Tag: M.W:100-200

20197-75-5, Methyl 1,4-Benzodioxan-6-carboxylate is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In the atmosphere of nitrogen,Dimethyl dimethyl phosphate (514 mg, 4.15 mmol, 1.5 eq) was dissolved in 5 ml of dry tetrahydrofuran,Cool to -60¡ãC with dry ice/ethanol.Slowly add n-butyllithium (2.2 mL, 2.5 mol/mL)N-hexane solution, 5.54 mmol, 2 eq),The mixture is stirred at this temperature for 30 minutes.A solution of the compound benzodioxane-6-carboxylic acid methyl ester (0402-119) (538 mg, 2.77 mmol, 1 eq) in tetrahydrofuran (1 ml) was slowly added dropwise.The mixture was stirred at -60¡ãC for 1 hour.After the reaction is completed, quenched with saturated aqueous ammonium chloride, using BEthyl acetate was extracted and the organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the target product (2-(Benzo)Dioxane-6-yl)-2-oxoethyl) dimethyl phosphate (754 mg, crude) was a yellow oil., 20197-75-5

The synthetic route of 20197-75-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3663-80-7,2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,as a common compound, the synthetic route is as follows.,3663-80-7

Method I Ba (1 mmol) and 2,3-dihydrobenzo[b][1,4]dioxin-6-carboxylic acid (or 2,3-dihydrobenzo[b][1,4]dioxin-2-carboxylic acid) (1 mmol) together with EDCI (1.5 mmol) and HOBt (0.05 mmol) in CH2Cl2 (20 mL) were refluxed at room temperature for 10 h. While the reaction completed, the solution was washed with water for three times (30 mL each time). The remaining water layer was extracted by EtOAc for three times (30 mL each time). The organic layers (CH2Cl2 and EtOAc) were combined and then evaporated. The separated solid was crystallized from mixture of DMF and ethanol (9:1) to obtain the corresponding compound as translucent solid. 4.5.20 (3-(4-Bromophenyl)-5-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl)(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanone (D5) Yellow crystal, mp: 198-201 ¡ãC. 1H NMR (CDCl3, 300 MHz) delta: 3.17-3.24 (d, J = 17.4 Hz, 1H), 3.67-3.75 (m, 1H), 3.80 (s, 3H), 4.32-4.37 (m, 1H), 4.58-4.62 (d, J = 10.8 Hz, 1H), 5.54-5.58 (m, 2H), 6.82-6.90 (m, 6H), 7.12-7.15 (d, J = 9.0 Hz, 2H), 7.49-7.52 (d, J = 8.1 Hz, 2H), 7.77-7.80 (d, J = 7.8 Hz, 2H). MS (ESI): 493.07 (C25H22BrN2O4, [M+H]+). Anal. Calcd for C25H21BrN2O4: C, 60.86; H, 4.29; Br, 16.20; N, 5.68; O, 12.97. Found: C, 60.68; H, 4.28; N, 5.71.

The synthetic route of 3663-80-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Yang, Yu-Shun; Li, Qing-Shan; Sun, Shuai; Zhang, Yan-Bin; Wang, Xiao-Liang; Zhang, Fei; Tang, Jian-Feng; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 20; 20; (2012); p. 6048 – 6058;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4442-54-0,2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid,as a common compound, the synthetic route is as follows.

Preparation of Compound 133, N-(4-Fluoro-3-nitrophenyl)-2,3-dihydro-1,4- benzodioxine-7-carboxamide[00173] 2,3-Dihydrobenzo[b][1 ,4]dioxine-6-carboxylic acid (2.77 g, 15.37 mmol) was dissoved in DMA (25 mL) and DIPEA (6.69 mL, 38.43 mmol) and HATU (5.85 g, 15.37 mmol) added under an inert atmosphere. The reaction was allowed to stir for 15 minutes then 4-fluoro-3-nitroaniline (2.000 g, 12.81 mmol) was added and the reaction stirred at ambient temperature overnight. The reaction was heated for a further 16 hours at 40 ¡ãC then concentrated in vacuo and water added. The solids were isolated by filtration, washed with water and dried in a vacuum oven. The solids were stirred in EtOAc for an hour and then filtered. The filtrate was evaporated down and the solids were triturated with DCM then filtered. The collected solids were combined to afford the desired material as a cream solid (3.50 g, 86 percent).1H NMR (400 MHz, DMSO, 30 ¡ãC) d 4.29 – 4.36 (4H, m), 7.02 (1 H, d), 7.50 – 7.63 (3H, m), 8.15 (1 H, ddd), 8.69 (1 H, dd), 10.46 (1 H, s). m/z (ES+) (M+H)+ = 319.

4442-54-0, As the paragraph descriping shows that 4442-54-0 is playing an increasingly important role.

Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; JONES, Keith; RYE, Carl; CHESSUM, Nicola; CHEESEMAN, Matthew; PASQUA, Adele Elisa; PIKE, Kurt Gordon; FAULDER, Paul Frank; WO2015/49535; (2015); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, cas is 2879-20-1, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

To a stirred solution of coptisine (250 mg, 0.70 mmol) in 5 N NaOH (1 ml), 6-acetyl-1,4-benzodioxane (1 mL,6.67 mmol) was added slowly. The reaction mixture was stirred at 60C for 3 h. The reaction mixture was extracted withCHCl3/MeOH (v/v = 10:1). The organic layer was washed to neutral with water, and dried over anhydrous MgSO4, andfiltered, and then concentrated under reduced pressure to give intermediate product. The intermediate product wasdissolved in anhydrous tetrahydrofuran (5 mL) followed by addition of HOAc (0.5 mL) and formaldehyde (1.5 mL, 15.06mmol) dropwise. The reaction mixture was kept refluxing for 3 h. After the reaction completed, the reaction mixture wasconcentrated and added with 2 N HCl (2 mL), then stirred at room temperature for 1 h and extracted with CHCl3/MeOH(v/v = 10:1). The organic layer was dried over anhydrous MgSO4 and then filtered and concentrated under reducedpressure to give crude product, which was purified via silica gel column chromatography (CHCl3/MeOH (v/v) =20:1) togive pure yellow solid (110 mg, 28.1% yield).1H-NMR (DMSO-d6) delta: 2.95 (s, 3H, ArCH3), 2.99-3.14 (m, 2H, NCH2CH2), 4.37 (br d, J= 9.0 Hz, 4H, O CH2CH2O), 4.54(br s, 2H, NCH2CH2), 6.19 (s, 2H, OCH2O), 6.24 (s, 1H, OCH2O), 6.44 (s, 1H, OCH2O), 6.86 (s, 1H, C=CH2), 6.99 (s,1H, C=CH2), 7.10 (d, J = 8.4 Hz, 1H, ArH),7.17 (s, 1H, ArH), 7.44 (s, 1H, ArH), 7.45 (d, J = 2.1 Hz, 2H, ArH), 7.54 (dd,J1 = 8.4 Hz, J2 = 2.1 Hz, 1H, ArH), 8.07 (s, 2H, ArH)., 2879-20-1

As the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

Reference£º
Patent; Institute of Mataria Medica, Chinese Academy of Medical Sciences; QIN, Hailin; WANG, Wenjie; ZHANG, Zhihui; WU, Lianqiu; DENG, Anjun; YU, Jinqian; LI, Zhihong; EP2789612; (2014); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde, cas is 29668-44-8, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

General procedure: To a mixture of aldehyde (10.0 mmol) in 30% methanol aqueous solution, NH2OH¡¤HCl (0.695 g, 10.0 mmol) was added slowly. After the NH2OH¡¤HCl was fully dissolved, Na2CO3 (0.53 g 5.0 mmol) was added and then the resulting mixture was stirred at room temperature for 2 h. The reaction mixture was diluted with water and extracted with CH2Cl2. The organic phase was dried to afford intermediate a’ as white solids., 29668-44-8

As the rapid development of chemical substances, we look forward to future research findings about 29668-44-8

Reference£º
Article; Niu, Chao; Yin, Li; Nie, Li Fei; Dou, Jun; Zhao, Jiang Yu; Li, Gen; Aisa, Haji Akber; Bioorganic and Medicinal Chemistry; vol. 24; 21; (2016); p. 5440 – 5448;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2879-20-1, 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: 2-phenyl-N-(pyridin-2-yl)imidazo[1,2-a]pyridin-3-amine 3a: A sealed tube was charged with acetophenone 1a (120 mg, 1 mmol), iodine (380.7 mg, 1.5 mmol) and DMSO (3 mL) at room temperature. The resulting mixture was stirred at 100 C. After disappearance of the reactant (monitored by TLC), 2-aminopyridine 2a (188 mg, 2.0 mmol) was added and the mixture was heated to 100 C for 2 h. After completion of the reaction and addition of water (50 mL), the mixture was extracted with EtOAc (3 ¡Á 50 mL). The extract was washed with 10% aqueous Na2S2O3 solution, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: Petr/EtOAc = 3:1) to yield the desired product 3a as a white solid (214.6 mg, 75% yield)

2879-20-1, The synthetic route of 2879-20-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Fei, Zhuan; Zhu, Yan-Ping; Liu, Mei-Cai; Jia, Feng-Cheng; Wu, An-Xin; Tetrahedron Letters; vol. 54; 10; (2013); p. 1222 – 1226;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

4442-53-9,2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid, cas is 4442-53-9, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

Synthesis of 7-(chlorosulfonyl)-2,3-dihydrobenzo[b] [l,4]dioxine-5-carboxylic acid (XIII):To a stirred solution of 2,3-dihydrobenzo[b][l,4]dioxine-5-carboxylic acid XII (0.5 g, 2.77 mmol) was added chlorosulphonic acid (1.2 ml, 16.6 mmol) at 0¡ãC under nitrogen atmosphere and the resulting mixture was heated at 70¡ãC for 3 h. After completion of reaction, the reaction mixture was cooled, quenched with ice and extracted with DCM. The organic layer was dried over Na2S04 and evaporated under reduced pressure to afford product XIII in 75percent yield.

As the rapid development of chemical substances, we look forward to future research findings about 4442-53-9

Reference£º
Patent; AGIOS PHARMACEUTICALS, INC.; SALITURO, Francesco, G.; SAUNDERS, Jeffrey, O.; WO2011/72174; (2011); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde, cas is 29668-44-8, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

General procedure: Aqueous NaOH (1.6 mL of 6 M solution) was added to a stirred solution of the urea-hydrogen peroxide complex (1:1) (6 g, 63.4 mmol) and aldehyde 3a-f (4.28 mmol) in 20 mL of CH3OH at rt. The reaction mixture was stirred at reflux for 1 h followed by the addition of the urea-hydrogen peroxide complex (1.5 g, 15.85 mmol) and reflux for 30 min. The reaction mixture was brought to rt, and the pH was adjusted to 3 with 18percent aqueous HCl. The precipitate was filtered, washed with 2 50 mL of ice water, and dried to afford 4a-f (82-94percent yield) as an off-white solid. For 4e, the reaction mixture was brought to rt, and the pH was adjusted to 3 with 18percent aqueous HCl. Methanol was evaporated, then the reaction mixture was diluted by 30 ml of water and extracted by CHCl3. Organic solution was washed by water, evaporated, and dried., 29668-44-8

As the rapid development of chemical substances, we look forward to future research findings about 29668-44-8

Reference£º
Article; Titov, Ilia Y.; Sagamanova, Irina K.; Gritsenko, Roman T.; Karmanova, Irina B.; Atamanenko, Olga P.; Semenova, Marina N.; Semenov, Victor V.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 6; (2011); p. 1578 – 1581;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

274910-19-9, (2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,274910-19-9

A solution of the above alcohol (3.75 g, 32.3 mmol) in Et2O (80mL) was cooled to 0 C and phosphorous tribromide (3.67 mL, 38.8mmol) was added dropwise. The solution was stirred at 0 C for 10min, then at 20 C for 1 h. Water (10 mL) was added cautiously toquench the excess of reagent and the mixture was diluted withdiethyl ether and washed with water (3 50 mL). The combinedorganic layers were washed with brine (100 mL), dried over Na2-SO4, filtered and concentrated under reduced pressure to obtain5-(bromomethyl)-2,3-dihydrobenzo[b][1,4]dioxine as a brownsolid (4.61 g, 62%). 1H NMR (CDCl3, 400 MHz) d 6.91-6.77 (m,3H), 4.52 (s, 2H), 4.35-4.33 (m, 2H), 4.29-4.27 (m, 2H). Found:[M+H-Br] = 149.5.

As the paragraph descriping shows that 274910-19-9 is playing an increasingly important role.

Reference£º
Article; Sutherland, Hamish S.; Tong, Amy S.T.; Choi, Peter J.; Conole, Daniel; Blaser, Adrian; Franzblau, Scott G.; Cooper, Christopher B.; Upton, Anna M.; Lotlikar, Manisha U.; Denny, William A.; Palmer, Brian D.; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 1797 – 1809;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

29668-44-8, 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,29668-44-8

General procedure: To a mixture of aldehyde 1 (10.0 mmol) in 30% methanol aqueous solution, NH2OH¡¤HCl (0.695 g, 10.0 mmol) was added slowly. After the NH2OH¡¤HCl was fully dissolved, Na2CO3 (0.53 g 5.0 mmol) was added and then the resulting mixture was stirred at room temperature for 2 h. The reaction mixture was diluted with water and extracted with CH2Cl2. The organic phase was dried to afford intermediate 2 as white solids.

The synthetic route of 29668-44-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pang, Guang Xian; Niu, Chao; Mamat, Nuramina; Aisa, Haji Akber; Bioorganic and Medicinal Chemistry Letters; vol. 27; 12; (2017); p. 2674 – 2677;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem