Properties and Exciting Facts About 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone

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I2/CuCl2-promoted one-pot three-component synthesis of aliphatic or aromatic substituted 1,2,3-thiadiazoles

An efficient I2/CuCl2-promoted one-pot three-component strategy for the construction of 1,2,3-thiadiazoles from aliphatic- or aromatic-substituted methyl ketones, p-toluenesulfonyl hydrazide, and potassium thiocyanate has been developed. Simple and commercially available starting materials, a broad substrate scope, and excellent functional group tolerability make this strategy practical for applications. Furthermore, 1,2,3-thiadiazole synthesis was realized by using potassium thiocyanate as an odorless sulfur source.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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I2 promoted domino oxidative cyclization for one-pot synthesis of 2-acylbenzothiazoles via metal-free sp3 C-H functionalization

An I2 promoted domino protocol was developed to construct 2-acylbenzothiazoles from simple and readily available aromatic ketones/unsaturated methyl ketones and o-aminobenzenethiols. The reaction proceeded smoothly under metal-free and peroxide-free conditions.

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Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Archives for Chemistry Experiments of 2,3-Dihydrobenzo[b][1,4]dioxin-6-amine

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COMPOUNDS

Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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FLAVIN DERIVATIVES

The present invention relates novel flavin derivatives and other flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives. The invention also provides method of making novel flavin derivatives.

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Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

A new application about 2,3-Dihydrobenzo[b][1,4]dioxin-6-amine

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Synthesis, characterization and biological screening of some new sulfonamides derivatives of 1,4-benzodioxane-6-amine

In the present study, a series of N-substituted derivatives of 1,4-benzodioxane-6-amine have been synthesized. The reaction of 1,4-benzodioxane-6-amine (1) with various alkyl/aryl sulfonyl chlorides (2a-k) yielded N-alkyl/aryl sulfonamides (3a-k), which further on treatment with benzyl chloride (4) in the presence of sodium hydride furnished into N-benzylated sulfonamides (6a-k) while the reaction of 3a-k with ethyl iodide (5 ) yielded N-ethylated sulfonamides 7a-k. These derivatives were characterized by IR, 1H-NMR and EI-MS and then screened against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and lipoxygenase (LOX) enzymes and were found to be good inhibitors of lipoxygenase only. The interaction between inhibitors and target enzymes were computationally observed which correlates with the experimental results.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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A simple procedure for the synthesis of 3-(substituted-sulfanyl)-4-hydroxy-6-substituted-pyran-2-ones

A series of 3-(substituted sulfanyl)-4-hydroxy-6-substituted-pyran-2-ones were synthesized for Human immunodeficiency virus-1 protease inhibition. These compounds were synthesized in a simple and convergent fashion to allow us a rapid preparation of many structurally diversified analogues. Thus the condensation of trimethylsilyl enol ethers of corresponding ketones, with 2-(S-substituted)propane-1,3-dioates afforded the corresponding pyrones in 24-70% isolated yields.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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Cinnamamides, novel liver X receptor antagonists that inhibit ligand-induced lipogenesis and fatty liver

Liver X receptor (LXR) is a member of the nuclear receptor superfamily, and it regulates various biologic processes, including de novo lipogenesis, cholesterol metabolism, and inflammation. Selective inhibition of LXR may aid the treatment of nonalcoholic 1fatty liver diseases. In the present study, we evaluated the effects of three cinnamamide derivatives on ligand-induced LXRalpha activation and explored whether these derivatives could attenuate steatosis in mice. N-(4-trifluoromethylphenyl) 3,4-dimethoxycinnamamide (TFCA) decreased the luciferase activity in LXRE-tk-Luc-transfected cells and also suppressed ligand-induced lipid accumulation and expression of the lipogenic genes in murine hepatocytes. Furthermore, it significantly attenuated hepatic 1neutral lipid accumulation in a ligand-induced fatty liver mouse 1system. Modeling study indicated that TFCA inhibited activation of the LXRalpha ligand-binding domain by hydrogen bonding to Arg305 in the H5 region of that domain. It regulated the transcriptional control exerted by LXRalpha by influencing coregulator exchange; this process involves dissociation of the thyroid hormone receptor-associated proteins (TRAP)/DRIP coactivator and recruitment of the nuclear receptor corepressor. These results show that TFCA has the potential to attenuate ligand-induced lipogenesis and fatty liver by selectively inhibiting LXRalpha in the liver.

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Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Extracurricular laboratory:new discovery of 2,3-Dihydrobenzo[b][1,4]dioxin-6-amine

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SHMT INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

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Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders

The present invention discloses compounds according to Formula I: wherein Cy, R1, L1, R3, R4, R5, La, and Ra are as defined herein. Novel benzimidazoles according to Formula I, able to inhibit JAK are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic diseases, inflammatory diseases, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or hypersecretion of interferons.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

The Absolute Best Science Experiment for (S)-1,4-Benzodioxane-2-carboxylic acid

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HETEROARYL DISULFIDE COMPOUNDS AS ALLOSTERIC EFFECTORS FOR INCREASING THE OXYGEN-BINDING AFFINITY OF HEMOGLOBIN

This invention relates to compounds of Formula I: (Formula I), and pharmaceutically acceptable salt thereof, which are allosteric effectors that increase the oxygen-being affinity of hemoglobin, which are useful in the treatment of sickle cell disease, high altitude tissue hypoxia, and other conditions.

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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem