUST-UNIVERSITAeT GOeTTINGEN; BECKER, Dorothea; JOVIN, Thomas M.; GRIESINGER, Christian; LEONOV, Andrei; RYAZANOV, Sergey; GIESE, Armin; OUTEIRO, Tiago F.; LAZARO, Diana F.; SCHOeN, Michael P.; SCHOeN, Margarete; (101 pag.)WO2018/206778; (2018); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3663-80-7,2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,as a common compound, the synthetic route is as follows.,3663-80-7

Method I Ba (1 mmol) and 2,3-dihydrobenzo[b][1,4]dioxin-6-carboxylic acid (or 2,3-dihydrobenzo[b][1,4]dioxin-2-carboxylic acid) (1 mmol) together with EDCI (1.5 mmol) and HOBt (0.05 mmol) in CH2Cl2 (20 mL) were refluxed at room temperature for 10 h. While the reaction completed, the solution was washed with water for three times (30 mL each time). The remaining water layer was extracted by EtOAc for three times (30 mL each time). The organic layers (CH2Cl2 and EtOAc) were combined and then evaporated. The separated solid was crystallized from mixture of DMF and ethanol (9:1) to obtain the corresponding compound as translucent solid. 4.5.22 (2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(5-(4-fluorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)methanone (D7) White crystal, mp: 159-161 ¡ãC. 1H NMR (CDCl3, 300 MHz) delta: 3.15-3.21 (d, J = 16.8 Hz, 1H), 3.70-3.74 (m, 1H), 4.32-4.37 (m, 1H), 4.53-4.57 (d, J = 11.1 Hz, 1H), 5.53-5.57 (m, 2H), 6.81-6.87 (m, 4H), 6.97-7.03 (m, 2H), 7.12-7.15 (d, J = 9.0 Hz, 2H), 7.44-7.47 (m, 3H), 7.71-7.74 (d, J = 7.2 Hz, 2H). MS (ESI): 403.14 (C24H20FN2O3, [M+H]+). Anal. Calcd for C24H19FN2O3: C, 71.63; H, 4.76; F, 4.72; N, 6.96; O, 11.93. Found: C, 71.24; H, 4.76; N, 6.98.

As the paragraph descriping shows that 3663-80-7 is playing an increasingly important role.

Reference£º
Article; Yang, Yu-Shun; Li, Qing-Shan; Sun, Shuai; Zhang, Yan-Bin; Wang, Xiao-Liang; Zhang, Fei; Tang, Jian-Feng; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 20; 20; (2012); p. 6048 – 6058;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem