Heterocyclic Building Blocks-benzodioxan

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3663-80-7,2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,as a common compound, the synthetic route is as follows.,3663-80-7

Method I Ba (1 mmol) and 2,3-dihydrobenzo[b][1,4]dioxin-6-carboxylic acid (or 2,3-dihydrobenzo[b][1,4]dioxin-2-carboxylic acid) (1 mmol) together with EDCI (1.5 mmol) and HOBt (0.05 mmol) in CH2Cl2 (20 mL) were refluxed at room temperature for 10 h. While the reaction completed, the solution was washed with water for three times (30 mL each time). The remaining water layer was extracted by EtOAc for three times (30 mL each time). The organic layers (CH2Cl2 and EtOAc) were combined and then evaporated. The separated solid was crystallized from mixture of DMF and ethanol (9:1) to obtain the corresponding compound as translucent solid. 4.5.24 (2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)(5-(4-fluorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)methanone (D9) White crystal, mp: 229-231 ¡ãC. 1H NMR (CDCl3, 300 MHz) delta: 3.18-3.24 (d, J = 17.1 Hz, 1H), 3.71-3.76 (m, 1H), 3.81 (s, 3H), 4.32-4.36 (m, 1H), 4.54-4.57 (m, 1H), 5.60-5.64 (m, 2H), 6.88-6.94 (m, 4H), 7.01-7.07 (m, 2H), 7.16-7.19 (d, J = 8.7 Hz, 2H), 7.29-7.31 (d, J = 7.5 Hz, 2H), 7.72-7.74 (d, J = 7.2 Hz, 2H). MS (ESI): 433.15 (C25H22FN2O4, [M+H]+). Anal. Calcd for C25H21FN2O4: C, 69.44; H, 4.89; F, 4.39; N, 6.48; O, 14.80. Found: C, 69.15; H, 4.86; N, 6.51.

3663-80-7 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid 2735450, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Article; Yang, Yu-Shun; Li, Qing-Shan; Sun, Shuai; Zhang, Yan-Bin; Wang, Xiao-Liang; Zhang, Fei; Tang, Jian-Feng; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 20; 20; (2012); p. 6048 – 6058;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

31127-39-6, 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,31127-39-6

To a solution of 500mg (2. 13MMOL) 5-BROMOMETHYL-THIOPHENE-2-CARBOXYLIC acid methyl ester and 381mg (2.13mmol) 2,3-dihydro-benzo [1, 4] dioxine-6- carbaldehyde oxime in 2ML dichloromethane were added 2. 0ml 2.2M aqueous sodium hydroxide solution and 902mg (2.55mmol) tertrabutylammonium hydrogen sulfate while vigorously stirring. After 10 minutes another 2. 0ML 2.2M aqueous sodium hydroxide solution and 902mg (2. 55MMOL) tertrabutylammonium hydrogen sulfate were added. This procedure was repeated one more time. After 20 minutes 8ml saturated aqueous bicarbonate solution was added. The aqueous phase was extracted three times with ethyl acetate and the combined organic phases were washed with brine and dried over NA2SO4. The solvent was evaporated and the residue was subjected to silica gel chromatography (hexane/ethyl acetate 4: 1, then 3: 1) to yield 214mg (0. 64MMOL) 5- (2, 3-Dihydro-benzo [1, 4] dioxin-6- ylmethyleneaminooxymethyl) -thiophene-2-carboxylic acid methyl ester; exact MW [M+H] calc’d: 334.07 ; MW found [M+H]: 334.2

31127-39-6 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime 5382382, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; WO2004/87693; (2004); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3663-80-7,2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,as a common compound, the synthetic route is as follows.,3663-80-7

To a solution of 5-chloro-lH-indole-2-carboxylic acid hydrazide (Preparation 1, 0. 50g, 2. 39mmol) in DMF (5rnL) was added HOBt (0. 32g, 2. 39mmol), DIPEA (0.83mL, 4. 78mmol) and 2,3-dihydrobenzo [1, 4] dioxine-2-carboxylic acid (0.43g, 2.39mmol) followed by EDCI (0. 55g, 2. 87mmol). The reaction mixture was stirred at rt for 16h, poured into water (75mL) and extracted with ethyl acetate (2 x 150mL). The combined organic extracts were washed with HCl (IN, 50mL), NaOH (1N, 50mL) and saturated sodium chloride solution (75mL). The organic layer was dried (MgS04) and concentrated in vacuo to give the title compound. m/z (ES+) = 372 [M+ H] + ; RT = 3. 57min.

The synthetic route of 3663-80-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PROSIDION LIMITED; WO2005/85194; (2005); A2;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2879-20-1, 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,2879-20-1

General procedure: N-Bromobutanimide (NBS, 356 mg, 2.0 mmol) and 4-Methylbenzenesulfonic acid (PTSA, 344 mg, 2.0 mmol) were added to a well-stirred solution of aryl methyl ketone 8a (240 mg, 2.0 mmol) in anhydrous MeCN (15 mL). The mixture was stirred at room temperature for 1 h, and then refluxed for another 1-2.5 h. After disappearance of aryl methyl ketone 8a (monitored by TLC), the solvent was removed under reduced pressure, then added 50mL water to the mixture, extracted with EtOAc 3 times (3 ¡Á 50 mL). The extract was washed with 10% NaCl solution, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was puried by column chromatography on silica gel to yield the desired product 4a as a white solid in 90% yield.

The synthetic route of 2879-20-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhu, Yan-Ping; Cai, Qun; Gao, Qing-He; Jia, Feng-Cheng; Liu, Mei-Cai; Gao, Meng; Wu, An-Xin; Tetrahedron; vol. 69; 31; (2013); p. 6392 – 6398;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17413-10-4,(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanamine,as a common compound, the synthetic route is as follows.,17413-10-4

To a solution of ethyl 8-(benzyloxy)-5-hydroxy-4-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate (145 mg) and triethylamine (113 muL) in methylene chloride (5 mL), trifluoromethanesulfonic anhydride (130 muL) was added dropwise under ice cooling, and the mixture was stirred at room temperature for 1 hour. The solvent in the reaction mixture was distilled off under reduced pressure. To the obtained residue, ((2,3-dihydro-1,4-benzodioxin-6-yl)methyl)amine (102 mg), triethylamine (170 muL) and dioxane (10 mL) were added, and the mixture was stirred at room temperature for 3 hours. The solvent in the reaction mixture was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography [eluent: 60-0% hexane/ethyl acetate] to obtain a brown oil (208 mg). To the obtained brown oil (208 mg), methanol (10 mL) and a 1 mol/L aqueous sodium hydroxide solution (10 mL) were added, and the mixture was heated with stirring at 60 to 70C for 2 hours and 30 minutes. After cooling of the reaction mixture, the solvent was distilled off under reduced pressure, and ethyl acetate and water were added to the residue. An organic layer was separated, washed with a saturated aqueous solution of sodium chloride and then dried over sodium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was suspended in a mixed solvent of methanol, 2-propanol and diisopropyl ether, and the deposit was collected by filtration to obtain a pale yellow solid of 8-(benzyloxy)-5-(((2,3-dihydro-1,4-benzodioxin-6-yl)methyl)amino)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one (57 mg). 1H-NMR (CDCl3) delta value: 2.93 (s, 3H), 4.25 (d, J=4.6 Hz, 2H), 4.28 (s, 4H), 5.23-5.33 (m, 3H), 5.73 (s, 1H), 6.81-6.94 (m, 3H), 7.35-7.44 (m, 3H), 7.65-7.74 (m, 2H), 8.89 (s, 1H).

17413-10-4 (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanamine 87102, abenzodioxans compound, is more and more widely used in various.

Reference£º
Patent; Toyama Chemical Co., Ltd.; KAWAI, Hyouei; MURATA, Daigo; SUZUMURA, Yuko; EP2810944; (2014); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

To a solution of 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-one (5.0g, 28.0mmol, 1.0 equiv.) in chloroform (100mL), CuBr2 (10.7g, 47.7mmol, 1.7 equiv.) was added in one aliquot. The reaction mixture was stirred at 70C for 20h. After cooling the mixture to room temperature, the excess CuBr2 and CuBr (formed as side product) were filtered off. The product was purified by flash chromatograph using DCM/Hex (4:1, v/v) as mobile phase. Yield, 67%. 1H NMR (400MHz, CDCl3) delta 4.27-4.29 (m, 2H), 4.31-4.34 (m, 2H), 4.37 (s, 2H), 6.91-6.93 (m, 1H), 7.49-7.52 (m, 2H) ppm. 13C NMR (100MHz, CDCl3) delta 30.89, 64.18, 64.85, 117.63, 118.53, 123.29, 127.73, 143.63, 148.91, 189.92ppm. HRMS (ESI) m/z calculated for C10H10O3Br [M+H]+ 256.9808, found 256.9799., 2879-20-1

The synthetic route of 2879-20-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Fonovi?, Ur?a Pe?ar; Knez, Damijan; Hrast, Martina; Zidar, Nace; Proj, Matic; Gobec, Stanislav; Kos, Janko; European Journal of Medicinal Chemistry; vol. 193; (2020);,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.,2879-20-1

General procedure: A mixture of acetophenone 1a(0.5 mmol), acetonitrile 2 (7.5 mmol), and I2 (0.75 mmol) in DMSO (2mL) was stirred at 110 C. After disappearance of the reactant (monitored by TLC), added 50 mL water to the mixture, then extracted with EtOAc 3 times. The extract was washed with Na2S2O3 solution, dried over anhydrous Na2SO4 and evaporation. The residue was puriedby column chromatography to afford 3a.

As the paragraph descriping shows that 2879-20-1 is playing an increasingly important role.

Reference£º
Article; Gao, Qinghe; Liu, Shan; Wu, Xia; Wu, Anxin; Tetrahedron Letters; vol. 55; 47; (2014); p. 6403 – 6406;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

The benzodioxans compound, cas is 2879-20-1 name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, mainly used in chemical industry, its synthesis route is as follows.

General procedure: Equimolar quantities of substituted benzaldehyde and 1-(2H-1,3-benzodioxol-5-yl)ethan-1-one or 1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethan-1-one were dissolved in 40% KOH and ethanol. The reactionmixture was then stirred for 10 h and poured into ice-cold water. Theprecipitated product was washed with water, dried, and recrystallizedfrom ethanol.

2879-20-1, As the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

Reference£º
Article; Parambi, Della Grace Thomas; Oh, Jong Min; Baek, Seung Cheol; Lee, Jae Pil; Tondo, Anna Rita; Nicolotti, Orazio; Kim, Hoon; Mathew, Bijo; Bioorganic Chemistry; vol. 93; (2019);,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2879-20-1, 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,2879-20-1

General procedure: Equimolar quantities of substituted benzaldehyde and 1-(2H-1,3-benzodioxol-5-yl)ethan-1-one or 1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethan-1-one were dissolved in 40% KOH and ethanol. The reactionmixture was then stirred for 10 h and poured into ice-cold water. Theprecipitated product was washed with water, dried, and recrystallizedfrom ethanol.

2879-20-1 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone 76143, abenzodioxans compound, is more and more widely used in various.

Reference£º
Article; Parambi, Della Grace Thomas; Oh, Jong Min; Baek, Seung Cheol; Lee, Jae Pil; Tondo, Anna Rita; Nicolotti, Orazio; Kim, Hoon; Mathew, Bijo; Bioorganic Chemistry; vol. 93; (2019);,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4442-53-9,2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid,as a common compound, the synthetic route is as follows.,4442-53-9

7-nitro-1,4-benzodioxane-5-carboxylic acid 160 ml of acetic acid, 160 ml of acetic anhydride and 100 g of 1,4-benzodioxane-5-carboxylic acid were introduced into a balloon flask provided with an agitator and a thermometer. The mixture was heated and a solution of 40 ml of nitric acid in 40 ml of acetic acid was added. The mixture was agitated at 40¡ã-45¡ã C. and then cooled. The crystals were dried off, washed and dried. 34 g of 7-nitro-1,4-benzodioxane-5-carboxylic acid were obtained (M.P.: 246¡ã C.; yield: 27percent).

4442-53-9 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid 78184, abenzodioxans compound, is more and more widely used in various.

Reference£º
Patent; Societe D’Etudes Scientifiques et Industrielles de L’ile-de-France; US4186135; (1980); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem