Heterocyclic Building Blocks-benzodioxan

An article One-pot synthesis of pyrimidine linked naphthoquinone-fused pyrroles by iodine-mediated multicomponent reactions WOS:000546177200016 published article about HYBRID MOLECULES; CYTOTOXICITY; DERIVATIVES; DISCOVERY; CANCER in [Panday, Anoop Kumar; Ali, Danish; Choudhury, Lokman H.] Indian Inst Technol Patna, Dept Chem, Bihta 801106, Bihar, India in 2020.0, Cited 40.0. Recommanded Product: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Herein we report iodine-mediated multicomponent reactions for the synthesis of naphthoquinone-fused pyrroles tethered with a pyrimidine moiety. The reaction of aryl methyl ketones (3) or terminal aryl alkynes (5) in the presence of molecular iodine in DMSO medium followed by sequential addition of barbituric acids (2) and 2-amino-1,4-naphthoquinone (1) provides the corresponding three-component hybrid molecules 4 having naphthoquinone-fused pyrroles tethered with a barbituric acid moiety. This three-component reaction proceeds via metal-free C-H oxidation followed by multi-component cyclization forming three new bonds (2 C-C, 1 C-N) in one pot. Alternatively, the same molecules can also be prepared from the reaction of arylglyoxals, 2-aminonaphthoquinone, and barbituric acids in the presence of a catalytic amount of iodine in methanol medium under reflux conditions. The salient features of these methodologies are: one-pot metal-free method, good yields, wide substrate scope, easy purification of products, and the presence of medicinally important naphthoquinone, pyrrole and pyrimidine moieties in the products.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Non-Heme-Type Ruthenium Catalyzed Chemo- and Site-Selective C-H Oxidation WOS:000516641100001 published article about NONHEME IRON CATALYSTS; BOND OXIDATION; ALKANE HYDROXYLATION; ATOM ECONOMY; COMPLEXES; OXYGENATION; FUNCTIONALIZATION; REACTIVITY; ACTIVATION; EVOLUTION in [Hayashi, Hiroki; Uchida, Tatsuya] Kyushu Univ, Fac Arts & Sci, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan; [Doiuchi, Daiki; Nakamura, Tatsuya] Kyushu Univ, Grad Sch Sci, Dept Chem, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan; [Uchida, Tatsuya] Kyushu Univ, Int Inst Carbon Neutral Energy Res WPI 12CNER, Nishi Ku, 744 Motooka, Fukuoka 8190395, Japan in 2020.0, Cited 86.0. Recommanded Product: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

Herein, we developed a Ru(II)(BPGA) complex that could be used to catalyze chemo- and site-selective C-H oxidation. The described ruthenium complex was designed by replacing one pyridyl group on tris(2-pyridylmethyl)amine with an electron-donating amide ligand that was critical for promoting this type of reaction. More importantly, higher reactivities and better chemo-, and site-selectivities were observed for reactions using the cis-ruthenium complex rather than the trans-one. This reaction could be used to convert sterically less hindered methyne and/or methylene C-H bonds of a various organic substrates, including natural products, into valuable alcohol or ketone products.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Doiuchi, D; Nakamura, T; Hayashi, H; Uchida, T or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

HPLC of Formula: C14H11N. Otevrel, J; Svestka, D; Bobal, P in [Otevrel, Jan; Svestka, David; Bobal, Pavel] Masaryk Univ, Dept Chem Drugs, Fac Pharm, Palackeho 1946-1, Brno 61242, Czech Republic published One-pot method for the synthesis of 1-aryl-2-aminoalkanol derivatives from the corresponding amides or nitriles in 2020, Cited 85. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3.

We have identified a novel one-pot method for the synthesis of beta-amino alcohols, which is based on C-H bond hydroxylation at the benzylic alpha-carbon atom with a subsequent nitrile or amide functional group reduction. This cascade process uses molecular oxygen as an oxidant and sodium bis(2-methoxyethoxy)aluminum hydride as a reductant. The substrate scope was examined on 30 entries and, although the respective products were provided in moderate yields only, the above simple protocol may serve as a direct and powerful entry to the sterically congested 1,2-amino alcohols that are difficult to prepare by other routes. The plausible mechanistic rationale for the observed results is given and the reaction was applied to a synthesis of a potentially bioactive target.

About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Otevrel, J; Svestka, D; Bobal, P or concate me.. HPLC of Formula: C14H11N

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Synthesis of new bicarbazole-linked triazoles as non-cytotoxic reactive oxygen species (ROS) inhibitors WOS:000473914300001 published article about POTENTIAL LEADS; DERIVATIVES; ALKALOIDS in [Iqbal, Shazia; Khan, Maria A.; Basha, Fatima Z.] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 75270, Pakistan; [Ansari, Zulqarnain; Fazal-Ur-Rehman, Saba] Univ Karachi, Dept Chem, Karachi, Pakistan; [Jabeen, Almas; Faheem, Aisha] Univ Karachi, Int Ctr Chem & Biol Sci, PCMD, Karachi, Pakistan in 2019.0, Cited 37.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Quality Control of 1-(4-Nitrophenyl)ethanone

Carbazole analogs 3 and 4 and a new library of bicarbazole-linked triazoles 6-11 were prepared via new synthetic methodology. Metal-catalyzed oxidative coupling reaction was utilized for the synthesis of bicarbazole acetylene 4 and different metals (Zn+2, Co+2, Fe+3, Ni+2, Cu+2, Mn+2) as catalyst were screened. Only Fe-catalyzed reaction was found to be excellent and gave homocoupled product 4. Cu-catalyzed 1,3-dipolar cycloaddition was also utilized to install triazole moiety for the synthesis of hybrid molecules 6-11. Based on reported anti-inflammatory activity of carbazole and triazole scaffolds, all compounds were screened for their reactive oxygen species (ROS) inhibitory potential. Results from these studies revealed triazole 9 as most active compound (IC50 value of 7.6 +/- 0.1 mu g/mL on human whole blood and 2.7 +/- 0.09 mu g/mL on isolated neutrophils) using ibuprofen as a standard. Therefore, class described herein can serve as attractive structural element for further studies on ROS inhibition.

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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Category: benzodioxans. In 2020.0 J ORG CHEM published article about CYCLIC SULFAMIDATE IMINES; HIGHLY SUBSTITUTED PYRIDINES; N-SULFONYL KETIMINES; BAYLIS-HILLMAN ACETATES; ONE-POT SYNTHESIS; MODULAR SYNTHESIS; TOPOISOMERASE-I; HYDROXYLATION; CYCLOADDITION; CONDENSATION in [Prakash, Meher; Gudimella, Santosh K.; Lodhi, Rajni; Guiri, Soumitra; Samanta, Sampak] Indian Inst Technol Indore, Discipline Chem, Indore 453552, Madhya Pradesh, India in 2020.0, Cited 81.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

A new metal-, oxidant-, and solvent-free ecofriendly domino method has been established for modular synthesis of a diverse range of medicinally promising hydroxyarylated unsymmetrical pyridines in good to high chemical yields with an excellent regioselectivity. This domino process involves a range of N-sulfonyl ketimines as C,N-binucleophiles, enolizable ketones, and aromatic/heteroaromatic aldehydes using ammonium acetate as an ideal promoter under neat conditions, which creates two new C-C bonds and one C-N bond. Notably, the neutral reaction conditions are mild enough to tolerate a range of functionalities and cover a variety of substrates, thus bestowing a powerful avenue to access tri- and tetrasubstituted pyridines including carbo- and heterocyclic fused ones. Interestingly, a practical, scalable, and high-yielding synthesis of pyridylphenol derivatives was successfully accomplished by our unique method.

Category: benzodioxans. Welcome to talk about 100-19-6, If you have any questions, you can contact Prakash, M; Gudimella, SK; Lodhi, R; Guiri, S; Samanta, S or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Graphene/pyrrolic-structured nitrogen-doped CNT nanocomposite supports for Pd-catalysed Heck coupling and chemoselective hydrogenation of nitroarenes WOS:000473543500003 published article about REDUCED GRAPHENE OXIDE; WALLED CARBON NANOTUBES; SUZUKI-MIYAURA; PALLADIUM NANOPARTICLES; SELECTIVE HYDROGENATION; HIERARCHICAL NANOSTRUCTURES; HETEROGENEOUS CATALYST; IMMOBILIZED PALLADIUM; IONIC LIQUID; EFFICIENT in [Labulo, Ayomide H.; Omondi, Bernard; Nyamori, Vincent O.] Univ KwaZulu Natal, Sch Chem & Phys, Westville Campus,Private Bag X54001, Durban, South Africa in 2019.0, Cited 110.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Recommanded Product: 100-19-6

This work focused on the synthesis of 3D Pd-based nanocomposites which were tested in Heck coupling reactions and for the hydrogenation of nitroarenes. This was achieved by fabrication of graphene oxide/nitrogen-doped carbon nanotubes (G/N-CNTs) by mechanical grinding of 2D graphene oxide (GO) and 1D oxygen-treated nitrogen-doped CNTs (N-CNTs-OT) in a 3:1 ratio, respectively. The fabrication of G/N-CNTs is to overcome the habitual aggregation and restacking of graphene sheets. Palladium nanoparticles (Pd NPs) were deposited on the 3D G/N-CNTs nanocomposites via metal organic chemical vapour deposition method. The 3D Pd-based nanocomposites were characterized by TEM, SEM, HRTEM, XRD, TGA, XPS, ICP-OES, elemental analysis, BET analysis and Raman spectroscopy. For the Heck coupling reactions, aryl halides, olefins and 3D Pd-based nanocomposites were mixed in a suitable solvent and the reaction carried under microwave irradiation.The chemoselective hydrogenation of nitroarenes was done with dry ethanol in a Paar reactor, purged with H-2 gas. These catalysts demonstrate excellent activity and selectivity in both reactions. The remarkable activity of the 3D Pd-based nanocomposites in Heck reactions and hydrogenation of nitroarenes may be attributed to the small particle size (3-10 nm) and a high degree of dispersion of Pd NPs. A comparative experiment was conducted with Pd/AC, Pd/CNTs, Pd/G/CNTs and Pd/rGO. Pd/G/N-CNTs-OT showed higher activity and selectivity than Pd/G/CNTs, Pd/G/N-CNTs, Pd/rGO and Pd/N-CNTs counterpart.

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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Quality Control of 1-(4-Nitrophenyl)ethanone. Recently I am researching about EFFICIENT SYNTHESIS; C-H; ENANTIOSELECTIVE SYNTHESIS; BOND FORMATION; CYCLIZATION REACTIONS; COUPLING REACTIONS; SULFUR YLIDES; METAL-FREE; HYDRAZONES; AZOALKENES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21602202]; Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LY19B020016]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Hu, SP; Du, SY; Yang, ZG; Ni, LF; Chen, ZK. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone

A general and expeditious approach for the copper mediated synthesis of multi-functionalized dihydropyrazoles from N-sulfonylhydrazones and sulfoxonium ylides has been achieved under aerobic oxidative conditions. The formal [4+1] cycloaddition reaction exhibits many notable features and can be easily scaled up to gram scale.

Quality Control of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Hu, SP; Du, SY; Yang, ZG; Ni, LF; Chen, ZK or concate me.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 100-19-6. Andleeb, H; Hameed, S; Ejaz, SA; Khan, I; Zaib, S; Lecka, J; Sevigny, J; Iqbal, J in [Andleeb, Hina; Hameed, Shahid; Khan, Imtiaz] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan; [Andleeb, Hina] Int Islamic Univ, Fac Basic & Appl Sci, Sulaiman Bin Abdullah Aba Al Khail Ctr Interdisci, Islamabad, Pakistan; [Ejaz, Syeda Abida; Zaib, Sumera; Iqbal, Jamshed] COMSATS Inst Informat Technol, Ctr Adv Drug Res, Abbottabad 22060, Pakistan; [Khan, Imtiaz] Univ Manchester, Sch Chem, Oxford Rd, Manchester M13 9PL, Lancs, England; [Khan, Imtiaz] Univ Manchester, Manchester Inst Biotechnol, 131 Princess St, Manchester M1 7DN, Lancs, England; [Lecka, Joanna; Sevigny, Jean] Univ Laval, Fac Med, Dept Microbiol Infectiol & Immunol, Quebec City, PQ G1V 0A6, Canada; [Lecka, Joanna; Sevigny, Jean] Univ Laval, CHU Quebec, Ctr Rech, Quebec City, PQ G1V 4G2, Canada published Probing the high potency of pyrazolyl pyrimidinetriones and thioxopyrimidinediones as selective and efficient non-nucleotide inhibitors of recombinant human ectonucleotidases in 2019.0, Cited 52.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

With the aim to discover novel, efficient and selective inhibitors of human alkaline phosphatase and nucleotide pyrophosphatase enzymes, two new series of pyrazolyl pyrimidinetriones (PPTs) (6a-g) and thioxopyrimidinediones (PTPs) (6h-n) were synthesized in good chemical yields using Knoevenagel condensation reaction between pyrazole carbaldehydes (4a-g) and pharmacologically active N-alkylated pyrimidinetrione (5a) and thioxopyrimidinedione (5b). The inhibition potential of the synthesized hybrid compounds was evaluated against human alkaline phosphatase (h-TNAP and h-IAP) and ectonucleotidase (h-NPP1 and h-NPP3) enzymes. Most of the tested analogs were highly potent with a variable degree of inhibition depending on the functionalized hybrid structure. The detailed structure-activity relationship (SAR) of PPT and PTP derivatives suggested that the compound with unsubstituted phenyl ring from PPT series led to selective and potent inhibition (6a; IC50= 0.33 +/- 0.02 mu M) of h-TNAP, whereas compound 6c selectively inhibited h-IAP isozyme with IC50 value of 0.86 +/- 0.04 mu M. Similarly, compounds 6b and 6h were identified as the lead scaffolds against h-NPP1 and h-NPP3, respectively. The probable binding modes for the most potent inhibitors were elucidated through molecular docking analysis. Structure-activity relationships, mechanism of action, cytotoxic effects and druglikeness properties are also discussed.

Recommanded Product: 100-19-6. Welcome to talk about 100-19-6, If you have any questions, you can contact Andleeb, H; Hameed, S; Ejaz, SA; Khan, I; Zaib, S; Lecka, J; Sevigny, J; Iqbal, J or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

An article Electrochemical Synthesis of beta-Ketosulfones from Switchable Starting Materials WOS:000508468200025 published article about H BOND FUNCTIONALIZATION; DIRECT OXYSULFONYLATION; SULFINIC ACIDS; KETO SULFONES; DIFUNCTIONALIZATION; CATALYSIS; ALKENES; ALKYNES; DERIVATIVES; STRATEGIES in in 2020.0, Cited 46.0. Category: benzodioxans. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6

A synthesis of beta-ketosulfones via sulfination of aryl methyl ketones and aryl acetylenes with sodium sulfinates under mild electrochemical conditions, in moderate to good chemical yields, is described. In particular, an electrochemical sulfination reaction of alkynes with sulfinate salts has never been explored. An environmentally friendly characteristic of this reaction is that it uses electricity as a valuable energy source for electrochemical synthesis of beta-ketosulfones. This strategy is more convenient and practical compared to previous approaches.

Welcome to talk about 100-19-6, If you have any questions, you can contact Yavari, I; Shaabanzadeh, S or send Email.. Category: benzodioxans

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 1-(4-Nitrophenyl)ethanone. Karuppusamy, A; Kannan, P in [Karuppusamy, A.; Kannan, P.] Anna Univ, Dept Chem, Chennai 600025, Tamil Nadu, India published Effect of substitution on pyrazoline based donor-acceptor molecules as luminescent and their electrochemical properties in 2020.0, Cited 47.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.

Highly fluorescent materials composed of donor-acceptor on pyrene-pyrazoline were synthesized and characterized by H-1 NMR and FT-IR techniques. The PP-OCH3, PP-Br and PP-NO2 exhibited blue, sky-blue, orange emissions under UV light 365 nm was confirmed by fluorescence spectrometer. The chromaticity diagram confirms their color purity of emission of organic materials. Photophysical properties namely optical band gap, quantum yield and lifetime of materials are investigated. Evaluation of Density Functional Theory confirm the responsibility of electron density on HOMO-LUMO energy levels. They demonstrated as semiconducting nature and disclose for the application in organic electronics.

Recommanded Product: 1-(4-Nitrophenyl)ethanone. Welcome to talk about 100-19-6, If you have any questions, you can contact Karuppusamy, A; Kannan, P or send Email.

Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem