Tag: M.W:100-200

As a common heterocyclic compound, it belong benzodioxans compound,2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid,4442-54-0,Molecular formula: C9H8O4,mainly used in chemical industry, its synthesis route is as follows.,4442-54-0

General procedure: To a mixture of compound 3 (0.05g, 0.17 mmol) and the appropriate aromatic carboxylic acid (0.34 mmol) in anhydrous DMF (2 mL) under argon atmosphere, DIPEA (0.128 mL, 0.72 mmol) and HATU (0.168 g, 0.442 mmol) were added. The reaction mixture was stirred at rt for 24h or at 80¡ãC for 20h (for only 4i), and then quenched with water (30 mL). The aqueous layer was extracted with ethyl acetate (3¡Á20 mL) and the combined organic layers were washed with water and brine, dried over anhydrous Na2SO4, filtered, and the solvent was removed under reduced pressure. The resultant residue was purified by flash column chromatography on silica gel using the proper elution system to furnish the target compounds 4a?i in pure form. 4.3.9 4-((2-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carboxamido)benzo[d]thiazol-6-yl)oxy)-N-methyl-picolinamide (4i) Flash column chromatography was performed using a mixture of hexane and ethyl acetate (1:4 v/v). Yellowish white solid; yield 80.0percent; mp 153-155 ¡ãC; IR (KBr) nu/cm-1: 3393, 3068, 2926, 1682, 1586, 1552; 1H NMR (400 MHz, DMSO-d6) delta 12.79 (br. s, 1H, NHCO), 8.79 (q, J = 4.8 Hz, 1H, CONHMe), 8.53 (d, J = 5.2 Hz, 1H, Py-H6), 7.97 (d, J = 2.4 Hz, 1H, Py-H3), 7.89 (d, J = 8.8 Hz, 1H, BT-H4), 7.75 (d, J = 2.0 Hz, 1H, BD-H5), 7.72 (dd, J = 8.4, 2.4 Hz, 1H, BD-H7), 7.43 (d, J = 2.8 Hz, 1H, BT-H7), 7.33 (dd, J = 8.8, 2.4 Hz, 1H, Py-H5), 7.21 (dd, J = 5.6, 2.4 Hz, 1H, BT-H5), 7.04 (d, J = 8.4 Hz, 1H, BD-H8), 4.37-4.32 (m, 4H, BD-(CH2)2), 2.80 (d, J = 4.8 Hz, 3H, CH3); 13C NMR (100 MHz, DMSO-d6) delta 166.48, 165.45, 164.24, 160.02, 152.98, 150.95, 149.72, 148.14, 147.00, 143.66, 133.70, 124.88, 122.63, 122.35, 120.32, 117.89, 117.69, 114.76, 114.62, 109.42, 26.48; HRMS (ESI-TOF) m/z calcd for C23H18N4O5SNa [M+Na]+: 485.0896, found: 485.0890.

With the synthetic route has been constantly updated, we look forward to future research findings about 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid,belong benzodioxans compound

Reference£º
Article; El-Damasy, Ashraf Kareem; Lee, Ju-Hyeon; Seo, Seon Hee; Cho, Nam-Chul; Pae, Ae Nim; Keum, Gyochang; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 201 – 216;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

(2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol, cas is 274910-19-9, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

274910-19-9, [00209j A mixture of Intermediate 1(500mg, 1.5 mmol), (2,3-dihydrobenzo[b][1,4] dioxin-5-yl)methanol (380 mg, 2.3 mmol) and Cs2CO3 (1000 mg, 3.1 mmol) in DMSO (5 mL) was stirred for 2 days at 120 C. The reaction mixture was diluted with water andbrine (1:1, 50 mL) and extracted with EtOAc (2 x 30 mL). The combined organics were washed with brine, dried over Na2504 and concentrated in vacuo. The crude product was purified by column chromatography to yield the Example 2A (400 mg, 0.97 mmol, 63% yield), as a brown oil. MS (ESI) m/z 412.2 (M+H).

With the rapid development of chemical substances, we look forward to future research findings about (2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WURTZ, Nicholas R.; VIET, Andrew Quoc; SHAW, Scott A.; VOKITS, Benjamin P.; KICK, Ellen K.; VALENTE, Meriah Neissel; DILGER, Andrew K.; PABBISETTY, Kumar Balashanmuga; JUSUF, Sutjano; (140 pag.)WO2016/40417; (2016); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

Name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, as a common heterocyclic compound, it belongs to benzodioxans compound, and cas is 2879-20-1, its synthesis route is as follows.,2879-20-1

A solution of 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethanone (XXXII) (4.68 g, 26.3 mmol), dimethylamine hydrochloride (2.78 g, 34.1 mmol), paraformaldehyde (1.18 g, 39.4 mmol) and 12 N HCl (50 muL) in ethanol (8.0 mL) was refluxed overnight. The solution was cooled to room temperature and the ethanol was evaporated under vacuum. The residue was treated with EtOAc, heated slightly and sonicated to disperse into fine particles. The solids were filtered and dried at room temperature to produce 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(dimethylamino) propan-1-one hydrochloride as a white solid, (7.73 g, quantitative yield). The solid was cooled in minimum about of water (12 mL) and cooled to 0 C. A 20% aqueous solution of NaOH was added until pH=10. The solution was extracted with DCM, dried and evaporated to produce 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(dimethylamino) propan-1-one (XXXIII) a colorless oil (2.485 g, 10.6 mmol, 40.2% yield) 1H NMR (CDCl3, 500 MHz): delta ppm 2.77 (s, 6H), 3.41 (m, 2H), 3.56 (m, 2H), 4.25 (m, 4H), 6.85 (m, 1H), 7.45 (m, 2H); ESIMS found C13H17NO3 m/z 236 (M+H).

With the complex challenges of chemical substances, we look forward to future research findings about 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone

Reference£º
Patent; Kumar KC, Sunil; Wallace, David Mark; Hood, John; Barroga, Charlene F.; US2014/243349; (2014); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2879-20-1, 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,2879-20-1

General procedure: A series of sixteen novel 1, 4-benzodioxane-based thiosemicarbazones(3a-p) was synthesized by reacting appropriatethiosemicarbazide (1a-p) (5 mmol) and 1, 4-benzodioxan-6-ylmethyl ketone (2) (5 mmol) in methanol (15 mL) using glacialacetic acid (1e2 drops) as catalyst. Reflux at 80 C for 6 h wascarried out and the product formation and the reaction completion were examined by thin layer chromatography. Upon completion,the reaction mixturewas allowed to cool at r.t and the solid productwas collected by suction filtration followed by washing with hotmethanol and then dried in vacuum. Finally, the target thiosemicarbazonesderivatives were recrystallized from chloroformmethanolmixture (1:1) in good to excellent yields. The X-raymeasurements were read by mounting a 3m single crystal on agreased MiTe Gen loop and was inspected through thediffractometer (Bruker D8 Venture APEX diffractometer) at 296 (2)K by means of graphite-monochromated MoeK a radiation(l 0.71073 A); diffractometer was complimented with an areadetector (Photon 100 CCD) along with a cooler (Oxford Cryostream).APEX-II software was used to collect Data [41] and SAINTwas operated for integration [42] The SADABS (multi-scanapproach) was used for correction in absorption [43]. and intrinsicphasing (SHELXT)was employed to the solve the structure [44]. Fullleast squares refinement of all detected reflections were used todetermine the final cell constants and assign positions of all atomsother than H to the consequential difference maps via refinementagainst F2. Whereas H atoms were assigned location and addedagainst F2 and were refined by riding model. SHELXL-97 wasimplemented to refine anisotropically [45]. The CCDC (CSD depositionnumbers 1874544) of the structure has been deposited. Thedetailed characterization of compounds 3a e 3p are given insupporting informations.

The synthetic route of 2879-20-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Shehzad, Muhammad Tariq; Khan, Ajmal; Islam, Muhammad; Hameed, Abdul; Khiat, Mohammed; Halim, Sobia Ahsan; Anwar, Muhammad U.; Shah, Syed Raza; Hussain, Javid; Csuk, Rene; Khan, Samra; Al-Harrasi, Ahmed; Shafiq, Zahid; Journal of Molecular Structure; vol. 1209; (2020);,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belongs to benzodioxans compound, name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, and cas is 2879-20-1, its synthesis route is as follows.,2879-20-1

General procedure: To 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-one(A) (1 mmol) alcohol solution (5 mL) was added substituted benzaldehyde(1 mmol). After dissolution, 50% NaOH (0.5 mL) was added. After confirming the completion of the reaction by thin layer chromatography, the sediment was filtered, washed with ethanol and dried to obtain chalcone

With the complex challenges of chemical substances, we look forward to future research findings about 2879-20-1,belong benzodioxans compound

Reference£º
Article; Yang, Yu-Shun; Yang, Bing; Zou, Yan; Li, Guigen; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 24; 13; (2016); p. 3052 – 3061;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belongs to benzodioxans compound, name is 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid, and cas is 4442-54-0, its synthesis route is as follows.,4442-54-0

In a round bottom flask, 1 ,4-Benzodioxane-6-carboxylic acid (1.00 g, .5.55 mmol) and thionyl chloride (6.04 mL, 83.33 mmol) was mixed together and refluxed for 2 h. The reaction was concentrated in vacuo, then 25 mL of toluene was added to the residue, and the slurry was concentrated again to obtain the title product 6 as a solid (0.77 g, 70percent)

With the rapid development of chemical substances, we look forward to future research findings about 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid

Reference£º
Patent; OHIO STATE INNOVATION FOUNDATION; SUO, Zucai; VYAVHARE, Vinod, P.; TAGGART, David, J.; WO2014/145207; (2014); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO209,mainly used in chemical industry, its synthesis route is as follows.,3663-80-7

General procedure: The dipeptides after appropriate deprotection and the amino acid methyl esters were coupled with 1,4-benzodioxane-2-carboxylic acid using DCC as acoupling reagent and TEA as a base in different reaction conditions like microwave, sonication, refluxing and conventional methods to give the desired products (2a-2e) (Scheme-2).

With the complex challenges of chemical substances, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,belong benzodioxans compound

Reference£º
Article; Malipeddi, Himaja; Gowda, Visruth; Das, Moonjit; Indian Journal of Heterocyclic Chemistry; vol. 25; 2; (2015); p. 113 – 118;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belongs to benzodioxans compound, name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, and cas is 2879-20-1, its synthesis route is as follows.,2879-20-1

General procedure: To 1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)ethan-1-one(A) (1 mmol) alcohol solution (5 mL) was added substituted benzaldehyde(1 mmol). After dissolution, 50% NaOH (0.5 mL) was added. After confirming the completion of the reaction by thin layer chromatography, the sediment was filtered, washed with ethanol and dried to obtain chalcone

With the complex challenges of chemical substances, we look forward to future research findings about 2879-20-1,belong benzodioxans compound

Reference£º
Article; Yang, Yu-Shun; Yang, Bing; Zou, Yan; Li, Guigen; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 24; 13; (2016); p. 3052 – 3061;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belong benzodioxans compound,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,2879-20-1,Molecular formula: C10H10O3,mainly used in chemical industry, its synthesis route is as follows.,2879-20-1

Sodium cyanoborohydride (18.7 mg, 0.3 mmol) was added to a mixture of intermediate 27 (50 mg, 0.2 mmol, hydrochloric acid salt), 6-acetyl-l,4-benzodioxane (CAS: 2879- 20-1; 70.7 mg, 3.97 mmol), triethylamine (0.069 mL, 0.5 mmol) and Ti(OiPr)4 (0.076 mL, 0.26 mmol) in anhydrous MeOH (0.48 mL). The resulting suspension was stirred at rt for 16 h and then the mixture was heated at 70 C and further stirred for 16 h. The mixture was cooled to rt and then filtered through a celite pad and the volatiles were evaporated in vacuo. Water and EtOAc were added. The organic phase was separated, dried over Na2S04, filtered and the filtrate was evaporated in vacuo. The resultant oil was purified by RP HPLC (Stationary phase: CI 8 XBridge 30 x 100 mm 5 muiotaeta), mobile phase: gradient from 47% 10 mM NH4CO3H pH 9 solution in water, 53% MeOH to 24% 10 mM NH4CO3H pH 9 solution in water, 76% MeOH) to yield product 40 as a white solid (20 mg, 27% yield).

With the synthetic route has been constantly updated, we look forward to future research findings about 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,belong benzodioxans compound

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose, Manuel; TRABANCO-SUAREZ, Andres, Avelino; MARTINEZ VITURRO, Carlos, Manuel; TRESADERN, Gary, John; ALCAZAR-VACA, Manuel, Jesus; (126 pag.)WO2018/109198; (2018); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

It is a common heterocyclic compound, the benzodioxans compound, 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid, cas is 3663-80-7 its synthesis route is as follows.,3663-80-7

Example 27 d6-[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)-piperazin-1-yl]-(2,3-dihydro-benzo1,4]dioxin-2-yl)-methanone hydrochloride salt A mixture of 1,4-benzodioxane-6-carboxylic acid (901 mg, 5 mmol), piperazine (431 mg, 5 mmol) and hexamethyldisilazane (1.61 g, 10 mmol) was heated to 110¡ã C. for 15 hours. The reaction was cooled, concentrated, and purified by column chromatography to yield 2,3-dihydro-benzo[1,4]dioxin-2-yl)-piperazin-1-yl-methanone (400 mg, 32percent). 1H NMR (300 MHz, CDCl3) delta 6.94-6.85 (m, 4H), 4.84 (dd, J=8.1, 2.4 Hz, 1H), 4.52 (dd, J=12.0, 2.4 Hz, 1H), 4.330 (dd, J=12.0, 8.1 Hz, 1H), 3.75 (m, 2H), 3.56 (m, 2H), 2.99-2.91 (m, 4H); ESI-MS m/z 249 (M+H).

With the complex challenges of chemical substances, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid

Reference£º
Patent; AUSPEX PHARMACEUTICALS, INC.; US2008/39473; (2008); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem