Tag: M.W:100-200

Methyl 1,4-Benzodioxan-6-carboxylate, cas is 20197-75-5, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

A stirred solution of compound 3 (0.1 mol) in ethanol (50 mL) was treated with the hydrazine hydrate (85%), under 90 C for 5 d. The sovlent was removed leaving oil which was dissolved in ethyl acetate (20 mL) and extracted with water (40 mL). After drying the organic layer with anhydrous Na2SO4 and evaporating the solvent under reduced pressure a solid appeared. The solid was recrystallized from ethanol to obtain the compound 6., 20197-75-5

As the rapid development of chemical substances, we look forward to future research findings about 20197-75-5

Reference£º
Article; Sun, Juan; Lv, Peng-Cheng; Guo, Feng-Jiao; Wang, Xin-Yi; Han, Xiao-; Zhang, Yang; Sheng, Gui-Hua; Qian, Shao-Song; Zhu, Hai-Liang; European Journal of Medicinal Chemistry; vol. 81; (2014); p. 420 – 426;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid, cas is 3663-80-7, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

Benzo-dioxane-2-carboxylic acid was added, 100 ml of absolute ethanol was added, and 10 ml of concentrated sulfuric acid was added, and the mixture was refluxed at 80 ¡ã C overnight (TLC). After the completion of the reaction, the reaction mixture was distilled under reduced pressure to one-fifth of its original volume, and 40 ml of water was added thereto. The mixture was extracted three times with ethyl acetate, washed with saturated NaHC03 solution and saturated NaCl solution, dried over MgS04 and distilled under reduced pressure to give The resulting ester, 2. Ommol, was dissolved in 30 ml of absolute ethanol and 2. l mmol of hydrazine hydrate 80 was added and refluxed overnight (TLC). Acetophenone (5.0 mmol) and benzaldehyde (5.1 mmol) were dissolved in 20 ml of ethanol, followed by magnetic separation. The resulting mixture was stirred at room temperature for 2 hours. After the completion of the reaction, the reaction mixture was distilled under reduced pressure until ethanol was distilled off. Stirring 10min to make the mixture hook, slowly dropping 40percent Na0H solution 10ml, magnetic stirring, room temperature reaction 2h (TLC detection reaction progress), the product of solid precipitation. After filtration, the solid was washed with a large amount of distilled water and finally washed three times with cold ethanol (3 ml each time) and dried. The product was mixed with ethanol and acetone (volume ratio of ethanol: acetone = 1: 1) The resulting hydrazide was dissolved in 25 ml of absolute ethanol and dissolved in 80 ¡ã C. The reaction was stirred at 80 ¡ã C for 20 h (TLC detection). After the completion of the reaction, the ethanol was evaporated to dryness under reduced pressure. The resulting mixture was subjected to column chromatography, and the first substance (raw material chalcone) was discarded using a developing solvent having a volume ratio of petroleum ether to ethyl acetate = 10: The mixed solution containing the second substance (target product) was distilled under reduced pressure to distill off the whole of the solvent to obtain the target product as a crude product, which was recrystallized from a mixture of ethanol and acetone (volume ratio of ethanol: acetone = 10: 1) The product (white crystals), 3663-80-7

With the rapid development of chemical substances, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid

Reference£º
Patent; Nanjing University; Zhu, Hai Liang; Yang, yushun; Ding, Shu Ting; Zhang, Fei; Zhang, Yan Bin; Wang, Xiao Liang; Tang, Jian Feng; (22 pag.)CN103304546; (2016); B;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, cas is 2879-20-1, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.

2879-20-1, General procedure: A mixture of acetophenone 4a (120 mg, 1.0 mmol), iodine (254 mg, 1.0 mmol), and CuO (88 mg, 1.1 mmol) in anhydrous methanol (10 mL) was heated at reflux, after disappearance of the reactant (1-12 h, monitored by TLC), 1,2-diamines 2a (108 mg, 1.0 mmol) and K3PO4*3H2O (266 mg, 1.0 mmol) was added and the mixture was stirred for 12 h at 40 C. The solvent was removed under reduced pressure, and 50 mL water was added to mixture, extracted with EtOAc three times (3¡Á50 mL). The extract was washed with Na2S2O3, dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by column chromatography on silica gel using petroleum ether/EtOAc as the eluent to give the expected products 6aa as pale yellow solid, (80% yield).

With the rapid development of chemical substances, we look forward to future research findings about 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone

Reference£º
Article; Lian, Mi; Li, Qi; Zhu, Yanping; Yin, Guodong; Wu, Anxin; Tetrahedron; vol. 68; 47; (2012); p. 9598 – 9605;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

31127-39-6, 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

177 mg of the intermediate XXV was dissolved in ethanol, a catalytic amount of palladium hydroxide was added, the air was replaced and hydrogen was introduced, and the reaction was carried out at 30-60 C. for 6 hours. After the reaction was completed, ethanol was distilled off under reduced pressure, and water was added to the residue. Ester extraction, without purification, gives the intermediate 1,4-benzodioxane-7-methylamine directly for the next reaction, 31127-39-6

The synthetic route of 31127-39-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; East China University of Science and Technology; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Li Jian; Lan Lefu; Ni Shuaishuai; Chen Feifei; Wei Hanwen; Li Baoli; Liu Yifu; Mao Fei; Zhu Jin; (157 pag.)CN108117534; (2018); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

2-(2,3-dihydrobenzo[b] [l,4]dioxin-6-yl)acetic acid (S10-2).; A mixture of 1 ,4- benzodioxan-6-yl methyl ketone (SI 0-1; 5.5 g, 30.9 mmol), sulfur (1.98 g, 61.8 mmol) and morpholine (6.73 g, 6.76 mL, 77.3 mmol) was refluxed at 140C for 14 h. After cooling to rt, the reaction mixture was diluted with 150 mL of CH2C12, transferred to a seperatory funnel and washed with 25 mL of ice-cold brine. The aqueous layer was further extracted with CH2C12 (2 x 75 mL). The organic layers were combined, dried with Na2S04, and filtered. Activated charcoal was added to the filtrate and after several minutes was filtered and concentrated to give 12.7 g of a brown oil. A mixture of this in 75 mL of 10% KOH (ag.) was refluxed for 12h. After cooling the reaction mixture was transferred to a seperatory funnel and washed with ether (30 mL), The aqueous layer was acidified with 6N HC1 (~25 mL) to pH 2 and extracted with CH2C12 (4 x 100 mL). The organic layers were combined, washed with distilled water (100 ml), dried with Na2S04 and filtered. This was treated with charcoal, filtered, and solvent removed under reduced pressure and the resulting residue was purified by chromatography (hexane:EtOAc, 90:10 to 70:30) to give 3.90 g (65%) of S10-2. 1H NMR (500 MHz, CDC13) delta 6.80-6.82 (m, 2H), 6.74 (dd, J= 2.0, 8.2 Hz, 1H), 4.24 (s, 4H), 3.53 (s, 2H); MS (ESI) m/z 195.1 [M+H]+., 2879-20-1

As the paragraph descriping shows that 2879-20-1 is playing an increasingly important role.

Reference£º
Patent; SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; CHIOSIS, Gabriela; TALDONE, Tony; SUN, Weilin; WO2011/44394; (2011); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

General procedure: Finely powdered CuO (0.8 g, 10.0 mmol) and I2 (2.53 g, 10.0 mmol) were added to a solution of aryl methyl ketone 9a (1.2 g, 10.0 mmol) in anhydrous MeOH (20 mL). The mixture was refluxed for 1-2.5 h. After disappearance of aryl methyl ketone 9a (monitored by TLC), the mixture was filtered and the solvent was removed under reduced pressure. The residue was poured into 10% Na2S2O3 solution (50 mL), the mixture was extracted with EtOAc (3 ¡Á 50 mL), and the organic layer was dried (Na2SO4). Removal of the solvent and purification of the residue by column chromatography gave the desired product 1a in 96% yield.

2879-20-1, The synthetic route of 2879-20-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhu, Yan-Ping; Cai, Qun; Gao, Qing-He; Jia, Feng-Cheng; Liu, Mei-Cai; Gao, Meng; Wu, An-Xin; Tetrahedron; vol. 69; 31; (2013); p. 6392 – 6398;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3663-80-7,2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,as a common compound, the synthetic route is as follows.,3663-80-7

2-iodophenol as raw materials, synthesis of racemic doxazosin, the reaction line as follows:1. Synthesis of Compound c: The same procedure as in Example 1, c.2. Synthesis of compound f (i.e., doxazosin racemate)Compounds c were weighed into eggplant flasks,Plus tetrahydrofuran dissolved,The mixture was stirred for 5-10 minutes at room temperature until compound c was completely dissolved.N, N’-carbonyldiimidazole (1.1 equiv) was weighed and dissolved in tetrahydrofuran,Was slowly added dropwise to the above solution,The mixture was stirred at room temperature for 1 hour,The solution A was obtained.Another take a pickle-shaped bottle,The compound g (2-piperazinyl-4-amino-6,7-dimethoxyquinazoline) (1.0 equiv)Followed by stirring for 10 minutes with tetrahydrofuran. Solution A was slowly added dropwise to solution B at 0 ¡ã C, and the reaction was allowed to proceed to room temperature for 4 hours after completion of dropwise addition. The solid was filtered off. The solid was dissolved in acetone and refluxed for 6 hours. Upon cooling to room temperature, the solid was filtered off and washed with acetone and dried to give a white solid as Compound f (doxazosin racemate). Yield 80percent

3663-80-7 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid 2735450, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Patent; Guangzhou Institute Of Biomedicine And Health Chinese Academy Of Sciences; Cai, Qian; Huang, Yusha; (17 pag.)CN105985328; (2016); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

274910-19-9, (2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,274910-19-9

N5-Cyclobutyl-N3-methyl-2-oxo-1, 2-d ihydropyrid ine-3,5-d icarboxamide (50 mg, 0.201mmol), (2,3-dihydrobenzo[b][1,4]dioxin-5-yl)methanol (50.0 mg, 0.301 mmol) and 2-(tributylphosphoranylidene)acetonitrile (0.166 mL, 0.632 mmol) were combined in toluene (1.5 mL)and the reaction mixture heated in a 5 mL microwave vial on a Biotage Initiator microwave at 120C for 30 mm. The reaction mixture was poured onto water (20 mL), and extracted with ethylacetate (3 x 10 mL). The combined organic portions were evaporated in vacuo to yield the crude product as a brown oil. The product was loaded in dichloromethane onto a 25 g SNAP silica cartridge and purified via Biotage 5P4 flash chromatography, eluting from 50 – 100 % ethyl acetate/cyclohexane. The relevant fractions were combined and evaporated in vacuo – yielding 76mg of product. The sample was dissolved in MeOH/DMSO (1 mL, 1:1) and purified by MDAP (Formic). The solvent was evaporated in vacuoto give the required product – N5-cyclobutyl-1-((2,3- dihyd robenzo[b] [1,4]d ioxin-5-yl)methyl)-N3-methyl-2-oxo-1, 2-d ihydropyrid ine-3,5-dicarboxamide(40 mg, 0.096 mmol, 47.7 % yield).LCMS (2 mm Formic): Rt = 0.95 mi [MH] = 398.1.

274910-19-9 (2,3-Dihydrobenzo[b][1,4]dioxin-5-yl)methanol 2776182, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; AYLOTT, Helen Elizabeth; COOPER, Anthony William James; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; HAYHOW, Thomas George Christopher; LINDON, Matthew J; PRESTON, Alexander G; SEAL, Jonathan Thomas; WALL, Ian David; WATSON, Robert J; WOOLVEN, James Michael; (308 pag.)WO2017/37116; (2017); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.

General procedure: A series of sixteen novel 1, 4-benzodioxane-based thiosemicarbazones(3a-p) was synthesized by reacting appropriatethiosemicarbazide (1a-p) (5 mmol) and 1, 4-benzodioxan-6-ylmethyl ketone (2) (5 mmol) in methanol (15 mL) using glacialacetic acid (1e2 drops) as catalyst. Reflux at 80 C for 6 h wascarried out and the product formation and the reaction completion were examined by thin layer chromatography. Upon completion,the reaction mixturewas allowed to cool at r.t and the solid productwas collected by suction filtration followed by washing with hotmethanol and then dried in vacuum. Finally, the target thiosemicarbazonesderivatives were recrystallized from chloroformmethanolmixture (1:1) in good to excellent yields. The X-raymeasurements were read by mounting a 3m single crystal on agreased MiTe Gen loop and was inspected through thediffractometer (Bruker D8 Venture APEX diffractometer) at 296 (2)K by means of graphite-monochromated MoeK a radiation(l 0.71073 A); diffractometer was complimented with an areadetector (Photon 100 CCD) along with a cooler (Oxford Cryostream).APEX-II software was used to collect Data [41] and SAINTwas operated for integration [42] The SADABS (multi-scanapproach) was used for correction in absorption [43]. and intrinsicphasing (SHELXT)was employed to the solve the structure [44]. Fullleast squares refinement of all detected reflections were used todetermine the final cell constants and assign positions of all atomsother than H to the consequential difference maps via refinementagainst F2. Whereas H atoms were assigned location and addedagainst F2 and were refined by riding model. SHELXL-97 wasimplemented to refine anisotropically [45]. The CCDC (CSD depositionnumbers 1874544) of the structure has been deposited. Thedetailed characterization of compounds 3a e 3p are given insupporting informations., 2879-20-1

2879-20-1 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone 76143, abenzodioxans compound, is more and more widely used in various fields.

Reference£º
Article; Shehzad, Muhammad Tariq; Khan, Ajmal; Islam, Muhammad; Hameed, Abdul; Khiat, Mohammed; Halim, Sobia Ahsan; Anwar, Muhammad U.; Shah, Syed Raza; Hussain, Javid; Csuk, Rene; Khan, Samra; Al-Harrasi, Ahmed; Shafiq, Zahid; Journal of Molecular Structure; vol. 1209; (2020);,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

A common heterocyclic compound, the benzodioxans compound, name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,cas is 2879-20-1, mainly used in chemical industry, its synthesis route is as follows.

General procedure: 3.3. Reaction procedure for the synthesis of 5a The reaction was conducted in a 10 mL of V-type ask equippedwith triangle magnetic stirring. In a typical reaction, 1a(0.20 mmol) was mixed with 2a (0.20 mmol) and 4a (0.20 mmol)and BF3Et2O (50 mol %) in nitromethane (1.0 mL). The mixturewas then stirred at 80 Cforve hours. After reaction, 5a wasobtained by isolation with preparative TLC (eluting solution: pe-troleum ether/ethyl acetate5/1 (v/v)) in 77% (0.15 mmol, 51.1 mg)yield.

2879-20-1, As the rapid development of chemical substances, we look forward to future research findings about 2879-20-1

Reference£º
Article; Wang, Man; Liu, Changhui; Gu, Yanlong; Tetrahedron; vol. 72; 43; (2016); p. 6854 – 6865;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem